Reviewed, UniProtKB/Swiss-Prot P52672 (CYSH_THIRO)

Names and origin

Protein names

Recommended name:
    Phosphoadenosine phosphosulfate reductase
    EC=1.8.4.8
Alternative name(s):
    PAPS reductase, thioredoxin dependent
    PAdoPS reductase
    3'-phosphoadenylylsulfate reductase
    PAPS sulfotransferase

Gene names

Name:

cysH

Organism

Thiocapsa roseopersicina

Taxonomic identifier

1058 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Thiocapsa

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Reduction of activated sulfate into sulfite.
Catalytic activity	Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the PAPS reductase family. CysH subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cysteine biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	phosphoadenylyl-sulfate reductase (thioredoxin) activity Inferred from electronic annotation. Source: HAMAP transferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	Phosphoadenosine phosphosulfate reductase		PRO_0000100651

Sequences

	Sequence		Length	Mass (Da)
	P52672-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 8677B99E6649255D	FASTA	239	27,695
	10 20 30 40 50 60 MSKPDLDAFL HGDDAALRET NRRLESMPAE DRVRWALEHL PPQHVLSSSF GTQSAVMLHL 70 80 90 100 110 120 VSRQMPEIPV ILVDTGYLFP ETYRLVDALT DRFGLNLKVY RPALSPAWQE AGLGRLWEQG 130 140 150 160 170 180 ADGIERYNRL NKIDPMERAL RDLDAGTWFA GLRRQQANSR AELPVLRRQD GRIKFHPIID 190 200 210 220 230 WHRPRRARYL RRHDLPDHPL RDQGYVSIGD VHTTVPLLPG MLEEETRFFG IKRECGLHR

References

[1]	"A cDNA clone from Arabidopsis thaliana encoding plastidic ferredoxin:sulfite reductase." Bruehl A., Haverkamp T., Gisselmann G., Schwenn J.D. Biochim. Biophys. Acta 1295:119-124(1996) [PubMed: 8695637] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSM 219 / 6311.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z23169 Genomic DNA. Translation: CAA80690.1.
PIR	S34193.
3D structure databases
HSSP	HSSP built from PDB template 1SUR based on UniProtKB P17854.
ModBase	Search...
Family and domain databases
HAMAP	MF_00063. [Tree]
InterPro	IPR004511. CysH. IPR002500. PAPS_reduct. IPR011800. PAPS_reductase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF01507. PAPS_reduct. 1 hit. [Graphical view]
TIGRFAMs	TIGR00434. cysH. 1 hit. TIGR02057. PAPS_reductase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSH_THIRO

Accession

Primary (citable) accession number: P52672

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 25, 2008
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)