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Protein

Signal transducer and transcription activator 6

Gene

Stat6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to hydrogen peroxide Source: Ensembl
  • cellular response to reactive nitrogen species Source: Ensembl
  • interleukin-4-mediated signaling pathway Source: UniProtKB
  • mammary gland epithelial cell proliferation Source: MGI
  • mammary gland morphogenesis Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • negative regulation of type 2 immune response Source: MGI
  • positive regulation of isotype switching to IgE isotypes Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of cell proliferation Source: MGI
  • signal transduction Source: MGI
  • T-helper 1 cell lineage commitment Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-186763. Downstream signal transduction.
R-MMU-3249367. STAT6-mediated induction of chemokines.
R-MMU-6785807. Interleukin-4 and 13 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and transcription activator 6
Gene namesi
Name:Stat6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:103034. Stat6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2189147.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001824342 – 837Signal transducer and transcription activator 6Add BLAST836

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei641Phosphotyrosine; by JAKBy similarity1

Post-translational modificationi

Tyrosine phosphorylated following stimulation by IL4/interleukin-4 and IL3/interleukin-3. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP52633.
MaxQBiP52633.
PaxDbiP52633.
PeptideAtlasiP52633.
PRIDEiP52633.

PTM databases

iPTMnetiP52633.
PhosphoSitePlusiP52633.

Miscellaneous databases

PMAP-CutDBiP52633.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002147.
ExpressionAtlasiP52633. baseline and differential.
GenevisibleiP52633. MM.

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203527. 6 interactors.
DIPiDIP-49680N.
IntActiP52633. 7 interactors.
STRINGi10090.ENSMUSP00000089708.

Chemistry databases

BindingDBiP52633.

Structurei

3D structure databases

ProteinModelPortaliP52633.
SMRiP52633.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini517 – 632SH2PROSITE-ProRule annotationAdd BLAST116

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi793 – 797LXXLL motif5

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
GeneTreeiENSGT00760000119236.
HOGENOMiHOG000230988.
HOVERGENiHBG107486.
InParanoidiP52633.
KOiK11225.
OMAiENSIPGN.
OrthoDBiEOG091G03O3.
TreeFamiTF318648.

Family and domain databases

CDDicd10377. SH2_STAT6. 1 hit.
Gene3Di1.10.532.10. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR028187. STAT6_C.
IPR035857. STAT6_SH2.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PF14596. STAT6_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52633-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLWGLISKM SPEKLQRLYV DFPQRLRHLL ADWLESQPWE FLVGSDAFCY
60 70 80 90 100
NMASALLSAT VQRLQATAGE QGKGNSILPH ISTLESIYQR DPLKLVATIR
110 120 130 140 150
QILQGEKKAV IEEFRHLPGP FHRKQEELKF TTALGRLQHR VRETRLLRES
160 170 180 190 200
LQQGAKTGQV SLQNLIDPPV NGPGPSEDLA TMLQGTVGDL EATQALVLKR
210 220 230 240 250
IQIWKRQQQL AGNGTPFEES LAGLQERCES LVEIYSQLQQ EIGAASGELE
260 270 280 290 300
PKTRASLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLQ
310 320 330 340 350
FLGTSAKPPM VRADMVTEKQ ARELSLAQGP GTGVESTGEI MNNTVPLENS
360 370 380 390 400
IPSNCCSALF KNLLLKKIKR CERKGTESVT EEKCAVLFST SFTLGPNKLL
410 420 430 440 450
IQLQALSLPL VVIVHGNQDN NAKATILWDN AFSEMDRVPF VVAERVPWEK
460 470 480 490 500
MCETLNLKFM AEVGTSRGLL PEHFLFLAQK IFNDNSLSVE AFQHRCVSWS
510 520 530 540 550
QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG FISKQYVTSL
560 570 580 590 600
LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSSQIENIQ PFSAKDLSIR
610 620 630 640 650
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVSTTIKMTV
660 670 680 690 700
ERDQPLPTPE PQMPAMVPPY DLGMAPDASM QLSSDMGYPP QSIHSFQSLE
710 720 730 740 750
ESMSVLPSFQ EPHLQMPPNM SQITMPFDQP HPQGLLQCQS QEHAVSSPEP
760 770 780 790 800
MLCSDVTMVE DSCLTQPVGG FPQGTWVSED MYPPLMPPTE QDLTKLLLEN
810 820 830
QGEAGGSLGS QPLLQPSPYG QSGISLSHLD LRTNPSW
Length:837
Mass (Da):93,497
Last modified:July 27, 2011 - v2
Checksum:i082E0A15C7457307
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133A → P in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti138Q → H in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti152 – 155QQGA → HLGP in AAA79006 (PubMed:7760829).Curated4
Sequence conflicti170V → L in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti180 – 182ATM → PTI in AAA79006 (PubMed:7760829).Curated3
Sequence conflicti192A → T in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti195A → P in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti199K → L in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti239Q → H in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti306A → T in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti327A → S in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti409P → S in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti443A → G in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti461A → V in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti753C → W in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti786M → L in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti804A → G in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti815Q → K in AAA79006 (PubMed:7760829).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47650 mRNA. Translation: AAA79006.1.
AF481809 mRNA. Translation: AAL82638.1.
AK163053 mRNA. Translation: BAE37172.1.
CH466578 Genomic DNA. Translation: EDL24514.1.
BC127054 mRNA. Translation: AAI27055.1.
CCDSiCCDS36082.1.
PIRiI57557.
RefSeqiNP_033310.2. NM_009284.2.
UniGeneiMm.121721.

Genome annotation databases

EnsembliENSMUST00000092074; ENSMUSP00000089708; ENSMUSG00000002147.
GeneIDi20852.
KEGGimmu:20852.
UCSCiuc007hka.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiSTAT6_MOUSE
AccessioniPrimary (citable) accession number: P52633
Secondary accession number(s): Q8R2F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: September 27, 2017
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families