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P52588

- PDI_MAIZE

UniProt

P52588 - PDI_MAIZE

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Protein
Protein disulfide-isomerase
Gene
PDI
Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer By similarity.

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Nucleophile By similarity
Sitei64 – 641Contributes to redox potential value By similarity
Sitei65 – 651Contributes to redox potential value By similarity
Active sitei66 – 661Nucleophile By similarity
Sitei131 – 1311Lowers pKa of C-terminal Cys of first active site By similarity
Active sitei408 – 4081Nucleophile By similarity
Sitei409 – 4091Contributes to redox potential value By similarity
Sitei410 – 4101Contributes to redox potential value By similarity
Active sitei411 – 4111Nucleophile By similarity
Sitei471 – 4711Lowers pKa of C-terminal Cys of second active site By similarity

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase (EC:5.3.4.1)
Short name:
PDI
Gene namesi
Name:PDI
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Organism-specific databases

GrameneiP52588.
MaizeGDBi86830.

Subcellular locationi

Endoplasmic reticulum lumen Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarity
Add
BLAST
Chaini24 – 513490Protein disulfide-isomerase
PRO_0000034210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi63 ↔ 66Redox-active By similarity
Glycosylationi279 – 2791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi408 ↔ 411Redox-active By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP52588.

Structurei

3D structure databases

ProteinModelPortaliP52588.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 145122Thioredoxin 1
Add
BLAST
Domaini366 – 485120Thioredoxin 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi510 – 5134Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Contains 2 thioredoxin domains.

Keywords - Domaini

Redox-active center, Repeat, Signal

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52588-1 [UniParc]FASTAAdd to Basket

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MAIRSKAWIS LLLALAVALS ARAEEEPAAA AEGEAVLTLD VDSFDEAVAK    50
HPFMVVEFYA PWCGHCKKLA PEYENAAKAL SKHDPPIVLA KVDANEEKNR 100
PLATKYEIQG FPTIKIFRDR GKNIQEYKGP READGIVDYL KKQVGPASKE 150
IKSPEDATAL IDDKKIYIVG IFAEFSGTEF TNFMEVAEKL RSDYDFGHTL 200
HANHLPRGDA AVERPLVRLL KPFDELVVDS KDFDVAALMK FIDASTIPRV 250
VTFDKNPDNH PYLMKFFQSS APKAMLFLNF STGPFDSFKS AYSAAAEEFK 300
DKEIKFLIGD IEASQGAFQY FGLKEDQTPL ILIQDGDSKK FLKVHVEADQ 350
IVAWLKEYFD GKLTPFRNSE PIPEVNNEPV KVVVADNVHD FVFKSGKNVL 400
IEFYAPWCGH CKKLAPILDE AATTLQSDEE VVIAKMDATA NDVPSEFDVQ 450
GYPTLYFVTP SGKVTSYDSG RTADDIVDFI KKSKETAAPH HHHHPGATGI 500
REGSRAEPVK DEL 513
Length:513
Mass (Da):57,097
Last modified:October 1, 1996 - v1
Checksum:i29302DD01A3DEB80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L39014 mRNA. Translation: AAB08519.1.
PIRiS69181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L39014 mRNA. Translation: AAB08519.1 .
PIRi S69181.

3D structure databases

ProteinModelPortali P52588.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P52588.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei P52588.
MaizeGDBi 86830.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 2 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of protein disulfide isomerase is elevated in the endosperm of the maize floury-2 mutant."
    Li C.P., Larkins B.A.
    Plant Mol. Biol. 30:873-882(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Wisconsin 64A.
    Tissue: Endosperm.

Entry informationi

Entry nameiPDI_MAIZE
AccessioniPrimary (citable) accession number: P52588
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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