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P52589

- PDI_WHEAT

UniProt

P52589 - PDI_WHEAT

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Protein
Protein disulfide-isomerase
Gene
PDI
Organism
Triticum aestivum (Wheat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer By similarity.

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Nucleophile By similarity
Sitei69 – 691Contributes to redox potential value By similarity
Sitei70 – 701Contributes to redox potential value By similarity
Active sitei71 – 711Nucleophile By similarity
Sitei136 – 1361Lowers pKa of C-terminal Cys of first active site By similarity
Active sitei412 – 4121Nucleophile By similarity
Sitei413 – 4131Contributes to redox potential value By similarity
Sitei414 – 4141Contributes to redox potential value By similarity
Active sitei415 – 4151Nucleophile By similarity
Sitei475 – 4751Lowers pKa of C-terminal Cys of second active site By similarity

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase (EC:5.3.4.1)
Short name:
PDI
Gene namesi
Name:PDI
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeTriticum
ProteomesiUP000019116: Unplaced

Organism-specific databases

GrameneiP52589.

Subcellular locationi

Endoplasmic reticulum lumen Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 By similarity
Add
BLAST
Chaini26 – 515490Protein disulfide-isomerase
PRO_0000034212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 ↔ 71Redox-active By similarity
Glycosylationi283 – 2831N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi412 ↔ 415Redox-active By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP52589.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 150125Thioredoxin 1
Add
BLAST
Domaini346 – 489144Thioredoxin 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi512 – 5154Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Contains 2 thioredoxin domains.

Keywords - Domaini

Redox-active center, Repeat, Signal

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52589-1 [UniParc]FASTAAdd to Basket

« Hide

MAISKVWISL LLALAVVLSA PAARAEEAAA AEEAAAAPEA VLTLHADNFD    50
DAIAKHPFIL VEFYAPWCGH CKSLAPEYEK AAQLLSKHDP AIVLAKVDAN 100
DEKNKPLAGK YEVQGFPTLK IFRSGGKNIQ EYKGPREAEG IVEYLKKQVG 150
PASKEIKAPE DATYLEDGKI HIVGVFTEFS GTEFTNFLEL AEKLRSDYDF 200
GHTVHANHLP RGDAAVERPL VRLFKPFDEL VVDSKDFDVS ALEKFIDASS 250
TPKVVTFDKN PDNHPYLLKY FQSNAPKAML FLNFSTGPFE SFKSAYYGAV 300
EEFSGKDVKF LIGDIEASQG AFQYNGLKED QAPLILIQDS DSKKFLKEQV 350
EAGQIVAWLK DYFDGKLTPF RKSEPIPEAN NEPVKVVVAD NIHDVVFKSA 400
KNVLIEFYAP WCGHCKKLAP ILDEAAATLQ SEEDVVIAKI DATANDVPGE 450
FDVQGYPTLY FVTPSGKKVS YEGGRTADEI VDYIKKNKET AGQAAAAATE 500
KAAEPAATEP LKDEL 515
Length:515
Mass (Da):56,533
Last modified:October 1, 1996 - v1
Checksum:i6630AB9A252A96B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11496 mRNA. Translation: AAA19660.1.
PIRiT06262.
UniGeneiTa.2019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11496 mRNA. Translation: AAA19660.1 .
PIRi T06262.
UniGenei Ta.2019.

3D structure databases

ProteinModelPortali P52589.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei P52589.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 2 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a wheat cDNA encoding protein disulfide isomerase."
    Shimoni Y., Segal G., Zhu X.Z., Galili G.
    Plant Physiol. 107:281-281(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Chinese Spring.

Entry informationi

Entry nameiPDI_WHEAT
AccessioniPrimary (citable) accession number: P52589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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