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P52652 (TFS2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative transcription elongation factor S-II
Alternative name(s):
TFIIS
Gene names
ORF Names:T24H10.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the TFS-II family.

Contains 1 TFIIS central domain.

Contains 1 TFIIS N-terminal domain.

Contains 1 TFIIS-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Putative transcription elongation factor S-II
PRO_0000121444

Regions

Domain5 – 8480TFIIS N-terminal
Domain148 – 263116TFIIS central
Zinc finger266 – 30641TFIIS-type

Sequences

Sequence LengthMass (Da)Tools
P52652 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 028C4ACE24273161

FASTA30834,873
        10         20         30         40         50         60 
MSALEETQSL CKQVDDICNN GMESVEQCNK LLDQLSKIPM SIEIIQKTNI GIKVNMMRKK 

        70         80         90        100        110        120 
VTDDAVAKRA KNIIKDWKNV VDGKSKSQDD GGAPPAKKHR KESVEEAKPE KKKIEAPYKR 

       130        140        150        160        170        180 
PEPSSRPEIV AQFASASFPP KHLENDETRL KSAQLLLSAL RFGDMPQGTL DPEELAVQIE 

       190        200        210        220        230        240 
EKLYSVHRDT NKSYSAAVRS RIFNLRDKKN LALRENVLTG VVRAEKFATM TSEEMASAEI 

       250        260        270        280        290        300 
REMRDKFTKE AILEHQMSVQ QGTPSDMFKC GKCGKKNCTY TQLQTRSSDE PMTTFVFCLE 


CGNRWKFC

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z54216 Genomic DNA. Translation: CAA90943.1.
PIRT25250.
RefSeqNP_495941.1. NM_063540.1.
UniGeneCel.14290.

3D structure databases

ProteinModelPortalP52652.
SMRP52652. Positions 5-96, 145-308.
ModBaseSearch...

Protein-protein interaction databases

STRING6239.T24H10.1.

Proteomic databases

PaxDbP52652.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaT24H10.1; T24H10.1; T24H10.1.
GeneID174450.
KEGGcel:CELE_T24H10.1.
UCSCT24H10.1. c. elegans.

Organism-specific databases

CTD174450.
WormBaseT24H10.1; CE03726; WBGene00012000.

Phylogenomic databases

eggNOGCOG1594.
GeneTreeENSGT00390000017794.
HOGENOMHOG000195015.
InParanoidP52652.
KOK03145.
OMAKTNIGIK.

Family and domain databases

Gene3D1.10.472.30. 1 hit.
1.20.930.10. 1 hit.
InterProIPR016492. TF_IIS-rel.
IPR003617. TFIIS/CRSP70_N_sub.
IPR003618. TFIIS_cen_dom.
IPR017923. TFIIS_N.
IPR017890. TFS2M.
IPR006289. TFSII.
IPR001222. Znf_TFIIS.
[Graphical view]
PfamPF08711. Med26. 1 hit.
PF01096. TFIIS_C. 1 hit.
PF07500. TFIIS_M. 1 hit.
[Graphical view]
PIRSFPIRSF006704. TF_IIS. 1 hit.
SMARTSM00510. TFS2M. 1 hit.
SM00509. TFS2N. 1 hit.
SM00440. ZnF_C2C2. 1 hit.
[Graphical view]
SUPFAMSSF46942. TFIIS_centre. 1 hit.
SSF47676. TFIIS_conserved. 1 hit.
TIGRFAMsTIGR01385. TFSII. 1 hit.
PROSITEPS51321. TFIIS_CENTRAL. 1 hit.
PS51319. TFIIS_N. 1 hit.
PS00466. ZF_TFIIS_1. 1 hit.
PS51133. ZF_TFIIS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio884086.

Entry information

Entry nameTFS2_CAEEL
AccessionPrimary (citable) accession number: P52652
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

SIMILARITY comments

Index of protein domains and families

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