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P52624 (UPP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uridine phosphorylase 1

Short name=UPase 1
Short name=UrdPase 1
EC=2.4.2.3
Gene names
Name:Upp1
Synonyms:Up, Upp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activity

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.

Subunit structure

Homodimer By similarity.

Induction

By a mixture of inflammatory cytokines: TNF-alpha, IL-1 and interferon gamma.

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Belongs to the PNP/UDP phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Uridine phosphorylase 1
PRO_0000063192

Sites

Binding site2181Substrate By similarity
Binding site2201Substrate By similarity

Experimental info

Sequence conflict2601S → G in BAA07916. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P52624 [UniParc].

Last modified May 23, 2003. Version 2.
Checksum: A7DFC46BF9129302

FASTA31134,086
        10         20         30         40         50         60 
MAATGTEAKD LENHHNDCFI QLSNPNIAAM KEDVLYHFNL STSTHDFPAM FGDVKFVCVG 

        70         80         90        100        110        120 
GSSSRMNTFI KYVAAELGLD HPGKEYPNIC AGTDRYAMYK AGPVLSVSHG MGIPSIGIML 

       130        140        150        160        170        180 
HELIKMLYHA RCSNITIIRI GTSGGIGLEP GSVVITQQAV NECFKPEFEQ IVLGKRVIRN 

       190        200        210        220        230        240 
TNLDAQLVQE LVQCSSDLNE FPMVVGNTMC TLDFYEGQGR LDGALCSYTE KDKQSYLRAA 

       250        260        270        280        290        300 
HAAGVRNIEM ESSVFATMCS ACGLKAAVVC VTLLDRLQGD QINTPHDVLV EYQQRPQRLV 

       310 
GHFIKKSLGR A 

« Hide

References

« Hide 'large scale' references
[1]"Purification, cloning, and expression of murine uridine phosphorylase."
Watanabe S., Hino A., Wada K., Eliason J.F., Uchida T.
J. Biol. Chem. 270:12191-12196(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 67-86 AND 277-293.
Strain: BALB/c.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D44464 mRNA. Translation: BAA07916.1.
BC036559 mRNA. Translation: AAH36559.1.
PIRA57501.
RefSeqNP_001152873.1. NM_001159401.1.
NP_001152874.1. NM_001159402.1.
NP_033503.2. NM_009477.3.
XP_006514730.1. XM_006514667.1.
UniGeneMm.4610.

3D structure databases

ProteinModelPortalP52624.
SMRP52624. Positions 16-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP52624. 1 interaction.
MINTMINT-4139554.

Chemistry

BindingDBP52624.
ChEMBLCHEMBL3718.

PTM databases

PhosphoSiteP52624.

Proteomic databases

PaxDbP52624.
PRIDEP52624.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020677; ENSMUSP00000020677; ENSMUSG00000020407.
ENSMUST00000101525; ENSMUSP00000099063; ENSMUSG00000020407.
ENSMUST00000164791; ENSMUSP00000127473; ENSMUSG00000020407.
GeneID22271.
KEGGmmu:22271.
UCSCuc007hzw.2. mouse.

Organism-specific databases

CTD7378.
MGIMGI:1097668. Upp1.

Phylogenomic databases

eggNOGCOG2820.
HOGENOMHOG000231747.
HOVERGENHBG047725.
InParanoidP52624.
KOK00757.
OMALGTGTHD.
OrthoDBEOG79W961.
PhylomeDBP52624.
TreeFamTF314310.

Enzyme and pathway databases

UniPathwayUPA00574; UER00633.

Gene expression databases

ArrayExpressP52624.
BgeeP52624.
CleanExMM_UPP1.
GenevestigatorP52624.

Family and domain databases

Gene3D3.40.50.1580. 1 hit.
InterProIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010059. Uridine_phosphorylase_euk.
[Graphical view]
PANTHERPTHR21234. PTHR21234. 1 hit.
PTHR21234:SF4. PTHR21234:SF4. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMSSF53167. SSF53167. 1 hit.
TIGRFAMsTIGR01719. euk_UDPppase. 1 hit.
PROSITEPS01232. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302379.
PROP52624.
SOURCESearch...

Entry information

Entry nameUPP1_MOUSE
AccessionPrimary (citable) accession number: P52624
Secondary accession number(s): Q8JZX0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 23, 2003
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot