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P52632

- STA5B_RAT

UniProt

P52632 - STA5B_RAT

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Protein
Signal transducer and activator of transcription 5B
Gene
Stat5b
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription By similarity.

GO - Molecular functioni

  1. DNA binding Source: RGD
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  3. calcium ion binding Source: InterPro
  4. chromatin binding Source: UniProtKB
  5. double-stranded DNA binding Source: RGD
  6. protein binding Source: RGD
  7. protein dimerization activity Source: UniProtKB
  8. sequence-specific DNA binding Source: RGD
  9. sequence-specific DNA binding transcription factor activity Source: RGD
  10. signal transducer activity Source: Ensembl

GO - Biological processi

  1. 2-oxoglutarate metabolic process Source: Ensembl
  2. JAK-STAT cascade Source: RGD
  3. JAK-STAT cascade involved in growth hormone signaling pathway Source: Ensembl
  4. Peyer's patch development Source: Ensembl
  5. T cell differentiation in thymus Source: Ensembl
  6. T cell homeostasis Source: Ensembl
  7. acute-phase response Source: RGD
  8. allantoin metabolic process Source: Ensembl
  9. cellular response to epidermal growth factor stimulus Source: UniProtKB
  10. cellular response to growth factor stimulus Source: UniProtKB
  11. citrate metabolic process Source: Ensembl
  12. creatine metabolic process Source: Ensembl
  13. creatinine metabolic process Source: Ensembl
  14. development of secondary female sexual characteristics Source: Ensembl
  15. development of secondary male sexual characteristics Source: Ensembl
  16. fatty acid metabolic process Source: Ensembl
  17. female pregnancy Source: Ensembl
  18. isoleucine metabolic process Source: Ensembl
  19. lactation Source: Ensembl
  20. lipid storage Source: Ensembl
  21. liver development Source: RGD
  22. luteinization Source: RGD
  23. natural killer cell differentiation Source: Ensembl
  24. negative regulation of apoptotic process Source: Ensembl
  25. negative regulation of erythrocyte differentiation Source: Ensembl
  26. oxaloacetate metabolic process Source: Ensembl
  27. positive regulation of B cell differentiation Source: Ensembl
  28. positive regulation of activated T cell proliferation Source: Ensembl
  29. positive regulation of cellular component movement Source: RGD
  30. positive regulation of gamma-delta T cell differentiation Source: Ensembl
  31. positive regulation of inflammatory response Source: Ensembl
  32. positive regulation of interleukin-2 biosynthetic process Source: Ensembl
  33. positive regulation of mitotic cell cycle Source: Ensembl
  34. positive regulation of multicellular organism growth Source: Ensembl
  35. positive regulation of natural killer cell differentiation Source: Ensembl
  36. positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
  37. positive regulation of natural killer cell proliferation Source: Ensembl
  38. positive regulation of smooth muscle cell proliferation Source: RGD
  39. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  40. progesterone metabolic process Source: Ensembl
  41. prolactin signaling pathway Source: UniProtKB
  42. regulation of cell adhesion Source: Ensembl
  43. regulation of epithelial cell differentiation Source: Ensembl
  44. regulation of steroid metabolic process Source: Ensembl
  45. regulation of transcription, DNA-templated Source: RGD
  46. response to estradiol Source: Ensembl
  47. response to ethanol Source: RGD
  48. response to hypoxia Source: RGD
  49. response to interleukin-15 Source: Ensembl
  50. response to interleukin-2 Source: Ensembl
  51. response to interleukin-4 Source: Ensembl
  52. response to lipopolysaccharide Source: RGD
  53. response to peptide hormone Source: RGD
  54. succinate metabolic process Source: Ensembl
  55. taurine metabolic process Source: Ensembl
  56. transcription from RNA polymerase II promoter Source: RGD
  57. valine metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_195025. Signaling by SCF-KIT.
REACT_195204. Signaling by Leptin.
REACT_196376. Interleukin-7 signaling.
REACT_196425. Growth hormone receptor signaling.
REACT_198628. Signaling by FGFR1 fusion mutants.
REACT_199232. Prolactin receptor signaling.
REACT_206819. Downstream signal transduction.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 5B
Gene namesi
Name:Stat5b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi3774. Stat5b.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Translocated into the nucleus in response to phosphorylation By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: RGD
  3. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 786786Signal transducer and activator of transcription 5B
PRO_0000182432Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281Phosphoserine By similarity
Modified residuei699 – 6991Phosphotyrosine; by HCK, JAK and PTK6 By similarity

Post-translational modificationi

Tyrosine phosphorylated. Tyrosine phosphorylated in response to signaling via activated FLT3 and KIT, resulting in translocation to the nucleus. Alternatively, can be phosphorylated by JAK2 By similarity. Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity By similarity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP52632.
PRIDEiP52632.

PTM databases

PhosphoSiteiP52632.

Expressioni

Gene expression databases

GenevestigatoriP52632.

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1 and SOCS7 By similarity. Interacts (via SH2 domain) with INSR.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026354.

Structurei

3D structure databases

ProteinModelPortaliP52632.
SMRiP52632. Positions 138-686.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini589 – 68698SH2
Add
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG245085.
GeneTreeiENSGT00740000115175.
HOGENOMiHOG000230988.
HOVERGENiHBG107486.
InParanoidiP52632.
KOiK11224.
OrthoDBiEOG73JKTT.
PhylomeDBiP52632.
TreeFamiTF318648.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52632-1 [UniParc]FASTAAdd to Basket

« Hide

MAMWIQAQQL QGDALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSIDLDN    50
PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR 100
CPMELVRCIR HILYNEQRLV REANNGSSPA GSLADAMSQK HLQINQTFEE 150
LRLITQDTES ELKKLQQTQE YFIIQYQESL RIQAQFAQLA QLNPQERMSR 200
ETALQQKQVS LETWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD 250
ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRLEHLC 300
QQLPIPGPVE EMLAEVNATI TDIISALSTS TFIIEKQPPQ VLKTQTKFAA 350
TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC 400
CVMEYHQATG TLSAHFRNMS LKRIKRSDRR GAESVTEEKF TILFDSQFSV 450
GGNELVFQVK TLSLPVVVIV HGSQDNNATA TVLWDNAFRE PGRVPFAVPD 500
KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNS SSNHLEDYNS 550
MSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK 600
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD 650
FSIRSLADRL GDLNYLIYVF PDRPKDEVYS KYYTPVPCER ATAKAADGYV 700
KPQIKQVVPE FVNASTDAGS GATYMDQAPS PVVCPQAHYN MYPQNPDSVL 750
DTDGDFDLED TMDVARRVEE LLGRPMDSQW IPHAQS 786
Length:786
Mass (Da):90,223
Last modified:October 1, 1996 - v1
Checksum:i52250DE6ACC8DBE3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti296 – 2961L → A in CAA66141. 1 Publication
Sequence conflicti328 – 3281S → V in CAA66141. 1 Publication
Sequence conflicti489 – 4891R → A in CAA66141. 1 Publication
Sequence conflicti690 – 6901R → P in CAA66141. 1 Publication
Sequence conflicti716 – 7161T → A in CAA66141. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91988 mRNA. Translation: CAA63043.1. Different termination.
X91988 mRNA. Translation: CAA63042.1.
X97541 mRNA. Translation: CAA66141.1.
RefSeqiNP_071775.1. NM_022380.1.
UniGeneiRn.54486.

Genome annotation databases

EnsembliENSRNOT00000026354; ENSRNOP00000026354; ENSRNOG00000019075.
GeneIDi25126.
KEGGirno:25126.
UCSCiRGD:3774. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91988 mRNA. Translation: CAA63043.1 . Different termination.
X91988 mRNA. Translation: CAA63042.1 .
X97541 mRNA. Translation: CAA66141.1 .
RefSeqi NP_071775.1. NM_022380.1.
UniGenei Rn.54486.

3D structure databases

ProteinModelPortali P52632.
SMRi P52632. Positions 138-686.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000026354.

PTM databases

PhosphoSitei P52632.

Proteomic databases

PaxDbi P52632.
PRIDEi P52632.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026354 ; ENSRNOP00000026354 ; ENSRNOG00000019075 .
GeneIDi 25126.
KEGGi rno:25126.
UCSCi RGD:3774. rat.

Organism-specific databases

CTDi 6777.
RGDi 3774. Stat5b.

Phylogenomic databases

eggNOGi NOG245085.
GeneTreei ENSGT00740000115175.
HOGENOMi HOG000230988.
HOVERGENi HBG107486.
InParanoidi P52632.
KOi K11224.
OrthoDBi EOG73JKTT.
PhylomeDBi P52632.
TreeFami TF318648.

Enzyme and pathway databases

Reactomei REACT_195025. Signaling by SCF-KIT.
REACT_195204. Signaling by Leptin.
REACT_196376. Interleukin-7 signaling.
REACT_196425. Growth hormone receptor signaling.
REACT_198628. Signaling by FGFR1 fusion mutants.
REACT_199232. Prolactin receptor signaling.
REACT_206819. Downstream signal transduction.

Miscellaneous databases

NextBioi 605525.
PROi P52632.

Gene expression databases

Genevestigatori P52632.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view ]
PANTHERi PTHR11801. PTHR11801. 1 hit.
Pfami PF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view ]
SUPFAMi SSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements."
    Ripperger J.A., Fritz S., Richter K., Hocke G.M., Lottspeich F., Fey G.H.
    J. Biol. Chem. 270:29998-30006(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Luo G., Yu-Lee L.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Noble.
    Tissue: Lymph node.

Entry informationi

Entry nameiSTA5B_RAT
AccessioniPrimary (citable) accession number: P52632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi