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P52710

- CBPY_PICPG

UniProt

P52710 - CBPY_PICPG

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Protein

Carboxypeptidase Y

Gene
PRC1, PAS_chr1-4_0013
Organism
Komagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in degradation of small peptides.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei249 – 2491 By similarity
Active sitei441 – 4411 By similarity
Active sitei498 – 4981 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y (EC:3.4.16.5)
Alternative name(s):
Carboxypeptidase YSCY
Gene namesi
Name:PRC1
Ordered Locus Names:PAS_chr1-4_0013
OrganismiKomagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Taxonomic identifieri644223 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKomagataella
ProteomesiUP000000314: Chromosome 1

Subcellular locationi

Vacuole
Note: Lysosome-like vacuoles.

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Propeptidei21 – 10787PRO_0000004291Add
BLAST
Chaini108 – 523416Carboxypeptidase YPRO_0000004292Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi162 ↔ 401 By similarity
Glycosylationi193 – 1931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi271 – 2711N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi296 ↔ 310 By similarity
Disulfide bondi320 ↔ 343 By similarity
Disulfide bondi327 ↔ 336 By similarity
Disulfide bondi365 ↔ 371 By similarity
Glycosylationi484 – 4841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi487 – 4871N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi644223.PAS_chr1-4_0013.

Structurei

3D structure databases

ProteinModelPortaliP52710.
SMRiP52710. Positions 108-522.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000198296.
KOiK13289.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52710-1 [UniParc]FASTAAdd to Basket

« Hide

MILHTYIILS LLTIFPKAIG LSLQMPMALE ASYASLVEKA TLAVGQEIDA    50
IQKGIQQGWL EVETRFPTIV SQLSYSTGPK FAIKKKDATF WDFYVESQEL 100
PNYRLRVKRN NPEVLKVDFT KQYSGYLDVE ADDKHFFYWF FESRNDPQND 150
PIILWLNGGP GCSSLTGLFF ELGSSRINEN LKPIFNPYSW NGNASIIYLD 200
QPVNVGFSYS SSSVSNTVVA GEDVYAFLQL FFQHFPEYQT NDFHIAGESY 250
AGHYIPVFAD EILSQKNRNF NLTSVLIGNG LTDPLTQYRY YEPMACGEGG 300
APSVLPADEC ENMLVTQDKC LSLIQACYDS QSAFTCAPAA IYCNNAQMGP 350
YQRTGKNVYD IRKECDGGSL CYKDLEFIDT YLNQKFVQDA LGAEVDTYES 400
CNFEINRNFL FAGDWMKPYH EHVSSLLNKG LPVLIYAGDK DFICNWLGNR 450
AWTDVLPWVD ADGFEKAEVQ DWLVNGRKAG EFKNYSNFTY LRVYDAGHMA 500
PYDQPENSHE MVNRWISGDF SFH 523
Length:523
Mass (Da):59,448
Last modified:October 1, 1996 - v1
Checksum:iCA6093BDE2E9D178
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87987 Genomic DNA. Translation: CAA61240.1.
FN392319 Genomic DNA. Translation: CAY67847.1.
PIRiS61713.
RefSeqiXP_002490128.1. XM_002490083.1.

Genome annotation databases

EnsemblFungiiCAY67847; CAY67847; PAS_chr1-4_0013.
GeneIDi8196853.
KEGGippa:PAS_chr1-4_0013.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87987 Genomic DNA. Translation: CAA61240.1 .
FN392319 Genomic DNA. Translation: CAY67847.1 .
PIRi S61713.
RefSeqi XP_002490128.1. XM_002490083.1.

3D structure databases

ProteinModelPortali P52710.
SMRi P52710. Positions 108-522.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 644223.PAS_chr1-4_0013.

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAY67847 ; CAY67847 ; PAS_chr1-4_0013 .
GeneIDi 8196853.
KEGGi ppa:PAS_chr1-4_0013.

Phylogenomic databases

eggNOGi COG2939.
HOGENOMi HOG000198296.
KOi K13289.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the Pichia pastoris PRC1 gene encoding carboxypeptidase Y."
    Ohi H., Ohtani W., Okazaki N., Furuhata N., Ohmura T.
    Yeast 12:31-40(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 108-142.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GS115 / ATCC 20864.

Entry informationi

Entry nameiCBPY_PICPG
AccessioniPrimary (citable) accession number: P52710
Secondary accession number(s): C4QX74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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