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Protein

Transcriptional activator HlyU

Gene

hlyU

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Up-regulates the expression of the hemolysin gene, hlyA, and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi47 – 66H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding transcription factor activity Source: TIGR
  • transcription regulatory region DNA binding Source: GO_Central

GO - Biological processi

  • pathogenesis Source: UniProtKB-KW
  • regulation of transcription, DNA-templated Source: TIGR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Virulence

Enzyme and pathway databases

BioCyciVCHO:VC0678-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator HlyU
Gene namesi
Name:hlyU
Ordered Locus Names:VC_0678
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606221 – 108Transcriptional activator HlyUAdd BLAST108

Interactioni

Protein-protein interaction databases

STRINGi243277.VC0678.

Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 28Combined sources17
Helixi31 – 40Combined sources10
Helixi47 – 54Combined sources8
Helixi58 – 70Combined sources13
Beta strandi73 – 79Combined sources7
Beta strandi82 – 87Combined sources6
Helixi90 – 103Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4K2EX-ray1.80A/B/C/D1-108[»]
4OOIX-ray2.20A/B/C/D1-108[»]
ProteinModelPortaliP52695.
SMRiP52695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 107HTH arsR-typePROSITE-ProRule annotationAdd BLAST95

Phylogenomic databases

eggNOGiENOG41080HT. Bacteria.
COG0640. LUCA.
KOiK22042.
OMAiMQQRADH.

Family and domain databases

CDDicd00090. HTH_ARSR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011991. ArsR-like_HTH.
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF01022. HTH_5. 1 hit.
PRINTSiPR00778. HTHARSR.
SMARTiView protein in SMART
SM00418. HTH_ARSR. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50987. HTH_ARSR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P52695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYLKGAPMN LQEMEKNSAK AVVLLKAMAN ERRLQILCML LDNELSVGEL
60 70 80 90 100
SSRLELSQSA LSQHLAWLRR DGLVNTRKEA QTVFYTLSST EVKAMIELLH

RLYCQANQ
Length:108
Mass (Da):12,293
Last modified:October 1, 1996 - v1
Checksum:i4FC1BE6DA960F217
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66866 Genomic DNA. Translation: CAA47336.1.
AJ002395 Genomic DNA. Translation: CAA05372.1.
AE003852 Genomic DNA. Translation: AAF93843.1.
PIRiS37313.
RefSeqiNP_230327.1. NC_002505.1.
WP_001888967.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93843; AAF93843; VC_0678.
GeneIDi2615467.
KEGGivch:VC0678.
PATRICifig|243277.26.peg.650.

Similar proteinsi

Entry informationi

Entry nameiHLYU_VIBCH
AccessioniPrimary (citable) accession number: P52695
Secondary accession number(s): Q9JMP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 31, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references