P52541 (DUT_HHV6Z) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Alternative name(s):
dUTP pyrophosphatase

Gene names

Name:	U45
Synonyms:	KA6L

Organism

Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) [Reference proteome]

Taxonomic identifier

36351 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Roseolovirus › Human herpesvirus 6B (strain HST)

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000182960

Sequences

	Sequence		Length	Mass (Da)
	P52541 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 7CF7104EFBC92F0B	FASTA	376	43,407
	10 20 30 40 50 60 MYSVISEKIS ETITLQRQTS SRYIEFFVFR NVDINELWTT DISEDKTHDV WPAINEKSFK 70 80 90 100 110 120 KFLENELTSY QRPISLLGIP QNGTVSKTCK REKQRETDCV NYVRKHGNPV TFYPRHRAKR 130 140 150 160 170 180 NANTDTCISE EPSILVSHHR NSKMDVFMDA NKITLVNREL IWVPHDQVRI VKLDISLCIP 190 200 210 220 230 240 DGFFGVIIGH SNDVFCECIT EIITDETDIS VFLMNLSEHS LMLLPGDVEF SINFLPCYIP 250 260 270 280 290 300 EPWEMINLSP PESAVFHLKT CREFIIKPNS YTIQCFDAMY VCADELKALM IPSKEIIKLG 310 320 330 340 350 360 LLIETYIWNK DTIPSIKIFN STRKTIYIPT GICIARIIFT CGHFCLSLMP ERAINRLQVL 370 DASSFFLFHY AAFSNA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Intragenomic linear amplification of human herpesvirus 6B oriLyt suggests acquisition of oriLyt by transposition." Stamey F.R., Dominguez G., Black J.B., Dambaugh T.R., Pellett P.E. J. Virol. 69:589-596(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A." Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N., Pellett P.E. J. Virol. 73:8040-8052(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF157706 Genomic DNA. Translation: AAB06343.1.
PIR	T44005.
RefSeq	NP_050226.1. NC_000898.1.
3D structure databases
ProteinModelPortal	P52541.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1497047.
Phylogenomic databases
ProtClustDB	PHA3125.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUT_HHV6Z

Accession

Primary (citable) accession number: P52541

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program