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P52697

- 6PGL_ECOLI

UniProt

P52697 - 6PGL_ECOLI

Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.1 Publication

    Catalytic activityi

    6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

    Pathwayi

    GO - Molecular functioni

    1. 6-phosphogluconolactonase activity Source: EcoliWiki

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Enzyme and pathway databases

    BioCyciEcoCyc:6PGLUCONOLACT-MONOMER.
    ECOL316407:JW0750-MONOMER.
    MetaCyc:6PGLUCONOLACT-MONOMER.
    UniPathwayiUPA00115; UER00409.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconolactonase (EC:3.1.1.31)
    Short name:
    6-P-gluconolactonase
    Short name:
    Pgl
    Gene namesi
    Name:pgl
    Synonyms:ybhE
    Ordered Locus Names:b0767, JW0750
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13231. pgl.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3313316-phosphogluconolactonasePRO_0000171132Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei287 – 2871N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP52697.
    PRIDEiP52697.

    Expressioni

    Gene expression databases

    GenevestigatoriP52697.

    Interactioni

    Protein-protein interaction databases

    IntActiP52697. 5 interactions.
    STRINGi511145.b0767.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 98
    Helixi10 – 123
    Beta strandi14 – 207
    Beta strandi26 – 338
    Beta strandi41 – 433
    Beta strandi47 – 548
    Turni55 – 584
    Beta strandi59 – 657
    Turni67 – 693
    Beta strandi72 – 798
    Beta strandi85 – 895
    Beta strandi93 – 1008
    Turni101 – 1044
    Beta strandi105 – 1128
    Beta strandi115 – 1239
    Beta strandi138 – 1458
    Helixi146 – 1483
    Beta strandi150 – 1567
    Beta strandi162 – 17110
    Beta strandi178 – 1836
    Beta strandi187 – 1948
    Turni195 – 1984
    Beta strandi199 – 2068
    Beta strandi213 – 2197
    Beta strandi231 – 2366
    Beta strandi240 – 2478
    Turni248 – 2514
    Beta strandi252 – 2587
    Beta strandi265 – 2728
    Beta strandi274 – 2763
    Beta strandi280 – 2823
    Beta strandi286 – 2927
    Turni294 – 2963
    Beta strandi298 – 3058
    Turni306 – 3094
    Beta strandi310 – 3189
    Beta strandi320 – 3223
    Beta strandi325 – 3317

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1RI6X-ray2.00A2-331[»]
    ProteinModelPortaliP52697.
    SMRiP52697. Positions 1-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP52697.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cycloisomerase 2 family.Curated

    Phylogenomic databases

    eggNOGiCOG2706.
    HOGENOMiHOG000257418.
    KOiK07404.
    OMAiDKRFLYV.
    OrthoDBiEOG615VK7.
    PhylomeDBiP52697.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    HAMAPiMF_01605. 6P_gluconolactonase.
    InterProiIPR022528. 6-phosphogluconolactonase_YbhE.
    IPR019405. Lactonase_7-beta_prop.
    IPR011045. N2O_reductase_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PfamiPF10282. Lactonase. 1 hit.
    [Graphical view]
    SUPFAMiSSF50974. SSF50974. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P52697-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQTVYIASP ESQQIHVWNL NHEGALTLTQ VVDVPGQVQP MVVSPDKRYL    50
    YVGVRPEFRV LAYRIAPDDG ALTFAAESAL PGSPTHISTD HQGQFVFVGS 100
    YNAGNVSVTR LEDGLPVGVV DVVEGLDGCH SANISPDNRT LWVPALKQDR 150
    ICLFTVSDDG HLVAQDPAEV TTVEGAGPRH MVFHPNEQYA YCVNELNSSV 200
    DVWELKDPHG NIECVQTLDM MPENFSDTRW AADIHITPDG RHLYACDRTA 250
    SLITVFSVSE DGSVLSKEGF QPTETQPRGF NVDHSGKYLI AAGQKSHHIS 300
    VYEIVGEQGL LHEKGRYAVG QGPMWVVVNA H 331
    Length:331
    Mass (Da):36,308
    Last modified:November 1, 1997 - v2
    Checksum:iD731044CFCF31A8F
    GO

    Sequence cautioni

    The sequence U27192 differs from that shown. Reason: Frameshift at position 110.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 5216QVQPM…RYLYV → RCSRWWSARTNVISML(PubMed:7665460)CuratedAdd
    BLAST
    Sequence conflicti319 – 33113VGQGP…VVNAH → SGRDQCGWWLTHTKR(PubMed:7665460)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U27192 Genomic DNA. No translation available.
    U00096 Genomic DNA. Translation: AAC73854.1.
    AP009048 Genomic DNA. Translation: BAA35431.1.
    PIRiG64812.
    RefSeqiNP_415288.1. NC_000913.3.
    YP_489040.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC73854; AAC73854; b0767.
    BAA35431; BAA35431; BAA35431.
    GeneIDi12932157.
    946398.
    KEGGiecj:Y75_p0740.
    eco:b0767.
    PATRICi32116735. VBIEscCol129921_0793.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U27192 Genomic DNA. No translation available.
    U00096 Genomic DNA. Translation: AAC73854.1 .
    AP009048 Genomic DNA. Translation: BAA35431.1 .
    PIRi G64812.
    RefSeqi NP_415288.1. NC_000913.3.
    YP_489040.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1RI6 X-ray 2.00 A 2-331 [» ]
    ProteinModelPortali P52697.
    SMRi P52697. Positions 1-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P52697. 5 interactions.
    STRINGi 511145.b0767.

    Proteomic databases

    PaxDbi P52697.
    PRIDEi P52697.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC73854 ; AAC73854 ; b0767 .
    BAA35431 ; BAA35431 ; BAA35431 .
    GeneIDi 12932157.
    946398.
    KEGGi ecj:Y75_p0740.
    eco:b0767.
    PATRICi 32116735. VBIEscCol129921_0793.

    Organism-specific databases

    EchoBASEi EB3020.
    EcoGenei EG13231. pgl.

    Phylogenomic databases

    eggNOGi COG2706.
    HOGENOMi HOG000257418.
    KOi K07404.
    OMAi DKRFLYV.
    OrthoDBi EOG615VK7.
    PhylomeDBi P52697.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00409 .
    BioCyci EcoCyc:6PGLUCONOLACT-MONOMER.
    ECOL316407:JW0750-MONOMER.
    MetaCyc:6PGLUCONOLACT-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P52697.
    PROi P52697.

    Gene expression databases

    Genevestigatori P52697.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    HAMAPi MF_01605. 6P_gluconolactonase.
    InterProi IPR022528. 6-phosphogluconolactonase_YbhE.
    IPR019405. Lactonase_7-beta_prop.
    IPR011045. N2O_reductase_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    Pfami PF10282. Lactonase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50974. SSF50974. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genetic analysis of the modABCD (molybdate transport) operon of Escherichia coli."
      Maupin-Furlow J.A., Rosentel J.K., Lee J.H., Deppenmeier U., Gunsalus R.P., Shanmugam K.T.
      J. Bacteriol. 177:4851-4856(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. Rudd K.E.
      Unpublished observations (MAR-1996)
      Cited for: IDENTIFICATION.
    6. "Identification of the Escherichia coli K-12 ybhE gene as pgl, encoding 6-phosphogluconolactonase."
      Thomason L.C., Court D.L., Datta A.R., Khanna R., Rosner J.L.
      J. Bacteriol. 186:8248-8253(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: K12 / MG1655 / ATCC 47076.
    7. "Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli."
      Zhang J., Sprung R., Pei J., Tan X., Kim S., Zhu H., Liu C.F., Grishin N.V., Zhao Y.
      Mol. Cell. Proteomics 8:215-225(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-287, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: K12 / JW1106 and K12 / MG1655 / ATCC 47076.
    8. "Structure of a putative 7-bladed propeller isomerase."
      Lima C.D., Kniewel R., Solorzano V., Wu J.
      Submitted (NOV-2003) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

    Entry informationi

    Entry namei6PGL_ECOLI
    AccessioniPrimary (citable) accession number: P52697
    Secondary accession number(s): P75760
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3