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P52701

- MSH6_HUMAN

UniProt

P52701 - MSH6_HUMAN

Protein

DNA mismatch repair protein Msh6

Gene

MSH6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 175 (01 Oct 2014)
      Sequence version 2 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.7 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1134 – 11418ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. chromatin binding Source: Ensembl
    3. damaged DNA binding Source: Ensembl
    4. DNA-dependent ATPase activity Source: RefGenome
    5. guanine/thymine mispair binding Source: Ensembl
    6. methylated histone binding Source: UniProtKB
    7. mismatched DNA binding Source: UniProtKB
    8. protein binding Source: UniProtKB

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. determination of adult lifespan Source: BHF-UCL
    3. DNA repair Source: BHF-UCL
    4. intrinsic apoptotic signaling pathway Source: BHF-UCL
    5. intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
    6. isotype switching Source: BHF-UCL
    7. meiotic mismatch repair Source: BHF-UCL
    8. mismatch repair Source: UniProtKB
    9. negative regulation of DNA recombination Source: BHF-UCL
    10. positive regulation of helicase activity Source: BHF-UCL
    11. reciprocal meiotic recombination Source: RefGenome
    12. response to UV Source: BHF-UCL
    13. somatic hypermutation of immunoglobulin genes Source: BHF-UCL
    14. somatic recombination of immunoglobulin gene segments Source: BHF-UCL

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA mismatch repair protein Msh6
    Short name:
    hMSH6
    Alternative name(s):
    G/T mismatch-binding protein
    Short name:
    GTBP
    Short name:
    GTMBP
    MutS-alpha 160 kDa subunit
    Short name:
    p160
    Gene namesi
    Name:MSH6
    Synonyms:GTBP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:7329. MSH6.

    Subcellular locationi

    Nucleus 1 Publication. Chromosome 1 Publication
    Note: Associates with H3K36me3 via its PWWP domain.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. Golgi apparatus Source: HPA
    3. intracellular membrane-bounded organelle Source: HPA
    4. MutSalpha complex Source: UniProtKB
    5. nuclear chromatin Source: Ensembl
    6. nuclear chromosome Source: RefGenome
    7. nucleus Source: HPA
    8. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Chromosome, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Hereditary non-polyposis colorectal cancer 5 (HNPCC5) [MIM:614350]: An autosomal dominant disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.7 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti20 – 201A → V in colorectal/endometrial cancer and HNPCC5; repair proficient. 1 Publication
    Corresponds to variant rs63750664 [ dbSNP | Ensembl ].
    VAR_043943
    Natural varianti25 – 251A → S Associated with HNPCC5; unknown pathologiacl significance; repair proficient.
    VAR_067294
    Natural varianti144 – 1441S → I in suspected HNPCC5 and CRC. 3 Publications
    Corresponds to variant rs3211299 [ dbSNP | Ensembl ].
    VAR_012955
    Natural varianti326 – 3261A → V Associated with HNPCC5; unknown pathological significance; repair proficient.
    VAR_067295
    Natural varianti396 – 3961L → V Associated with HNPCC5; unknown pathological significance; repair proficient. 2 Publications
    Corresponds to variant rs2020908 [ dbSNP | Ensembl ].
    VAR_012958
    Natural varianti492 – 4921M → V Associated with HNPCC5; unknown pathological significance; repair proficient. 2 Publications
    VAR_042275
    Natural varianti503 – 5031S → C Associated with HNPCC5; unknown pathological significance; repair proficient. 1 Publication
    VAR_038036
    Natural varianti522 – 5221Q → R in CRC; also associated with HNPCC5; repair proficient. 1 Publication
    VAR_043951
    Natural varianti610 – 6101K → N Associated with HNPCC5; unknown pathological significance; repair proficient.
    VAR_067296
    Natural varianti772 – 7721R → W in HNPCC5. 1 Publication
    VAR_043958
    Natural varianti850 – 8501Y → C Associated with HNPCC5 and CRC; unknown pathological significance; repair proficient. 2 Publications
    VAR_012963
    Natural varianti878 – 8781V → A in suspected HNPCC5, colorectal/endometrial cancer and CRC; repair proficient. 7 Publications
    Corresponds to variant rs2020912 [ dbSNP | Ensembl ].
    VAR_012964
    Natural varianti976 – 9761R → H in CRC; sporadic; also associated with HNPCC5; repair proficient. 1 Publication
    VAR_012965
    Natural varianti1026 – 10261D → Y Associated with HNPCC5; unknown pathological significance; repair proficient.
    VAR_067297
    Natural varianti1087 – 10871P → S Associated with HNPCC5; unknown pathological significance; repair proficient.
    Corresponds to variant rs63750998 [ dbSNP | Ensembl ].
    VAR_067298
    Natural varianti1163 – 11631E → V in HNPCC5. 1 Publication
    Corresponds to variant rs63750252 [ dbSNP | Ensembl ].
    VAR_043969
    Natural varianti1225 – 12251T → M Associated with HNPCC5; unknown pathological significance; repair proficient.
    VAR_067299
    Endometrial cancer (ENDMC) [MIM:608089]: A malignancy of endometrium, the mucous lining of the uterus. Most endometrial cancers are adenocarcinomas, cancers that begin in cells that make and release mucus and other fluids.2 Publications
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Mismatch repair cancer syndrome (MMRCS) [MIM:276300]: An autosomal recessive, rare, childhood cancer predisposition syndrome encompassing a broad tumor spectrum. This includes hematological malignancies, central nervous system tumors, Lynch syndrome-associated malignancies such as colorectal tumors as well as multiple intestinal polyps, embryonic tumors and rhabdomyosarcoma. Multiple cafe-au-lait macules, a feature reminiscent of neurofibromatosis type 1, are often found as first manifestation of the underlying cancer. Areas of skin hypopigmentation have also been reported in MMRCS patients.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi103 – 1031Y → A: Abolishes binding to H3K36me3 and DNA mismatch repair activity. 1 Publication
    Mutagenesisi105 – 1062WW → AA: Abolishes binding to H3K36me3 and DNA mismatch repair activity.
    Mutagenesisi1140 – 11401K → R: No effect on mismatch binding, complete loss of DNA repair function when associated with MSH2 mutant R-675. 1 Publication

    Keywords - Diseasei

    Disease mutation, Hereditary nonpolyposis colorectal cancer

    Organism-specific databases

    MIMi276300. phenotype.
    608089. phenotype.
    614350. phenotype.
    Orphaneti252202. Constitutional mismatch repair deficiency syndrome.
    144. Hereditary nonpolyposis colon cancer.
    587. Muir-Torre syndrome.
    99817. Non-polyposis Turcot syndrome.
    PharmGKBiPA184.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13601360DNA mismatch repair protein Msh6PRO_0000115207Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141Phosphoserine5 Publications
    Modified residuei41 – 411Phosphoserine2 Publications
    Modified residuei43 – 431Phosphoserine2 Publications
    Modified residuei70 – 701N6-acetyllysine1 Publication
    Modified residuei79 – 791Phosphoserine2 Publications
    Modified residuei91 – 911Phosphoserine2 Publications
    Modified residuei137 – 1371Phosphoserine4 Publications
    Modified residuei200 – 2001Phosphoserine2 Publications
    Modified residuei219 – 2191Phosphoserine3 Publications
    Modified residuei227 – 2271Phosphoserine5 Publications
    Modified residuei252 – 2521Phosphoserine3 Publications
    Modified residuei254 – 2541Phosphoserine2 Publications
    Modified residuei256 – 2561Phosphoserine2 Publications
    Modified residuei261 – 2611Phosphoserine4 Publications
    Modified residuei269 – 2691Phosphothreonine2 Publications
    Modified residuei274 – 2741Phosphoserine2 Publications
    Modified residuei275 – 2751Phosphoserine2 Publications
    Modified residuei279 – 2791Phosphoserine2 Publications
    Modified residuei280 – 2801Phosphoserine2 Publications
    Modified residuei309 – 3091Phosphoserine3 Publications
    Modified residuei504 – 5041N6-acetyllysine1 Publication
    Modified residuei830 – 8301Phosphoserine2 Publications

    Post-translational modificationi

    The N-terminus is blocked.
    Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway.7 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP52701.
    PaxDbiP52701.
    PeptideAtlasiP52701.
    PRIDEiP52701.

    PTM databases

    PhosphoSiteiP52701.

    Miscellaneous databases

    PMAP-CutDBP52701.

    Expressioni

    Gene expression databases

    ArrayExpressiP52701.
    BgeeiP52701.
    CleanExiHS_MSH6.
    GenevestigatoriP52701.

    Organism-specific databases

    HPAiCAB009091.
    HPA028376.
    HPA028446.

    Interactioni

    Subunit structurei

    Heterodimer consisting of MSH2-MSH6 (MutS alpha). Forms a ternary complex with MutL alpha (MLH1-PMS1). Interacts with EXO1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with ATR.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MSH2P432465EBI-395529,EBI-355888

    Protein-protein interaction databases

    BioGridi109211. 57 interactions.
    DIPiDIP-32972N.
    IntActiP52701. 18 interactions.
    MINTiMINT-131993.
    STRINGi9606.ENSP00000234420.

    Structurei

    Secondary structure

    1
    1360
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi74 – 796
    Beta strandi94 – 985
    Beta strandi106 – 1094
    Beta strandi120 – 1256
    Beta strandi127 – 1337
    Beta strandi135 – 1373
    Beta strandi139 – 1435
    Helixi145 – 1473
    Beta strandi148 – 1514
    Turni157 – 1593
    Helixi170 – 18314
    Helixi187 – 1915
    Turni192 – 1954
    Beta strandi197 – 1993
    Helixi366 – 3694
    Helixi371 – 3733
    Turni375 – 3773
    Helixi400 – 4034
    Helixi408 – 41912
    Beta strandi423 – 4297
    Beta strandi432 – 4365
    Helixi437 – 44711
    Beta strandi453 – 4564
    Beta strandi458 – 4625
    Helixi463 – 4653
    Helixi466 – 47510
    Beta strandi480 – 4856
    Helixi489 – 4979
    Helixi505 – 5073
    Beta strandi511 – 5177
    Helixi519 – 5213
    Beta strandi526 – 5283
    Beta strandi538 – 5469
    Beta strandi554 – 5618
    Turni563 – 5653
    Beta strandi568 – 5758
    Helixi580 – 5889
    Beta strandi591 – 5977
    Turni598 – 6003
    Helixi603 – 6097
    Turni610 – 6156
    Beta strandi616 – 6216
    Turni624 – 6263
    Helixi630 – 63910
    Turni640 – 6434
    Beta strandi644 – 6474
    Helixi657 – 6615
    Beta strandi667 – 6693
    Beta strandi671 – 6733
    Helixi675 – 6773
    Helixi678 – 69316
    Helixi697 – 7015
    Beta strandi706 – 7083
    Helixi712 – 7154
    Helixi737 – 7426
    Beta strandi746 – 7483
    Beta strandi750 – 7534
    Helixi758 – 7625
    Helixi768 – 77912
    Helixi785 – 79915
    Helixi802 – 81211
    Helixi818 – 82912
    Helixi831 – 8366
    Helixi838 – 8414
    Helixi847 – 87933
    Helixi885 – 8906
    Turni894 – 8963
    Beta strandi897 – 9004
    Helixi906 – 9138
    Helixi918 – 9236
    Helixi936 – 95520
    Helixi959 – 9613
    Beta strandi968 – 9703
    Helixi973 – 9753
    Beta strandi978 – 9814
    Turni983 – 9864
    Beta strandi995 – 9995
    Beta strandi1002 – 10054
    Turni1008 – 10103
    Helixi1011 – 104131
    Helixi1044 – 106623
    Beta strandi1070 – 10723
    Turni1082 – 10843
    Beta strandi1089 – 10946
    Beta strandi1111 – 11166
    Beta strandi1120 – 11223
    Beta strandi1129 – 11335
    Beta strandi1136 – 11383
    Helixi1140 – 115415
    Turni1155 – 11573
    Beta strandi1160 – 11678
    Beta strandi1171 – 11766
    Helixi1189 – 120315
    Beta strandi1209 – 12135
    Turni1215 – 12184
    Helixi1221 – 123717
    Beta strandi1242 – 12465
    Helixi1250 – 12556
    Turni1256 – 12583
    Beta strandi1260 – 126910
    Beta strandi1285 – 12928
    Helixi1298 – 13058
    Helixi1310 – 132213
    Turni1323 – 13264
    Turni1330 – 13323

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2GFUNMR-A68-201[»]
    2O8BX-ray2.75B341-1360[»]
    2O8CX-ray3.37B341-1360[»]
    2O8DX-ray3.00B341-1360[»]
    2O8EX-ray3.30B341-1360[»]
    2O8FX-ray3.25B341-1360[»]
    ProteinModelPortaliP52701.
    SMRiP52701. Positions 68-201, 362-1335.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP52701.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini92 – 15463PWWPPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi34 – 374Poly-Ala
    Compositional biasi201 – 2099Poly-Glu
    Compositional biasi1118 – 11236Poly-Glu

    Domaini

    The PWWP domain specifically recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3).1 Publication

    Sequence similaritiesi

    Belongs to the DNA mismatch repair MutS family.Curated
    Contains 1 PWWP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0249.
    HOGENOMiHOG000243127.
    HOVERGENiHBG000101.
    InParanoidiP52701.
    KOiK08737.
    OMAiALKDCMR.
    OrthoDBiEOG7K9K27.
    PhylomeDBiP52701.
    TreeFamiTF105842.

    Family and domain databases

    Gene3Di3.40.1170.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR017261. DNA_mismatch_repair_Msh6.
    IPR015536. DNA_mismatch_repair_MSH6_C.
    IPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR016151. DNA_mismatch_repair_MutS_N.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    IPR027417. P-loop_NTPase.
    IPR000313. PWWP_dom.
    [Graphical view]
    PANTHERiPTHR11361:SF31. PTHR11361:SF31. 1 hit.
    PfamiPF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    PF00855. PWWP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037677. DNA_mis_repair_Msh6. 1 hit.
    SMARTiSM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    SM00293. PWWP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF55271. SSF55271. 1 hit.
    PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    PS50812. PWWP. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform GTBP-N (identifier: P52701-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRQSTLYSF FPKSPALSDA NKASARASRE GGRAAAAPGA SPSPGGDAAW     50
    SEAGPGPRPL ARSASPPKAK NLNGGLRRSV APAAPTSCDF SPGDLVWAKM 100
    EGYPWWPCLV YNHPFDGTFI REKGKSVRVH VQFFDDSPTR GWVSKRLLKP 150
    YTGSKSKEAQ KGGHFYSAKP EILRAMQRAD EALNKDKIKR LELAVCDEPS 200
    EPEEEEEMEV GTTYVTDKSE EDNEIESEEE VQPKTQGSRR SSRQIKKRRV 250
    ISDSESDIGG SDVEFKPDTK EEGSSDEISS GVGDSESEGL NSPVKVARKR 300
    KRMVTGNGSL KRKSSRKETP SATKQATSIS SETKNTLRAF SAPQNSESQA 350
    HVSGGGDDSS RPTVWYHETL EWLKEEKRRD EHRRRPDHPD FDASTLYVPE 400
    DFLNSCTPGM RKWWQIKSQN FDLVICYKVG KFYELYHMDA LIGVSELGLV 450
    FMKGNWAHSG FPEIAFGRYS DSLVQKGYKV ARVEQTETPE MMEARCRKMA 500
    HISKYDRVVR REICRIITKG TQTYSVLEGD PSENYSKYLL SLKEKEEDSS 550
    GHTRAYGVCF VDTSLGKFFI GQFSDDRHCS RFRTLVAHYP PVQVLFEKGN 600
    LSKETKTILK SSLSCSLQEG LIPGSQFWDA SKTLRTLLEE EYFREKLSDG 650
    IGVMLPQVLK GMTSESDSIG LTPGEKSELA LSALGGCVFY LKKCLIDQEL 700
    LSMANFEEYI PLDSDTVSTT RSGAIFTKAY QRMVLDAVTL NNLEIFLNGT 750
    NGSTEGTLLE RVDTCHTPFG KRLLKQWLCA PLCNHYAIND RLDAIEDLMV 800
    VPDKISEVVE LLKKLPDLER LLSKIHNVGS PLKSQNHPDS RAIMYEETTY 850
    SKKKIIDFLS ALEGFKVMCK IIGIMEEVAD GFKSKILKQV ISLQTKNPEG 900
    RFPDLTVELN RWDTAFDHEK ARKTGLITPK AGFDSDYDQA LADIRENEQS 950
    LLEYLEKQRN RIGCRTIVYW GIGRNRYQLE IPENFTTRNL PEEYELKSTK 1000
    KGCKRYWTKT IEKKLANLIN AEERRDVSLK DCMRRLFYNF DKNYKDWQSA 1050
    VECIAVLDVL LCLANYSRGG DGPMCRPVIL LPEDTPPFLE LKGSRHPCIT 1100
    KTFFGDDFIP NDILIGCEEE EQENGKAYCV LVTGPNMGGK STLMRQAGLL 1150
    AVMAQMGCYV PAEVCRLTPI DRVFTRLGAS DRIMSGESTF FVELSETASI 1200
    LMHATAHSLV LVDELGRGTA TFDGTAIANA VVKELAETIK CRTLFSTHYH 1250
    SLVEDYSQNV AVRLGHMACM VENECEDPSQ ETITFLYKFI KGACPKSYGF 1300
    NAARLANLPE EVIQKGHRKA REFEKMNQSL RLFREVCLAS ERSTVDAEAV 1350
    HKLLTLIKEL 1360
    Length:1,360
    Mass (Da):152,786
    Last modified:June 21, 2005 - v2
    Checksum:i4A4AA9F8ECB8FFE9
    GO
    Isoform GTBP-alt (identifier: P52701-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1058-1068: DVLLCLANYSR → GKTLNKLVLRL
         1069-1360: Missing.

    Show »
    Length:1,068
    Mass (Da):120,563
    Checksum:iE1E62571A314B51E
    GO
    Isoform 3 (identifier: P52701-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         80-209: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,230
    Mass (Da):137,957
    Checksum:iBDA2B64A2EA0D51F
    GO
    Isoform 4 (identifier: P52701-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-302: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,058
    Mass (Da):119,796
    Checksum:i3D50E59BEED4B837
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 5722AAPGA…AGPGP → GCPRGLSFPRRGCGLERGWA WA in BAA23674. (PubMed:9455487)CuratedAdd
    BLAST
    Sequence conflicti36 – 5722AAPGA…AGPGP → GCPRGLSFPRRGCGLERGWA WA in BAA23675. (PubMed:9455487)CuratedAdd
    BLAST
    Sequence conflicti868 – 8681M → V in BAG65496. (PubMed:14702039)Curated
    Sequence conflicti1358 – 13603KEL → D in AAL87401. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131K → T.1 Publication
    Corresponds to variant rs41294988 [ dbSNP | Ensembl ].
    VAR_038032
    Natural varianti20 – 201A → V in colorectal/endometrial cancer and HNPCC5; repair proficient. 1 Publication
    Corresponds to variant rs63750664 [ dbSNP | Ensembl ].
    VAR_043943
    Natural varianti25 – 251A → S Associated with HNPCC5; unknown pathologiacl significance; repair proficient.
    VAR_067294
    Natural varianti25 – 251A → V.
    Corresponds to variant rs35462442 [ dbSNP | Ensembl ].
    VAR_038033
    Natural varianti39 – 391G → E.6 Publications
    Corresponds to variant rs1042821 [ dbSNP | Ensembl ].
    VAR_004490
    Natural varianti54 – 541G → A in CRC; unknown pathological significance. 1 Publication
    Corresponds to variant rs63751098 [ dbSNP | Ensembl ].
    VAR_043944
    Natural varianti65 – 651S → L.1 Publication
    Corresponds to variant rs41294984 [ dbSNP | Ensembl ].
    VAR_038034
    Natural varianti99 – 991K → N in CRC; unknown pathological significance. 1 Publication
    VAR_043945
    Natural varianti128 – 1281R → L No impairment of heterodimerization with MSH2 and of in vitro mismatch repair capacity. 1 Publication
    VAR_043946
    Natural varianti144 – 1441S → I in suspected HNPCC5 and CRC. 3 Publications
    Corresponds to variant rs3211299 [ dbSNP | Ensembl ].
    VAR_012955
    Natural varianti220 – 2201E → D.1 Publication
    Corresponds to variant rs1800938 [ dbSNP | Ensembl ].
    VAR_012956
    Natural varianti221 – 2211E → D.1 Publication
    Corresponds to variant rs41557217 [ dbSNP | Ensembl ].
    VAR_042274
    Natural varianti285 – 2851S → I in CRC. 1 Publication
    VAR_012957
    Natural varianti295 – 2951K → R in multiple colorectal adenoma.
    VAR_043947
    Natural varianti326 – 3261A → V Associated with HNPCC5; unknown pathological significance; repair proficient.
    VAR_067295
    Natural varianti340 – 3401F → S in CRC, breast cancer and leukemia. 1 Publication
    VAR_043948
    Natural varianti396 – 3961L → V Associated with HNPCC5; unknown pathological significance; repair proficient. 2 Publications
    Corresponds to variant rs2020908 [ dbSNP | Ensembl ].
    VAR_012958
    Natural varianti435 – 4351L → P Mismatch repair deficient.
    VAR_068710
    Natural varianti449 – 4491L → P in colorectal/endometrial cancer; unknown pathological significance. 1 Publication
    VAR_043949
    Natural varianti468 – 4681R → H.1 Publication
    Corresponds to variant rs41295268 [ dbSNP | Ensembl ].
    VAR_038035
    Natural varianti492 – 4921M → V Associated with HNPCC5; unknown pathological significance; repair proficient. 2 Publications
    VAR_042275
    Natural varianti503 – 5031S → C Associated with HNPCC5; unknown pathological significance; repair proficient. 1 Publication
    VAR_038036
    Natural varianti509 – 5091V → A.1 Publication
    VAR_043950
    Natural varianti522 – 5221Q → R in CRC; also associated with HNPCC5; repair proficient. 1 Publication
    VAR_043951
    Natural varianti538 – 5381Y → S.
    Corresponds to variant rs728619 [ dbSNP | Ensembl ].
    VAR_038037
    Natural varianti566 – 5661G → R in CRC; partial functional loss. 1 Publication
    VAR_012959
    Natural varianti580 – 5801S → L.1 Publication
    Corresponds to variant rs41295270 [ dbSNP | Ensembl ].
    VAR_038038
    Natural varianti585 – 5851L → P Mismatch repair deficient.
    VAR_068711
    Natural varianti610 – 6101K → N Associated with HNPCC5; unknown pathological significance; repair proficient.
    VAR_067296
    Natural varianti619 – 6191E → D in CRC; unknown pathological significance. 1 Publication
    VAR_043952
    Natural varianti623 – 6231P → A.1 Publication
    Corresponds to variant rs3136334 [ dbSNP | Ensembl ].
    VAR_029244
    Natural varianti623 – 6231P → L No impairment of heterodimerization with MSH2 and of in vitro mismatch repair capacity. 1 Publication
    VAR_043953
    Natural varianti677 – 6771S → T Mismatch repair proficient.
    VAR_068712
    Natural varianti685 – 6851G → A in CRC. 1 Publication
    VAR_043954
    Natural varianti698 – 6981Q → E in HNPCC; unknown pathological significance. 1 Publication
    VAR_012960
    Natural varianti725 – 7251I → M in CRC; unknown pathological significance. 1 Publication
    VAR_043955
    Natural varianti728 – 7281K → T No impairment of heterodimerization with MSH2 and of in vitro mismatch repair capacity. 1 Publication
    Corresponds to variant rs35552856 [ dbSNP | Ensembl ].
    VAR_043956
    Natural varianti772 – 7721R → Q in CRC. 1 Publication
    VAR_043957
    Natural varianti772 – 7721R → W in HNPCC5. 1 Publication
    VAR_043958
    Natural varianti787 – 7871A → V in CRC; unknown pathological significance. 1 Publication
    VAR_043959
    Natural varianti800 – 8001V → A in CRC; somatic mutation. 1 Publication
    VAR_043960
    Natural varianti800 – 8001V → L May be a rare polymorphism. 1 Publication
    VAR_012961
    Natural varianti803 – 8031D → G in CRC. 1 Publication
    VAR_012962
    Natural varianti850 – 8501Y → C Associated with HNPCC5 and CRC; unknown pathological significance; repair proficient. 2 Publications
    VAR_012963
    Natural varianti854 – 8541K → M in CRC; unknown pathological significance. 2 Publications
    Corresponds to variant rs34374438 [ dbSNP | Ensembl ].
    VAR_043961
    Natural varianti878 – 8781V → A in suspected HNPCC5, colorectal/endometrial cancer and CRC; repair proficient. 7 Publications
    Corresponds to variant rs2020912 [ dbSNP | Ensembl ].
    VAR_012964
    Natural varianti886 – 8861I → V.1 Publication
    Corresponds to variant rs2020914 [ dbSNP | Ensembl ].
    VAR_014902
    Natural varianti901 – 9011R → H in colorectal/endometrial cancer. 1 Publication
    VAR_043962
    Natural varianti976 – 9761R → H in CRC; sporadic; also associated with HNPCC5; repair proficient. 1 Publication
    VAR_012965
    Natural varianti1021 – 10211A → D in CRC; unknown pathological significance; repair proficient. 1 Publication
    VAR_043963
    Natural varianti1026 – 10261D → Y Associated with HNPCC5; unknown pathological significance; repair proficient.
    VAR_067297
    Natural varianti1031 – 10311D → V in CRC; somatic mutation. 1 Publication
    VAR_043964
    Natural varianti1076 – 10761R → C in CRC; unknown pathological significance. 1 Publication
    VAR_043965
    Natural varianti1087 – 10871P → S Associated with HNPCC5; unknown pathological significance; repair proficient.
    Corresponds to variant rs63750998 [ dbSNP | Ensembl ].
    VAR_067298
    Natural varianti1087 – 10871P → T in CRC. 1 Publication
    Corresponds to variant rs63750998 [ dbSNP | Ensembl ].
    VAR_012966
    Natural varianti1095 – 10951R → H in CRC; unknown pathological significance; mismatch repair proficient. 1 Publication
    VAR_043966
    Natural varianti1100 – 11001T → M in CRC; unknown pathological significance. 1 Publication
    VAR_043967
    Natural varianti1158 – 11581C → R in CRC; somatic mutation. 1 Publication
    VAR_043968
    Natural varianti1163 – 11631E → V in HNPCC5. 1 Publication
    Corresponds to variant rs63750252 [ dbSNP | Ensembl ].
    VAR_043969
    Natural varianti1193 – 11931E → K Found in an endometrial cancer sample; displays marked impairment of heterodimerization with MSH2 and of in vitro mismatch repair capacity. 1 Publication
    VAR_043970
    Natural varianti1213 – 12131D → V.1 Publication
    VAR_004491
    Natural varianti1219 – 12191T → I in CRC; unknown pathological significance. 1 Publication
    VAR_043971
    Natural varianti1225 – 12251T → M Associated with HNPCC5; unknown pathological significance; repair proficient.
    VAR_067299
    Natural varianti1232 – 12321V → L.1 Publication
    Corresponds to variant rs41295276 [ dbSNP | Ensembl ].
    VAR_038039
    Natural varianti1234 – 12341E → Q.
    Corresponds to variant rs35717727 [ dbSNP | Ensembl ].
    VAR_038040
    Natural varianti1248 – 12481H → D in CRC; unknown pathological significance. 1 Publication
    VAR_043972
    Natural varianti1260 – 12601V → I.1 Publication
    VAR_004492
    Natural varianti1284 – 12841T → M in CRC. 1 Publication
    VAR_043973
    Natural varianti1321 – 13211R → G.1 Publication
    Corresponds to variant rs41295278 [ dbSNP | Ensembl ].
    VAR_038041
    Natural varianti1354 – 13541L → Q in CRC; unknown pathological significance; mismatch repair proficient. 1 Publication
    VAR_043974

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 302302Missing in isoform 4. 1 PublicationVSP_055020Add
    BLAST
    Alternative sequencei80 – 209130Missing in isoform 3. 1 PublicationVSP_054419Add
    BLAST
    Alternative sequencei1058 – 106811DVLLCLANYSR → GKTLNKLVLRL in isoform GTBP-alt. CuratedVSP_003291Add
    BLAST
    Alternative sequencei1069 – 1360292Missing in isoform GTBP-alt. CuratedVSP_003292Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73737
    , U73732, U73733, U73734, U73736 Genomic DNA. Translation: AAB47425.1.
    D89645 Genomic DNA. Translation: BAA23674.1.
    D89646 mRNA. Translation: BAA23675.1.
    AK293921 mRNA. Translation: BAG57302.1.
    AK304735 mRNA. Translation: BAG65496.1.
    AY082894 Genomic DNA. Translation: AAL87401.1.
    AC006509 Genomic DNA. No translation available.
    BC004246 mRNA. Translation: AAH04246.1.
    U54777 mRNA. Translation: AAB39212.2.
    U28946 mRNA. Translation: AAC50461.1.
    CCDSiCCDS1836.1. [P52701-1]
    CCDS62906.1. [P52701-3]
    CCDS62907.1. [P52701-4]
    PIRiJC5839.
    RefSeqiNP_000170.1. NM_000179.2. [P52701-1]
    NP_001268421.1. NM_001281492.1. [P52701-3]
    NP_001268422.1. NM_001281493.1.
    NP_001268423.1. NM_001281494.1.
    UniGeneiHs.445052.

    Genome annotation databases

    EnsembliENST00000234420; ENSP00000234420; ENSG00000116062. [P52701-1]
    ENST00000538136; ENSP00000438580; ENSG00000116062. [P52701-4]
    ENST00000540021; ENSP00000446475; ENSG00000116062. [P52701-3]
    GeneIDi2956.
    KEGGihsa:2956.
    UCSCiuc002rwc.2. human. [P52701-2]
    uc002rwd.4. human. [P52701-1]

    Polymorphism databases

    DMDMi68067672.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    Hereditary non-polyposis colorectal cancer db
    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73737
    , U73732 , U73733 , U73734 , U73736 Genomic DNA. Translation: AAB47425.1 .
    D89645 Genomic DNA. Translation: BAA23674.1 .
    D89646 mRNA. Translation: BAA23675.1 .
    AK293921 mRNA. Translation: BAG57302.1 .
    AK304735 mRNA. Translation: BAG65496.1 .
    AY082894 Genomic DNA. Translation: AAL87401.1 .
    AC006509 Genomic DNA. No translation available.
    BC004246 mRNA. Translation: AAH04246.1 .
    U54777 mRNA. Translation: AAB39212.2 .
    U28946 mRNA. Translation: AAC50461.1 .
    CCDSi CCDS1836.1. [P52701-1 ]
    CCDS62906.1. [P52701-3 ]
    CCDS62907.1. [P52701-4 ]
    PIRi JC5839.
    RefSeqi NP_000170.1. NM_000179.2. [P52701-1 ]
    NP_001268421.1. NM_001281492.1. [P52701-3 ]
    NP_001268422.1. NM_001281493.1.
    NP_001268423.1. NM_001281494.1.
    UniGenei Hs.445052.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2GFU NMR - A 68-201 [» ]
    2O8B X-ray 2.75 B 341-1360 [» ]
    2O8C X-ray 3.37 B 341-1360 [» ]
    2O8D X-ray 3.00 B 341-1360 [» ]
    2O8E X-ray 3.30 B 341-1360 [» ]
    2O8F X-ray 3.25 B 341-1360 [» ]
    ProteinModelPortali P52701.
    SMRi P52701. Positions 68-201, 362-1335.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109211. 57 interactions.
    DIPi DIP-32972N.
    IntActi P52701. 18 interactions.
    MINTi MINT-131993.
    STRINGi 9606.ENSP00000234420.

    PTM databases

    PhosphoSitei P52701.

    Polymorphism databases

    DMDMi 68067672.

    Proteomic databases

    MaxQBi P52701.
    PaxDbi P52701.
    PeptideAtlasi P52701.
    PRIDEi P52701.

    Protocols and materials databases

    DNASUi 2956.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000234420 ; ENSP00000234420 ; ENSG00000116062 . [P52701-1 ]
    ENST00000538136 ; ENSP00000438580 ; ENSG00000116062 . [P52701-4 ]
    ENST00000540021 ; ENSP00000446475 ; ENSG00000116062 . [P52701-3 ]
    GeneIDi 2956.
    KEGGi hsa:2956.
    UCSCi uc002rwc.2. human. [P52701-2 ]
    uc002rwd.4. human. [P52701-1 ]

    Organism-specific databases

    CTDi 2956.
    GeneCardsi GC02P047924.
    GeneReviewsi MSH6.
    HGNCi HGNC:7329. MSH6.
    HPAi CAB009091.
    HPA028376.
    HPA028446.
    MIMi 276300. phenotype.
    600678. gene.
    608089. phenotype.
    614350. phenotype.
    neXtProti NX_P52701.
    Orphaneti 252202. Constitutional mismatch repair deficiency syndrome.
    144. Hereditary nonpolyposis colon cancer.
    587. Muir-Torre syndrome.
    99817. Non-polyposis Turcot syndrome.
    PharmGKBi PA184.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0249.
    HOGENOMi HOG000243127.
    HOVERGENi HBG000101.
    InParanoidi P52701.
    KOi K08737.
    OMAi ALKDCMR.
    OrthoDBi EOG7K9K27.
    PhylomeDBi P52701.
    TreeFami TF105842.

    Miscellaneous databases

    EvolutionaryTracei P52701.
    GeneWikii MSH6.
    GenomeRNAii 2956.
    NextBioi 11716.
    PMAP-CutDB P52701.
    PROi P52701.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P52701.
    Bgeei P52701.
    CleanExi HS_MSH6.
    Genevestigatori P52701.

    Family and domain databases

    Gene3Di 3.40.1170.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR017261. DNA_mismatch_repair_Msh6.
    IPR015536. DNA_mismatch_repair_MSH6_C.
    IPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR016151. DNA_mismatch_repair_MutS_N.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    IPR027417. P-loop_NTPase.
    IPR000313. PWWP_dom.
    [Graphical view ]
    PANTHERi PTHR11361:SF31. PTHR11361:SF31. 1 hit.
    Pfami PF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    PF00855. PWWP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037677. DNA_mis_repair_Msh6. 1 hit.
    SMARTi SM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    SM00293. PWWP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF55271. SSF55271. 1 hit.
    PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    PS50812. PWWP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT GLU-39.
    2. "Alternative splicing of GTBP in normal human tissues."
      Shiwaku H.O., Wakatsuki S., Mori Y., Fukushige S., Horii A.
      DNA Res. 4:359-362(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
      Tissue: Cerebellum and Uterus.
    4. NIEHS SNPs program
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLU-39; VAL-396; ALA-623 AND VAL-886.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    7. "GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells."
      Palombo F., Gallinari P., Iaccarino I., Lettieri T., Hughes M., D'Arrigo A., Truong O., Hsuan J.J., Jiricny J.
      Science 268:1912-1914(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-1360, PARTIAL PROTEIN SEQUENCE.
    8. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-116.
    9. "Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells."
      Drummond J.T., Li G.-M., Longley M.J., Modrich P.
      Science 268:1909-1912(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, PARTIAL PROTEIN SEQUENCE.
    10. "Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism."
      Blackwell L.J., Martik D., Bjornson K.P., Bjornson E.S., Modrich P.
      J. Biol. Chem. 273:32055-32062(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "DNA-dependent activation of the hMutSalpha ATPase."
      Blackwell L.J., Bjornson K.P., Modrich P.
      J. Biol. Chem. 273:32049-32054(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha."
      Iaccarino I., Marra G., Palombo F., Jiricny J.
      EMBO J. 17:2677-2686(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF LYS-1140.
    13. "Functional analysis of human MutSalpha and MutSbeta complexes in yeast."
      Clark A.B., Cook M.E., Tran H.T., Gordenin D.A., Resnick M.A., Kunkel T.A.
      Nucleic Acids Res. 27:736-742(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: MISMATCH-BINDING.
    14. "hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA."
      Gradia S., Subramanian D., Wilson T., Acharya S., Makhov A., Griffith J., Fishel R.
      Mol. Cell 3:255-261(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    15. "The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch."
      Gradia S., Acharya S., Fishel R.
      J. Biol. Chem. 275:3922-3930(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    16. Cited for: FUNCTION.
    17. "hMutS alpha is protected from ubiquitin-proteasome-dependent degradation by atypical protein kinase C zeta phosphorylation."
      Hernandez-Pigeon H., Quillet-Mary A., Louat T., Schambourg A., Humbert O., Selves J., Salles B., Laurent G., Lautier D.
      J. Mol. Biol. 348:63-74(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY PRKCZ.
    18. "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures."
      Wang Y., Cortez D., Yazdi P., Neff N., Elledge S.J., Qin J.
      Genes Dev. 14:927-939(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF MSH6 AS MEMBER OF BASC.
    19. "Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer."
      Miyaki M., Konishi M., Tanaka K., Kikuchi-Yanoshita R., Muraoka M., Yasuno M., Igari T., Koike M., Chiba M., Mori T.
      Nat. Genet. 17:271-272(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN HNPCC5.
    20. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219; SER-227 AND SER-261, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    21. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-41 AND SER-43, VARIANT [LARGE SCALE ANALYSIS] GLU-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    22. "Novel biallelic mutations in MSH6 and PMS2 genes: gene conversion as a likely cause of PMS2 gene inactivation."
      Auclair J., Leroux D., Desseigne F., Lasset C., Saurin J.C., Joly M.O., Pinson S., Xu X.L., Montmain G., Ruano E., Navarro C., Puisieux A., Wang Q.
      Hum. Mutat. 28:1084-1090(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN MMRCS.
    23. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    24. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    25. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-309, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    26. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-79; SER-91; SER-137; SER-200; SER-227; SER-252; SER-254; SER-256 AND SER-261, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    27. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70 AND LYS-504, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    28. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-137; SER-227 AND SER-830, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    29. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    30. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-137; SER-219; SER-227; SER-252; SER-261; THR-269; SER-274; SER-275; SER-279; SER-280 AND SER-309, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    31. "The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSalpha."
      Li F., Mao G., Tong D., Huang J., Gu L., Yang W., Li G.M.
      Cell 153:590-600(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-103 AND 105-TRP-TRP-106.
    32. "Structure of the human MutSalpha DNA lesion recognition complex."
      Warren J.J., Pohlhaus T.J., Changela A., Iyer R.R., Modrich P.L., Beese L.S.
      Mol. Cell 26:579-592(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS).
    33. Cited for: VARIANTS VAL-1213 AND ILE-1260.
    34. "Association of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations."
      Wu Y., Berends M.J.W., Mensink R.G.J., Kempinga C., Sijmons R.H., van Der Zee A.G.J., Hollema H., Kleibeuker J.H., Buys C.H.C.M., Hofstra R.M.W.
      Am. J. Hum. Genet. 65:1291-1298(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS HNPCC5 ILE-144 AND CYS-850.
    35. "Germ-line msh6 mutations in colorectal cancer families."
      Kolodner R.D., Tytell J.D., Schmeits J.L., Kane M.F., Das Gupta R., Weger J., Wahlberg S., Fox E.A., Peel D., Ziogas A., Garber J.E., Syngal S., Anton-Culver H., Li F.P.
      Cancer Res. 59:5068-5074(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CRC ILE-285; ARG-566; GLY-803 AND THR-1087, VARIANTS GLU-39; ASP-220; VAL-396 AND LEU-800.
    36. "Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer."
      Wang Q., Lasset C., Desseigne F., Saurin J.-C., Maugard C., Navarro C., Ruano E., Descos L., Trillet-Lenoir V., Bosset J.-F., Puisieux A.
      Hum. Genet. 105:79-85(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HNPCC5 GLU-698.
    37. "Frequent microsatellite instability and mismatch repair gene mutations in young Chinese patients with colorectal cancer."
      Chan T.L., Yuen S.T., Chung L.P., Ho J.W.C., Kwan K.Y.M., Chan A.S.Y., Ho J.C.Y., Leung S.Y., Wyllie A.H.
      J. Natl. Cancer Inst. 91:1221-1226(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CRC MET-1284.
    38. "Do MSH6 mutations contribute to double primary cancers of the colorectum and endometrium?"
      Charames G.S., Millar A.L., Pal T., Narod S., Bapat B.
      Hum. Genet. 107:623-629(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS COLORECTAL/ENDOMETRIAL CANCER VAL-20; ALA-878 AND HIS-901.
    39. "Sequence analysis of the mismatch repair gene hMSH6 in the germline of patients with familial and sporadic colorectal cancer."
      Plaschke J., Kruppa C., Tischler R., Bocker T., Pistorius S., Dralle H., Rueschoff J., Saeger H.D., Fishel R., Schackert H.K.
      Int. J. Cancer 85:606-613(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CRC SER-340, VARIANT GLU-39.
    40. "Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype."
      Ohmiya N., Matsumoto S., Yamamoto H., Baranovskaya S., Malkhosyan S.R., Perucho M.
      Gene 272:301-313(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CRC ALA-685; GLN-772; ALA-800; MET-854; ALA-878; VAL-1031 AND ARG-1158.
    41. Cited for: VARIANT HNPCC5 ALA-878.
    42. Cited for: VARIANTS CRC ILE-144; ARG-522; MET-725; CYS-850; ALA-878; ASP-1021; MET-1100; ILE-1219 AND ASP-1248.
    43. "Involvement of hMSH6 in the development of hereditary and sporadic colorectal cancer revealed by immunostaining is based on germline mutations, but rarely on somatic inactivation."
      Plaschke J., Krueger S., Pistorius S., Theissig F., Saeger H.D., Schackert H.K.
      Int. J. Cancer 97:643-648(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CRC HIS-976.
    44. "Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene."
      Wagner A., Barrows A., Wijnen J.T., van der Klift H., Franken P.F., Verkuijlen P., Nakagawa H., Geugien M., Jaghmohan-Changur S., Breukel C., Meijers-Heijboer H., Morreau H., van Puijenbroek M., Burn J., Coronel S., Kinarski Y., Okimoto R., Watson P.
      , Lynch J.F., de la Chapelle A., Lynch H.T., Fodde R.
      Am. J. Hum. Genet. 72:1088-1100(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HNPCC5 VAL-492.
    45. "Two mismatch repair gene mutations found in a colon cancer patient - which one is pathogenic?"
      Kariola R., Otway R., Loennqvist K.E., Raevaara T.E., Macrae F., Vos Y.J., Kohonen-Corish M., Hofstra R.M.W., Nystroem-Lahti M.
      Hum. Genet. 112:105-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CRC HIS-1095 AND GLN-1354.
    46. Cited for: VARIANT CRC ALA-54, VARIANTS GLU-39; ALA-509; MET-854 AND ALA-878.
    47. "MSH6 missense mutations are often associated with no or low cancer susceptibility."
      Kariola R., Hampel H., Frankel W.L., Raevaara T.E., de la Chapelle A., Nystroem-Lahti M.
      Br. J. Cancer 91:1287-1292(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LEU-128; LEU-623; THR-728 AND LYS-1193, CHARACTERIZATION OF VARIANTS LEU-128; LEU-623; THR-728 AND LYS-1193.
    48. "Eight novel MSH6 germline mutations in patients with familial and nonfamilial colorectal cancer selected by loss of protein expression in tumor tissue."
      The German HNPCC consortium
      Plaschke J., Krueger S., Dietmaier W., Gebert J., Sutter C., Mangold E., Pagenstecher C., Holinski-Feder E., Schulmann K., Moeslein G., Rueschoff J., Engel C., Evans G., Schackert H.K.
      Hum. Mutat. 23:285-285(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HNPCC5 TRP-772.
    49. "Germline mutations in MLH1, MSH2 and MSH6 in Korean hereditary non-polyposis colorectal cancer families."
      Shin Y.-K., Heo S.-C., Shin J.-H., Hong S.-H., Ku J.-L., Yoo B.-C., Kim I.-J., Park J.-G.
      Hum. Mutat. 24:351-351(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HNPCC5 VAL-1163.
    50. "Mutation analysis of the MLH1, MSH2 and MSH6 genes in patients with double primary cancers of the colorectum and the endometrium: a population-based study in northern Sweden."
      Cederquist K., Emanuelsson M., Goeransson I., Holinski-Feder E., Mueller-Koch Y., Golovleva I., Groenberg H.
      Int. J. Cancer 109:370-376(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT COLORECTAL/ENDOMETRIAL CANCER PRO-449.
    51. "Lower incidence of colorectal cancer and later age of disease onset in 27 families with pathogenic MSH6 germline mutations compared with families with MLH1 or MSH2 mutations: the German hereditary nonpolyposis colorectal cancer consortium."
      Plaschke J., Engel C., Krueger S., Holinski-Feder E., Pagenstecher C., Mangold E., Moeslein G., Schulmann K., Gebert J., von Knebel Doeberitz M., Rueschoff J., Loeffler M., Schackert H.K.
      J. Clin. Oncol. 22:4486-4494(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS CRC ASN-99; ASP-619; VAL-787; ALA-878 AND CYS-1076.
    52. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-221 AND VAL-492.
    53. "Classification of ambiguous mutations in DNA mismatch repair genes identified in a population-based study of colorectal cancer."
      Barnetson R.A., Cartwright N., van Vliet A., Haq N., Drew K., Farrington S., Williams N., Warner J., Campbell H., Porteous M.E., Dunlop M.G.
      Hum. Mutat. 29:367-374(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS THR-13; LEU-65; ILE-144; HIS-468; CYS-503; LEU-580; ALA-878; LEU-1232 AND GLY-1321.
    54. "A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants."
      Drost M., Zonneveld J.B., van Hees S., Rasmussen L.J., Hofstra R.M., de Wind N.
      Hum. Mutat. 33:488-494(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF VARIANT HNPCC5 VAL-20, CHARACTERIZATION OF VARIANTS CRC HIS-976 AND ASP-1021, CHARACTERIZATION OF VARIANTS SER-25; VAL-326; VAL-396; VAL-492; CYS-503; ARG-522; ASN-610; CYS-850; ALA-878; TYR-1026; SER-1087 AND MET-1225.
    55. "Mismatch repair analysis of inherited MSH2 and/or MSH6 variation pairs found in cancer patients."
      Kantelinen J., Kansikas M., Candelin S., Hampel H., Smith B., Holm L., Kariola R., Nystrom M.
      Hum. Mutat. 33:1294-1301(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF VARIANTS PRO-435; PRO-585; THR-677; ALA-878; HIS-1095 AND GLN-1354.

    Entry informationi

    Entry nameiMSH6_HUMAN
    AccessioniPrimary (citable) accession number: P52701
    Secondary accession number(s): B4DF41
    , B4E3I4, F5H2F9, O43706, O43917, Q8TCX4, Q9BTB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 175 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3