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Reviewed, UniProtKB/Swiss-Prot P52722 (MT1_DANRE)

Last modified November 24, 2009. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Metallothionein-1
      Short name=MT-1
Gene names
Name: mt
Synonyms: mt1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

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Protein attributes

Sequence length60 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

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Ontologies

Keywords
   LigandMetal-binding
Metal-thiolate cluster
Gene Ontology (GO)
   Biological processresponse to cadmium ion

Inferred from direct assay. Source: ZFIN

   Molecular functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6060Metallothionein-1
PRO_0000197268

Regions

Region1 – 2828Beta
Region29 – 6032Alpha

Sites

Metal binding41Cluster B
Metal binding61Cluster B
Metal binding121Cluster B
Metal binding141Cluster B
Metal binding181Cluster B
Metal binding201Cluster B
Metal binding231Cluster B
Metal binding251Cluster B
Metal binding281Cluster B
Metal binding321Cluster A
Metal binding331Cluster A
Metal binding351Cluster A
Metal binding361Cluster A
Metal binding401Cluster A
Metal binding431Cluster A
Metal binding471Cluster A
Metal binding491Cluster A
Metal binding541Cluster A
Metal binding581Cluster A
Metal binding591Cluster A

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Sequences

Sequence LengthMass (Da)Tools
P52722-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E5223E7C292BB700

FASTA605,960
        10         20         30         40         50         60 
MDPCECAKTG ACNCGATCKC TNCQCTTCKK SCCSCCPSGC SKCASGCVCK GNSCGTSCCQ

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References

[1]"The use of metallothionein genes for determining the phylogenetic and evolutionary relationship between extant teleosts."
Kille P., Olsson P.-E.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X97278 mRNA. Translation: CAA65933.1.
IPIIPI00481680.
RefSeqNP_571150.1.
UniGeneDr.20068

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP52722.

Proteomic databases

PRIDEP52722.

Genome annotation databases

EnsemblENSDART00000061007; ENSDARP00000061006; ENSDARG00000041623; Danio rerio. [Genome view]
GeneID30282.
KEGGdre:30282.

Organism-specific databases

CTD30282.
ZFINZDB-GENE-990415-159. mt.

Phylogenomic databases

HOGENOMP52722.
HOVERGENP52722.

Gene expression databases

ArrayExpressP52722.
BgeeP52722.

Family and domain databases

InterProIPR017854. Metallothionein_sfam.
IPR003019. Metallothionein_sfam_euk.
IPR000006. Metallothionein_vert.
IPR018064. Metallothionein_vert_metal_BS.
[Graphical view]
Gene3DG3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHERPTHR23299. Metallothionein_vert. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameMT1_DANRE
AccessionPrimary (citable) accession number: P52722
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 24, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

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Relevant documents

Metallothioneins

Classification of metallothioneins and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents