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P52699

- BLAB_SERMA

UniProt

P52699 - BLAB_SERMA

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Protein

Beta-lactamase IMP-1

Gene
N/A
Organism
Serratia marcescens
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Cofactori

Binds 2 zinc ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi95 – 951Zinc 1By similarity
Metal bindingi97 – 971Zinc 1By similarity
Metal bindingi99 – 991Zinc 2By similarity
Metal bindingi157 – 1571Zinc 1By similarity
Metal bindingi176 – 1761Zinc 2By similarity
Metal bindingi215 – 2151Zinc 2By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase IMP-1 (EC:3.5.2.6)
Alternative name(s):
BLAIMP
Beta-lactamase type II
Penicillinase
OrganismiSerratia marcescens
Taxonomic identifieri615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 246228Beta-lactamase IMP-1PRO_0000016946Add
BLAST

Interactioni

Structurei

Secondary structure

1
246
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 316Combined sources
Beta strandi34 – 4310Combined sources
Turni44 – 463Combined sources
Beta strandi47 – 5812Combined sources
Beta strandi61 – 666Combined sources
Helixi71 – 8212Combined sources
Turni83 – 853Combined sources
Beta strandi87 – 926Combined sources
Beta strandi94 – 974Combined sources
Helixi98 – 1014Combined sources
Helixi104 – 1096Combined sources
Beta strandi114 – 1174Combined sources
Helixi118 – 1269Combined sources
Beta strandi133 – 1364Combined sources
Beta strandi138 – 1447Combined sources
Turni145 – 1473Combined sources
Beta strandi148 – 1514Combined sources
Beta strandi155 – 1606Combined sources
Beta strandi163 – 1664Combined sources
Turni167 – 1704Combined sources
Beta strandi171 – 1755Combined sources
Turni191 – 1933Combined sources
Helixi194 – 20512Combined sources
Beta strandi209 – 2168Combined sources
Helixi222 – 23615Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DD6X-ray2.00A/B19-246[»]
1VGNX-ray2.63A/B19-246[»]
1WUOX-ray2.01A/B/C/D19-246[»]
1WUPX-ray3.00A/B/C/D19-246[»]
2DOOX-ray2.43A/B19-246[»]
4C1FX-ray2.01A/B19-246[»]
4C1GX-ray1.71A/B19-246[»]
ProteinModelPortaliP52699.
SMRiP52699. Positions 19-239.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52699.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52699-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKLSVFFIF LFCSIATAAE SLPDLKIEKL DEGVYVHTSF EEVNGWGVVP
60 70 80 90 100
KHGLVVLVNA EAYLIDTPFT AKDTEKLVTW FVERGYKIKG SISSHFHSDS
110 120 130 140 150
TGGIEWLNSR SIPTYASELT NELLKKDGKV QATNSFSGVN YWLVKNKIEV
160 170 180 190 200
FYPGPGHTPD NVVVWLPERK ILFGGCFIKP YGLGNLGDAN IEAWPKSAKL
210 220 230 240
LKSKYGKAKL VVPSHSEVGD ASLLKLTLEQ AVKGLNESKK PSKPSN
Length:246
Mass (Da):27,120
Last modified:October 1, 1996 - v1
Checksum:i9B2599E8F1B22D36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S71932 Genomic DNA. Translation: AAB30289.1.
D50438 Genomic DNA. Translation: BAA08930.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S71932 Genomic DNA. Translation: AAB30289.1 .
D50438 Genomic DNA. Translation: BAA08930.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DD6 X-ray 2.00 A/B 19-246 [» ]
1VGN X-ray 2.63 A/B 19-246 [» ]
1WUO X-ray 2.01 A/B/C/D 19-246 [» ]
1WUP X-ray 3.00 A/B/C/D 19-246 [» ]
2DOO X-ray 2.43 A/B 19-246 [» ]
4C1F X-ray 2.01 A/B 19-246 [» ]
4C1G X-ray 1.71 A/B 19-246 [» ]
ProteinModelPortali P52699.
SMRi P52699. Positions 19-239.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P52699.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P52699.

Family and domain databases

Gene3Di 3.60.15.10. 1 hit.
InterProi IPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view ]
Pfami PF00753. Lactamase_B. 1 hit.
[Graphical view ]
SMARTi SM00849. Lactamase_B. 1 hit.
[Graphical view ]
SUPFAMi SSF56281. SSF56281. 1 hit.
PROSITEi PS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance."
    Osano E., Arakawa Y., Wacharotayankun R., Ohta M., Horii T., Ito H., Yoshimura F., Kato N.
    Antimicrob. Agents Chemother. 38:71-78(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AK9373 / TN9106.

Entry informationi

Entry nameiBLAB_SERMA
AccessioniPrimary (citable) accession number: P52699
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3