P52696 (YBHD_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized HTH-type transcriptional regulator YbhD

Gene names

Name:	ybhD
Ordered Locus Names:	b0768, JW5896

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Sequence similarities	Contains 1 HTH lysR-type DNA-binding domain.
Sequence caution	The sequence BAA35432.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Uncharacterized HTH-type transcriptional regulator YbhD		PRO_0000105780
Regions
	Domain	1 – 60	60	HTH lysR-type
	DNA binding	20 – 40	21	H-T-H motif Potential

Sequences

	Sequence		Length	Mass (Da)
	P52696 [UniParc]. Last modified April 27, 2001. Version 3. Checksum: 8B02C4808B4665D2	FASTA	317	36,058
	10 20 30 40 50 60 MKHELSSMKA FVILAESSSF NNAAKLLNIT QPALTRRIKK MEEDLHVQLF ERTTRKVTLT 70 80 90 100 110 120 KAGKRLLPEA RELIKKFDET LFNIRDMNAY HRGMVTLACI PTAVFYFLPL AIGKFNELYP 130 140 150 160 170 180 NIKVRILEQG TNNCMESVLC NESDFGINMN NVTNSSIDFT PLVNEPFVLA CRRDHPLAKK 190 200 210 220 230 240 QLVEWQELVG YKMIGVRSSS GNRLLIEQQL ADKPWKLDWF YEVRHLSTSL GLVEAGLGIS 250 260 270 280 290 300 ALPGLAMPHA PYSSIIGIPL VEPVIRRTLG IIRRKDAVLS PAAERFFALL INLWTDDKDN 310 LWTNIVERQR HALQEIG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T. DNA Res. 3:137-155(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	Shanmugam K.T. Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-317. Strain: K12.
[5]	Robison K. Unpublished observations (DEC-1995) Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. Translation: AAC73855.2. AP009048 Genomic DNA. Translation: BAA35432.1. Different initiation. U27192 Genomic DNA. No translation available.
PIR	H64812.
RefSeq	NP_415289.4. NC_000913.2. YP_489041.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P52696.
SMR	P52696. Positions 4-286.
ModBase	Search...
Protein-protein interaction databases
STRING	511145.b0768.
Proteomic databases
PRIDE	P52696.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC73855; AAC73855; b0768. BAA35432; BAA35432; BAA35432.
GeneID	12932150. 944869.
KEGG	ecj:Y75_p0741. eco:b0768.
PATRIC	32116737. VBIEscCol129921_0794.
Organism-specific databases
EchoBASE	EB3019.
EcoGene	EG13230. ybhD.
Phylogenomic databases
eggNOG	COG0583.
HOGENOM	HOG000233514.
OMA	SCIPTAV.
ProtClustDB	CLSK879749.
Enzyme and pathway databases
BioCyc	EcoCyc:G6398-MONOMER. ECOL316407:JW5896-MONOMER.
Gene expression databases
Genevestigator	P52696.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR005119. LysR_subst-bd. IPR000847. Tscrpt_reg_HTH_LysR. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00126. HTH_1. 1 hit. PF03466. LysR_substrate. 1 hit. [Graphical view]
PRINTS	PR00039. HTHLYSR.
PROSITE	PS50931. HTH_LYSR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YBHD_ECOLI

Accession

Primary (citable) accession number: P52696
Secondary accession number(s): P75761

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	April 27, 2001
Last modified:	May 1, 2013
This is version 92 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program