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Protein

Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

Gene

alh-8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity).By similarity

Catalytic activityi

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.
3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei307 – 3071NucleophilePROSITE-ProRule annotation
Binding sitei407 – 4071NADSequence analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi199 – 2035NADSequence analysis
Nucleotide bindingi251 – 2566NADSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-CEL-70895. Branched-chain amino acid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (EC:1.2.1.18, EC:1.2.1.27)
Short name:
MMSDH
Short name:
Malonate-semialdehyde dehydrogenase [acylating]
Gene namesi
Name:alh-8
ORF Names:F13D12.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF13D12.4a; CE02183; WBGene00000114; alh-8.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222MitochondrionBy similarityAdd
BLAST
Chaini23 – 523501Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrialPRO_0000007191Add
BLAST

Proteomic databases

EPDiP52713.
PaxDbiP52713.
PRIDEiP52713.

2D gel databases

World-2DPAGE0011:P52713.
0020:P52713.

Expressioni

Gene expression databases

BgeeiWBGene00000114.
ExpressionAtlasiP52713. baseline.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi40105. 1 interaction.
DIPiDIP-25038N.
MINTiMINT-1076511.
STRINGi6239.F13D12.4a.2.

Structurei

3D structure databases

ProteinModelPortaliP52713.
SMRiP52713. Positions 20-510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2449. Eukaryota.
ENOG410XNP1. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271507.
InParanoidiP52713.
KOiK00140.
OMAiSNVKPNM.
OrthoDBiEOG091G06SO.
PhylomeDBiP52713.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
PANTHERiPTHR11699:SF183. PTHR11699:SF183. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRLARVQP KCQQLAHFST SKSAAAAPTV KLWIDGQAVE SKTTDFVELT
60 70 80 90 100
NPATNEVIAM VPNATQAEMQ AAVDSAKNAF NTWKNTSPLT RQQCMFKLQA
110 120 130 140 150
LIKRDMKKLA ESITIEQGKT LPDAEGDVSR GLQVVEHACS VPSLMMGETL
160 170 180 190 200
PNVSRDMDTH SYRIPLGVTA GICPFNFPAM IPLWMFPVAL ATGNTMVIKP
210 220 230 240 250
SEQDPGAAQL LVELAKEAGV PDGCVNIIHG QHSAVNFICD NPDIKAISFV
260 270 280 290 300
GGDAAGKHIY ERGAKNGKRV QSNMGAKNHG VIMADANKEQ TLNQLTAAAF
310 320 330 340 350
GAAGQRCMAL TTAVLVGEAR AWLPELVEKA KNLKVNAGWK PDTDIGPLIS
360 370 380 390 400
KQSKARVLRL IESAKKEGAQ VPLDGSNITV PGFENGNFVG PTILAGVKPN
410 420 430 440 450
MTCYREEIFG PVLVVMEAEN LNEAIEIINN NPYGNGTAIF TSNGATARKF
460 470 480 490 500
TNEVDVGQIG INVPIPVPLP MFSFTGSRGS FLGDLNFYGK AGIQFYTQWK
510 520
TVTQYWNESL TELKPQMSFP QLK
Length:523
Mass (Da):56,462
Last modified:October 1, 1996 - v1
Checksum:i2871499FE3267A29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49127 Genomic DNA. Translation: CAA88946.1.
PIRiT20828.
RefSeqiNP_001022078.1. NM_001026907.2.
UniGeneiCel.17786.

Genome annotation databases

EnsemblMetazoaiF13D12.4a.1; F13D12.4a.1; WBGene00000114.
F13D12.4a.2; F13D12.4a.2; WBGene00000114.
F13D12.4a.3; F13D12.4a.3; WBGene00000114.
GeneIDi174800.
KEGGicel:CELE_F13D12.4.
UCSCiF13D12.4a.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49127 Genomic DNA. Translation: CAA88946.1.
PIRiT20828.
RefSeqiNP_001022078.1. NM_001026907.2.
UniGeneiCel.17786.

3D structure databases

ProteinModelPortaliP52713.
SMRiP52713. Positions 20-510.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40105. 1 interaction.
DIPiDIP-25038N.
MINTiMINT-1076511.
STRINGi6239.F13D12.4a.2.

2D gel databases

World-2DPAGE0011:P52713.
0020:P52713.

Proteomic databases

EPDiP52713.
PaxDbiP52713.
PRIDEiP52713.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF13D12.4a.1; F13D12.4a.1; WBGene00000114.
F13D12.4a.2; F13D12.4a.2; WBGene00000114.
F13D12.4a.3; F13D12.4a.3; WBGene00000114.
GeneIDi174800.
KEGGicel:CELE_F13D12.4.
UCSCiF13D12.4a.2. c. elegans.

Organism-specific databases

CTDi174800.
WormBaseiF13D12.4a; CE02183; WBGene00000114; alh-8.

Phylogenomic databases

eggNOGiKOG2449. Eukaryota.
ENOG410XNP1. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271507.
InParanoidiP52713.
KOiK00140.
OMAiSNVKPNM.
OrthoDBiEOG091G06SO.
PhylomeDBiP52713.

Enzyme and pathway databases

ReactomeiR-CEL-70895. Branched-chain amino acid catabolism.

Miscellaneous databases

PROiP52713.

Gene expression databases

BgeeiWBGene00000114.
ExpressionAtlasiP52713. baseline.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
PANTHERiPTHR11699:SF183. PTHR11699:SF183. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMMSA_CAEEL
AccessioniPrimary (citable) accession number: P52713
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.