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P52682

- BLAN_SERMA

UniProt

P52682 - BLAN_SERMA

Protein

Carbapenem-hydrolyzing beta-lactamase Sme-1

Gene

smeA

Organism
Serratia marcescens
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Can hydrolyze carbapenem compounds.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731Acyl-ester intermediateBy similarity
    Active sitei172 – 1721Proton acceptorBy similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Enzyme and pathway databases

    SABIO-RKP52682.

    Protein family/group databases

    MEROPSiS11.A01.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbapenem-hydrolyzing beta-lactamase Sme-1 (EC:3.5.2.6)
    Gene namesi
    Name:smeA
    Synonyms:bpl-1, bplA
    OrganismiSerratia marcescens
    Taxonomic identifieri615 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 27271 PublicationAdd
    BLAST
    Chaini28 – 294267Carbapenem-hydrolyzing beta-lactamase Sme-1PRO_0000017001Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP52682.
    SMRiP52682. Positions 28-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni238 – 2403Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P52682-1 [UniParc]FASTAAdd to Basket

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    MSNKVNFKTA SFLFSVCLAL SAFNAHANKS DAAAKQIKKL EEDFDGRIGV    50
    FAIDTGSGNT FGYRSDERFP LCSSFKGFLA AAVLERVQQK KLDINQKVKY 100
    ESRDLEYHSP ITTKYKGSGM TLGDMASAAL QYSDNGATNI IMERFLGGPE 150
    GMTKFMRSIG DNEFRLDRWE LELNTAIPGD KRDTSTPKAV ANSLNKLALG 200
    NVLNAKVKAI YQNWLKGNTT GDARIRASVP ADWVVGDKTG SCGAIGTAND 250
    YAVIWPKNRA PLIVSIYTTR KSKDDKHSDK TIAEASRIAI QAID 294
    Length:294
    Mass (Da):32,197
    Last modified:October 1, 1996 - v1
    Checksum:iC33AAD6AA2293094
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28968 Genomic DNA. Translation: CAA82281.1.
    Z30237 Genomic DNA. Translation: CAA82944.1.
    PIRiS44080.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z28968 Genomic DNA. Translation: CAA82281.1 .
    Z30237 Genomic DNA. Translation: CAA82944.1 .
    PIRi S44080.

    3D structure databases

    ProteinModelPortali P52682.
    SMRi P52682. Positions 28-294.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S11.A01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK P52682.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of the gene for a carbapenem-hydrolyzing class A beta-lactamase, Sme-1, from Serratia marcescens S6."
      Naas T., Vandel L., Sougakoff W., Livermore D.M., Nordmann P.
      Antimicrob. Agents Chemother. 38:1262-1270(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 28-38.
      Strain: S6.
    2. "Characterization of an LysR family protein, SmeR from Serratia marcescens S6, its effect on expression of the carbapenem-hydrolyzing beta-lactamase Sme-1, and comparison of this regulator with other beta-lactamase regulators."
      Naas T., Livermore D.M., Nordmann P.
      Antimicrob. Agents Chemother. 39:629-637(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
      Strain: S6.

    Entry informationi

    Entry nameiBLAN_SERMA
    AccessioniPrimary (citable) accession number: P52682
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3