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P52541 (DUT_HHV6Z) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:U45
Synonyms:KA6L
OrganismHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) [Reference proteome]
Taxonomic identifier36351 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182960

Sequences

Sequence LengthMass (Da)Tools
P52541 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 7CF7104EFBC92F0B

FASTA37643,407
        10         20         30         40         50         60 
MYSVISEKIS ETITLQRQTS SRYIEFFVFR NVDINELWTT DISEDKTHDV WPAINEKSFK 

        70         80         90        100        110        120 
KFLENELTSY QRPISLLGIP QNGTVSKTCK REKQRETDCV NYVRKHGNPV TFYPRHRAKR 

       130        140        150        160        170        180 
NANTDTCISE EPSILVSHHR NSKMDVFMDA NKITLVNREL IWVPHDQVRI VKLDISLCIP 

       190        200        210        220        230        240 
DGFFGVIIGH SNDVFCECIT EIITDETDIS VFLMNLSEHS LMLLPGDVEF SINFLPCYIP 

       250        260        270        280        290        300 
EPWEMINLSP PESAVFHLKT CREFIIKPNS YTIQCFDAMY VCADELKALM IPSKEIIKLG 

       310        320        330        340        350        360 
LLIETYIWNK DTIPSIKIFN STRKTIYIPT GICIARIIFT CGHFCLSLMP ERAINRLQVL 

       370 
DASSFFLFHY AAFSNA 

« Hide

References

« Hide 'large scale' references
[1]"Intragenomic linear amplification of human herpesvirus 6B oriLyt suggests acquisition of oriLyt by transposition."
Stamey F.R., Dominguez G., Black J.B., Dambaugh T.R., Pellett P.E.
J. Virol. 69:589-596(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A."
Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N., Pellett P.E.
J. Virol. 73:8040-8052(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF157706 Genomic DNA. Translation: AAB06343.1.
PIRT44005.
RefSeqNP_050226.1. NC_000898.1.

3D structure databases

ProteinModelPortalP52541.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1497047.

Phylogenomic databases

ProtClustDBPHA3125.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUT_HHV6Z
AccessionPrimary (citable) accession number: P52541
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families