Reviewed,
UniProtKB/Swiss-Prot P52723 (MT_CARAU)
Last modified
November 24, 2009.
Version 50.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (2) |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Metallothionein Short name=MT | ||
| Gene names |
| ||
| Organism | Carassius auratus (Goldfish) | ||
| Taxonomic identifier | 7957 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Carassius |
Protein attributes
| Sequence length | 60 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Metal-thiolate cluster |
| Gene Ontology (GO) | |
| Molecular function | metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 60 | 60 | Metallothionein | PRO_0000197270 | |||||
Regions | |||||||||
| Region | 1 – 28 | 28 | Beta | ||||||
| Region | 29 – 60 | 32 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 4 | 1 | Cluster B | ||||||
| Metal binding | 6 | 1 | Cluster B | ||||||
| Metal binding | 12 | 1 | Cluster B | ||||||
| Metal binding | 14 | 1 | Cluster B | ||||||
| Metal binding | 18 | 1 | Cluster B | ||||||
| Metal binding | 20 | 1 | Cluster B | ||||||
| Metal binding | 23 | 1 | Cluster B | ||||||
| Metal binding | 25 | 1 | Cluster B | ||||||
| Metal binding | 28 | 1 | Cluster B | ||||||
| Metal binding | 32 | 1 | Cluster A | ||||||
| Metal binding | 33 | 1 | Cluster A | ||||||
| Metal binding | 35 | 1 | Cluster A | ||||||
| Metal binding | 36 | 1 | Cluster A | ||||||
| Metal binding | 40 | 1 | Cluster A | ||||||
| Metal binding | 43 | 1 | Cluster A | ||||||
| Metal binding | 47 | 1 | Cluster A | ||||||
| Metal binding | 49 | 1 | Cluster A | ||||||
| Metal binding | 54 | 1 | Cluster A | ||||||
| Metal binding | 58 | 1 | Cluster A | ||||||
| Metal binding | 59 | 1 | Cluster A | ||||||
Experimental info | |||||||||
| Sequence conflict | 5 | 1 | D → E in AAB32777. Ref.2 | ||||||
| Sequence conflict | 34 | 1 | S → F in AAB32777. Ref.2 | ||||||
| Sequence conflict | 50 | 1 | K → N in AAB32777. Ref.2 | ||||||
Sequences
References
| [1] | "The use of metallothionein genes for determining the phylogenetic and evolutionary relationship between extant teleosts." Kille P., Olsson P.-E. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "PCR-cloning of goldfish and tilapia metallothionein complementary DNAs." Chan K.M. Biochem. Biophys. Res. Commun. 205:368-374(1994) [PubMed: 7999050] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| X97271 mRNA. Translation: CAA65926.1. S75039 mRNA. Translation: AAB32777.1. | |
| PIR | JC2419. |
3D structure databases | |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | P52723. |
Family and domain databases | |
| InterPro | IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MT_CARAU | ||||||||
| Accession | Primary (citable) accession number: P52723 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |
