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P52588

- PDI_MAIZE

UniProt

P52588 - PDI_MAIZE

Protein

Protein disulfide-isomerase

Gene

PDI

Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.By similarity

    Catalytic activityi

    Catalyzes the rearrangement of -S-S- bonds in proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei63 – 631NucleophileBy similarity
    Sitei64 – 641Contributes to redox potential valueBy similarity
    Sitei65 – 651Contributes to redox potential valueBy similarity
    Active sitei66 – 661NucleophileBy similarity
    Sitei131 – 1311Lowers pKa of C-terminal Cys of first active siteBy similarity
    Active sitei408 – 4081NucleophileBy similarity
    Sitei409 – 4091Contributes to redox potential valueBy similarity
    Sitei410 – 4101Contributes to redox potential valueBy similarity
    Active sitei411 – 4111NucleophileBy similarity
    Sitei471 – 4711Lowers pKa of C-terminal Cys of second active siteBy similarity

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein disulfide-isomerase (EC:5.3.4.1)
    Short name:
    PDI
    Gene namesi
    Name:PDI
    OrganismiZea mays (Maize)
    Taxonomic identifieri4577 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

    Organism-specific databases

    GrameneiP52588.
    MaizeGDBi86830.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 513490Protein disulfide-isomerasePRO_0000034210Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi63 ↔ 66Redox-activePROSITE-ProRule annotation
    Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi408 ↔ 411Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP52588.

    Structurei

    3D structure databases

    ProteinModelPortaliP52588.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 145122Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini366 – 485120Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi510 – 5134Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 2 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Family and domain databases

    Gene3Di3.40.30.10. 3 hits.
    InterProiIPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 2 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 4 hits.
    TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 2 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P52588-1 [UniParc]FASTAAdd to Basket

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    MAIRSKAWIS LLLALAVALS ARAEEEPAAA AEGEAVLTLD VDSFDEAVAK    50
    HPFMVVEFYA PWCGHCKKLA PEYENAAKAL SKHDPPIVLA KVDANEEKNR 100
    PLATKYEIQG FPTIKIFRDR GKNIQEYKGP READGIVDYL KKQVGPASKE 150
    IKSPEDATAL IDDKKIYIVG IFAEFSGTEF TNFMEVAEKL RSDYDFGHTL 200
    HANHLPRGDA AVERPLVRLL KPFDELVVDS KDFDVAALMK FIDASTIPRV 250
    VTFDKNPDNH PYLMKFFQSS APKAMLFLNF STGPFDSFKS AYSAAAEEFK 300
    DKEIKFLIGD IEASQGAFQY FGLKEDQTPL ILIQDGDSKK FLKVHVEADQ 350
    IVAWLKEYFD GKLTPFRNSE PIPEVNNEPV KVVVADNVHD FVFKSGKNVL 400
    IEFYAPWCGH CKKLAPILDE AATTLQSDEE VVIAKMDATA NDVPSEFDVQ 450
    GYPTLYFVTP SGKVTSYDSG RTADDIVDFI KKSKETAAPH HHHHPGATGI 500
    REGSRAEPVK DEL 513
    Length:513
    Mass (Da):57,097
    Last modified:October 1, 1996 - v1
    Checksum:i29302DD01A3DEB80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L39014 mRNA. Translation: AAB08519.1.
    PIRiS69181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L39014 mRNA. Translation: AAB08519.1 .
    PIRi S69181.

    3D structure databases

    ProteinModelPortali P52588.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P52588.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei P52588.
    MaizeGDBi 86830.

    Family and domain databases

    Gene3Di 3.40.30.10. 3 hits.
    InterProi IPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 4 hits.
    TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 2 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of protein disulfide isomerase is elevated in the endosperm of the maize floury-2 mutant."
      Li C.P., Larkins B.A.
      Plant Mol. Biol. 30:873-882(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Wisconsin 64A.
      Tissue: Endosperm.

    Entry informationi

    Entry nameiPDI_MAIZE
    AccessioniPrimary (citable) accession number: P52588
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3