P52596 (DHE3_VITVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate dehydrogenase
Short name=GDH
EC=1.4.1.3

Gene names

Name:

GDH

Organism

Vitis vinifera (Grape)

Taxonomic identifier

29760 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › Vitales › Vitaceae › Vitis

Protein attributes

Sequence length	411 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.
Sequence similarities	Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	glutamate dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 411	411	Glutamate dehydrogenase		PRO_0000182752
Sites
	Active site	102	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P52596 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: A6C8F63237CF06B5	FASTA	411	44,546
	10 20 30 40 50 60 MNALAATNRN FRHASRILGL DSKLEKSLLI PFREIKVECT IPKDDGSLAT YVGFRVQHDN 70 80 90 100 110 120 ARGPMKGGIR YHPEVDPDEV NALAQLMTWK TAVVDIPYGG AKGGIGCTPK DLSMSELERL 130 140 150 160 170 180 TRVFTQKIHD LIGTHTDVPA PDMGTNAQTM AWILDEYSKF HGHSPAVVTG KPIALGGSLG 190 200 210 220 230 240 REAATGRGVV FATEALLAQH GKSIKGLTFV IQGFGNVGSW VARLIGERGG KIIAVSDVTG 250 260 270 280 290 300 AVKNQNGLDI VDLLRHKEET GCLTNFSGGD HMDPNELLTH ECDVLIPCAL GGVLNKENAA 310 320 330 340 350 360 DVKAKFIIEA ANHPTDPEAD EILSKKGGVI LPDIYANAGG VTVSYFEWVQ NIQGFMWEEE 370 380 390 400 410 KVNNELQKYM TKAFHNIKAM CQSHNCSLRM GAFTLAVNRV ACATTLRGWE A

References

[1]	"The amino-acid sequence similarity of plant glutamate dehydrogenase to the extremophilic archaeal enzyme conforms to its stress-related function." Syntichaki K.M., Loulakakis K.A., Roubelakis-Angelakis K.A. Gene 168:87-92(1996) [PubMed: 8626071] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Sultanina. Tissue: Shoot.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X86924 mRNA. Translation: CAA60507.1.
PIR	S54797.
UniGene	Vvi.123.
3D structure databases
ProteinModelPortal	P52596.
ModBase	Search...
Protein-protein interaction databases
STRING	P52596.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR006095. Glu/Leu/Phe/Val_DH. IPR006096. Glu/Leu/Phe/Val_DH_C. IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom. IPR014362. Glu_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00208. ELFV_dehydrog. 1 hit. PF02812. ELFV_dehydrog_N. 1 hit. [Graphical view]
PIRSF	PIRSF000185. Glu_DH. 1 hit.
PRINTS	PR00082. GLFDHDRGNASE.
SMART	SM00839. ELFV_dehydrog. 1 hit. [Graphical view]
PROSITE	PS00074. GLFV_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHE3_VITVI

Accession

Primary (citable) accession number: P52596

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program