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Protein

Vascular endothelial growth factor homolog

Gene

A2R

Organism
Orf virus (strain NZ2) (OV NZ-2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Induces endothelial proliferation.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor homolog
Gene namesi
ORF Names:A2R
OrganismiOrf virus (strain NZ2) (OV NZ-2)
Taxonomic identifieri10259 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeParapoxvirus
Virus hostiCapra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 133113Vascular endothelial growth factor homologPRO_0000023417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 78By similarity
Disulfide bondi61 – 61InterchainBy similarity
Disulfide bondi67 ↔ 112By similarity
Disulfide bondi70 – 70InterchainBy similarity
Disulfide bondi71 ↔ 114By similarity
Glycosylationi85 – 851N-linked (GlcNAc...); by hostSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

DIPiDIP-29295N.

Structurei

Secondary structure

1
133
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi27 – 348Combined sources
Beta strandi35 – 4410Combined sources
Helixi45 – 473Combined sources
Beta strandi58 – 6912Combined sources
Beta strandi71 – 733Combined sources
Beta strandi76 – 9116Combined sources
Beta strandi97 – 993Combined sources
Beta strandi101 – 11616Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GNNX-ray2.30A/B/C/D21-133[»]
3V6BX-ray3.20A21-133[»]
ProteinModelPortaliP52584.
SMRiP52584. Positions 23-117.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52584.

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLVGILVA VCLHQYLLNA DSNTKGWSEV LKGSECKPRP IVVPVSETHP
60 70 80 90 100
ELTSQRFNPP CVTLMRCGGC CNDESLECVP TEEVNVSMEL LGASGSGSNG
110 120 130
MQRLSFVEHK KCDCRPRFTT TPPTTTRPPR RRR
Length:133
Mass (Da):14,715
Last modified:October 1, 1996 - v1
Checksum:i917C0F6883030C39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67520 Genomic DNA. Translation: AAB29220.2.
PIRiB49530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67520 Genomic DNA. Translation: AAB29220.2.
PIRiB49530.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GNNX-ray2.30A/B/C/D21-133[»]
3V6BX-ray3.20A21-133[»]
ProteinModelPortaliP52584.
SMRiP52584. Positions 23-117.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29295N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP52584.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus."
    Lyttle D.J., Fraser K.M., Fleming S.B., Mercer A.A., Robinson A.J.
    J. Virol. 68:84-92(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiVEGFH_ORFN2
AccessioniPrimary (citable) accession number: P52584
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 14, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.