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Protein

Carboxypeptidase Y

Gene

PRC1

Organism
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in degradation of small peptides.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei249By similarity1
Active sitei441By similarity1
Active sitei498By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERipicpa-cbpy Carboxypeptidase_S10
MEROPSiS10.001

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y (EC:3.4.16.5)
Alternative name(s):
Carboxypeptidase YSCY
Gene namesi
Name:PRC1
Ordered Locus Names:PAS_chr1-4_0013
OrganismiKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Taxonomic identifieri644223 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella
Proteomesi
  • UP000000314 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000000429121 – 1071 PublicationAdd BLAST87
ChainiPRO_0000004292108 – 523Carboxypeptidase YAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi162 ↔ 401By similarity
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi296 ↔ 310By similarity
Disulfide bondi320 ↔ 343By similarity
Disulfide bondi327 ↔ 336By similarity
Disulfide bondi365 ↔ 371By similarity
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi487N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi644223.XP_002490128.1

Structurei

3D structure databases

ProteinModelPortaliP52710
SMRiP52710
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
HOGENOMiHOG000198296
InParanoidiP52710
KOiK13289
OMAiMDNALPR
OrthoDBiEOG092C1EU7

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR008442 Propeptide_carboxypepY
IPR033124 Ser_caboxypep_his_AS
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF05388 Carbpep_Y_N, 1 hit
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILHTYIILS LLTIFPKAIG LSLQMPMALE ASYASLVEKA TLAVGQEIDA
60 70 80 90 100
IQKGIQQGWL EVETRFPTIV SQLSYSTGPK FAIKKKDATF WDFYVESQEL
110 120 130 140 150
PNYRLRVKRN NPEVLKVDFT KQYSGYLDVE ADDKHFFYWF FESRNDPQND
160 170 180 190 200
PIILWLNGGP GCSSLTGLFF ELGSSRINEN LKPIFNPYSW NGNASIIYLD
210 220 230 240 250
QPVNVGFSYS SSSVSNTVVA GEDVYAFLQL FFQHFPEYQT NDFHIAGESY
260 270 280 290 300
AGHYIPVFAD EILSQKNRNF NLTSVLIGNG LTDPLTQYRY YEPMACGEGG
310 320 330 340 350
APSVLPADEC ENMLVTQDKC LSLIQACYDS QSAFTCAPAA IYCNNAQMGP
360 370 380 390 400
YQRTGKNVYD IRKECDGGSL CYKDLEFIDT YLNQKFVQDA LGAEVDTYES
410 420 430 440 450
CNFEINRNFL FAGDWMKPYH EHVSSLLNKG LPVLIYAGDK DFICNWLGNR
460 470 480 490 500
AWTDVLPWVD ADGFEKAEVQ DWLVNGRKAG EFKNYSNFTY LRVYDAGHMA
510 520
PYDQPENSHE MVNRWISGDF SFH
Length:523
Mass (Da):59,448
Last modified:October 1, 1996 - v1
Checksum:iCA6093BDE2E9D178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87987 Genomic DNA Translation: CAA61240.1
FN392319 Genomic DNA Translation: CAY67847.1
PIRiS61713
RefSeqiXP_002490128.1, XM_002490083.1

Genome annotation databases

EnsemblFungiiCAY67847; CAY67847; PAS_chr1-4_0013
GeneIDi8196853
KEGGippa:PAS_chr1-4_0013

Similar proteinsi

Entry informationi

Entry nameiCBPY_KOMPG
AccessioniPrimary (citable) accession number: P52710
Secondary accession number(s): C4QX74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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