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Protein

Transcription initiation factor IIA subunit 2

Gene

GTF2A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • TBP-class protein binding Source: BHF-UCL
  • transcription coactivator activity Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140307-MONOMER.
ReactomeiR-HSA-167161. HIV Transcription Initiation.
R-HSA-167162. RNA Polymerase II HIV Promoter Escape.
R-HSA-167172. Transcription of the HIV genome.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-6807505. RNA polymerase II transcribes snRNA genes.
R-HSA-73776. RNA Polymerase II Promoter Escape.
R-HSA-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-HSA-75953. RNA Polymerase II Transcription Initiation.
R-HSA-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
SIGNORiP52657.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIA subunit 2
Alternative name(s):
General transcription factor IIA subunit 2
TFIIA p12 subunit
Short name:
TFIIA-12
Short name:
TFIIAS
Transcription initiation factor IIA gamma chain
Short name:
TFIIA-gamma
Gene namesi
Name:GTF2A2
Synonyms:TF2A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:4647. GTF2A2.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: HPA
  • nucleoplasm Source: HPA
  • transcription factor TFIIA complex Source: BHF-UCL
  • transcription factor TFIID complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2958.
OpenTargetsiENSG00000140307.
PharmGKBiPA29034.

Polymorphism and mutation databases

BioMutaiGTF2A2.
DMDMi1729806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001940421 – 109Transcription initiation factor IIA subunit 2Add BLAST109

Proteomic databases

EPDiP52657.
MaxQBiP52657.
PaxDbiP52657.
PeptideAtlasiP52657.
PRIDEiP52657.
TopDownProteomicsiP52657.

PTM databases

iPTMnetiP52657.
PhosphoSitePlusiP52657.

Expressioni

Gene expression databases

BgeeiENSG00000140307.
CleanExiHS_GTF2A2.
ExpressionAtlasiP52657. baseline and differential.
GenevisibleiP52657. HS.

Organism-specific databases

HPAiHPA056239.

Interactioni

Subunit structurei

TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). Interacts with NCOA6 general coactivator (By similarity). TFIIA forms a complex with TBP. Interacts with SV40 Large T antigen.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GTF2A1P526556EBI-1045262,EBI-389518
TBPP202262EBI-1045262,EBI-355371

GO - Molecular functioni

  • protein heterodimerization activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • TBP-class protein binding Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi109213. 8 interactors.
DIPiDIP-40648N.
IntActiP52657. 3 interactors.
STRINGi9606.ENSP00000379372.

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 7Combined sources4
Helixi10 – 24Combined sources15
Helixi30 – 50Combined sources21
Beta strandi55 – 68Combined sources14
Beta strandi71 – 82Combined sources12
Beta strandi87 – 98Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NVPX-ray2.10D2-109[»]
5FURelectron microscopy8.50D3-99[»]
5IY6electron microscopy7.20O1-109[»]
5IY7electron microscopy8.60O1-109[»]
5IY8electron microscopy7.90O1-109[»]
5IY9electron microscopy6.30O1-109[»]
5IYAelectron microscopy5.40O1-109[»]
5IYBelectron microscopy3.90O1-109[»]
5IYCelectron microscopy3.90O1-109[»]
5IYDelectron microscopy3.90O1-109[»]
ProteinModelPortaliP52657.
SMRiP52657.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52657.

Family & Domainsi

Sequence similaritiesi

Belongs to the TFIIA subunit 2 family.Curated

Phylogenomic databases

eggNOGiKOG3463. Eukaryota.
COG5123. LUCA.
GeneTreeiENSGT00390000014572.
HOGENOMiHOG000167251.
HOVERGENiHBG000826.
InParanoidiP52657.
KOiK03123.
OMAiATAYYEF.
OrthoDBiEOG091G0X1Z.
PhylomeDBiP52657.
TreeFamiTF315131.

Family and domain databases

CDDicd10014. TFIIA_gamma_C. 1 hit.
cd10145. TFIIA_gamma_N. 1 hit.
Gene3Di1.10.287.190. 1 hit.
2.30.18.10. 1 hit.
InterProiIPR009083. TFIIA_a-hlx.
IPR009088. TFIIA_b-brl.
IPR003194. TFIIA_gsu.
IPR015871. TFIIA_gsu_C.
IPR015872. TFIIA_gsu_N.
[Graphical view]
PANTHERiPTHR10966. PTHR10966. 1 hit.
PfamiPF02751. TFIIA_gamma_C. 1 hit.
PF02268. TFIIA_gamma_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009415. Hum_TFIIA_gamma. 1 hit.
ProDomiPD009224. TFIIA_gsu_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47396. SSF47396. 1 hit.
SSF50784. SSF50784. 1 hit.

Sequencei

Sequence statusi: Complete.

P52657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYQLYRNTT LGNSLQESLD ELIQSQQITP QLALQVLLQF DKAINAALAQ
60 70 80 90 100
RVRNRVNFRG SLNTYRFCDN VWTFVLNDVE FREVTELIKV DKVKIVACDG

KNTGSNTTE
Length:109
Mass (Da):12,457
Last modified:October 1, 1996 - v1
Checksum:i938E7DC8B9982AE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81713 mRNA. Translation: CAA57357.1.
U14193 mRNA. Translation: AAA64951.1.
U21242 mRNA. Translation: AAB58247.1.
BT007362 mRNA. Translation: AAP36026.1.
CR542192 mRNA. Translation: CAG46989.1.
AC092755 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77573.1.
BC000287 mRNA. Translation: AAH00287.1.
BC001919 mRNA. Translation: AAH01919.1.
CCDSiCCDS10173.1.
PIRiI38952.
RefSeqiNP_001307858.1. NM_001320929.1.
NP_001307859.1. NM_001320930.1.
NP_004483.1. NM_004492.2.
UniGeneiHs.512934.

Genome annotation databases

EnsembliENST00000396060; ENSP00000379372; ENSG00000140307.
ENST00000396061; ENSP00000379373; ENSG00000140307.
ENST00000396063; ENSP00000379375; ENSG00000140307.
GeneIDi2958.
KEGGihsa:2958.
UCSCiuc002agg.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81713 mRNA. Translation: CAA57357.1.
U14193 mRNA. Translation: AAA64951.1.
U21242 mRNA. Translation: AAB58247.1.
BT007362 mRNA. Translation: AAP36026.1.
CR542192 mRNA. Translation: CAG46989.1.
AC092755 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77573.1.
BC000287 mRNA. Translation: AAH00287.1.
BC001919 mRNA. Translation: AAH01919.1.
CCDSiCCDS10173.1.
PIRiI38952.
RefSeqiNP_001307858.1. NM_001320929.1.
NP_001307859.1. NM_001320930.1.
NP_004483.1. NM_004492.2.
UniGeneiHs.512934.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NVPX-ray2.10D2-109[»]
5FURelectron microscopy8.50D3-99[»]
5IY6electron microscopy7.20O1-109[»]
5IY7electron microscopy8.60O1-109[»]
5IY8electron microscopy7.90O1-109[»]
5IY9electron microscopy6.30O1-109[»]
5IYAelectron microscopy5.40O1-109[»]
5IYBelectron microscopy3.90O1-109[»]
5IYCelectron microscopy3.90O1-109[»]
5IYDelectron microscopy3.90O1-109[»]
ProteinModelPortaliP52657.
SMRiP52657.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109213. 8 interactors.
DIPiDIP-40648N.
IntActiP52657. 3 interactors.
STRINGi9606.ENSP00000379372.

PTM databases

iPTMnetiP52657.
PhosphoSitePlusiP52657.

Polymorphism and mutation databases

BioMutaiGTF2A2.
DMDMi1729806.

Proteomic databases

EPDiP52657.
MaxQBiP52657.
PaxDbiP52657.
PeptideAtlasiP52657.
PRIDEiP52657.
TopDownProteomicsiP52657.

Protocols and materials databases

DNASUi2958.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396060; ENSP00000379372; ENSG00000140307.
ENST00000396061; ENSP00000379373; ENSG00000140307.
ENST00000396063; ENSP00000379375; ENSG00000140307.
GeneIDi2958.
KEGGihsa:2958.
UCSCiuc002agg.3. human.

Organism-specific databases

CTDi2958.
DisGeNETi2958.
GeneCardsiGTF2A2.
HGNCiHGNC:4647. GTF2A2.
HPAiHPA056239.
MIMi600519. gene.
neXtProtiNX_P52657.
OpenTargetsiENSG00000140307.
PharmGKBiPA29034.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3463. Eukaryota.
COG5123. LUCA.
GeneTreeiENSGT00390000014572.
HOGENOMiHOG000167251.
HOVERGENiHBG000826.
InParanoidiP52657.
KOiK03123.
OMAiATAYYEF.
OrthoDBiEOG091G0X1Z.
PhylomeDBiP52657.
TreeFamiTF315131.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140307-MONOMER.
ReactomeiR-HSA-167161. HIV Transcription Initiation.
R-HSA-167162. RNA Polymerase II HIV Promoter Escape.
R-HSA-167172. Transcription of the HIV genome.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-6807505. RNA polymerase II transcribes snRNA genes.
R-HSA-73776. RNA Polymerase II Promoter Escape.
R-HSA-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-HSA-75953. RNA Polymerase II Transcription Initiation.
R-HSA-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
SIGNORiP52657.

Miscellaneous databases

ChiTaRSiGTF2A2. human.
EvolutionaryTraceiP52657.
GenomeRNAii2958.
PROiP52657.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140307.
CleanExiHS_GTF2A2.
ExpressionAtlasiP52657. baseline and differential.
GenevisibleiP52657. HS.

Family and domain databases

CDDicd10014. TFIIA_gamma_C. 1 hit.
cd10145. TFIIA_gamma_N. 1 hit.
Gene3Di1.10.287.190. 1 hit.
2.30.18.10. 1 hit.
InterProiIPR009083. TFIIA_a-hlx.
IPR009088. TFIIA_b-brl.
IPR003194. TFIIA_gsu.
IPR015871. TFIIA_gsu_C.
IPR015872. TFIIA_gsu_N.
[Graphical view]
PANTHERiPTHR10966. PTHR10966. 1 hit.
PfamiPF02751. TFIIA_gamma_C. 1 hit.
PF02268. TFIIA_gamma_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009415. Hum_TFIIA_gamma. 1 hit.
ProDomiPD009224. TFIIA_gsu_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47396. SSF47396. 1 hit.
SSF50784. SSF50784. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiT2AG_HUMAN
AccessioniPrimary (citable) accession number: P52657
Secondary accession number(s): A8MYQ7, Q6FGB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.