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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:U45
OrganismiHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
Taxonomic identifieri36351 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000006930 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001829601 – 376Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST376

Proteomic databases

PRIDEiP52541

Structurei

3D structure databases

ProteinModelPortaliP52541
SMRiP52541
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000AY

Family and domain databases

Gene3Di2.70.40.10, 3 hits
HAMAPiMF_04031 HSV_DUT, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR034745 HSV_DUT
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 2 hits

Sequencei

Sequence statusi: Complete.

P52541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSVISEKIS ETITLQRQTS SRYIEFFVFR NVDINELWTT DISEDKTHDV
60 70 80 90 100
WPAINEKSFK KFLENELTSY QRPISLLGIP QNGTVSKTCK REKQRETDCV
110 120 130 140 150
NYVRKHGNPV TFYPRHRAKR NANTDTCISE EPSILVSHHR NSKMDVFMDA
160 170 180 190 200
NKITLVNREL IWVPHDQVRI VKLDISLCIP DGFFGVIIGH SNDVFCECIT
210 220 230 240 250
EIITDETDIS VFLMNLSEHS LMLLPGDVEF SINFLPCYIP EPWEMINLSP
260 270 280 290 300
PESAVFHLKT CREFIIKPNS YTIQCFDAMY VCADELKALM IPSKEIIKLG
310 320 330 340 350
LLIETYIWNK DTIPSIKIFN STRKTIYIPT GICIARIIFT CGHFCLSLMP
360 370
ERAINRLQVL DASSFFLFHY AAFSNA
Length:376
Mass (Da):43,407
Last modified:October 1, 1996 - v1
Checksum:i7CF7104EFBC92F0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157706 Genomic DNA Translation: AAB06343.1
PIRiT44005
RefSeqiNP_050226.1, NC_000898.1

Genome annotation databases

GeneIDi1497047
KEGGivg:1497047

Similar proteinsi

Entry informationi

Entry nameiDUT_HHV6Z
AccessioniPrimary (citable) accession number: P52541
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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