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Protein

Endoplasmic reticulum resident protein 29

Gene

Erp29

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.

GO - Molecular functioni

  • chaperone binding Source: ParkinsonsUK-UCL
  • protein homodimerization activity Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum resident protein 29
Short name:
ERp29
Alternative name(s):
Endoplasmic reticulum resident protein 31
Short name:
ERp31
Gene namesi
Name:Erp29
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi619781 Erp29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi157C → S: Loss of function. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Add BLAST32
ChainiPRO_000002119933 – 260Endoplasmic reticulum resident protein 29Add BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Phosphotyrosine; by PKDCCBy similarity1
Modified residuei66Phosphotyrosine; by PKDCCBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP52555
PRIDEiP52555

2D gel databases

World-2DPAGE0004:P52555

PTM databases

iPTMnetiP52555
PhosphoSitePlusiP52555
SwissPalmiP52555

Expressioni

Tissue specificityi

Ubiquitous. Mostly expressed in secretory tissues.

Inductioni

By stress.

Gene expression databases

BgeeiENSRNOG00000001348
GenevisibleiP52555 RN

Interactioni

Subunit structurei

Homodimer. Part of a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ERP29P300402EBI-917740,EBI-8762218From Homo sapiens.

GO - Molecular functioni

  • chaperone binding Source: ParkinsonsUK-UCL
  • protein homodimerization activity Source: ParkinsonsUK-UCL

Protein-protein interaction databases

CORUMiP52555
IntActiP52555, 4 interactors
STRINGi10116.ENSRNOP00000001822

Structurei

Secondary structure

1260
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 38Combined sources3
Helixi43 – 49Combined sources7
Helixi50 – 52Combined sources3
Beta strandi53 – 61Combined sources9
Turni67 – 70Combined sources4
Helixi71 – 79Combined sources9
Helixi80 – 82Combined sources3
Beta strandi84 – 93Combined sources10
Helixi100 – 108Combined sources9
Beta strandi111 – 114Combined sources4
Beta strandi116 – 124Combined sources9
Beta strandi130 – 134Combined sources5
Helixi138 – 146Combined sources9
Helixi160 – 170Combined sources11
Helixi174 – 187Combined sources14
Turni188 – 190Combined sources3
Turni193 – 195Combined sources3
Helixi196 – 211Combined sources16
Helixi215 – 229Combined sources15
Turni234 – 236Combined sources3
Helixi237 – 249Combined sources13
Beta strandi252 – 254Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G7DNMR-A155-260[»]
1G7ENMR-A33-154[»]
2M66NMR-A155-260[»]
ProteinModelPortaliP52555
SMRiP52555
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52555

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi257 – 260Prevents secretion from ER4

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX2F Eukaryota
ENOG4111I8S LUCA
GeneTreeiENSGT00390000018566
HOGENOMiHOG000046371
HOVERGENiHBG051508
InParanoidiP52555
KOiK09586
OMAiDGCIKEF
PhylomeDBiP52555

Family and domain databases

CDDicd00238 ERp29c, 1 hit
cd03007 PDI_a_ERp29_N, 1 hit
Gene3Di1.20.1150.12, 1 hit
InterProiView protein in InterPro
IPR016855 ERp29
IPR011679 ERp29_C
IPR036356 ERp29_C_sf
IPR012883 ERp29_N
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF07749 ERp29, 1 hit
PF07912 ERp29_N, 1 hit
PIRSFiPIRSF027352 ER_p29, 1 hit
SUPFAMiSSF47933 SSF47933, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVPGAVS LSPLLSVLLG LLLLSAPHGA SGLHTKGALP LDTVTFYKVI
60 70 80 90 100
PKSKFVLVKF DTQYPYGEKQ DEFKRLAENS ASSDDLLVAE VGISDYGDKL
110 120 130 140 150
NMELSEKYKL DKESYPVFYL FRDGDFENPV PYSGAVKVGA IQRWLKGQGV
160 170 180 190 200
YLGMPGCLPA YDALAGQFIE ASSREARQAI LKQGQDGLSG VKETDKKWAS
210 220 230 240 250
QYLKIMGKIL DQGEDFPASE LARISKLIEN KMSEGKKEEL QRSLNILTAF
260
RKKGAEKEEL
Length:260
Mass (Da):28,575
Last modified:November 1, 1997 - v2
Checksum:i8D9EBAA756ED6CA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36482 mRNA Translation: AAC15239.1
Y10264 mRNA Translation: CAA71313.1
AY004254 Genomic DNA Translation: AAF93170.1
BC091129 mRNA Translation: AAH91129.1
RefSeqiNP_446413.1, NM_053961.2
UniGeneiRn.32904

Genome annotation databases

EnsembliENSRNOT00000001822; ENSRNOP00000001822; ENSRNOG00000001348
ENSRNOT00000081016; ENSRNOP00000072413; ENSRNOG00000001348
GeneIDi117030
KEGGirno:117030
UCSCiRGD:619781 rat

Similar proteinsi

Entry informationi

Entry nameiERP29_RAT
AccessioniPrimary (citable) accession number: P52555
Secondary accession number(s): P80749, Q5BKC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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