##gff-version 3
P52589	UniProtKB	Signal peptide	1	25	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52589	UniProtKB	Chain	26	515	.	.	.	ID=PRO_0000034212;Note=Protein disulfide-isomerase	
P52589	UniProtKB	Domain	26	150	.	.	.	Note=Thioredoxin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691	
P52589	UniProtKB	Domain	346	489	.	.	.	Note=Thioredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691	
P52589	UniProtKB	Region	494	515	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P52589	UniProtKB	Motif	512	515	.	.	.	Note=Prevents secretion from ER;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10138	
P52589	UniProtKB	Active site	68	68	.	.	.	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52589	UniProtKB	Active site	71	71	.	.	.	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52589	UniProtKB	Active site	412	412	.	.	.	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52589	UniProtKB	Active site	415	415	.	.	.	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52589	UniProtKB	Site	69	69	.	.	.	Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52589	UniProtKB	Site	70	70	.	.	.	Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52589	UniProtKB	Site	136	136	.	.	.	Note=Lowers pKa of C-terminal Cys of first active site;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52589	UniProtKB	Site	413	413	.	.	.	Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52589	UniProtKB	Site	414	414	.	.	.	Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52589	UniProtKB	Site	475	475	.	.	.	Note=Lowers pKa of C-terminal Cys of second active site;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52589	UniProtKB	Glycosylation	283	283	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P52589	UniProtKB	Disulfide bond	68	71	.	.	.	Note=Redox-active;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691	
P52589	UniProtKB	Disulfide bond	412	415	.	.	.	Note=Redox-active;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691