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Protein

Regulator of sigma S factor FliZ

Gene

fliZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

During the post-exponential growth phase transiently interferes with RpoS (sigma S) activity without affecting expression of RpoS itself. It is probably not an anti-sigma factor as its overexpression is detrimental in rapidly growing cells where there is almost no sigma S factor. There is a strong overlap between Crl-activated genes and FliZ-down-regulated genes. FliZ acts as a timing device for expression of the genes for the adhesive curli fimbriae by indirectly decreasing expression of the curli regulator CsgD.1 Publication

GO - Molecular functioni

  • core promoter binding Source: EcoCyc
  • sigma factor antagonist activity Source: EcoCyc

GO - Biological processi

  • DNA integration Source: InterPro
  • regulation of bacterial-type flagellum-dependent cell motility Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:EG11356-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of sigma S factor FliZ
Gene namesi
Name:fliZ
Synonyms:yedH
Ordered Locus Names:b1921, JW1906
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11356 fliZ

Pathology & Biotechi

Disruption phenotypei

Not required for motility, disruption leads to derepression of the adhesive curli fimbriae genes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000872881 – 183Regulator of sigma S factor FliZAdd BLAST183

Proteomic databases

PaxDbiP52627
PRIDEiP52627

Expressioni

Inductioni

Induced in early post-exponential phase, its expression decreases again at OD578 2-2.5.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4263070, 103 interactors
IntActiP52627, 7 interactors
STRINGi316385.ECDH10B_2062

Structurei

3D structure databases

ProteinModelPortaliP52627
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4108M9K Bacteria
ENOG4111I0Y LUCA
HOGENOMiHOG000121298
KOiK02425
OMAiLHCKEQS

Family and domain databases

InterProiView protein in InterPro
IPR022523 Flagellar_regulator_FliZ
IPR004107 Integrase_SAM-like_N
PfamiView protein in Pfam
PF02899 Phage_int_SAM_1, 1 hit
TIGRFAMsiTIGR03823 FliZ, 1 hit

Sequencei

Sequence statusi: Complete.

P52627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVQHLKRRP LSRYLKDFKH SQTHCAHCRK LLDRITLVRD GKIVNKIEIS
60 70 80 90 100
RLDTLLDENG WQTEQKSWAA LCRFCGDLHC KTQSDFFDII GFKQFLFEQT
110 120 130 140 150
EMSPGTVREY VVRLRRLGNH LHEQNISLDQ LQDGFLDEIL APWLPTTSTN
160 170 180
NYRIALRKYQ HYQRQTCTRL VQKSSSLPSS DIY
Length:183
Mass (Da):21,658
Last modified:October 1, 1996 - v1
Checksum:iCBFF9A95BDDC4711
GO

Sequence cautioni

The sequence AAC43544 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18539 Genomic DNA Translation: AAC43544.1 Different initiation.
U00096 Genomic DNA Translation: AAC74988.2
AP009048 Genomic DNA Translation: BAA15741.1
L36677 Genomic DNA No translation available.
PIRiF64955
RefSeqiNP_416431.2, NC_000913.3
WP_001350518.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74988; AAC74988; b1921
BAA15741; BAA15741; BAA15741
GeneIDi946833
KEGGiecj:JW1906
eco:b1921
PATRICifig|1411691.4.peg.328

Similar proteinsi

Entry informationi

Entry nameiFLIZ_ECOLI
AccessioniPrimary (citable) accession number: P52627
Secondary accession number(s): P76317
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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