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P52710

- CBPY_PICPG

UniProt

P52710 - CBPY_PICPG

Protein

Carboxypeptidase Y

Gene

PRC1

Organism
Komagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in degradation of small peptides.

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei249 – 2491By similarity
    Active sitei441 – 4411By similarity
    Active sitei498 – 4981By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y (EC:3.4.16.5)
    Alternative name(s):
    Carboxypeptidase YSCY
    Gene namesi
    Name:PRC1
    Ordered Locus Names:PAS_chr1-4_0013
    OrganismiKomagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris)
    Taxonomic identifieri644223 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKomagataella
    ProteomesiUP000000314: Chromosome 1

    Subcellular locationi

    Vacuole
    Note: Lysosome-like vacuoles.

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 107871 PublicationPRO_0000004291Add
    BLAST
    Chaini108 – 523416Carboxypeptidase YPRO_0000004292Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi162 ↔ 401By similarity
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi296 ↔ 310By similarity
    Disulfide bondi320 ↔ 343By similarity
    Disulfide bondi327 ↔ 336By similarity
    Disulfide bondi365 ↔ 371By similarity
    Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Interactioni

    Protein-protein interaction databases

    STRINGi644223.PAS_chr1-4_0013.

    Structurei

    3D structure databases

    ProteinModelPortaliP52710.
    SMRiP52710. Positions 108-522.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2939.
    HOGENOMiHOG000198296.
    KOiK13289.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P52710-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILHTYIILS LLTIFPKAIG LSLQMPMALE ASYASLVEKA TLAVGQEIDA    50
    IQKGIQQGWL EVETRFPTIV SQLSYSTGPK FAIKKKDATF WDFYVESQEL 100
    PNYRLRVKRN NPEVLKVDFT KQYSGYLDVE ADDKHFFYWF FESRNDPQND 150
    PIILWLNGGP GCSSLTGLFF ELGSSRINEN LKPIFNPYSW NGNASIIYLD 200
    QPVNVGFSYS SSSVSNTVVA GEDVYAFLQL FFQHFPEYQT NDFHIAGESY 250
    AGHYIPVFAD EILSQKNRNF NLTSVLIGNG LTDPLTQYRY YEPMACGEGG 300
    APSVLPADEC ENMLVTQDKC LSLIQACYDS QSAFTCAPAA IYCNNAQMGP 350
    YQRTGKNVYD IRKECDGGSL CYKDLEFIDT YLNQKFVQDA LGAEVDTYES 400
    CNFEINRNFL FAGDWMKPYH EHVSSLLNKG LPVLIYAGDK DFICNWLGNR 450
    AWTDVLPWVD ADGFEKAEVQ DWLVNGRKAG EFKNYSNFTY LRVYDAGHMA 500
    PYDQPENSHE MVNRWISGDF SFH 523
    Length:523
    Mass (Da):59,448
    Last modified:October 1, 1996 - v1
    Checksum:iCA6093BDE2E9D178
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87987 Genomic DNA. Translation: CAA61240.1.
    FN392319 Genomic DNA. Translation: CAY67847.1.
    PIRiS61713.
    RefSeqiXP_002490128.1. XM_002490083.1.

    Genome annotation databases

    EnsemblFungiiCAY67847; CAY67847; PAS_chr1-4_0013.
    GeneIDi8196853.
    KEGGippa:PAS_chr1-4_0013.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87987 Genomic DNA. Translation: CAA61240.1 .
    FN392319 Genomic DNA. Translation: CAY67847.1 .
    PIRi S61713.
    RefSeqi XP_002490128.1. XM_002490083.1.

    3D structure databases

    ProteinModelPortali P52710.
    SMRi P52710. Positions 108-522.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 644223.PAS_chr1-4_0013.

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAY67847 ; CAY67847 ; PAS_chr1-4_0013 .
    GeneIDi 8196853.
    KEGGi ppa:PAS_chr1-4_0013.

    Phylogenomic databases

    eggNOGi COG2939.
    HOGENOMi HOG000198296.
    KOi K13289.
    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the Pichia pastoris PRC1 gene encoding carboxypeptidase Y."
      Ohi H., Ohtani W., Okazaki N., Furuhata N., Ohmura T.
      Yeast 12:31-40(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 108-142.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GS115 / ATCC 20864.

    Entry informationi

    Entry nameiCBPY_PICPG
    AccessioniPrimary (citable) accession number: P52710
    Secondary accession number(s): C4QX74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3