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Protein

Regulator of sigma S factor FliZ

Gene

fliZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

During the post-exponential growth phase transiently interferes with RpoS (sigma S) activity without affecting expression of RpoS itself. It is probably not an anti-sigma factor as its overexpression is detrimental in rapidly growing cells where there is almost no sigma S factor. There is a strong overlap between Crl-activated genes and FliZ-down-regulated genes. FliZ acts as a timing device for expression of the genes for the adhesive curli fimbriae by indirectly decreasing expression of the curli regulator CsgD.1 Publication

GO - Molecular functioni

  • core promoter binding Source: EcoCyc
  • sigma factor antagonist activity Source: EcoCyc

GO - Biological processi

  • DNA integration Source: InterPro
  • regulation of bacterial-type flagellum-dependent cell motility Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG11356-MONOMER.
ECOL316407:JW1906-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of sigma S factor FliZ
Gene namesi
Name:fliZ
Synonyms:yedH
Ordered Locus Names:b1921, JW1906
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11356. fliZ.

Pathology & Biotechi

Disruption phenotypei

Not required for motility, disruption leads to derepression of the adhesive curli fimbriae genes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Regulator of sigma S factor FliZPRO_0000087288Add
BLAST

Proteomic databases

PaxDbiP52627.
PRIDEiP52627.

Expressioni

Inductioni

Induced in early post-exponential phase, its expression decreases again at OD578 2-2.5.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4263070. 103 interactions.
IntActiP52627. 7 interactions.
STRINGi511145.b1921.

Structurei

3D structure databases

ProteinModelPortaliP52627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4108M9K. Bacteria.
ENOG4111I0Y. LUCA.
HOGENOMiHOG000121298.
KOiK02425.
OMAiLHCKEQS.
OrthoDBiEOG60GRVW.

Family and domain databases

InterProiIPR022523. Flagellar_regulator_FliZ.
IPR004107. Integrase_SAM-like_N.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03823. FliZ. 1 hit.

Sequencei

Sequence statusi: Complete.

P52627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVQHLKRRP LSRYLKDFKH SQTHCAHCRK LLDRITLVRD GKIVNKIEIS
60 70 80 90 100
RLDTLLDENG WQTEQKSWAA LCRFCGDLHC KTQSDFFDII GFKQFLFEQT
110 120 130 140 150
EMSPGTVREY VVRLRRLGNH LHEQNISLDQ LQDGFLDEIL APWLPTTSTN
160 170 180
NYRIALRKYQ HYQRQTCTRL VQKSSSLPSS DIY
Length:183
Mass (Da):21,658
Last modified:October 1, 1996 - v1
Checksum:iCBFF9A95BDDC4711
GO

Sequence cautioni

The sequence AAC43544.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18539 Genomic DNA. Translation: AAC43544.1. Different initiation.
U00096 Genomic DNA. Translation: AAC74988.2.
AP009048 Genomic DNA. Translation: BAA15741.1.
L36677 Genomic DNA. No translation available.
PIRiF64955.
RefSeqiNP_416431.2. NC_000913.3.
WP_001350518.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74988; AAC74988; b1921.
BAA15741; BAA15741; BAA15741.
GeneIDi946833.
KEGGiecj:JW1906.
eco:b1921.
PATRICi32119177. VBIEscCol129921_2003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18539 Genomic DNA. Translation: AAC43544.1. Different initiation.
U00096 Genomic DNA. Translation: AAC74988.2.
AP009048 Genomic DNA. Translation: BAA15741.1.
L36677 Genomic DNA. No translation available.
PIRiF64955.
RefSeqiNP_416431.2. NC_000913.3.
WP_001350518.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP52627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263070. 103 interactions.
IntActiP52627. 7 interactions.
STRINGi511145.b1921.

Proteomic databases

PaxDbiP52627.
PRIDEiP52627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74988; AAC74988; b1921.
BAA15741; BAA15741; BAA15741.
GeneIDi946833.
KEGGiecj:JW1906.
eco:b1921.
PATRICi32119177. VBIEscCol129921_2003.

Organism-specific databases

EchoBASEiEB1331.
EcoGeneiEG11356. fliZ.

Phylogenomic databases

eggNOGiENOG4108M9K. Bacteria.
ENOG4111I0Y. LUCA.
HOGENOMiHOG000121298.
KOiK02425.
OMAiLHCKEQS.
OrthoDBiEOG60GRVW.

Enzyme and pathway databases

BioCyciEcoCyc:EG11356-MONOMER.
ECOL316407:JW1906-MONOMER.

Miscellaneous databases

PROiP52627.

Family and domain databases

InterProiIPR022523. Flagellar_regulator_FliZ.
IPR004107. Integrase_SAM-like_N.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03823. FliZ. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Escherichia coli fliAZY operon."
    Mytelka D.S., Chamberlin M.J.
    J. Bacteriol. 178:24-34(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / RP437.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "An alternative sigma factor controls transcription of flagellar class-III operons in Escherichia coli: gene sequence, overproduction, purification and characterization."
    Liu X., Matsumura P.
    Gene 164:81-84(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
    Strain: K12.
  6. "Inverse regulatory coordination of motility and curli-mediated adhesion in Escherichia coli."
    Pesavento C., Becker G., Sommerfeldt N., Possling A., Tschowri N., Mehlis A., Hengge R.
    Genes Dev. 22:2434-2446(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: K12 / MC4100 / ATCC 35695 / DSM 6574 and K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiFLIZ_ECOLI
AccessioniPrimary (citable) accession number: P52627
Secondary accession number(s): P76317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.