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Protein

Carbapenem-hydrolyzing beta-lactamase Sme-1

Gene

smeA

Organism
Serratia marcescens
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Can hydrolyze carbapenem compounds.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Acyl-ester intermediateBy similarity1
Active sitei172Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

SABIO-RKP52682.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbapenem-hydrolyzing beta-lactamase Sme-1 (EC:3.5.2.6)
Gene namesi
Name:smeA
Synonyms:bpl-1, bplA
OrganismiSerratia marcescens
Taxonomic identifieri615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000001700128 – 294Carbapenem-hydrolyzing beta-lactamase Sme-1Add BLAST267

Structurei

3D structure databases

ProteinModelPortaliP52682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni238 – 240Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK19316.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKVNFKTA SFLFSVCLAL SAFNAHANKS DAAAKQIKKL EEDFDGRIGV
60 70 80 90 100
FAIDTGSGNT FGYRSDERFP LCSSFKGFLA AAVLERVQQK KLDINQKVKY
110 120 130 140 150
ESRDLEYHSP ITTKYKGSGM TLGDMASAAL QYSDNGATNI IMERFLGGPE
160 170 180 190 200
GMTKFMRSIG DNEFRLDRWE LELNTAIPGD KRDTSTPKAV ANSLNKLALG
210 220 230 240 250
NVLNAKVKAI YQNWLKGNTT GDARIRASVP ADWVVGDKTG SCGAIGTAND
260 270 280 290
YAVIWPKNRA PLIVSIYTTR KSKDDKHSDK TIAEASRIAI QAID
Length:294
Mass (Da):32,197
Last modified:October 1, 1996 - v1
Checksum:iC33AAD6AA2293094
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28968 Genomic DNA. Translation: CAA82281.1.
Z30237 Genomic DNA. Translation: CAA82944.1.
PIRiS44080.
RefSeqiWP_063864724.1. NG_050134.1.

Genome annotation databases

KEGGiag:CAA82281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28968 Genomic DNA. Translation: CAA82281.1.
Z30237 Genomic DNA. Translation: CAA82944.1.
PIRiS44080.
RefSeqiWP_063864724.1. NG_050134.1.

3D structure databases

ProteinModelPortaliP52682.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:CAA82281.

Phylogenomic databases

KOiK19316.

Enzyme and pathway databases

SABIO-RKP52682.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBLAN_SERMA
AccessioniPrimary (citable) accession number: P52682
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.