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P52671

- UDP_KLEPN

UniProt

P52671 - UDP_KLEPN

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Protein

Uridine phosphorylase

Gene

udp

Organism
Klebsiella pneumoniae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity).By similarity

Catalytic activityi

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. uridine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. UMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00574; UER00633.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine phosphorylase (EC:2.4.2.3)
Short name:
UPase
Short name:
UrdPase
Gene namesi
Name:udp
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Uridine phosphorylasePRO_0000063188Add
BLAST

Proteomic databases

PRIDEiP52671.

Interactioni

Subunit structurei

Homohexamer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP52671.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.Curated

Family and domain databases

Gene3Di3.40.50.1580. 2 hits.
InterProiIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 2 hits.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52671-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKSDVFHLG LTKNDLQGAT LAIVPGDPER VEKIAALMDK PVKLASHREF
60 70 80 90 100
TSWRAELDGK SLIVCSTGIG GPSTSIRVEE LASTLGVDSR TLTPRIGTTG
110 120 130 140 150
AIQPHINVGD VLVTTASVRL DGASLHFAPM EFPAVETSTA TRAGEARKSI
160 170 180 190 200
GATTIGVTAS DTFYPGQERY DTSGRERNSR SHIVRTLSIL YQQQTYDTYS
210 220 230 240 250
RVERFKGSME EWQAMGVMNY EMESATVLTM CASQGLRAGM VAGVIVNRTQ
260 270
QEIPNAETMK STESQFAVKI VVEAARRLL
Length:279
Mass (Da):30,274
Last modified:October 1, 1996 - v1
Checksum:iC650E02F10FA327C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87882 Genomic DNA. Translation: CAA61137.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87882 Genomic DNA. Translation: CAA61137.1 .

3D structure databases

ProteinModelPortali P52671.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P52671.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00574 ; UER00633 .

Family and domain databases

Gene3Di 3.40.50.1580. 2 hits.
InterProi IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view ]
PANTHERi PTHR21234. PTHR21234. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 2 hits.
PROSITEi PS01232. PNP_UDP_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and nucleotide sequence of purine nucleoside phosphorylase and uridine phosphorylase genes from Klebsiella sp."
    Takehara M., Ling F., Izawa S., Inoue Y., Kimura A.
    Biosci. Biotechnol. Biochem. 59:1987-1990(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LF1202.

Entry informationi

Entry nameiUDP_KLEPN
AccessioniPrimary (citable) accession number: P52671
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3