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P52633 (STAT6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Signal transducer and transcription activator 6
Gene names
Name:Stat6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length837 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. Ref.6

Subunit structure

Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif By similarity.

Subcellular location

Cytoplasm. Nucleus. Note: Translocated into the nucleus in response to phosphorylation.

Post-translational modification

Tyrosine phosphorylated following stimulation by IL4/interleukin-4 and IL3/interleukin-3. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling. Ref.6

Sequence similarities

Belongs to the transcription factor STAT family.

Contains 1 SH2 domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   DomainSH2 domain
   LigandDNA-binding
   Molecular functionActivator
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT-helper 1 cell lineage commitment

Inferred from genetic interaction PubMed 20706986. Source: MGI

cellular response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

cellular response to reactive nitrogen species

Inferred from electronic annotation. Source: Ensembl

interleukin-4-mediated signaling pathway

Inferred from mutant phenotype Ref.6. Source: UniProtKB

mammary gland epithelial cell proliferation

Inferred from mutant phenotype PubMed 22588720. Source: MGI

mammary gland morphogenesis

Inferred from mutant phenotype PubMed 22588720. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 20956546. Source: MGI

negative regulation of type 2 immune response

Inferred from genetic interaction PubMed 10438949. Source: MGI

positive regulation of isotype switching to IgE isotypes

Inferred from genetic interaction PubMed 10490661. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 21217760. Source: MGI

regulation of cell proliferation

Inferred from direct assay PubMed 12093868. Source: MGI

signal transduction

Inferred from mutant phenotype PubMed 17658279. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 12093868PubMed 12634107. Source: MGI

membrane raft

Inferred from electronic annotation. Source: Ensembl

nuclear chromatin

Inferred from direct assay PubMed 15187136. Source: BHF-UCL

nucleus

Inferred from direct assay PubMed 12093868. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 10490661. Source: MGI

RNA polymerase II core promoter sequence-specific DNA binding

Inferred from direct assay PubMed 22588720. Source: MGI

calcium ion binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding

Inferred from direct assay PubMed 15659391. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

signal transducer activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 837836Signal transducer and transcription activator 6
PRO_0000182434

Regions

Domain517 – 632116SH2
Motif793 – 7975LXXLL motif

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue6411Phosphotyrosine; by JAK By similarity

Experimental info

Sequence conflict1331A → P in AAA79006. Ref.1
Sequence conflict1381Q → H in AAA79006. Ref.1
Sequence conflict152 – 1554QQGA → HLGP in AAA79006. Ref.1
Sequence conflict1701V → L in AAA79006. Ref.1
Sequence conflict180 – 1823ATM → PTI in AAA79006. Ref.1
Sequence conflict1921A → T in AAA79006. Ref.1
Sequence conflict1951A → P in AAA79006. Ref.1
Sequence conflict1991K → L in AAA79006. Ref.1
Sequence conflict2391Q → H in AAA79006. Ref.1
Sequence conflict3061A → T in AAA79006. Ref.1
Sequence conflict3271A → S in AAA79006. Ref.1
Sequence conflict4091P → S in AAA79006. Ref.1
Sequence conflict4431A → G in AAA79006. Ref.1
Sequence conflict4611A → V in AAA79006. Ref.1
Sequence conflict7531C → W in AAA79006. Ref.1
Sequence conflict7861M → L in AAA79006. Ref.1
Sequence conflict8041A → G in AAA79006. Ref.1
Sequence conflict8151Q → K in AAA79006. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P52633 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 082E0A15C7457307

FASTA83793,497
        10         20         30         40         50         60 
MSLWGLISKM SPEKLQRLYV DFPQRLRHLL ADWLESQPWE FLVGSDAFCY NMASALLSAT 

        70         80         90        100        110        120 
VQRLQATAGE QGKGNSILPH ISTLESIYQR DPLKLVATIR QILQGEKKAV IEEFRHLPGP 

       130        140        150        160        170        180 
FHRKQEELKF TTALGRLQHR VRETRLLRES LQQGAKTGQV SLQNLIDPPV NGPGPSEDLA 

       190        200        210        220        230        240 
TMLQGTVGDL EATQALVLKR IQIWKRQQQL AGNGTPFEES LAGLQERCES LVEIYSQLQQ 

       250        260        270        280        290        300 
EIGAASGELE PKTRASLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLQ 

       310        320        330        340        350        360 
FLGTSAKPPM VRADMVTEKQ ARELSLAQGP GTGVESTGEI MNNTVPLENS IPSNCCSALF 

       370        380        390        400        410        420 
KNLLLKKIKR CERKGTESVT EEKCAVLFST SFTLGPNKLL IQLQALSLPL VVIVHGNQDN 

       430        440        450        460        470        480 
NAKATILWDN AFSEMDRVPF VVAERVPWEK MCETLNLKFM AEVGTSRGLL PEHFLFLAQK 

       490        500        510        520        530        540 
IFNDNSLSVE AFQHRCVSWS QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG 

       550        560        570        580        590        600 
FISKQYVTSL LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSSQIENIQ PFSAKDLSIR 

       610        620        630        640        650        660 
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVSTTIKMTV ERDQPLPTPE 

       670        680        690        700        710        720 
PQMPAMVPPY DLGMAPDASM QLSSDMGYPP QSIHSFQSLE ESMSVLPSFQ EPHLQMPPNM 

       730        740        750        760        770        780 
SQITMPFDQP HPQGLLQCQS QEHAVSSPEP MLCSDVTMVE DSCLTQPVGG FPQGTWVSED 

       790        800        810        820        830 
MYPPLMPPTE QDLTKLLLEN QGEAGGSLGS QPLLQPSPYG QSGISLSHLD LRTNPSW 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis."
Quelle F.W., Shimoda K., Thierfelder W., Fischer C.L., Kim A., Ruben S.M., Cleveland J.L., Pierce J.H., Keegan A.D., Nelms K., Paul W.E., Ihle J.N.
Mol. Cell. Biol. 15:3336-3343(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Murine signal transducer and activator of transcription 6 (mSTAT6)."
Leyva F.J., Evans C.M., Tuvim M.J., Dickey B.F.
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6."
Lu X., Chen J., Sasmono R.T., Hsi E.D., Sarosiek K.A., Tiganis T., Lossos I.S.
Mol. Cell. Biol. 27:2166-2179(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN IL4/INTERLEUKIN-4 SIGNALING, PHOSPHORYLATION, DEPHOSPHORYLATION BY PTPN2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L47650 mRNA. Translation: AAA79006.1.
AF481809 mRNA. Translation: AAL82638.1.
AK163053 mRNA. Translation: BAE37172.1.
CH466578 Genomic DNA. Translation: EDL24514.1.
BC127054 mRNA. Translation: AAI27055.1.
CCDSCCDS36082.1.
PIRI57557.
RefSeqNP_033310.2. NM_009284.2.
UniGeneMm.121721.

3D structure databases

ProteinModelPortalP52633.
SMRP52633. Positions 13-631.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203527. 5 interactions.
DIPDIP-49680N.
IntActP52633. 3 interactions.

Chemistry

ChEMBLCHEMBL2189147.

PTM databases

PhosphoSiteP52633.

Proteomic databases

MaxQBP52633.
PaxDbP52633.
PRIDEP52633.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000092074; ENSMUSP00000089708; ENSMUSG00000002147.
GeneID20852.
KEGGmmu:20852.
UCSCuc007hka.1. mouse.

Organism-specific databases

CTD6778.
MGIMGI:103034. Stat6.

Phylogenomic databases

eggNOGNOG278979.
GeneTreeENSGT00740000115175.
HOGENOMHOG000230988.
HOVERGENHBG107486.
InParanoidQ8R2F1.
KOK11225.
OMAKFQAGVR.
OrthoDBEOG73JKTT.
TreeFamTF318648.

Gene expression databases

ArrayExpressP52633.
BgeeP52633.
GenevestigatorP52633.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR028187. STAT6_C.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERPTHR11801. PTHR11801. 1 hit.
PfamPF00017. SH2. 1 hit.
PF14596. STAT6_C. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSTAT6. mouse.
NextBio299643.
PMAP-CutDBP52633.
PROP52633.
SOURCESearch...

Entry information

Entry nameSTAT6_MOUSE
AccessionPrimary (citable) accession number: P52633
Secondary accession number(s): Q8R2F1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot