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P52624

- UPP1_MOUSE

UniProt

P52624 - UPP1_MOUSE

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Protein

Uridine phosphorylase 1

Gene

Upp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activityi

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei218 – 2181SubstrateBy similarity
Binding sitei220 – 2201SubstrateBy similarity

GO - Molecular functioni

  1. uridine phosphorylase activity Source: MGI

GO - Biological processi

  1. cellular response to glucose starvation Source: Ensembl
  2. nucleotide catabolic process Source: InterPro
  3. pyrimidine nucleotide metabolic process Source: MGI
  4. UMP salvage Source: UniProtKB-UniPathway
  5. uridine metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_241108. Pyrimidine catabolism.
REACT_259385. Pyrimidine salvage reactions.
UniPathwayiUPA00574; UER00633.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine phosphorylase 1 (EC:2.4.2.3)
Short name:
UPase 1
Short name:
UrdPase 1
Gene namesi
Name:Upp1
Synonyms:Up, Upp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1097668. Upp1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Uridine phosphorylase 1PRO_0000063192Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

MaxQBiP52624.
PaxDbiP52624.
PRIDEiP52624.

PTM databases

PhosphoSiteiP52624.

Expressioni

Inductioni

By a mixture of inflammatory cytokines: TNF-alpha, IL-1 and interferon gamma.

Gene expression databases

BgeeiP52624.
CleanExiMM_UPP1.
ExpressionAtlasiP52624. baseline and differential.
GenevestigatoriP52624.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP52624. 1 interaction.
MINTiMINT-4139554.

Structurei

3D structure databases

ProteinModelPortaliP52624.
SMRiP52624. Positions 16-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.Curated

Phylogenomic databases

eggNOGiCOG2820.
HOGENOMiHOG000231747.
HOVERGENiHBG047725.
InParanoidiP52624.
KOiK00757.
OMAiYHAKCSN.
OrthoDBiEOG79W961.
PhylomeDBiP52624.
TreeFamiTF314310.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010059. Uridine_phosphorylase_euk.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01719. euk_UDPppase. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52624-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATGTEAKD LENHHNDCFI QLSNPNIAAM KEDVLYHFNL STSTHDFPAM
60 70 80 90 100
FGDVKFVCVG GSSSRMNTFI KYVAAELGLD HPGKEYPNIC AGTDRYAMYK
110 120 130 140 150
AGPVLSVSHG MGIPSIGIML HELIKMLYHA RCSNITIIRI GTSGGIGLEP
160 170 180 190 200
GSVVITQQAV NECFKPEFEQ IVLGKRVIRN TNLDAQLVQE LVQCSSDLNE
210 220 230 240 250
FPMVVGNTMC TLDFYEGQGR LDGALCSYTE KDKQSYLRAA HAAGVRNIEM
260 270 280 290 300
ESSVFATMCS ACGLKAAVVC VTLLDRLQGD QINTPHDVLV EYQQRPQRLV
310
GHFIKKSLGR A
Length:311
Mass (Da):34,086
Last modified:May 23, 2003 - v2
Checksum:iA7DFC46BF9129302
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti260 – 2601S → G in BAA07916. (PubMed:7744869)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D44464 mRNA. Translation: BAA07916.1.
BC036559 mRNA. Translation: AAH36559.1.
CCDSiCCDS24432.1.
PIRiA57501.
RefSeqiNP_001152873.1. NM_001159401.1.
NP_001152874.1. NM_001159402.1.
NP_033503.2. NM_009477.3.
XP_006514730.1. XM_006514667.1.
UniGeneiMm.4610.

Genome annotation databases

EnsembliENSMUST00000020677; ENSMUSP00000020677; ENSMUSG00000020407.
ENSMUST00000101525; ENSMUSP00000099063; ENSMUSG00000020407.
ENSMUST00000164791; ENSMUSP00000127473; ENSMUSG00000020407.
GeneIDi22271.
KEGGimmu:22271.
UCSCiuc007hzw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D44464 mRNA. Translation: BAA07916.1 .
BC036559 mRNA. Translation: AAH36559.1 .
CCDSi CCDS24432.1.
PIRi A57501.
RefSeqi NP_001152873.1. NM_001159401.1.
NP_001152874.1. NM_001159402.1.
NP_033503.2. NM_009477.3.
XP_006514730.1. XM_006514667.1.
UniGenei Mm.4610.

3D structure databases

ProteinModelPortali P52624.
SMRi P52624. Positions 16-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P52624. 1 interaction.
MINTi MINT-4139554.

Chemistry

BindingDBi P52624.
ChEMBLi CHEMBL3718.

PTM databases

PhosphoSitei P52624.

Proteomic databases

MaxQBi P52624.
PaxDbi P52624.
PRIDEi P52624.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020677 ; ENSMUSP00000020677 ; ENSMUSG00000020407 .
ENSMUST00000101525 ; ENSMUSP00000099063 ; ENSMUSG00000020407 .
ENSMUST00000164791 ; ENSMUSP00000127473 ; ENSMUSG00000020407 .
GeneIDi 22271.
KEGGi mmu:22271.
UCSCi uc007hzw.2. mouse.

Organism-specific databases

CTDi 7378.
MGIi MGI:1097668. Upp1.

Phylogenomic databases

eggNOGi COG2820.
HOGENOMi HOG000231747.
HOVERGENi HBG047725.
InParanoidi P52624.
KOi K00757.
OMAi YHAKCSN.
OrthoDBi EOG79W961.
PhylomeDBi P52624.
TreeFami TF314310.

Enzyme and pathway databases

UniPathwayi UPA00574 ; UER00633 .
Reactomei REACT_241108. Pyrimidine catabolism.
REACT_259385. Pyrimidine salvage reactions.

Miscellaneous databases

NextBioi 302379.
PROi P52624.
SOURCEi Search...

Gene expression databases

Bgeei P52624.
CleanExi MM_UPP1.
ExpressionAtlasi P52624. baseline and differential.
Genevestigatori P52624.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
InterProi IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010059. Uridine_phosphorylase_euk.
[Graphical view ]
PANTHERi PTHR21234. PTHR21234. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01719. euk_UDPppase. 1 hit.
PROSITEi PS01232. PNP_UDP_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Purification, cloning, and expression of murine uridine phosphorylase."
    Watanabe S., Hino A., Wada K., Eliason J.F., Uchida T.
    J. Biol. Chem. 270:12191-12196(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 67-86 AND 277-293.
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiUPP1_MOUSE
AccessioniPrimary (citable) accession number: P52624
Secondary accession number(s): Q8JZX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 23, 2003
Last modified: November 26, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3