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Reviewed, UniProtKB/Swiss-Prot P52713 (MMSA_CAEEL)

Last modified November 3, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
      Short name=MMSDH
      Short name=Malonate-semialdehyde dehydrogenase [acylating]
    EC=1.2.1.27
    EC=1.2.1.18
Gene names
Name: alh-8
ORF Names: F13D12.4
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA By similarity.

Catalytic activity

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.

3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2222Mitochondrion By similarity
Chain23 – 523501Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
PRO_0000007191

Regions

Nucleotide binding199 – 2035NAD Potential
Nucleotide binding251 – 2566NAD Potential

Sites

Active site3071Nucleophile By similarity
Binding site4071NAD Potential

Sequences

Sequence LengthMass (Da)Tools
P52713-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 2871499FE3267A29

FASTA52356,462
        10         20         30         40         50         60 
MLSRLARVQP KCQQLAHFST SKSAAAAPTV KLWIDGQAVE SKTTDFVELT NPATNEVIAM 

        70         80         90        100        110        120 
VPNATQAEMQ AAVDSAKNAF NTWKNTSPLT RQQCMFKLQA LIKRDMKKLA ESITIEQGKT 

       130        140        150        160        170        180 
LPDAEGDVSR GLQVVEHACS VPSLMMGETL PNVSRDMDTH SYRIPLGVTA GICPFNFPAM 

       190        200        210        220        230        240 
IPLWMFPVAL ATGNTMVIKP SEQDPGAAQL LVELAKEAGV PDGCVNIIHG QHSAVNFICD 

       250        260        270        280        290        300 
NPDIKAISFV GGDAAGKHIY ERGAKNGKRV QSNMGAKNHG VIMADANKEQ TLNQLTAAAF 

       310        320        330        340        350        360 
GAAGQRCMAL TTAVLVGEAR AWLPELVEKA KNLKVNAGWK PDTDIGPLIS KQSKARVLRL 

       370        380        390        400        410        420 
IESAKKEGAQ VPLDGSNITV PGFENGNFVG PTILAGVKPN MTCYREEIFG PVLVVMEAEN 

       430        440        450        460        470        480 
LNEAIEIINN NPYGNGTAIF TSNGATARKF TNEVDVGQIG INVPIPVPLP MFSFTGSRGS 

       490        500        510        520 
FLGDLNFYGK AGIQFYTQWK TVTQYWNESL TELKPQMSFP QLK 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.

Cross-references

Sequence databases

Z49127 Genomic DNA. Translation: CAA88946.1.
PIRT20828.
RefSeqNP_001022078.1.
UniGeneCel.17786

3D structure databases

HSSPHSSP built from PDB template 1O9J based on UniProtKB Q28399.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:25038N.
IntActP52713. 1 interaction.
STRINGP52713.

Proteomic databases

PRIDEP52713.

Genome annotation databases

EnsemblF13D12.4a.1; F13D12.4a.1; F13D12.4; Caenorhabditis elegans. [Genome view]
F13D12.4a.2; F13D12.4a.2; F13D12.4; Caenorhabditis elegans. [Genome view]
F13D12.4a.3; F13D12.4a.3; F13D12.4; Caenorhabditis elegans. [Genome view]
GeneID174800.
KEGGcel:F13D12.4.
UCSCF13D12.4a.2. c. elegans.

Organism-specific databases

CTD174800.
WormBaseWBGene00000114. alh-8.
WormPepF13D12.4. CE02183. [WorfDB]

Phylogenomic databases

OMAAIFVGES.

Enzyme and pathway databases

BRENDA1.2.1.18. 672.
1.2.1.27. 672.

Gene expression databases

ArrayExpressP52713.

Family and domain databases

InterProIPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PTHR11699:SF27. MMSDH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01722. MMSDH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio885562.

Entry information

Entry nameMMSA_CAEEL
AccessionPrimary (citable) accession number: P52713
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 3, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents