P52672 (CYSH_THIRO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoadenosine phosphosulfate reductase
EC=1.8.4.8

Alternative name(s):
3'-phosphoadenylylsulfate reductase
PAPS reductase, thioredoxin dependent
PAPS sulfotransferase
PAdoPS reductase

Gene names

Name:

cysH

Organism

Thiocapsa roseopersicina

Taxonomic identifier

1058 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Thiocapsa

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reduction of activated sulfate into sulfite. HAMAP MF_00063
Catalytic activity	Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin. HAMAP MF_00063
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3. HAMAP MF_00063
Subcellular location	Cytoplasm By similarity HAMAP MF_00063.
Sequence similarities	Belongs to the PAPS reductase family. CysH subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cysteine biosynthetic process Inferred from electronic annotation. Source: InterPro sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoadenylyl-sulfate reductase (thioredoxin) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	Phosphoadenosine phosphosulfate reductase HAMAP MF_00063		PRO_0000100651

Sequences

	Sequence		Length	Mass (Da)
	P52672 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 8677B99E6649255D	FASTA	239	27,695
	10 20 30 40 50 60 MSKPDLDAFL HGDDAALRET NRRLESMPAE DRVRWALEHL PPQHVLSSSF GTQSAVMLHL 70 80 90 100 110 120 VSRQMPEIPV ILVDTGYLFP ETYRLVDALT DRFGLNLKVY RPALSPAWQE AGLGRLWEQG 130 140 150 160 170 180 ADGIERYNRL NKIDPMERAL RDLDAGTWFA GLRRQQANSR AELPVLRRQD GRIKFHPIID 190 200 210 220 230 WHRPRRARYL RRHDLPDHPL RDQGYVSIGD VHTTVPLLPG MLEEETRFFG IKRECGLHR

References

[1]	"A cDNA clone from Arabidopsis thaliana encoding plastidic ferredoxin:sulfite reductase." Bruehl A., Haverkamp T., Gisselmann G., Schwenn J.D. Biochim. Biophys. Acta 1295:119-124(1996) [PubMed: 8695637] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSM 219 / 6311.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z23169 Genomic DNA. Translation: CAA80690.1.
PIR	S34193.
3D structure databases
ProteinModelPortal	P52672.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00063. CysH. [Tree]
InterPro	IPR004511. PAPS/APS_Rdtase. IPR002500. PAPS_reduct. IPR011800. PAPS_reductase_CysH. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF01507. PAPS_reduct. 1 hit. [Graphical view]
TIGRFAMs	TIGR00434. CysH. 1 hit. TIGR02057. PAPS_reductase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSH_THIRO

Accession

Primary (citable) accession number: P52672

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program