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Protein

Threonine--tRNA ligase, cytoplasmic

Gene

tars-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

GO - Molecular functioni

GO - Biological processi

  • determination of adult lifespan Source: WormBase
  • threonyl-tRNA aminoacylation Source: GO_Central

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine--tRNA ligase, cytoplasmic (EC:6.1.1.3)
Alternative name(s):
Threonyl-tRNA synthetase
Short name:
ThrRS
Gene namesi
Name:tars-1Imported
Synonyms:trs-1Imported
ORF Names:C47D12.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC47D12.6a ; CE05434 ; WBGene00006617 ; tars-1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001011221 – 725Threonine--tRNA ligase, cytoplasmicAdd BLAST725

Proteomic databases

EPDiP52709
PaxDbiP52709
PeptideAtlasiP52709
PRIDEiP52709

Expressioni

Gene expression databases

BgeeiWBGene00006617
ExpressionAtlasiP52709 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi40095, 2 interactors
DIPiDIP-24299N
STRINGi6239.C47D12.6a

Structurei

3D structure databases

ProteinModelPortaliP52709
SMRiP52709
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1637 Eukaryota
COG0441 LUCA
GeneTreeiENSGT00390000002149
HOGENOMiHOG000003878
InParanoidiP52709
KOiK01868
OMAiYWEGRSD
OrthoDBiEOG091G01UL
PhylomeDBiP52709

Family and domain databases

CDDicd00771 ThrRS_core, 1 hit
Gene3Di3.10.20.30, 1 hit
3.40.50.800, 1 hit
HAMAPiMF_00184 Thr_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR012675 Beta-grasp_dom_sf
IPR004095 TGS
IPR012676 TGS-like
IPR002320 Thr-tRNA-ligase_IIa
IPR018163 Thr/Ala-tRNA-synth_IIc_edit
IPR033728 ThrRS_core
IPR012947 tRNA_SAD
PANTHERiPTHR11451 PTHR11451, 1 hit
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF02824 TGS, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PF07973 tRNA_SAD, 1 hit
PRINTSiPR01047 TRNASYNTHTHR
SMARTiView protein in SMART
SM00863 tRNA_SAD, 1 hit
SUPFAMiSSF55186 SSF55186, 1 hit
SSF81271 SSF81271, 1 hit
TIGRFAMsiTIGR00418 thrS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

P52709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLNCFRIFV HIQKPTQIFK PFYRSLSSEA SDKYHFVNGH KMSKAPTDMA
60 70 80 90 100
PWPAFIEERI KLWDKLKAEY DAEIAAKESE PIQITLPDGK IHEGKTWRTT
110 120 130 140 150
PFEIAERISK GLAEAAVIAK VNGAVWDLDR PFEGNAKLEL LKFDDDEAKQ
160 170 180 190 200
VFWHSSAHVL GEAMERYCGG HLCYGPPIQE GFYYDMWHEN RTICPDDFPK
210 220 230 240 250
IDQIVKAAVK DKQKFERLEM TKEDLLEMFK YNEFKVRIIT EKIHTPKTTV
260 270 280 290 300
YRCGPLIDLC RGPHVRHTGK VKAMAITKNS SSYWEGKADA ESLQRLYGIS
310 320 330 340 350
FPDSKQLKEW QKLQEEAAKR DHRKLGKEHD LFFFHQLSPG SAFWYPKGAH
360 370 380 390 400
IYNKLVDFIR KQYRRRGFTE VITPNMYNKK LWETSGHWQH YSEDMFKIEV
410 420 430 440 450
EKEEFGLKPM NCPGHCLMFG HMPHTYNELP FRFADFGVLH RNEMSGALTG
460 470 480 490 500
LTRVRRFQQD DAHIFCRQDQ ISEEIKQCLD FLEYAYEKVF GFTFKLNLST
510 520 530 540 550
RPEGFLGNIE TWDKAEADLT NALNASGRKW VLNPGDGAFY GPKIDITIQD
560 570 580 590 600
ALKRNFQCAT IQLDFQLPNQ FDLSYFDEKG EKQRPVMIHR AVLGSVERMT
610 620 630 640 650
AILTESYGGK WPFWLSPRQC KIITVHESVR DYANDVKKQI FEAGFEIEYE
660 670 680 690 700
ENCGDTMNKQ VRKAQLAQFN FILVIGAKEK ENGTVNVRTR DNAVRGEVAL
710 720
DKLISKFRRF ADEYVADTEK SEEWA
Length:725
Mass (Da):84,417
Last modified:October 1, 1996 - v1
Checksum:iC234CCB61CDF5BDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69902 Genomic DNA Translation: CAA93762.1
PIRiT19994
RefSeqiNP_001022033.1, NM_001026862.3
UniGeneiCel.17250

Genome annotation databases

EnsemblMetazoaiC47D12.6a; C47D12.6a; WBGene00006617
GeneIDi174790
KEGGicel:CELE_C47D12.6
UCSCiC47D12.6b.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiSYTC_CAEEL
AccessioniPrimary (citable) accession number: P52709
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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