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P52624

- UPP1_MOUSE

UniProt

P52624 - UPP1_MOUSE

Protein

Uridine phosphorylase 1

Gene

Upp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (23 May 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

    Catalytic activityi

    Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei218 – 2181SubstrateBy similarity
    Binding sitei220 – 2201SubstrateBy similarity

    GO - Molecular functioni

    1. uridine phosphorylase activity Source: MGI

    GO - Biological processi

    1. cellular response to glucose starvation Source: Ensembl
    2. nucleotide catabolic process Source: InterPro
    3. pyrimidine nucleotide metabolic process Source: MGI
    4. UMP salvage Source: UniProtKB-UniPathway
    5. uridine metabolic process Source: MGI

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00574; UER00633.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uridine phosphorylase 1 (EC:2.4.2.3)
    Short name:
    UPase 1
    Short name:
    UrdPase 1
    Gene namesi
    Name:Upp1
    Synonyms:Up, Upp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1097668. Upp1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Uridine phosphorylase 1PRO_0000063192Add
    BLAST

    Post-translational modificationi

    The N-terminus is blocked.

    Proteomic databases

    MaxQBiP52624.
    PaxDbiP52624.
    PRIDEiP52624.

    PTM databases

    PhosphoSiteiP52624.

    Expressioni

    Inductioni

    By a mixture of inflammatory cytokines: TNF-alpha, IL-1 and interferon gamma.

    Gene expression databases

    ArrayExpressiP52624.
    BgeeiP52624.
    CleanExiMM_UPP1.
    GenevestigatoriP52624.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiP52624. 1 interaction.
    MINTiMINT-4139554.

    Structurei

    3D structure databases

    ProteinModelPortaliP52624.
    SMRiP52624. Positions 16-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PNP/UDP phosphorylase family.Curated

    Phylogenomic databases

    eggNOGiCOG2820.
    HOGENOMiHOG000231747.
    HOVERGENiHBG047725.
    InParanoidiP52624.
    KOiK00757.
    OMAiYHAKCSN.
    OrthoDBiEOG79W961.
    PhylomeDBiP52624.
    TreeFamiTF314310.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    InterProiIPR018017. Nucleoside_phosphorylase.
    IPR018016. Nucleoside_phosphorylase_CS.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR010059. Uridine_phosphorylase_euk.
    [Graphical view]
    PANTHERiPTHR21234. PTHR21234. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01719. euk_UDPppase. 1 hit.
    PROSITEiPS01232. PNP_UDP_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52624-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATGTEAKD LENHHNDCFI QLSNPNIAAM KEDVLYHFNL STSTHDFPAM    50
    FGDVKFVCVG GSSSRMNTFI KYVAAELGLD HPGKEYPNIC AGTDRYAMYK 100
    AGPVLSVSHG MGIPSIGIML HELIKMLYHA RCSNITIIRI GTSGGIGLEP 150
    GSVVITQQAV NECFKPEFEQ IVLGKRVIRN TNLDAQLVQE LVQCSSDLNE 200
    FPMVVGNTMC TLDFYEGQGR LDGALCSYTE KDKQSYLRAA HAAGVRNIEM 250
    ESSVFATMCS ACGLKAAVVC VTLLDRLQGD QINTPHDVLV EYQQRPQRLV 300
    GHFIKKSLGR A 311
    Length:311
    Mass (Da):34,086
    Last modified:May 23, 2003 - v2
    Checksum:iA7DFC46BF9129302
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti260 – 2601S → G in BAA07916. (PubMed:7744869)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D44464 mRNA. Translation: BAA07916.1.
    BC036559 mRNA. Translation: AAH36559.1.
    CCDSiCCDS24432.1.
    PIRiA57501.
    RefSeqiNP_001152873.1. NM_001159401.1.
    NP_001152874.1. NM_001159402.1.
    NP_033503.2. NM_009477.3.
    XP_006514730.1. XM_006514667.1.
    UniGeneiMm.4610.

    Genome annotation databases

    EnsembliENSMUST00000020677; ENSMUSP00000020677; ENSMUSG00000020407.
    ENSMUST00000101525; ENSMUSP00000099063; ENSMUSG00000020407.
    ENSMUST00000164791; ENSMUSP00000127473; ENSMUSG00000020407.
    GeneIDi22271.
    KEGGimmu:22271.
    UCSCiuc007hzw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D44464 mRNA. Translation: BAA07916.1 .
    BC036559 mRNA. Translation: AAH36559.1 .
    CCDSi CCDS24432.1.
    PIRi A57501.
    RefSeqi NP_001152873.1. NM_001159401.1.
    NP_001152874.1. NM_001159402.1.
    NP_033503.2. NM_009477.3.
    XP_006514730.1. XM_006514667.1.
    UniGenei Mm.4610.

    3D structure databases

    ProteinModelPortali P52624.
    SMRi P52624. Positions 16-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P52624. 1 interaction.
    MINTi MINT-4139554.

    Chemistry

    BindingDBi P52624.
    ChEMBLi CHEMBL3718.

    PTM databases

    PhosphoSitei P52624.

    Proteomic databases

    MaxQBi P52624.
    PaxDbi P52624.
    PRIDEi P52624.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020677 ; ENSMUSP00000020677 ; ENSMUSG00000020407 .
    ENSMUST00000101525 ; ENSMUSP00000099063 ; ENSMUSG00000020407 .
    ENSMUST00000164791 ; ENSMUSP00000127473 ; ENSMUSG00000020407 .
    GeneIDi 22271.
    KEGGi mmu:22271.
    UCSCi uc007hzw.2. mouse.

    Organism-specific databases

    CTDi 7378.
    MGIi MGI:1097668. Upp1.

    Phylogenomic databases

    eggNOGi COG2820.
    HOGENOMi HOG000231747.
    HOVERGENi HBG047725.
    InParanoidi P52624.
    KOi K00757.
    OMAi YHAKCSN.
    OrthoDBi EOG79W961.
    PhylomeDBi P52624.
    TreeFami TF314310.

    Enzyme and pathway databases

    UniPathwayi UPA00574 ; UER00633 .

    Miscellaneous databases

    NextBioi 302379.
    PROi P52624.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P52624.
    Bgeei P52624.
    CleanExi MM_UPP1.
    Genevestigatori P52624.

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    InterProi IPR018017. Nucleoside_phosphorylase.
    IPR018016. Nucleoside_phosphorylase_CS.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR010059. Uridine_phosphorylase_euk.
    [Graphical view ]
    PANTHERi PTHR21234. PTHR21234. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01719. euk_UDPppase. 1 hit.
    PROSITEi PS01232. PNP_UDP_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification, cloning, and expression of murine uridine phosphorylase."
      Watanabe S., Hino A., Wada K., Eliason J.F., Uchida T.
      J. Biol. Chem. 270:12191-12196(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 67-86 AND 277-293.
      Strain: BALB/c.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiUPP1_MOUSE
    AccessioniPrimary (citable) accession number: P52624
    Secondary accession number(s): Q8JZX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 23, 2003
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3