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P52724 (MTB_CHAAC) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Metallothionein B
Short name=MT-B
Gene names
Name:mtb
OrganismChaenocephalus aceratus (Blackfin icefish) (Chaenichthys aceratus)
Taxonomic identifier36190 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Notothenioidei › Channichthyidae › Chaenocephalus

Protein attributes

Sequence length60 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
   LigandMetal-binding
Metal-thiolate cluster
Gene Ontology (GO)
   Molecular functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6060Metallothionein B
PRO_0000197274

Regions

Region1 – 2828Beta
Region29 – 6032Alpha

Sites

Metal binding41Divalent metal cation; cluster B
Metal binding61Divalent metal cation; cluster B
Metal binding121Divalent metal cation; cluster B
Metal binding141Divalent metal cation; cluster B
Metal binding181Divalent metal cation; cluster B
Metal binding201Divalent metal cation; cluster B
Metal binding231Divalent metal cation; cluster B
Metal binding251Divalent metal cation; cluster B
Metal binding281Divalent metal cation; cluster B
Metal binding321Divalent metal cation; cluster A
Metal binding331Divalent metal cation; cluster A
Metal binding351Divalent metal cation; cluster A
Metal binding361Divalent metal cation; cluster A
Metal binding401Divalent metal cation; cluster A
Metal binding431Divalent metal cation; cluster A
Metal binding471Divalent metal cation; cluster A
Metal binding491Divalent metal cation; cluster A
Metal binding541Divalent metal cation; cluster A
Metal binding581Divalent metal cation; cluster A
Metal binding591Divalent metal cation; cluster A

Sequences

Sequence LengthMass (Da)Tools
P52724 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: EF61F4AD61B9124A

FASTA606,006
        10         20         30         40         50         60 
MDPCECTKSG TCNCGGSCTC TNCSCTSCKK SCCPCCPSGC TKCASGCVCK GKTCDTSCCQ

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References

[1]"Difference in hepatic metallothionein content in Antarctic red-blooded and haemoglobinless fish: undetectable metallothionein levels in haemoglobinless fish is accompanied by accumulation of untranslated metallothionein mRNA."
Scudiero R., Carginale V., Riggio M., Capasso C., Capasso A., Kille P., di Prisco G., Parisi E.
Biochem. J. 322:207-211(1997) [PubMed: 9078263] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z72483 mRNA. Translation: CAA96564.1.

3D structure databases

ProteinModelPortalP52724.
SMRP52724. Positions 2-29, 31-60.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
Gene3DG3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHERPTHR23299. Metallothionein_vert. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. Metallothionein_sfam. 1 hit.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTB_CHAAC
AccessionPrimary (citable) accession number: P52724
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 19, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Metallothioneins

Classification of metallothioneins and list of entries

SIMILARITY comments

Index of protein domains and families

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