##gff-version 3
P52564	UniProtKB	Chain	1	334	.	.	.	ID=PRO_0000086386;Note=Dual specificity mitogen-activated protein kinase kinase 6	
P52564	UniProtKB	Domain	53	314	.	.	.	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
P52564	UniProtKB	Region	1	34	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P52564	UniProtKB	Region	4	19	.	.	.	Note=D domain;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P52564	UniProtKB	Region	311	334	.	.	.	Note=DVD domain	
P52564	UniProtKB	Compositional bias	20	34	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P52564	UniProtKB	Active site	179	179	.	.	.	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027	
P52564	UniProtKB	Binding site	59	67	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
P52564	UniProtKB	Binding site	82	82	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
P52564	UniProtKB	Site	14	15	.	.	.	Note=Cleavage%3B by anthrax lethal factor	
P52564	UniProtKB	Modified residue	207	207	.	.	.	Note=(Microbial infection) O-acetylserine%3B by Yersinia YopJ%3B alternate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16728640,ECO:0000269|PubMed:22802624;Dbxref=PMID:16728640,PMID:22802624	
P52564	UniProtKB	Modified residue	207	207	.	.	.	Note=Phosphoserine%3B by MAP3K%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16728640;Dbxref=PMID:16728640	
P52564	UniProtKB	Modified residue	211	211	.	.	.	Note=(Microbial infection) O-acetylthreonine%3B by Yersinia YopJ%3B alternate;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16728640,ECO:0000269|PubMed:22802624;Dbxref=PMID:16728640,PMID:22802624	
P52564	UniProtKB	Modified residue	211	211	.	.	.	Note=Phosphothreonine%3B by MAP3K%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16728640;Dbxref=PMID:16728640	
P52564	UniProtKB	Alternative sequence	1	56	.	.	.	ID=VSP_004882;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8621675;Dbxref=PMID:8621675	
P52564	UniProtKB	Mutagenesis	207	207	.	.	.	Note=Inactivation. S->A	
P52564	UniProtKB	Mutagenesis	207	207	.	.	.	Note=Constitutive activation according to PubMed:8622669%2C but not to PubMed:8621675. S->E	
P52564	UniProtKB	Mutagenesis	211	211	.	.	.	Note=Inactivation. T->A	
P52564	UniProtKB	Mutagenesis	211	211	.	.	.	Note=Constitutive activation according to PubMed:8622669%2C but not to PubMed:8621675. T->E	
P52564	UniProtKB	Sequence conflict	125	125	.	.	.	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P52564	UniProtKB	Helix	50	52	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Beta strand	53	61	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Beta strand	63	72	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Turn	73	76	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Beta strand	77	84	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Helix	90	104	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Turn	105	108	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8P7J	
P52564	UniProtKB	Turn	110	112	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VN9	
P52564	UniProtKB	Beta strand	115	120	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Beta strand	122	130	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Beta strand	133	135	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Helix	136	145	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Helix	152	172	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Helix	182	184	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Beta strand	185	187	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3ENM	
P52564	UniProtKB	Beta strand	193	195	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Helix	201	203	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3ENM	
P52564	UniProtKB	Helix	207	212	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VN9	
P52564	UniProtKB	Helix	222	225	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Helix	236	252	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Helix	263	272	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Turn	280	282	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Helix	285	294	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Helix	299	301	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Helix	305	308	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Helix	312	319	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME	
P52564	UniProtKB	Helix	324	332	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3FME