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P52633

- STAT6_MOUSE

UniProt

P52633 - STAT6_MOUSE

Protein

Signal transducer and transcription activator 6

Gene

Stat6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.1 Publication

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. DNA binding Source: MGI
    3. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
    4. sequence-specific DNA binding Source: MGI
    5. sequence-specific DNA binding transcription factor activity Source: Ensembl
    6. signal transducer activity Source: InterPro

    GO - Biological processi

    1. cellular response to hydrogen peroxide Source: Ensembl
    2. cellular response to reactive nitrogen species Source: Ensembl
    3. interleukin-4-mediated signaling pathway Source: UniProtKB
    4. mammary gland epithelial cell proliferation Source: MGI
    5. mammary gland morphogenesis Source: MGI
    6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    7. negative regulation of type 2 immune response Source: MGI
    8. positive regulation of isotype switching to IgE isotypes Source: MGI
    9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    10. regulation of cell proliferation Source: MGI
    11. signal transduction Source: MGI
    12. T-helper 1 cell lineage commitment Source: MGI
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_227400. STAT6-mediated induction of chemokines.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducer and transcription activator 6
    Gene namesi
    Name:Stat6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:103034. Stat6.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Translocated into the nucleus in response to phosphorylation.

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. membrane raft Source: Ensembl
    3. nuclear chromatin Source: BHF-UCL
    4. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 837836Signal transducer and transcription activator 6PRO_0000182434Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei641 – 6411Phosphotyrosine; by JAKBy similarity

    Post-translational modificationi

    Tyrosine phosphorylated following stimulation by IL4/interleukin-4 and IL3/interleukin-3. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP52633.
    PaxDbiP52633.
    PRIDEiP52633.

    PTM databases

    PhosphoSiteiP52633.

    Miscellaneous databases

    PMAP-CutDBP52633.

    Expressioni

    Gene expression databases

    ArrayExpressiP52633.
    BgeeiP52633.
    GenevestigatoriP52633.

    Interactioni

    Subunit structurei

    Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif By similarity.By similarity

    Protein-protein interaction databases

    BioGridi203527. 5 interactions.
    DIPiDIP-49680N.
    IntActiP52633. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP52633.
    SMRiP52633. Positions 13-631.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini517 – 632116SH2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi793 – 7975LXXLL motif

    Sequence similaritiesi

    Belongs to the transcription factor STAT family.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG278979.
    GeneTreeiENSGT00740000115175.
    HOGENOMiHOG000230988.
    HOVERGENiHBG107486.
    InParanoidiQ8R2F1.
    KOiK11225.
    OMAiKFQAGVR.
    OrthoDBiEOG73JKTT.
    TreeFamiTF318648.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR028187. STAT6_C.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view]
    PANTHERiPTHR11801. PTHR11801. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF14596. STAT6_C. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view]
    SUPFAMiSSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P52633-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLWGLISKM SPEKLQRLYV DFPQRLRHLL ADWLESQPWE FLVGSDAFCY    50
    NMASALLSAT VQRLQATAGE QGKGNSILPH ISTLESIYQR DPLKLVATIR 100
    QILQGEKKAV IEEFRHLPGP FHRKQEELKF TTALGRLQHR VRETRLLRES 150
    LQQGAKTGQV SLQNLIDPPV NGPGPSEDLA TMLQGTVGDL EATQALVLKR 200
    IQIWKRQQQL AGNGTPFEES LAGLQERCES LVEIYSQLQQ EIGAASGELE 250
    PKTRASLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLQ 300
    FLGTSAKPPM VRADMVTEKQ ARELSLAQGP GTGVESTGEI MNNTVPLENS 350
    IPSNCCSALF KNLLLKKIKR CERKGTESVT EEKCAVLFST SFTLGPNKLL 400
    IQLQALSLPL VVIVHGNQDN NAKATILWDN AFSEMDRVPF VVAERVPWEK 450
    MCETLNLKFM AEVGTSRGLL PEHFLFLAQK IFNDNSLSVE AFQHRCVSWS 500
    QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG FISKQYVTSL 550
    LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSSQIENIQ PFSAKDLSIR 600
    SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVSTTIKMTV 650
    ERDQPLPTPE PQMPAMVPPY DLGMAPDASM QLSSDMGYPP QSIHSFQSLE 700
    ESMSVLPSFQ EPHLQMPPNM SQITMPFDQP HPQGLLQCQS QEHAVSSPEP 750
    MLCSDVTMVE DSCLTQPVGG FPQGTWVSED MYPPLMPPTE QDLTKLLLEN 800
    QGEAGGSLGS QPLLQPSPYG QSGISLSHLD LRTNPSW 837
    Length:837
    Mass (Da):93,497
    Last modified:July 27, 2011 - v2
    Checksum:i082E0A15C7457307
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti133 – 1331A → P in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti138 – 1381Q → H in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti152 – 1554QQGA → HLGP in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti170 – 1701V → L in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti180 – 1823ATM → PTI in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti192 – 1921A → T in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti195 – 1951A → P in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti199 – 1991K → L in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti239 – 2391Q → H in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti306 – 3061A → T in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti327 – 3271A → S in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti409 – 4091P → S in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti443 – 4431A → G in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti461 – 4611A → V in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti753 – 7531C → W in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti786 – 7861M → L in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti804 – 8041A → G in AAA79006. (PubMed:7760829)Curated
    Sequence conflicti815 – 8151Q → K in AAA79006. (PubMed:7760829)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L47650 mRNA. Translation: AAA79006.1.
    AF481809 mRNA. Translation: AAL82638.1.
    AK163053 mRNA. Translation: BAE37172.1.
    CH466578 Genomic DNA. Translation: EDL24514.1.
    BC127054 mRNA. Translation: AAI27055.1.
    CCDSiCCDS36082.1.
    PIRiI57557.
    RefSeqiNP_033310.2. NM_009284.2.
    UniGeneiMm.121721.

    Genome annotation databases

    EnsembliENSMUST00000092074; ENSMUSP00000089708; ENSMUSG00000002147.
    GeneIDi20852.
    KEGGimmu:20852.
    UCSCiuc007hka.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L47650 mRNA. Translation: AAA79006.1 .
    AF481809 mRNA. Translation: AAL82638.1 .
    AK163053 mRNA. Translation: BAE37172.1 .
    CH466578 Genomic DNA. Translation: EDL24514.1 .
    BC127054 mRNA. Translation: AAI27055.1 .
    CCDSi CCDS36082.1.
    PIRi I57557.
    RefSeqi NP_033310.2. NM_009284.2.
    UniGenei Mm.121721.

    3D structure databases

    ProteinModelPortali P52633.
    SMRi P52633. Positions 13-631.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203527. 5 interactions.
    DIPi DIP-49680N.
    IntActi P52633. 3 interactions.

    Chemistry

    ChEMBLi CHEMBL2189147.

    PTM databases

    PhosphoSitei P52633.

    Proteomic databases

    MaxQBi P52633.
    PaxDbi P52633.
    PRIDEi P52633.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000092074 ; ENSMUSP00000089708 ; ENSMUSG00000002147 .
    GeneIDi 20852.
    KEGGi mmu:20852.
    UCSCi uc007hka.1. mouse.

    Organism-specific databases

    CTDi 6778.
    MGIi MGI:103034. Stat6.

    Phylogenomic databases

    eggNOGi NOG278979.
    GeneTreei ENSGT00740000115175.
    HOGENOMi HOG000230988.
    HOVERGENi HBG107486.
    InParanoidi Q8R2F1.
    KOi K11225.
    OMAi KFQAGVR.
    OrthoDBi EOG73JKTT.
    TreeFami TF318648.

    Enzyme and pathway databases

    Reactomei REACT_227400. STAT6-mediated induction of chemokines.

    Miscellaneous databases

    ChiTaRSi STAT6. mouse.
    NextBioi 299643.
    PMAP-CutDB P52633.
    PROi P52633.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P52633.
    Bgeei P52633.
    Genevestigatori P52633.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR028187. STAT6_C.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view ]
    PANTHERi PTHR11801. PTHR11801. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF14596. STAT6_C. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis."
      Quelle F.W., Shimoda K., Thierfelder W., Fischer C.L., Kim A., Ruben S.M., Cleveland J.L., Pierce J.H., Keegan A.D., Nelms K., Paul W.E., Ihle J.N.
      Mol. Cell. Biol. 15:3336-3343(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Murine signal transducer and activator of transcription 6 (mSTAT6)."
      Leyva F.J., Evans C.M., Tuvim M.J., Dickey B.F.
      Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6."
      Lu X., Chen J., Sasmono R.T., Hsi E.D., Sarosiek K.A., Tiganis T., Lossos I.S.
      Mol. Cell. Biol. 27:2166-2179(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN IL4/INTERLEUKIN-4 SIGNALING, PHOSPHORYLATION, DEPHOSPHORYLATION BY PTPN2.

    Entry informationi

    Entry nameiSTAT6_MOUSE
    AccessioniPrimary (citable) accession number: P52633
    Secondary accession number(s): Q8R2F1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3