Reviewed,
UniProtKB/Swiss-Prot P52682 (BLAN_SERMA)
Last modified
July 28, 2009.
Version 48.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Carbapenem-hydrolyzing beta-lactamase Sme-1 EC=3.5.2.6 | ||||
| Gene names |
| ||||
| Organism | Serratia marcescens | ||||
| Taxonomic identifier | 615 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia |
Protein attributes
| Sequence length | 294 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Can hydrolyze carbapenem compounds. |
| Catalytic activity | A beta-lactam + H2O = a substituted beta-amino acid. |
| Sequence similarities | Belongs to the class-A beta-lactamase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Antibiotic resistance |
| Domain | Signal |
| Molecular function | Hydrolase |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | beta-lactam antibiotic catabolic process Inferred from electronic annotation. Source: InterPro response to antibioticInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | beta-lactamase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 27 | 27 | Ref.1 | ||||||
| Chain | 28 – 294 | 267 | Carbapenem-hydrolyzing beta-lactamase Sme-1 | PRO_0000017001 | |||||
Regions | |||||||||
| Region | 238 – 240 | 3 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 73 | 1 | Acyl-ester intermediate By similarity | ||||||
| Active site | 172 | 1 | Proton acceptor By similarity | ||||||
Sequences
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References
| [1] | "Cloning and sequence analysis of the gene for a carbapenem-hydrolyzing class A beta-lactamase, Sme-1, from Serratia marcescens S6." Naas T., Vandel L., Sougakoff W., Livermore D.M., Nordmann P. Antimicrob. Agents Chemother. 38:1262-1270(1994) [PubMed: 8092824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 28-38. Strain: S6. |
| [2] | "Characterization of an LysR family protein, SmeR from Serratia marcescens S6, its effect on expression of the carbapenem-hydrolyzing beta-lactamase Sme-1, and comparison of this regulator with other beta-lactamase regulators." Naas T., Livermore D.M., Nordmann P. Antimicrob. Agents Chemother. 39:629-637(1995) [PubMed: 7793864] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32. Strain: S6. |
Cross-references
Sequence databases | |
|---|---|
| Z28968 Genomic DNA. Translation: CAA82281.1. Z30237 Genomic DNA. Translation: CAA82944.1. | |
| PIR | S44080. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1DY6 based on UniProtKB Q54488. |
| SMR | P52682. Positions 28-294. |
| ModBase | Search... |
Genome annotation databases | |
| UCSC | F13H8.10a. c. elegans. |
Enzyme and pathway databases | |
| BRENDA | 3.5.2.6. 457. |
Family and domain databases | |
| InterPro | IPR001466. Beta_lactamase-related. IPR000871. Beta_lactamase_A/D. [Graphical view] |
| Pfam | PF00144. Beta-lactamase. 1 hit. [Graphical view] |
| PRINTS | PR00118. BLACTAMASEA. |
| PROSITE | PS00146. BETA_LACTAMASE_A. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | BLAN_SERMA | ||||||||
| Accession | Primary (citable) accession number: P52682 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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