##gff-version 3
P52588	UniProtKB	Signal peptide	1	23	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52588	UniProtKB	Chain	24	513	.	.	.	ID=PRO_0000034210;Note=Protein disulfide-isomerase	
P52588	UniProtKB	Domain	24	145	.	.	.	Note=Thioredoxin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691	
P52588	UniProtKB	Domain	366	485	.	.	.	Note=Thioredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691	
P52588	UniProtKB	Region	485	513	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P52588	UniProtKB	Motif	510	513	.	.	.	Note=Prevents secretion from ER;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10138	
P52588	UniProtKB	Active site	63	63	.	.	.	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52588	UniProtKB	Active site	66	66	.	.	.	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52588	UniProtKB	Active site	408	408	.	.	.	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52588	UniProtKB	Active site	411	411	.	.	.	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52588	UniProtKB	Site	64	64	.	.	.	Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52588	UniProtKB	Site	65	65	.	.	.	Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52588	UniProtKB	Site	131	131	.	.	.	Note=Lowers pKa of C-terminal Cys of first active site;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52588	UniProtKB	Site	409	409	.	.	.	Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52588	UniProtKB	Site	410	410	.	.	.	Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52588	UniProtKB	Site	471	471	.	.	.	Note=Lowers pKa of C-terminal Cys of second active site;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52588	UniProtKB	Glycosylation	279	279	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P52588	UniProtKB	Disulfide bond	63	66	.	.	.	Note=Redox-active;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691	
P52588	UniProtKB	Disulfide bond	408	411	.	.	.	Note=Redox-active;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691