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P52633

- STAT6_MOUSE

UniProt

P52633 - STAT6_MOUSE

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Protein

Signal transducer and transcription activator 6

Gene

Stat6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.1 Publication

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. DNA binding Source: MGI
  3. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding Source: MGI
  5. sequence-specific DNA binding transcription factor activity Source: Ensembl
  6. signal transducer activity Source: InterPro

GO - Biological processi

  1. cellular response to hydrogen peroxide Source: Ensembl
  2. cellular response to reactive nitrogen species Source: Ensembl
  3. interleukin-4-mediated signaling pathway Source: UniProtKB
  4. mammary gland epithelial cell proliferation Source: MGI
  5. mammary gland morphogenesis Source: MGI
  6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  7. negative regulation of type 2 immune response Source: MGI
  8. positive regulation of isotype switching to IgE isotypes Source: MGI
  9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  10. regulation of cell proliferation Source: MGI
  11. signal transduction Source: MGI
  12. T-helper 1 cell lineage commitment Source: MGI
  13. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_227400. STAT6-mediated induction of chemokines.
REACT_230639. Downstream signal transduction.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and transcription activator 6
Gene namesi
Name:Stat6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:103034. Stat6.

Subcellular locationi

Cytoplasm. Nucleus
Note: Translocated into the nucleus in response to phosphorylation.

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. membrane raft Source: Ensembl
  3. nuclear chromatin Source: BHF-UCL
  4. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 837836Signal transducer and transcription activator 6PRO_0000182434Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei641 – 6411Phosphotyrosine; by JAKBy similarity

Post-translational modificationi

Tyrosine phosphorylated following stimulation by IL4/interleukin-4 and IL3/interleukin-3. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP52633.
PaxDbiP52633.
PRIDEiP52633.

PTM databases

PhosphoSiteiP52633.

Miscellaneous databases

PMAP-CutDBP52633.

Expressioni

Gene expression databases

BgeeiP52633.
ExpressionAtlasiP52633. baseline and differential.
GenevestigatoriP52633.

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif (By similarity).By similarity

Protein-protein interaction databases

BioGridi203527. 5 interactions.
DIPiDIP-49680N.
IntActiP52633. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliP52633.
SMRiP52633. Positions 13-631.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini517 – 632116SH2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi793 – 7975LXXLL motif

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG278979.
GeneTreeiENSGT00760000119236.
HOGENOMiHOG000230988.
HOVERGENiHBG107486.
InParanoidiP52633.
KOiK11225.
OMAiKFQAGVR.
OrthoDBiEOG73JKTT.
TreeFamiTF318648.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR028187. STAT6_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF14596. STAT6_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52633-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLWGLISKM SPEKLQRLYV DFPQRLRHLL ADWLESQPWE FLVGSDAFCY
60 70 80 90 100
NMASALLSAT VQRLQATAGE QGKGNSILPH ISTLESIYQR DPLKLVATIR
110 120 130 140 150
QILQGEKKAV IEEFRHLPGP FHRKQEELKF TTALGRLQHR VRETRLLRES
160 170 180 190 200
LQQGAKTGQV SLQNLIDPPV NGPGPSEDLA TMLQGTVGDL EATQALVLKR
210 220 230 240 250
IQIWKRQQQL AGNGTPFEES LAGLQERCES LVEIYSQLQQ EIGAASGELE
260 270 280 290 300
PKTRASLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLQ
310 320 330 340 350
FLGTSAKPPM VRADMVTEKQ ARELSLAQGP GTGVESTGEI MNNTVPLENS
360 370 380 390 400
IPSNCCSALF KNLLLKKIKR CERKGTESVT EEKCAVLFST SFTLGPNKLL
410 420 430 440 450
IQLQALSLPL VVIVHGNQDN NAKATILWDN AFSEMDRVPF VVAERVPWEK
460 470 480 490 500
MCETLNLKFM AEVGTSRGLL PEHFLFLAQK IFNDNSLSVE AFQHRCVSWS
510 520 530 540 550
QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG FISKQYVTSL
560 570 580 590 600
LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSSQIENIQ PFSAKDLSIR
610 620 630 640 650
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVSTTIKMTV
660 670 680 690 700
ERDQPLPTPE PQMPAMVPPY DLGMAPDASM QLSSDMGYPP QSIHSFQSLE
710 720 730 740 750
ESMSVLPSFQ EPHLQMPPNM SQITMPFDQP HPQGLLQCQS QEHAVSSPEP
760 770 780 790 800
MLCSDVTMVE DSCLTQPVGG FPQGTWVSED MYPPLMPPTE QDLTKLLLEN
810 820 830
QGEAGGSLGS QPLLQPSPYG QSGISLSHLD LRTNPSW
Length:837
Mass (Da):93,497
Last modified:July 27, 2011 - v2
Checksum:i082E0A15C7457307
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331A → P in AAA79006. (PubMed:7760829)Curated
Sequence conflicti138 – 1381Q → H in AAA79006. (PubMed:7760829)Curated
Sequence conflicti152 – 1554QQGA → HLGP in AAA79006. (PubMed:7760829)Curated
Sequence conflicti170 – 1701V → L in AAA79006. (PubMed:7760829)Curated
Sequence conflicti180 – 1823ATM → PTI in AAA79006. (PubMed:7760829)Curated
Sequence conflicti192 – 1921A → T in AAA79006. (PubMed:7760829)Curated
Sequence conflicti195 – 1951A → P in AAA79006. (PubMed:7760829)Curated
Sequence conflicti199 – 1991K → L in AAA79006. (PubMed:7760829)Curated
Sequence conflicti239 – 2391Q → H in AAA79006. (PubMed:7760829)Curated
Sequence conflicti306 – 3061A → T in AAA79006. (PubMed:7760829)Curated
Sequence conflicti327 – 3271A → S in AAA79006. (PubMed:7760829)Curated
Sequence conflicti409 – 4091P → S in AAA79006. (PubMed:7760829)Curated
Sequence conflicti443 – 4431A → G in AAA79006. (PubMed:7760829)Curated
Sequence conflicti461 – 4611A → V in AAA79006. (PubMed:7760829)Curated
Sequence conflicti753 – 7531C → W in AAA79006. (PubMed:7760829)Curated
Sequence conflicti786 – 7861M → L in AAA79006. (PubMed:7760829)Curated
Sequence conflicti804 – 8041A → G in AAA79006. (PubMed:7760829)Curated
Sequence conflicti815 – 8151Q → K in AAA79006. (PubMed:7760829)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47650 mRNA. Translation: AAA79006.1.
AF481809 mRNA. Translation: AAL82638.1.
AK163053 mRNA. Translation: BAE37172.1.
CH466578 Genomic DNA. Translation: EDL24514.1.
BC127054 mRNA. Translation: AAI27055.1.
CCDSiCCDS36082.1.
PIRiI57557.
RefSeqiNP_033310.2. NM_009284.2.
UniGeneiMm.121721.

Genome annotation databases

EnsembliENSMUST00000092074; ENSMUSP00000089708; ENSMUSG00000002147.
GeneIDi20852.
KEGGimmu:20852.
UCSCiuc007hka.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47650 mRNA. Translation: AAA79006.1 .
AF481809 mRNA. Translation: AAL82638.1 .
AK163053 mRNA. Translation: BAE37172.1 .
CH466578 Genomic DNA. Translation: EDL24514.1 .
BC127054 mRNA. Translation: AAI27055.1 .
CCDSi CCDS36082.1.
PIRi I57557.
RefSeqi NP_033310.2. NM_009284.2.
UniGenei Mm.121721.

3D structure databases

ProteinModelPortali P52633.
SMRi P52633. Positions 13-631.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203527. 5 interactions.
DIPi DIP-49680N.
IntActi P52633. 3 interactions.

Chemistry

BindingDBi P52633.
ChEMBLi CHEMBL2189147.

PTM databases

PhosphoSitei P52633.

Proteomic databases

MaxQBi P52633.
PaxDbi P52633.
PRIDEi P52633.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000092074 ; ENSMUSP00000089708 ; ENSMUSG00000002147 .
GeneIDi 20852.
KEGGi mmu:20852.
UCSCi uc007hka.1. mouse.

Organism-specific databases

CTDi 6778.
MGIi MGI:103034. Stat6.

Phylogenomic databases

eggNOGi NOG278979.
GeneTreei ENSGT00760000119236.
HOGENOMi HOG000230988.
HOVERGENi HBG107486.
InParanoidi P52633.
KOi K11225.
OMAi KFQAGVR.
OrthoDBi EOG73JKTT.
TreeFami TF318648.

Enzyme and pathway databases

Reactomei REACT_227400. STAT6-mediated induction of chemokines.
REACT_230639. Downstream signal transduction.

Miscellaneous databases

ChiTaRSi Stat6. mouse.
NextBioi 299643.
PMAP-CutDB P52633.
PROi P52633.
SOURCEi Search...

Gene expression databases

Bgeei P52633.
ExpressionAtlasi P52633. baseline and differential.
Genevestigatori P52633.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR028187. STAT6_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view ]
PANTHERi PTHR11801. PTHR11801. 1 hit.
Pfami PF00017. SH2. 1 hit.
PF14596. STAT6_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view ]
SUPFAMi SSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis."
    Quelle F.W., Shimoda K., Thierfelder W., Fischer C.L., Kim A., Ruben S.M., Cleveland J.L., Pierce J.H., Keegan A.D., Nelms K., Paul W.E., Ihle J.N.
    Mol. Cell. Biol. 15:3336-3343(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Murine signal transducer and activator of transcription 6 (mSTAT6)."
    Leyva F.J., Evans C.M., Tuvim M.J., Dickey B.F.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6."
    Lu X., Chen J., Sasmono R.T., Hsi E.D., Sarosiek K.A., Tiganis T., Lossos I.S.
    Mol. Cell. Biol. 27:2166-2179(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN IL4/INTERLEUKIN-4 SIGNALING, PHOSPHORYLATION, DEPHOSPHORYLATION BY PTPN2.

Entry informationi

Entry nameiSTAT6_MOUSE
AccessioniPrimary (citable) accession number: P52633
Secondary accession number(s): Q8R2F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3