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P52541

- DUT_HHV6Z

UniProt

P52541 - DUT_HHV6Z

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
U45, KA6L
Organism
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:U45
Synonyms:KA6L
OrganismiHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus)
Taxonomic identifieri36351 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000006930: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182960Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP52541.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.

Family and domain databases

InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.

Sequencei

Sequence statusi: Complete.

P52541-1 [UniParc]FASTAAdd to Basket

« Hide

MYSVISEKIS ETITLQRQTS SRYIEFFVFR NVDINELWTT DISEDKTHDV    50
WPAINEKSFK KFLENELTSY QRPISLLGIP QNGTVSKTCK REKQRETDCV 100
NYVRKHGNPV TFYPRHRAKR NANTDTCISE EPSILVSHHR NSKMDVFMDA 150
NKITLVNREL IWVPHDQVRI VKLDISLCIP DGFFGVIIGH SNDVFCECIT 200
EIITDETDIS VFLMNLSEHS LMLLPGDVEF SINFLPCYIP EPWEMINLSP 250
PESAVFHLKT CREFIIKPNS YTIQCFDAMY VCADELKALM IPSKEIIKLG 300
LLIETYIWNK DTIPSIKIFN STRKTIYIPT GICIARIIFT CGHFCLSLMP 350
ERAINRLQVL DASSFFLFHY AAFSNA 376
Length:376
Mass (Da):43,407
Last modified:October 1, 1996 - v1
Checksum:i7CF7104EFBC92F0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF157706 Genomic DNA. Translation: AAB06343.1.
PIRiT44005.
RefSeqiNP_050226.1. NC_000898.1.

Genome annotation databases

GeneIDi1497047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF157706 Genomic DNA. Translation: AAB06343.1 .
PIRi T44005.
RefSeqi NP_050226.1. NC_000898.1.

3D structure databases

ProteinModelPortali P52541.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1497047.

Family and domain databases

InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Intragenomic linear amplification of human herpesvirus 6B oriLyt suggests acquisition of oriLyt by transposition."
    Stamey F.R., Dominguez G., Black J.B., Dambaugh T.R., Pellett P.E.
    J. Virol. 69:589-596(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A."
    Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N., Pellett P.E.
    J. Virol. 73:8040-8052(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_HHV6Z
AccessioniPrimary (citable) accession number: P52541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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