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P52639 (L_BDVV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length1711 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently three subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. In replicase mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals By similarity.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.

Subunit structure

Interacts with the P protein. Ref.3

Subcellular location

Virion Potential. Host nucleus Ref.4.

Sequence similarities

Contains 1 RdRp catalytic domain.

Sequence caution

The sequence AAA20228.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform Large structural protein (identifier: P52639-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Matrix protein (identifier: P0C795-1)

The sequence of this isoform can be found in the external entry P0C795.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoform Envelope glycoprotein p57 precursor (identifier: P52638-1)

The sequence of this isoform can be found in the external entry P52638.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 17111711RNA-directed RNA polymerase L
PRO_0000079207

Regions

Domain543 – 715173RdRp catalytic
Motif844 – 8529Nuclear localization signal

Natural variations

Natural variant15261A → G.

Sequences

Sequence LengthMass (Da)Tools
Isoform Large structural protein [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: 554DF018E0E17877

FASTA1,711191,734
        10         20         30         40         50         60 
MSFHASLLRE EETPRPVAGI NRTDQSLKNP LLGTEVSFCL KSSSLPHHVR ALGQIKARNL 

        70         80         90        100        110        120 
ASCDYYLLFR QVVLPPEVYP IGVLIRAAEA ILTVIVSAWK LDHMTKTLYS SVRYALTNPR 

       130        140        150        160        170        180 
VRAQLELHIA YQRIVGQVSY SREADIGPKR LGNMSLQFIQ SLVIATIDTT SCLMTYNHFL 

       190        200        210        220        230        240 
AAADTAKSRC HLLIASVVQG ALWEQGSFLD HIINMIDIID SINLPHDDYF TIIKSIFPYS 

       250        260        270        280        290        300 
QGLVMGRHNV SVSSDFASVF AIPELCPQLD SLLKKLLQLD PVLLLMVSSV QKSWYFPEIR 

       310        320        330        340        350        360 
MVDGSREQLH KMRVELETPQ ALLSYGHTLL SIFRAEFIKG YVSKNAKWPP VHLLPGCDKS 

       370        380        390        400        410        420 
IKNARELGRW SPAFDRRWQL FEKVVILRIA DLDMDPDFND IVSDKAIISS RRDWVFEYNA 

       430        440        450        460        470        480 
AAFWKKYGER LERPPARSGP SRLVNALIDG RLDNIPALLE PFYRGAVEFE DRLTVLVPKE 

       490        500        510        520        530        540 
KELKVKGRFF SKQTLAIRIY QVVAEAALKN EVMPYLKTHS MTMSSTALTH LLNRLSHTIT 

       550        560        570        580        590        600 
KGDSFVINLD YSSWCNGFRP ELQAPICRQL DQMFNCGYFF RTGCTLPCFT TFIIQDRFNP 

       610        620        630        640        650        660 
PYSLSGEPVE DGVTCAVGTK TMGEGMRQKL WTILTSCWEI IALREINVTF NILGQGDNQT 

       670        680        690        700        710        720 
IIIHKSASQN NQLLAERALG ALYKHARLAG HNLKVEECWV SDCLYEYGKK LFFRGVPVPG 

       730        740        750        760        770        780 
CLKQLSRVTD STGELFPNLY SKLACLTSSC LSAAMADTSP WVALATGVCL YLIELYVELP 

       790        800        810        820        830        840 
PAIIQDESLL TTLCLVGPSI GGLPTPATLP SVFFRGMSDP LPFQLALLQT LIKTTGVTCS 

       850        860        870        880        890        900 
LVNRVVKLRI APYPDWLSLV TDPTSLNIAQ VYRPERQIRR WIEEAIATSS HSSRIATFFQ 

       910        920        930        940        950        960 
QPLTEMAQLL ARDLSTMMPL RPRDMSALFA LSNVAYGLSI IDLFQKSSTV VSASQAVHIE 

       970        980        990       1000       1010       1020 
DVALESVRYK ESIIQGLLDT TEGYNMQPYL EGCTYLAAKQ LRRLTWGRDL VGVTMPFVAE 

      1030       1040       1050       1060       1070       1080 
QFHPHSSVGA KAELYLDAII YCPQETLRSH HLTTRGDQPL YLGSNTAVKV QRGEITGLAK 

      1090       1100       1110       1120       1130       1140 
SRAANLVKDT LVLHQWYKVR KVTDPHLNTL MARFLLEKGY TSDARPSIQG GTLTHRLPSR 

      1150       1160       1170       1180       1190       1200 
GDSRQGLTGY VNILSTWLRF SSDYLHSFSK SSDDYTIHFQ HVFTYGCLYA DSVIRSGGVI 

      1210       1220       1230       1240       1250       1260 
STPYLLSASC KTCFEKIDSE EFVLACEPQY RGAEWLISKP VTVPEQITDA EVEFDPCVSA 

      1270       1280       1290       1300       1310       1320 
SYCLGILIGK SFLVDIRASG HDIMEQRTWA NLERFSVSDM QKLPWSIVIR SLWRFLIGAR 

      1330       1340       1350       1360       1370       1380 
LLQFEKAGLI RMLYAATGPT FSFLMKVFQD SALLMDCAPL DRLSPRINFH SRGDLVAKLV 

      1390       1400       1410       1420       1430       1440 
LLPFINPGIV EIEVSGINSK YHAVSEANMD LYIAAAKSVG VKPTQFVEET NDFTARGHHH 

      1450       1460       1470       1480       1490       1500 
GCYSLSWSKS RNQSQVLKMV VRKLKLCVLY IYPTVDPAVA LDLCHLPALT IILVLGGDPA 

      1510       1520       1530       1540       1550       1560 
YYERLLEMDL CGAVSSRVDI PHSLAARTHR GFAVGPDAGP GVIRLDRLES VCYAHPCLEE 

      1570       1580       1590       1600       1610       1620 
LEFNAYLDSE LVDISDMCCL PLATPCKALF RPIYRSLQSF RLALMDNYSF VMDLIMIRGL 

      1630       1640       1650       1660       1670       1680 
DIRPHLEEFD ELLVVGQHIL GQPVLVEVVY YVGVVRKRPV LARHPWSADL KRITVGGRAP 

      1690       1700       1710 
CPSAARLRDE DCQGSLLVGL PAGLTQLLII D 

« Hide

Isoform Matrix protein [UniParc].

See P0C795.

Isoform Envelope glycoprotein p57 precursor [UniParc].

See P52638.

References

[1]"Genomic organization of Borna disease virus."
Briese T., Schneemann A., Lewis A.J., Park Y.-S., Kim S., Ludwig H., Lipkin W.I.
Proc. Natl. Acad. Sci. U.S.A. 91:4362-4366(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Conservation of coding potential and terminal sequences in four different isolates of Borna disease virus."
Pleschka S., Staeheli P., Kolodziejek J., Richt J.A., Nowotny N., Schwemmle M.
J. Gen. Virol. 82:2681-2690(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: V/FR.
[3]"Expression and characterization of the Borna disease virus polymerase."
Walker M.P., Jordan I., Briese T., Fischer N., Lipkin W.I.
J. Virol. 74:4425-4428(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH P PROTEIN.
[4]"Characterization of the nuclear localization signal of the borna disease virus polymerase."
Walker M.P., Lipkin W.I.
J. Virol. 76:8460-8467(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[5]"Borna disease virus and infection in humans."
Ikuta K., Ibrahim M.S., Kobayashi T., Tomonaga K.
Front. Biosci. 7:470-495(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U04608 Genomic RNA. Translation: AAA20228.1. Different initiation.
AJ311521 Genomic RNA. Translation: CAC70639.1.
RefSeqNP_042024.2. NC_001607.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1494405.

Family and domain databases

InterProIPR026890. Mononeg_mRNAcap.
IPR014023. Mononeg_RNA_pol_cat.
IPR025786. RNA-direct_RNA_pol_L.
[Graphical view]
PfamPF14318. Mononeg_mRNAcap. 1 hit.
PF00946. Mononeg_RNA_pol. 1 hit.
[Graphical view]
PROSITEPS50526. RDRP_SSRNA_NEG_NONSEG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameL_BDVV
AccessionPrimary (citable) accession number: P52639
Secondary accession number(s): Q912Z6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 20, 2005
Last modified: April 16, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families