Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P52541

- DUT_HHV6Z

UniProt

P52541 - DUT_HHV6Z

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

U45

Organism
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:U45
Synonyms:KA6L
OrganismiHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
Taxonomic identifieri36351 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000006930: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182960Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP52541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.

Sequencei

Sequence statusi: Complete.

P52541-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYSVISEKIS ETITLQRQTS SRYIEFFVFR NVDINELWTT DISEDKTHDV
60 70 80 90 100
WPAINEKSFK KFLENELTSY QRPISLLGIP QNGTVSKTCK REKQRETDCV
110 120 130 140 150
NYVRKHGNPV TFYPRHRAKR NANTDTCISE EPSILVSHHR NSKMDVFMDA
160 170 180 190 200
NKITLVNREL IWVPHDQVRI VKLDISLCIP DGFFGVIIGH SNDVFCECIT
210 220 230 240 250
EIITDETDIS VFLMNLSEHS LMLLPGDVEF SINFLPCYIP EPWEMINLSP
260 270 280 290 300
PESAVFHLKT CREFIIKPNS YTIQCFDAMY VCADELKALM IPSKEIIKLG
310 320 330 340 350
LLIETYIWNK DTIPSIKIFN STRKTIYIPT GICIARIIFT CGHFCLSLMP
360 370
ERAINRLQVL DASSFFLFHY AAFSNA
Length:376
Mass (Da):43,407
Last modified:October 1, 1996 - v1
Checksum:i7CF7104EFBC92F0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157706 Genomic DNA. Translation: AAB06343.1.
PIRiT44005.
RefSeqiNP_050226.1. NC_000898.1.

Genome annotation databases

GeneIDi1497047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157706 Genomic DNA. Translation: AAB06343.1 .
PIRi T44005.
RefSeqi NP_050226.1. NC_000898.1.

3D structure databases

ProteinModelPortali P52541.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1497047.

Family and domain databases

InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Intragenomic linear amplification of human herpesvirus 6B oriLyt suggests acquisition of oriLyt by transposition."
    Stamey F.R., Dominguez G., Black J.B., Dambaugh T.R., Pellett P.E.
    J. Virol. 69:589-596(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A."
    Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N., Pellett P.E.
    J. Virol. 73:8040-8052(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_HHV6Z
AccessioniPrimary (citable) accession number: P52541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3