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Protein

Sphingosine 1-phosphate receptor 2

Gene

S1pr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton reorganization Source: MGI
  • filopodium assembly Source: MGI
  • negative regulation of excitatory postsynaptic potential Source: MGI
  • positive regulation of establishment of endothelial barrier Source: MGI
  • positive regulation of peptidyl-threonine phosphorylation Source: UniProtKB
  • sphingosine-1-phosphate signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 2
Short name:
S1P receptor 2
Short name:
S1P2
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 5
Lysophospholipid receptor B2
Sphingosine 1-phosphate receptor Edg-5
Short name:
S1P receptor Edg-5
Gene namesi
Name:S1pr2
Synonyms:Edg5, Gpcr13, Lpb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:99569. S1pr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularBy similarityAdd BLAST34
Transmembranei35 – 59Helical; Name=1By similarityAdd BLAST25
Topological domaini60 – 66CytoplasmicBy similarity7
Transmembranei67 – 95Helical; Name=2By similarityAdd BLAST29
Topological domaini96 – 109ExtracellularBy similarityAdd BLAST14
Transmembranei110 – 128Helical; Name=3By similarityAdd BLAST19
Topological domaini129 – 147CytoplasmicBy similarityAdd BLAST19
Transmembranei148 – 173Helical; Name=4By similarityAdd BLAST26
Topological domaini174 – 189ExtracellularBy similarityAdd BLAST16
Transmembranei190 – 210Helical; Name=5By similarityAdd BLAST21
Topological domaini211 – 233CytoplasmicBy similarityAdd BLAST23
Transmembranei234 – 255Helical; Name=6By similarityAdd BLAST22
Topological domaini256 – 271ExtracellularBy similarityAdd BLAST16
Transmembranei272 – 292Helical; Name=7By similarityAdd BLAST21
Topological domaini293 – 352CytoplasmicBy similarityAdd BLAST60

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi276.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694281 – 352Sphingosine 1-phosphate receptor 2Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...)2 Publications1
Lipidationi305S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP52592.
PaxDbiP52592.
PeptideAtlasiP52592.
PRIDEiP52592.

PTM databases

iPTMnetiP52592.
PhosphoSitePlusiP52592.

Expressioni

Tissue specificityi

Most abundant in heart and lung; low, but clearly observed in kidney, liver and thymus; much lower but detectable in brain, testis, stomach and intestine. Not significantly detected in any of the sections of embryonic day (E) 14-18, except in embryonic brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000043895.
GenevisibleiP52592. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60681N.
STRINGi10090.ENSMUSP00000053394.

Structurei

3D structure databases

ProteinModelPortaliP52592.
SMRiP52592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHTX. Eukaryota.
ENOG41100F8. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiP52592.
KOiK04292.
OMAiDYACPVR.
OrthoDBiEOG091G0DD4.
TreeFamiTF330052.

Family and domain databases

InterProiIPR004063. EDG5_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF17. PTHR22750:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01525. EDG5RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGLYSEYLN PEKVLEHYNY TKETLDMQET TSRKVASAFI IILCCAIVVE
60 70 80 90 100
NLLVLIAVAR NSKFHSAMYL FLGNLAASDL LAGVAFVANT LLSGHVTLSL
110 120 130 140 150
TPVQWFAREG SAFITLSASV FSLLAIAIER QVALAKVKLY GSDKSCRMLM
160 170 180 190 200
LIGASWLISL ILGGLPILGW NCLNQLEACS TVLPLYAKHY VLCVVTIFSV
210 220 230 240 250
ILLAIVALYV RIYFVVRSSH ADVAGPQTLA LLKTVTIVLG VFIICWLPAF
260 270 280 290 300
SILLLDSTCP VRACPVLYKA HYFFAFATLN SLLNPVIYTW RSRDLRREVL
310 320 330 340 350
RPLQCWRRGK GVTGRRGGNP GHRLLPLRSS SSLERGMHMP TSPTFLEGNT

VV
Length:352
Mass (Da):38,829
Last modified:July 27, 2011 - v3
Checksum:i6A3E426B0FE54406
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110G → V in AAD16976 (PubMed:9931453).Curated1
Sequence conflicti110G → V in AAA16846 (PubMed:8288218).Curated1
Sequence conflicti166P → S in AAA16846 (PubMed:8288218).Curated1
Sequence conflicti175Q → K in AAA16846 (PubMed:8288218).Curated1
Sequence conflicti189H → R in AAA16846 (PubMed:8288218).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108020 Genomic DNA. Translation: AAD16976.1.
AK085114 mRNA. Translation: BAC39368.1.
AK134275 mRNA. Translation: BAE22078.1.
AK151062 mRNA. Translation: BAE30079.1.
AK159605 mRNA. Translation: BAE35224.1.
AK170436 mRNA. Translation: BAE41795.1.
CH466522 Genomic DNA. Translation: EDL25146.1.
BC096760 mRNA. Translation: AAH96760.1.
L20334 mRNA. Translation: AAA16846.1.
CCDSiCCDS22888.1.
PIRiE48909.
RefSeqiNP_034463.2. NM_010333.4.
XP_006510082.1. XM_006510019.3.
UniGeneiMm.46493.

Genome annotation databases

EnsembliENSMUST00000054197; ENSMUSP00000053394; ENSMUSG00000043895.
GeneIDi14739.
KEGGimmu:14739.
UCSCiuc009ojt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108020 Genomic DNA. Translation: AAD16976.1.
AK085114 mRNA. Translation: BAC39368.1.
AK134275 mRNA. Translation: BAE22078.1.
AK151062 mRNA. Translation: BAE30079.1.
AK159605 mRNA. Translation: BAE35224.1.
AK170436 mRNA. Translation: BAE41795.1.
CH466522 Genomic DNA. Translation: EDL25146.1.
BC096760 mRNA. Translation: AAH96760.1.
L20334 mRNA. Translation: AAA16846.1.
CCDSiCCDS22888.1.
PIRiE48909.
RefSeqiNP_034463.2. NM_010333.4.
XP_006510082.1. XM_006510019.3.
UniGeneiMm.46493.

3D structure databases

ProteinModelPortaliP52592.
SMRiP52592.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60681N.
STRINGi10090.ENSMUSP00000053394.

Chemistry databases

GuidetoPHARMACOLOGYi276.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP52592.
PhosphoSitePlusiP52592.

Proteomic databases

MaxQBiP52592.
PaxDbiP52592.
PeptideAtlasiP52592.
PRIDEiP52592.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054197; ENSMUSP00000053394; ENSMUSG00000043895.
GeneIDi14739.
KEGGimmu:14739.
UCSCiuc009ojt.2. mouse.

Organism-specific databases

CTDi9294.
MGIiMGI:99569. S1pr2.

Phylogenomic databases

eggNOGiENOG410IHTX. Eukaryota.
ENOG41100F8. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiP52592.
KOiK04292.
OMAiDYACPVR.
OrthoDBiEOG091G0DD4.
TreeFamiTF330052.

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

ChiTaRSiS1pr2. mouse.
PROiP52592.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043895.
GenevisibleiP52592. MM.

Family and domain databases

InterProiIPR004063. EDG5_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF17. PTHR22750:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01525. EDG5RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS1PR2_MOUSE
AccessioniPrimary (citable) accession number: P52592
Secondary accession number(s): Q8C3Q7, Q9R236
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.