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P52560

- RELA_STRCO

UniProt

P52560 - RELA_STRCO

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Protein

GTP pyrophosphokinase

Gene

relA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. PppGpp could play an essential role in triggering antibiotic production under some nutritional conditions.

Catalytic activityi

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. GTP binding Source: UniProtKB-KW
  4. GTP diphosphokinase activity Source: UniProtKB-EC
  5. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: CACAO
  2. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP pyrophosphokinase (EC:2.7.6.5)
Alternative name(s):
(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I
Gene namesi
Name:relA
Ordered Locus Names:SCO1513
ORF Names:SCL2.03c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 847847GTP pyrophosphokinasePRO_0000166564Add
BLAST

Expressioni

Inductioni

By amino acid starvation. Activation through the binding of uncharged tRNA in the acceptor sites of translating ribosomes By similarity.By similarity

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1513.

Structurei

3D structure databases

ProteinModelPortaliP52560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 24698HDAdd
BLAST
Domaini768 – 84275ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.Curated
Contains 1 ACT domain.PROSITE-ProRule annotation
Contains 1 HD domain.Curated

Phylogenomic databases

eggNOGiCOG0317.
HOGENOMiHOG000018301.
InParanoidiP52560.
KOiK00951.
OMAiIGYITRG.
OrthoDBiEOG6SV551.
PhylomeDBiP52560.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52560-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDEAQPLTA AKPESASASA AKPAPSAPQA KNDTHGPIQH APAAPVDKPA
60 70 80 90 100
EQQPRPKPLP AERPQNAPVV RAPAGQPARS GSSNRVRARL ARLGVQRANP
110 120 130 140 150
YNPVLEPLLR IVRGNDPKIE TSTLRQIERA YQVAERWHRG QKRKSGDPYI
160 170 180 190 200
THPLAVTTIL AELGMDPATL MAGLLHDTVE DTEYGLEDLR RDFGDVVTLL
210 220 230 240 250
VDGVTKLDKV KFGEAAQAET VRKMVVAMAK DPRVLVIKLA DRLHNMRTMR
260 270 280 290 300
YLKREKQEKK ARETLEIYAP LAHRLGMNTI KWELEDLAFA ILYPKMYDEI
310 320 330 340 350
VRLVAERAPK RDEYLAVVTD EVQQDLRAAR IKATVTGRPK HYYSVYQKMI
360 370 380 390 400
VRGRDFAEIY DLVGIRVLVD TVRDCYAALG TVHARWNPVP GRFKDYIAMP
410 420 430 440 450
KFNMYQSLHT TVIGPGGKPV ELQIRTFDMH RRAEYGIAAH WKYKQEAVAG
460 470 480 490 500
ASKVRTDAPK SSGKSKDDHL NDMAWLRQLL DWQKETEDPG EFLESLRFDL
510 520 530 540 550
SRNEVFVFTP KGDVIALPAG ATPVDFAYAV HTEVGHRTIG ARVNGRLVPL
560 570 580 590 600
ESTLDNGDLV EVFTSKAAGA GPSRDWLGFV KSPRARNKIR AWFSKERRDE
610 620 630 640 650
AIEQGKDAIV RAMRKQNLPI QRILTGDSLV TLAHEMRYSD ISALYAAIGE
660 670 680 690 700
GHVSAPNIVQ KLVQALGGEE AATEEIDESV PPSRGRGRKR RANADPGVVV
710 720 730 740 750
KGVEDVWVKL ARCCTPVPGD PIIGFVTRGS GVSVHRSDCV NVDSLSREPE
760 770 780 790 800
RILEVEWAPT QSSVFLVAIQ VEALDRSRLL SDVTRVLSDQ HVNILSAAVQ
810 820 830 840
TSRDRVATSR FTFEMGDPKH LGHVLKAVRG VEGVYDVYRV TSARRPS
Length:847
Mass (Da):94,182
Last modified:October 1, 1996 - v1
Checksum:i544040B21A0D512E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti197 – 1971V → L in CAA63297. (PubMed:8631867)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87267 Genomic DNA. Translation: CAA60717.1.
X92520 Genomic DNA. Translation: CAA63297.1.
AL939109 Genomic DNA. Translation: CAB70915.1.
PIRiS70687.
RefSeqiNP_625792.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB70915; CAB70915; CAB70915.
GeneIDi1096939.
KEGGisco:SCO1513.
PATRICi23732602. VBIStrCoe124346_1522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87267 Genomic DNA. Translation: CAA60717.1 .
X92520 Genomic DNA. Translation: CAA63297.1 .
AL939109 Genomic DNA. Translation: CAB70915.1 .
PIRi S70687.
RefSeqi NP_625792.1. NC_003888.3.

3D structure databases

ProteinModelPortali P52560.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO1513.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB70915 ; CAB70915 ; CAB70915 .
GeneIDi 1096939.
KEGGi sco:SCO1513.
PATRICi 23732602. VBIStrCoe124346_1522.

Phylogenomic databases

eggNOGi COG0317.
HOGENOMi HOG000018301.
InParanoidi P52560.
KOi K00951.
OMAi IGYITRG.
OrthoDBi EOG6SV551.
PhylomeDBi P52560.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization and disruption of a (p)ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2)."
    Chakraburtty R., White J., Takano E., Bibb M.J.
    Mol. Microbiol. 19:357-368(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.
  2. "A relA/spoT homologous gene from Streptomyces coelicolor A3(2) controls antibiotic biosynthetic genes."
    Martinez-Costa O.H., Arias P., Romero N.M., Parro V., Mellado R.P., Malpartida F.
    J. Biol. Chem. 271:10627-10634(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / J802.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiRELA_STRCO
AccessioniPrimary (citable) accession number: P52560
Secondary accession number(s): P72401
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3