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P52710 (CBPY_PICPG) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase Y

EC=3.4.16.5
Alternative name(s):
Carboxypeptidase YSCY
Gene names
Name:PRC1
Ordered Locus Names:PAS_chr1-4_0013
OrganismKomagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) [Reference proteome]
Taxonomic identifier644223 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKomagataella

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in degradation of small peptides.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole. Note: Lysosome-like vacuoles.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 10787
PRO_0000004291
Chain108 – 523416Carboxypeptidase Y
PRO_0000004292

Sites

Active site2491 By similarity
Active site4411 By similarity
Active site4981 By similarity

Amino acid modifications

Glycosylation1931N-linked (GlcNAc...) Potential
Glycosylation2711N-linked (GlcNAc...) Potential
Glycosylation4841N-linked (GlcNAc...) Potential
Glycosylation4871N-linked (GlcNAc...) Potential
Disulfide bond162 ↔ 401 By similarity
Disulfide bond296 ↔ 310 By similarity
Disulfide bond320 ↔ 343 By similarity
Disulfide bond327 ↔ 336 By similarity
Disulfide bond365 ↔ 371 By similarity

Sequences

Sequence LengthMass (Da)Tools
P52710 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: CA6093BDE2E9D178

FASTA52359,448
        10         20         30         40         50         60 
MILHTYIILS LLTIFPKAIG LSLQMPMALE ASYASLVEKA TLAVGQEIDA IQKGIQQGWL 

        70         80         90        100        110        120 
EVETRFPTIV SQLSYSTGPK FAIKKKDATF WDFYVESQEL PNYRLRVKRN NPEVLKVDFT 

       130        140        150        160        170        180 
KQYSGYLDVE ADDKHFFYWF FESRNDPQND PIILWLNGGP GCSSLTGLFF ELGSSRINEN 

       190        200        210        220        230        240 
LKPIFNPYSW NGNASIIYLD QPVNVGFSYS SSSVSNTVVA GEDVYAFLQL FFQHFPEYQT 

       250        260        270        280        290        300 
NDFHIAGESY AGHYIPVFAD EILSQKNRNF NLTSVLIGNG LTDPLTQYRY YEPMACGEGG 

       310        320        330        340        350        360 
APSVLPADEC ENMLVTQDKC LSLIQACYDS QSAFTCAPAA IYCNNAQMGP YQRTGKNVYD 

       370        380        390        400        410        420 
IRKECDGGSL CYKDLEFIDT YLNQKFVQDA LGAEVDTYES CNFEINRNFL FAGDWMKPYH 

       430        440        450        460        470        480 
EHVSSLLNKG LPVLIYAGDK DFICNWLGNR AWTDVLPWVD ADGFEKAEVQ DWLVNGRKAG 

       490        500        510        520 
EFKNYSNFTY LRVYDAGHMA PYDQPENSHE MVNRWISGDF SFH 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the Pichia pastoris PRC1 gene encoding carboxypeptidase Y."
Ohi H., Ohtani W., Okazaki N., Furuhata N., Ohmura T.
Yeast 12:31-40(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 108-142.
[2]"Genome sequence of the recombinant protein production host Pichia pastoris."
De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S., Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.
Nat. Biotechnol. 27:561-566(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GS115 / ATCC 20864.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X87987 Genomic DNA. Translation: CAA61240.1.
FN392319 Genomic DNA. Translation: CAY67847.1.
PIRS61713.
RefSeqXP_002490128.1. XM_002490083.1.

3D structure databases

ProteinModelPortalP52710.
SMRP52710. Positions 108-522.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING644223.PAS_chr1-4_0013.

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAY67847; CAY67847; PAS_chr1-4_0013.
GeneID8196853.
KEGGppa:PAS_chr1-4_0013.

Phylogenomic databases

eggNOGCOG2939.
HOGENOMHOG000198296.
KOK13289.
OrthoDBEOG7XDBR1.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPY_PICPG
AccessionPrimary (citable) accession number: P52710
Secondary accession number(s): C4QX74
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 22, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries