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Protein

Protein disulfide-isomerase

Gene

PDI

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.By similarity

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63NucleophileBy similarity1
Sitei64Contributes to redox potential valueBy similarity1
Sitei65Contributes to redox potential valueBy similarity1
Active sitei66NucleophileBy similarity1
Sitei131Lowers pKa of C-terminal Cys of first active siteBy similarity1
Active sitei408NucleophileBy similarity1
Sitei409Contributes to redox potential valueBy similarity1
Sitei410Contributes to redox potential valueBy similarity1
Active sitei411NucleophileBy similarity1
Sitei471Lowers pKa of C-terminal Cys of second active siteBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase (EC:5.3.4.1)
Short name:
PDI
Gene namesi
Name:PDI
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi86830

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000003421024 – 513Protein disulfide-isomeraseAdd BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 66Redox-activePROSITE-ProRule annotation
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi408 ↔ 411Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP52588
PRIDEiP52588

Expressioni

Gene expression databases

ExpressionAtlasiP52588 differential

Interactioni

Protein-protein interaction databases

STRINGi4577.GRMZM2G091481_P01

Structurei

3D structure databases

ProteinModelPortaliP52588
SMRiP52588
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 145Thioredoxin 1PROSITE-ProRule annotationAdd BLAST122
Domaini366 – 485Thioredoxin 2PROSITE-ProRule annotationAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi510 – 513Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 2 hits
SUPFAMiSSF52833 SSF52833, 4 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 2 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 2 hits
PS51352 THIOREDOXIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRSKAWIS LLLALAVALS ARAEEEPAAA AEGEAVLTLD VDSFDEAVAK
60 70 80 90 100
HPFMVVEFYA PWCGHCKKLA PEYENAAKAL SKHDPPIVLA KVDANEEKNR
110 120 130 140 150
PLATKYEIQG FPTIKIFRDR GKNIQEYKGP READGIVDYL KKQVGPASKE
160 170 180 190 200
IKSPEDATAL IDDKKIYIVG IFAEFSGTEF TNFMEVAEKL RSDYDFGHTL
210 220 230 240 250
HANHLPRGDA AVERPLVRLL KPFDELVVDS KDFDVAALMK FIDASTIPRV
260 270 280 290 300
VTFDKNPDNH PYLMKFFQSS APKAMLFLNF STGPFDSFKS AYSAAAEEFK
310 320 330 340 350
DKEIKFLIGD IEASQGAFQY FGLKEDQTPL ILIQDGDSKK FLKVHVEADQ
360 370 380 390 400
IVAWLKEYFD GKLTPFRNSE PIPEVNNEPV KVVVADNVHD FVFKSGKNVL
410 420 430 440 450
IEFYAPWCGH CKKLAPILDE AATTLQSDEE VVIAKMDATA NDVPSEFDVQ
460 470 480 490 500
GYPTLYFVTP SGKVTSYDSG RTADDIVDFI KKSKETAAPH HHHHPGATGI
510
REGSRAEPVK DEL
Length:513
Mass (Da):57,097
Last modified:October 1, 1996 - v1
Checksum:i29302DD01A3DEB80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39014 mRNA Translation: AAB08519.1
PIRiS69181
UniGeneiZm.2951

Similar proteinsi

Entry informationi

Entry nameiPDI_MAIZE
AccessioniPrimary (citable) accession number: P52588
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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