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P52589

- PDI_WHEAT

UniProt

P52589 - PDI_WHEAT

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Protein

Protein disulfide-isomerase

Gene

PDI

Organism
Triticum aestivum (Wheat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.By similarity

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681NucleophileBy similarity
Sitei69 – 691Contributes to redox potential valueBy similarity
Sitei70 – 701Contributes to redox potential valueBy similarity
Active sitei71 – 711NucleophileBy similarity
Sitei136 – 1361Lowers pKa of C-terminal Cys of first active siteBy similarity
Active sitei412 – 4121NucleophileBy similarity
Sitei413 – 4131Contributes to redox potential valueBy similarity
Sitei414 – 4141Contributes to redox potential valueBy similarity
Active sitei415 – 4151NucleophileBy similarity
Sitei475 – 4751Lowers pKa of C-terminal Cys of second active siteBy similarity

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase (EC:5.3.4.1)
Short name:
PDI
Gene namesi
Name:PDI
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeTriticum
ProteomesiUP000019116: Unplaced

Organism-specific databases

GrameneiP52589.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525By similarityAdd
BLAST
Chaini26 – 515490Protein disulfide-isomerasePRO_0000034212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 ↔ 71Redox-activePROSITE-ProRule annotation
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi412 ↔ 415Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP52589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 150125Thioredoxin 1PROSITE-ProRule annotationAdd
BLAST
Domaini346 – 489144Thioredoxin 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi512 – 5154Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 2 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat, Signal

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52589-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAISKVWISL LLALAVVLSA PAARAEEAAA AEEAAAAPEA VLTLHADNFD
60 70 80 90 100
DAIAKHPFIL VEFYAPWCGH CKSLAPEYEK AAQLLSKHDP AIVLAKVDAN
110 120 130 140 150
DEKNKPLAGK YEVQGFPTLK IFRSGGKNIQ EYKGPREAEG IVEYLKKQVG
160 170 180 190 200
PASKEIKAPE DATYLEDGKI HIVGVFTEFS GTEFTNFLEL AEKLRSDYDF
210 220 230 240 250
GHTVHANHLP RGDAAVERPL VRLFKPFDEL VVDSKDFDVS ALEKFIDASS
260 270 280 290 300
TPKVVTFDKN PDNHPYLLKY FQSNAPKAML FLNFSTGPFE SFKSAYYGAV
310 320 330 340 350
EEFSGKDVKF LIGDIEASQG AFQYNGLKED QAPLILIQDS DSKKFLKEQV
360 370 380 390 400
EAGQIVAWLK DYFDGKLTPF RKSEPIPEAN NEPVKVVVAD NIHDVVFKSA
410 420 430 440 450
KNVLIEFYAP WCGHCKKLAP ILDEAAATLQ SEEDVVIAKI DATANDVPGE
460 470 480 490 500
FDVQGYPTLY FVTPSGKKVS YEGGRTADEI VDYIKKNKET AGQAAAAATE
510
KAAEPAATEP LKDEL
Length:515
Mass (Da):56,533
Last modified:October 1, 1996 - v1
Checksum:i6630AB9A252A96B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11496 mRNA. Translation: AAA19660.1.
PIRiT06262.
UniGeneiTa.2019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11496 mRNA. Translation: AAA19660.1 .
PIRi T06262.
UniGenei Ta.2019.

3D structure databases

ProteinModelPortali P52589.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei P52589.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 2 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a wheat cDNA encoding protein disulfide isomerase."
    Shimoni Y., Segal G., Zhu X.Z., Galili G.
    Plant Physiol. 107:281-281(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Chinese Spring.

Entry informationi

Entry nameiPDI_WHEAT
AccessioniPrimary (citable) accession number: P52589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3