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P52671 (UDP_KLEPN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uridine phosphorylase

Short name=UPase
Short name=UrdPase
EC=2.4.2.3
Gene names
Name:udp
OrganismKlebsiella pneumoniae
Taxonomic identifier573 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.

Catalytic activity

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.

Subunit structure

Homohexamer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the PNP/UDP phosphorylase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
Gene Ontology (GO)
   Biological_processUMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionuridine phosphorylase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Uridine phosphorylase
PRO_0000063188

Sequences

Sequence LengthMass (Da)Tools
P52671 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: C650E02F10FA327C

FASTA27930,274
        10         20         30         40         50         60 
MSKSDVFHLG LTKNDLQGAT LAIVPGDPER VEKIAALMDK PVKLASHREF TSWRAELDGK 

        70         80         90        100        110        120 
SLIVCSTGIG GPSTSIRVEE LASTLGVDSR TLTPRIGTTG AIQPHINVGD VLVTTASVRL 

       130        140        150        160        170        180 
DGASLHFAPM EFPAVETSTA TRAGEARKSI GATTIGVTAS DTFYPGQERY DTSGRERNSR 

       190        200        210        220        230        240 
SHIVRTLSIL YQQQTYDTYS RVERFKGSME EWQAMGVMNY EMESATVLTM CASQGLRAGM 

       250        260        270 
VAGVIVNRTQ QEIPNAETMK STESQFAVKI VVEAARRLL 

« Hide

References

[1]"Molecular cloning and nucleotide sequence of purine nucleoside phosphorylase and uridine phosphorylase genes from Klebsiella sp."
Takehara M., Ling F., Izawa S., Inoue Y., Kimura A.
Biosci. Biotechnol. Biochem. 59:1987-1990(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LF1202.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X87882 Genomic DNA. Translation: CAA61137.1.

3D structure databases

ProteinModelPortalP52671.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP52671.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00574; UER00633.

Family and domain databases

Gene3D3.40.50.1580. 2 hits.
InterProIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERPTHR21234. PTHR21234. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMSSF53167. SSF53167. 2 hits.
PROSITEPS01232. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUDP_KLEPN
AccessionPrimary (citable) accession number: P52671
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways