Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal transducer and transcription activator 6

Gene

Stat6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to hydrogen peroxide Source: Ensembl
  • cellular response to reactive nitrogen species Source: Ensembl
  • interleukin-4-mediated signaling pathway Source: UniProtKB
  • mammary gland epithelial cell proliferation Source: MGI
  • mammary gland morphogenesis Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • negative regulation of type 2 immune response Source: MGI
  • positive regulation of isotype switching to IgE isotypes Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of cell proliferation Source: MGI
  • signal transduction Source: MGI
  • T-helper 1 cell lineage commitment Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-186763 Downstream signal transduction
R-MMU-3249367 STAT6-mediated induction of chemokines
R-MMU-6785807 Interleukin-4 and 13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and transcription activator 6
Gene namesi
Name:Stat6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:103034 Stat6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2189147

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001824342 – 837Signal transducer and transcription activator 6Add BLAST836

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei641Phosphotyrosine; by JAKBy similarity1

Post-translational modificationi

Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4. Tyrosine phosphorylated following stimulation by IL3/interleukin-3. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling.1 Publication
Mono-ADP-ribosylated by PARP14.By similarity

Keywords - PTMi

Acetylation, ADP-ribosylation, Phosphoprotein

Proteomic databases

EPDiP52633
MaxQBiP52633
PaxDbiP52633
PeptideAtlasiP52633
PRIDEiP52633

PTM databases

iPTMnetiP52633
PhosphoSitePlusiP52633

Miscellaneous databases

PMAP-CutDBiP52633

Expressioni

Gene expression databases

BgeeiENSMUSG00000002147
ExpressionAtlasiP52633 baseline and differential
GenevisibleiP52633 MM

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Parp14Q2EMV93EBI-647085,EBI-1534943

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2035276 interactors.
DIPiDIP-49680N
IntActiP52633 9 interactors.
STRINGi10090.ENSMUSP00000089708

Chemistry databases

BindingDBiP52633

Structurei

3D structure databases

ProteinModelPortaliP52633
SMRiP52633
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini517 – 632SH2PROSITE-ProRule annotationAdd BLAST116

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi793 – 797LXXLL motif5

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236
HOGENOMiHOG000230988
HOVERGENiHBG107486
InParanoidiP52633
KOiK11225
OMAiENSIPGN
OrthoDBiEOG091G03O3
TreeFamiTF318648

Family and domain databases

CDDicd10377 SH2_STAT6, 1 hit
Gene3Di1.10.532.101 hit
2.60.40.6301 hit
3.30.505.101 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR028187 STAT6_C
IPR035857 STAT6_SH2
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF14596 STAT6_C, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00964 STAT_int, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF48092 SSF48092, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52633-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLWGLISKM SPEKLQRLYV DFPQRLRHLL ADWLESQPWE FLVGSDAFCY
60 70 80 90 100
NMASALLSAT VQRLQATAGE QGKGNSILPH ISTLESIYQR DPLKLVATIR
110 120 130 140 150
QILQGEKKAV IEEFRHLPGP FHRKQEELKF TTALGRLQHR VRETRLLRES
160 170 180 190 200
LQQGAKTGQV SLQNLIDPPV NGPGPSEDLA TMLQGTVGDL EATQALVLKR
210 220 230 240 250
IQIWKRQQQL AGNGTPFEES LAGLQERCES LVEIYSQLQQ EIGAASGELE
260 270 280 290 300
PKTRASLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLQ
310 320 330 340 350
FLGTSAKPPM VRADMVTEKQ ARELSLAQGP GTGVESTGEI MNNTVPLENS
360 370 380 390 400
IPSNCCSALF KNLLLKKIKR CERKGTESVT EEKCAVLFST SFTLGPNKLL
410 420 430 440 450
IQLQALSLPL VVIVHGNQDN NAKATILWDN AFSEMDRVPF VVAERVPWEK
460 470 480 490 500
MCETLNLKFM AEVGTSRGLL PEHFLFLAQK IFNDNSLSVE AFQHRCVSWS
510 520 530 540 550
QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG FISKQYVTSL
560 570 580 590 600
LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSSQIENIQ PFSAKDLSIR
610 620 630 640 650
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVSTTIKMTV
660 670 680 690 700
ERDQPLPTPE PQMPAMVPPY DLGMAPDASM QLSSDMGYPP QSIHSFQSLE
710 720 730 740 750
ESMSVLPSFQ EPHLQMPPNM SQITMPFDQP HPQGLLQCQS QEHAVSSPEP
760 770 780 790 800
MLCSDVTMVE DSCLTQPVGG FPQGTWVSED MYPPLMPPTE QDLTKLLLEN
810 820 830
QGEAGGSLGS QPLLQPSPYG QSGISLSHLD LRTNPSW
Length:837
Mass (Da):93,497
Last modified:July 27, 2011 - v2
Checksum:i082E0A15C7457307
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133A → P in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti138Q → H in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti152 – 155QQGA → HLGP in AAA79006 (PubMed:7760829).Curated4
Sequence conflicti170V → L in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti180 – 182ATM → PTI in AAA79006 (PubMed:7760829).Curated3
Sequence conflicti192A → T in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti195A → P in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti199K → L in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti239Q → H in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti306A → T in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti327A → S in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti409P → S in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti443A → G in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti461A → V in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti753C → W in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti786M → L in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti804A → G in AAA79006 (PubMed:7760829).Curated1
Sequence conflicti815Q → K in AAA79006 (PubMed:7760829).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47650 mRNA Translation: AAA79006.1
AF481809 mRNA Translation: AAL82638.1
AK163053 mRNA Translation: BAE37172.1
CH466578 Genomic DNA Translation: EDL24514.1
BC127054 mRNA Translation: AAI27055.1
CCDSiCCDS36082.1
PIRiI57557
RefSeqiNP_033310.2, NM_009284.2
UniGeneiMm.121721

Genome annotation databases

EnsembliENSMUST00000092074; ENSMUSP00000089708; ENSMUSG00000002147
GeneIDi20852
KEGGimmu:20852
UCSCiuc007hka.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSTAT6_MOUSE
AccessioniPrimary (citable) accession number: P52633
Secondary accession number(s): Q8R2F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome