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Protein

Carbapenem-hydrolyzing beta-lactamase transcriptional activator

Gene

nmcR

Organism
Enterobacter cloacae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

This protein is a positive regulator of gene expression of carbapenem-hydrolyzing beta-lactamase (NmcA).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi22 – 41H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Carbapenem-hydrolyzing beta-lactamase transcriptional activator
Gene namesi
Name:nmcR
OrganismiEnterobacter cloacae
Taxonomic identifieri550 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056921 – 295Carbapenem-hydrolyzing beta-lactamase transcriptional activatorAdd BLAST295

Structurei

3D structure databases

ProteinModelPortaliP52676.
SMRiP52676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 62HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50931. HTH_LYSR. 1 hit.

Sequencei

Sequence statusi: Complete.

P52676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRARLPLNAL RAFEASARYL NFTKAGLELH VSQAAVSQQV RTLEQMLGVA
60 70 80 90 100
LFTRVPRGLQ LTDEGMHLLP SITEALQMMS SAMDKFHEGK IKEVLTIAVV
110 120 130 140 150
GTFAIGWLLP RITAFLNENP WIDIRILTHN NVVNLAAEGI DASIRFGTGG
160 170 180 190 200
WINTENILLF QAPHTVLCSP ETSKKLYIPS DLKKVCLLRS YRKEEWNNWF
210 220 230 240 250
KAAGIDPWTI TGPIFDSTRL MIDAVKLGDY AALVPYHMFQ KELNERSVAK
260 270 280 290
PFEIYATLGG YWLTLQKSRV NHNSEALNVF KEWIIEHSRE FVLKS
Length:295
Mass (Da):33,444
Last modified:October 1, 1996 - v1
Checksum:iEE3D263AE2EBFC7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21956 Genomic DNA. Translation: CAA79966.1.
PIRiS35914.
RefSeqiWP_045143249.1. NZ_JYMF01000060.1.

Similar proteinsi

Entry informationi

Entry nameiNMCR_ENTCL
AccessioniPrimary (citable) accession number: P52676
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 31, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program