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Protein

Threonine--tRNA ligase, cytoplasmic

Gene

trs-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

GO - Molecular functioni

GO - Biological processi

  • determination of adult lifespan Source: WormBase
  • threonyl-tRNA aminoacylation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine--tRNA ligase, cytoplasmic (EC:6.1.1.3)
Alternative name(s):
Threonyl-tRNA synthetase
Short name:
ThrRS
Gene namesi
Name:trs-1
ORF Names:C47D12.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC47D12.6a; CE05434; WBGene00006617; tars-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001011221 – 725Threonine--tRNA ligase, cytoplasmicAdd BLAST725

Proteomic databases

EPDiP52709.
PaxDbiP52709.
PeptideAtlasiP52709.
PRIDEiP52709.

Expressioni

Gene expression databases

BgeeiWBGene00006617.
ExpressionAtlasiP52709. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi40095. 2 interactors.
DIPiDIP-24299N.
MINTiMINT-1112314.
STRINGi6239.C47D12.6a.

Structurei

3D structure databases

ProteinModelPortaliP52709.
SMRiP52709.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1637. Eukaryota.
COG0441. LUCA.
GeneTreeiENSGT00390000002149.
HOGENOMiHOG000003878.
InParanoidiP52709.
KOiK01868.
OMAiPYEVARG.
OrthoDBiEOG091G01UL.
PhylomeDBiP52709.

Family and domain databases

CDDicd00771. ThrRS_core. 1 hit.
Gene3Di3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR033728. ThrRS_core.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLNCFRIFV HIQKPTQIFK PFYRSLSSEA SDKYHFVNGH KMSKAPTDMA
60 70 80 90 100
PWPAFIEERI KLWDKLKAEY DAEIAAKESE PIQITLPDGK IHEGKTWRTT
110 120 130 140 150
PFEIAERISK GLAEAAVIAK VNGAVWDLDR PFEGNAKLEL LKFDDDEAKQ
160 170 180 190 200
VFWHSSAHVL GEAMERYCGG HLCYGPPIQE GFYYDMWHEN RTICPDDFPK
210 220 230 240 250
IDQIVKAAVK DKQKFERLEM TKEDLLEMFK YNEFKVRIIT EKIHTPKTTV
260 270 280 290 300
YRCGPLIDLC RGPHVRHTGK VKAMAITKNS SSYWEGKADA ESLQRLYGIS
310 320 330 340 350
FPDSKQLKEW QKLQEEAAKR DHRKLGKEHD LFFFHQLSPG SAFWYPKGAH
360 370 380 390 400
IYNKLVDFIR KQYRRRGFTE VITPNMYNKK LWETSGHWQH YSEDMFKIEV
410 420 430 440 450
EKEEFGLKPM NCPGHCLMFG HMPHTYNELP FRFADFGVLH RNEMSGALTG
460 470 480 490 500
LTRVRRFQQD DAHIFCRQDQ ISEEIKQCLD FLEYAYEKVF GFTFKLNLST
510 520 530 540 550
RPEGFLGNIE TWDKAEADLT NALNASGRKW VLNPGDGAFY GPKIDITIQD
560 570 580 590 600
ALKRNFQCAT IQLDFQLPNQ FDLSYFDEKG EKQRPVMIHR AVLGSVERMT
610 620 630 640 650
AILTESYGGK WPFWLSPRQC KIITVHESVR DYANDVKKQI FEAGFEIEYE
660 670 680 690 700
ENCGDTMNKQ VRKAQLAQFN FILVIGAKEK ENGTVNVRTR DNAVRGEVAL
710 720
DKLISKFRRF ADEYVADTEK SEEWA
Length:725
Mass (Da):84,417
Last modified:October 1, 1996 - v1
Checksum:iC234CCB61CDF5BDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69902 Genomic DNA. Translation: CAA93762.1.
PIRiT19994.
RefSeqiNP_001022033.1. NM_001026862.3.
UniGeneiCel.17250.

Genome annotation databases

EnsemblMetazoaiC47D12.6a; C47D12.6a; WBGene00006617.
GeneIDi174790.
KEGGicel:CELE_C47D12.6.
UCSCiC47D12.6b.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69902 Genomic DNA. Translation: CAA93762.1.
PIRiT19994.
RefSeqiNP_001022033.1. NM_001026862.3.
UniGeneiCel.17250.

3D structure databases

ProteinModelPortaliP52709.
SMRiP52709.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40095. 2 interactors.
DIPiDIP-24299N.
MINTiMINT-1112314.
STRINGi6239.C47D12.6a.

Proteomic databases

EPDiP52709.
PaxDbiP52709.
PeptideAtlasiP52709.
PRIDEiP52709.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC47D12.6a; C47D12.6a; WBGene00006617.
GeneIDi174790.
KEGGicel:CELE_C47D12.6.
UCSCiC47D12.6b.1. c. elegans.

Organism-specific databases

CTDi174790.
WormBaseiC47D12.6a; CE05434; WBGene00006617; tars-1.

Phylogenomic databases

eggNOGiKOG1637. Eukaryota.
COG0441. LUCA.
GeneTreeiENSGT00390000002149.
HOGENOMiHOG000003878.
InParanoidiP52709.
KOiK01868.
OMAiPYEVARG.
OrthoDBiEOG091G01UL.
PhylomeDBiP52709.

Miscellaneous databases

PROiP52709.

Gene expression databases

BgeeiWBGene00006617.
ExpressionAtlasiP52709. baseline and differential.

Family and domain databases

CDDicd00771. ThrRS_core. 1 hit.
Gene3Di3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR033728. ThrRS_core.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYTC_CAEEL
AccessioniPrimary (citable) accession number: P52709
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.