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P52682

- BLAN_SERMA

UniProt

P52682 - BLAN_SERMA

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Protein
Carbapenem-hydrolyzing beta-lactamase Sme-1
Gene
smeA, bpl-1, bplA
Organism
Serratia marcescens
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Can hydrolyze carbapenem compounds.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Acyl-ester intermediate By similarity
Active sitei172 – 1721Proton acceptor By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

SABIO-RKP52682.

Protein family/group databases

MEROPSiS11.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbapenem-hydrolyzing beta-lactamase Sme-1 (EC:3.5.2.6)
Gene namesi
Name:smeA
Synonyms:bpl-1, bplA
OrganismiSerratia marcescens
Taxonomic identifieri615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 Publication
Add
BLAST
Chaini28 – 294267Carbapenem-hydrolyzing beta-lactamase Sme-1
PRO_0000017001Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP52682.
SMRiP52682. Positions 28-294.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni238 – 2403Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52682-1 [UniParc]FASTAAdd to Basket

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MSNKVNFKTA SFLFSVCLAL SAFNAHANKS DAAAKQIKKL EEDFDGRIGV    50
FAIDTGSGNT FGYRSDERFP LCSSFKGFLA AAVLERVQQK KLDINQKVKY 100
ESRDLEYHSP ITTKYKGSGM TLGDMASAAL QYSDNGATNI IMERFLGGPE 150
GMTKFMRSIG DNEFRLDRWE LELNTAIPGD KRDTSTPKAV ANSLNKLALG 200
NVLNAKVKAI YQNWLKGNTT GDARIRASVP ADWVVGDKTG SCGAIGTAND 250
YAVIWPKNRA PLIVSIYTTR KSKDDKHSDK TIAEASRIAI QAID 294
Length:294
Mass (Da):32,197
Last modified:October 1, 1996 - v1
Checksum:iC33AAD6AA2293094
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28968 Genomic DNA. Translation: CAA82281.1.
Z30237 Genomic DNA. Translation: CAA82944.1.
PIRiS44080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z28968 Genomic DNA. Translation: CAA82281.1 .
Z30237 Genomic DNA. Translation: CAA82944.1 .
PIRi S44080.

3D structure databases

ProteinModelPortali P52682.
SMRi P52682. Positions 28-294.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S11.A01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK P52682.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence analysis of the gene for a carbapenem-hydrolyzing class A beta-lactamase, Sme-1, from Serratia marcescens S6."
    Naas T., Vandel L., Sougakoff W., Livermore D.M., Nordmann P.
    Antimicrob. Agents Chemother. 38:1262-1270(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 28-38.
    Strain: S6.
  2. "Characterization of an LysR family protein, SmeR from Serratia marcescens S6, its effect on expression of the carbapenem-hydrolyzing beta-lactamase Sme-1, and comparison of this regulator with other beta-lactamase regulators."
    Naas T., Livermore D.M., Nordmann P.
    Antimicrob. Agents Chemother. 39:629-637(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
    Strain: S6.

Entry informationi

Entry nameiBLAN_SERMA
AccessioniPrimary (citable) accession number: P52682
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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