Multidrug resistance protein Y - Escherichia coli (strain K12)

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Reviewed, UniProtKB/Swiss-Prot P52600 (EMRY_ECOLI)

Last modified February 9, 2010. Version 79. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Multidrug resistance protein Y

Gene names

Name:	emrY
Ordered Locus Names:	b2367, JW2364

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

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Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

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General annotation (Comments)

Subcellular location	Cell inner membrane; Multi-pass membrane protein Ref.5.
Sequence similarities	Belongs to the major facilitator superfamily. EmrB family.

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Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 512

512

Multidrug resistance protein Y

PRO_0000173325

Regions

Topological domain

1 – 8

Cytoplasmic Potential

Transmembrane

9 – 29

Potential

Topological domain

Periplasmic Potential

Transmembrane

31 – 51

Potential

Topological domain

52 – 53

Cytoplasmic Potential

Transmembrane

54 – 74

Potential

Topological domain

75 – 84

Periplasmic Potential

Transmembrane

85 – 105

Potential

Transmembrane

106 – 126

Potential

Topological domain

127 – 141

Periplasmic Potential

Transmembrane

142 – 162

Potential

Topological domain

163 – 172

Cytoplasmic Potential

Transmembrane

173 – 193

Potential

Topological domain

194 – 204

Periplasmic Potential

Transmembrane

205 – 225

Potential

Topological domain

226 – 234

Cytoplasmic Potential

Transmembrane

235 – 255

Potential

Topological domain

256 – 273

Periplasmic Potential

Transmembrane

274 – 294

Potential

Topological domain

295 – 307

Cytoplasmic Potential

Transmembrane

308 – 328

Potential

Topological domain

329 – 338

Periplasmic Potential

Transmembrane

339 – 359

Potential

Topological domain

360 – 364

Cytoplasmic Potential

Transmembrane

365 – 385

Potential

Topological domain

386 – 486

101

Periplasmic Potential

Transmembrane

487 – 507

Potential

Topological domain

508 – 512

Cytoplasmic Potential

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Sequences

Sequence

Length

Mass (Da)

Tools

P52600-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 3A2DC008D3E8D8F5
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FASTA

512

56,001

        10         20         30         40         50         60 
MAITKSTPAP LTGGTLWCVT IALSLATFMQ MLDSTISNVA IPTISGFLGA STDEGTWVIT 

        70         80         90        100        110        120 
SFGVANAIAI PVTGRLAQRI GELRLFLLSV TFFSLSSLMC SLSTNLDVLI FFRVVQGLMA 

       130        140        150        160        170        180 
GPLIPLSQSL LLRNYPPEKR TFALALWSMT VIIAPICGPI LGGYICDNFS WGWIFLINVP 

       190        200        210        220        230        240 
MGIIVLTLCL TLLKGRETET SPVKMNLPGL TLLVLGVGGL QIMLDKGRDL DWFNSSTIII 

       250        260        270        280        290        300 
LTVVSVISLI SLVIWESTSE NPILDLSLFK SRNFTIGIVS ITCAYLFYSG AIVLMPQLLQ 

       310        320        330        340        350        360 
ETMGYNAIWA GLAYAPIGIM PLLISPLIGR YGNKIDMRLL VTFSFLMYAV CYYWRSVTFM 

       370        380        390        400        410        420 
PTIDFTGIIL PQFFQGFAVA CFFLPLTTIS FSGLPDNKFA NASSMSNFFR TLSGSVGTSL 

       430        440        450        460        470        480 
TMTLWGRRES LHHSQLTATI DQFNPVFNSS SQIMDKYYGS LSGVLNEINN EITQQSLSIS 

       490        500        510 
ANEIFRMAAI AFILLTVLVW FAKPPFTAKG VG

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Utsumi R. Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. Horiuchi T. DNA Res. 4:91-113(1997) [PubMed: 9205837] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Global topology analysis of the Escherichia coli inner membrane proteome." Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G. Science 308:1321-1323(2005) [PubMed: 15919996] [Abstract] Cited for: SUBCELLULAR LOCATION. Strain: K12 / MG1655 / ATCC 47076.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	D78168 Genomic DNA. Translation: BAA11237.1. U00096 Genomic DNA. Translation: AAC75426.1. AP009048 Genomic DNA. Translation: BAA16230.1.
PIR	D65010.
RefSeq	AP_002967.1. NP_416868.1.
3D structure databases
SMR	P52600. Positions 25-421.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-9507N.
STRING	P52600.
Proteomic databases
PRIDE	P52600.
Genome annotation databases
GeneID	946835.
GenomeReviews	Gene locus JW2364 in contig AP009048_GR. Gene locus b2367 in contig U00096_GR.
KEGG	ecj:JW2364. eco:b2367.
Organism-specific databases
EchoBASE	EB3068.
EcoGene	EG13283. emrY.
CMR	Search...
Phylogenomic databases
eggNOG	COG0477.
HOGENOM	HBG759108.
OMA	ETIDQFN.
Enzyme and pathway databases
BioCyc	EcoCyc:EMRY-MONOMER. ECOL168927:B2367-MONOMER.
Gene expression databases
Genevestigator	P52600.
Family and domain databases
InterPro	IPR004638. drug-R_transpt_efflux_EmrB. IPR011701. MFS_1. IPR016196. MFS_general_subst_transpt. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00711. efflux_EmrB. 1 hit.
PROSITE	PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

EMRY_ECOLI

Accession

Primary (citable) accession number: P52600

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	February 9, 2010
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents