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P52541

- DUT_HHV6Z

UniProt

P52541 - DUT_HHV6Z

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

U45

Organism
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:U45
    Synonyms:KA6L
    OrganismiHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
    Taxonomic identifieri36351 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000006930: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182960Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP52541.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P52541-1 [UniParc]FASTAAdd to Basket

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    MYSVISEKIS ETITLQRQTS SRYIEFFVFR NVDINELWTT DISEDKTHDV    50
    WPAINEKSFK KFLENELTSY QRPISLLGIP QNGTVSKTCK REKQRETDCV 100
    NYVRKHGNPV TFYPRHRAKR NANTDTCISE EPSILVSHHR NSKMDVFMDA 150
    NKITLVNREL IWVPHDQVRI VKLDISLCIP DGFFGVIIGH SNDVFCECIT 200
    EIITDETDIS VFLMNLSEHS LMLLPGDVEF SINFLPCYIP EPWEMINLSP 250
    PESAVFHLKT CREFIIKPNS YTIQCFDAMY VCADELKALM IPSKEIIKLG 300
    LLIETYIWNK DTIPSIKIFN STRKTIYIPT GICIARIIFT CGHFCLSLMP 350
    ERAINRLQVL DASSFFLFHY AAFSNA 376
    Length:376
    Mass (Da):43,407
    Last modified:October 1, 1996 - v1
    Checksum:i7CF7104EFBC92F0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF157706 Genomic DNA. Translation: AAB06343.1.
    PIRiT44005.
    RefSeqiNP_050226.1. NC_000898.1.

    Genome annotation databases

    GeneIDi1497047.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF157706 Genomic DNA. Translation: AAB06343.1 .
    PIRi T44005.
    RefSeqi NP_050226.1. NC_000898.1.

    3D structure databases

    ProteinModelPortali P52541.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1497047.

    Family and domain databases

    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Intragenomic linear amplification of human herpesvirus 6B oriLyt suggests acquisition of oriLyt by transposition."
      Stamey F.R., Dominguez G., Black J.B., Dambaugh T.R., Pellett P.E.
      J. Virol. 69:589-596(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A."
      Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N., Pellett P.E.
      J. Virol. 73:8040-8052(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_HHV6Z
    AccessioniPrimary (citable) accession number: P52541
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3