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Protein

Probable multidrug resistance protein EmrY

Gene

emrY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoCyc
  • response to antibiotic Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:EMRY-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable multidrug resistance protein EmrY
Gene namesi
Name:emrY
Ordered Locus Names:b2367, JW2364
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13283 emrY

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30PeriplasmicSequence analysis1
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 53CytoplasmicSequence analysis2
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 84PeriplasmicSequence analysis10
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 141PeriplasmicSequence analysisAdd BLAST15
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 172CytoplasmicSequence analysis10
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 204PeriplasmicSequence analysisAdd BLAST11
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 234CytoplasmicSequence analysis9
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 273PeriplasmicSequence analysisAdd BLAST18
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 307CytoplasmicSequence analysisAdd BLAST13
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 338PeriplasmicSequence analysis10
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 364CytoplasmicSequence analysis5
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386 – 486PeriplasmicSequence analysisAdd BLAST101
Transmembranei487 – 507HelicalSequence analysisAdd BLAST21
Topological domaini508 – 512CytoplasmicSequence analysis5

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutants are more sensitive to nalidixic acid, mitomycin C and other stresses such as hydrogen peroxide or UV irradiation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001733251 – 512Probable multidrug resistance protein EmrYAdd BLAST512

Proteomic databases

PaxDbiP52600
PRIDEiP52600

Expressioni

Inductioni

Growth phase-dependent transcription is induced by tetracycline. Expression may be controlled by both RpoS and the Mar system.1 Publication

Interactioni

Subunit structurei

Part of the tripartite efflux system EmrYK-TolC, which is composed of an inner membrane transporter, EmrY, a membrane fusion protein, EmrK, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes (By similarity).By similarity

Protein-protein interaction databases

BioGridi4260556, 101 interactors
DIPiDIP-9507N
IntActiP52600, 2 interactors
STRINGi316385.ECDH10B_2532

Structurei

3D structure databases

ProteinModelPortaliP52600
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C0R Bacteria
ENOG410XNN3 LUCA
HOGENOMiHOG000112190
InParanoidiP52600
KOiK07786
OMAiNNYFREV
PhylomeDBiP52600

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004638 Drug-R_transpt_efflux_EmrB
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR00711 efflux_EmrB, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P52600-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITKSTPAP LTGGTLWCVT IALSLATFMQ MLDSTISNVA IPTISGFLGA
60 70 80 90 100
STDEGTWVIT SFGVANAIAI PVTGRLAQRI GELRLFLLSV TFFSLSSLMC
110 120 130 140 150
SLSTNLDVLI FFRVVQGLMA GPLIPLSQSL LLRNYPPEKR TFALALWSMT
160 170 180 190 200
VIIAPICGPI LGGYICDNFS WGWIFLINVP MGIIVLTLCL TLLKGRETET
210 220 230 240 250
SPVKMNLPGL TLLVLGVGGL QIMLDKGRDL DWFNSSTIII LTVVSVISLI
260 270 280 290 300
SLVIWESTSE NPILDLSLFK SRNFTIGIVS ITCAYLFYSG AIVLMPQLLQ
310 320 330 340 350
ETMGYNAIWA GLAYAPIGIM PLLISPLIGR YGNKIDMRLL VTFSFLMYAV
360 370 380 390 400
CYYWRSVTFM PTIDFTGIIL PQFFQGFAVA CFFLPLTTIS FSGLPDNKFA
410 420 430 440 450
NASSMSNFFR TLSGSVGTSL TMTLWGRRES LHHSQLTATI DQFNPVFNSS
460 470 480 490 500
SQIMDKYYGS LSGVLNEINN EITQQSLSIS ANEIFRMAAI AFILLTVLVW
510
FAKPPFTAKG VG
Length:512
Mass (Da):56,001
Last modified:October 1, 1996 - v1
Checksum:i3A2DC008D3E8D8F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78168 Genomic DNA Translation: BAA11237.1
U00096 Genomic DNA Translation: AAC75426.1
AP009048 Genomic DNA Translation: BAA16230.1
PIRiD65010
RefSeqiNP_416868.1, NC_000913.3
WP_001018714.1, NZ_CP014272.1

Genome annotation databases

EnsemblBacteriaiAAC75426; AAC75426; b2367
BAA16230; BAA16230; BAA16230
GeneIDi946835
KEGGiecj:JW2364
eco:b2367
PATRICifig|1411691.4.peg.4362

Similar proteinsi

Entry informationi

Entry nameiEMRY_ECOLI
AccessioniPrimary (citable) accession number: P52600
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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