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Protein

Carboxypeptidase Y

Gene

PRC1

Organism
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in degradation of small peptides.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei249By similarity1
Active sitei441By similarity1
Active sitei498By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERipicpa-cbpy. Carboxypeptidase_S10.
MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y (EC:3.4.16.5)
Alternative name(s):
Carboxypeptidase YSCY
Gene namesi
Name:PRC1
Ordered Locus Names:PAS_chr1-4_0013
OrganismiKomagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Taxonomic identifieri644223 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeKomagataella
Proteomesi
  • UP000000314 Componenti: Chromosome 1

Subcellular locationi

  • Vacuole

  • Note: Lysosome-like vacuoles.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000000429121 – 1071 PublicationAdd BLAST87
ChainiPRO_0000004292108 – 523Carboxypeptidase YAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi162 ↔ 401By similarity
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1
Glycosylationi271N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi296 ↔ 310By similarity
Disulfide bondi320 ↔ 343By similarity
Disulfide bondi327 ↔ 336By similarity
Disulfide bondi365 ↔ 371By similarity
Glycosylationi484N-linked (GlcNAc...)Sequence analysis1
Glycosylationi487N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi644223.XP_002490128.1.

Structurei

3D structure databases

ProteinModelPortaliP52710.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOGENOMiHOG000198296.
InParanoidiP52710.
KOiK13289.
OMAiPLTQYEY.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR008442. Propeptide_carboxypepY.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILHTYIILS LLTIFPKAIG LSLQMPMALE ASYASLVEKA TLAVGQEIDA
60 70 80 90 100
IQKGIQQGWL EVETRFPTIV SQLSYSTGPK FAIKKKDATF WDFYVESQEL
110 120 130 140 150
PNYRLRVKRN NPEVLKVDFT KQYSGYLDVE ADDKHFFYWF FESRNDPQND
160 170 180 190 200
PIILWLNGGP GCSSLTGLFF ELGSSRINEN LKPIFNPYSW NGNASIIYLD
210 220 230 240 250
QPVNVGFSYS SSSVSNTVVA GEDVYAFLQL FFQHFPEYQT NDFHIAGESY
260 270 280 290 300
AGHYIPVFAD EILSQKNRNF NLTSVLIGNG LTDPLTQYRY YEPMACGEGG
310 320 330 340 350
APSVLPADEC ENMLVTQDKC LSLIQACYDS QSAFTCAPAA IYCNNAQMGP
360 370 380 390 400
YQRTGKNVYD IRKECDGGSL CYKDLEFIDT YLNQKFVQDA LGAEVDTYES
410 420 430 440 450
CNFEINRNFL FAGDWMKPYH EHVSSLLNKG LPVLIYAGDK DFICNWLGNR
460 470 480 490 500
AWTDVLPWVD ADGFEKAEVQ DWLVNGRKAG EFKNYSNFTY LRVYDAGHMA
510 520
PYDQPENSHE MVNRWISGDF SFH
Length:523
Mass (Da):59,448
Last modified:October 1, 1996 - v1
Checksum:iCA6093BDE2E9D178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87987 Genomic DNA. Translation: CAA61240.1.
FN392319 Genomic DNA. Translation: CAY67847.1.
PIRiS61713.
RefSeqiXP_002490128.1. XM_002490083.1.

Genome annotation databases

EnsemblFungiiCAY67847; CAY67847; PAS_chr1-4_0013.
GeneIDi8196853.
KEGGippa:PAS_chr1-4_0013.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87987 Genomic DNA. Translation: CAA61240.1.
FN392319 Genomic DNA. Translation: CAY67847.1.
PIRiS61713.
RefSeqiXP_002490128.1. XM_002490083.1.

3D structure databases

ProteinModelPortaliP52710.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi644223.XP_002490128.1.

Protein family/group databases

ESTHERipicpa-cbpy. Carboxypeptidase_S10.
MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAY67847; CAY67847; PAS_chr1-4_0013.
GeneIDi8196853.
KEGGippa:PAS_chr1-4_0013.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOGENOMiHOG000198296.
InParanoidiP52710.
KOiK13289.
OMAiPLTQYEY.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR008442. Propeptide_carboxypepY.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPY_KOMPG
AccessioniPrimary (citable) accession number: P52710
Secondary accession number(s): C4QX74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.