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Protein

Acyl carrier protein, mitochondrial

Gene

NDUFAB1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity).By similarity

GO - Molecular functioni

  • fatty acid binding Source: AgBase
  • NADH dehydrogenase (ubiquinone) activity Source: AgBase
  • oxidoreductase activity Source: AgBase

GO - Biological processi

  • fatty acid biosynthetic process Source: AgBase
  • mitochondrial electron transport, NADH to ubiquinone Source: AgBase
Complete GO annotation...

Keywords - Biological processi

Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Respiratory chain, Transport

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier protein, mitochondrial
Short name:
ACP
Alternative name(s):
CI-SDAP
NADH-ubiquinone oxidoreductase 9.6 kDa subunit
Gene namesi
Name:NDUFAB1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: AgBase
  • mitochondrial membrane Source: AgBase
  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL614865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6868Mitochondrion1 PublicationAdd
BLAST
Chaini69 – 15688Acyl carrier protein, mitochondrialPRO_0000180271Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei88 – 881N6-acetyllysineBy similarity
Modified residuei112 – 1121O-(pantetheine 4'-phosphoryl)serineSequence analysis

Keywords - PTMi

Acetylation, Phosphopantetheine, Phosphoprotein

Proteomic databases

PaxDbiP52505.
PRIDEiP52505.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

IntActiP52505. 42 interactions.
STRINGi9913.ENSBTAP00000008382.

Chemistry

BindingDBiP52505.

Structurei

3D structure databases

ProteinModelPortaliP52505.
SMRiP52505. Positions 69-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 acyl carrier domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1748. Eukaryota.
COG0236. LUCA.
HOGENOMiHOG000178184.
HOVERGENiHBG024318.
InParanoidiP52505.
KOiK03955.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_01217. Acyl_carrier.
InterProiIPR003231. Acyl_carrier.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
ProDomiPD000887. PD000887. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52505-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRVLCACV RRLPTAFAPL PRLPTLAAAR PLSTTLFAAE TRTRPGAPLP
60 70 80 90 100
ALVLAQVPGR VTQLCRQYSD APPLTLEGIK DRVLYVLKLY DKIDPEKLSV
110 120 130 140 150
NSHFMKDLGL DSLDQVEIIM AMEDEFGFEI PDIDAEKLMC PQEIVDYIAD

KKDVYE
Length:156
Mass (Da):17,402
Last modified:April 4, 2006 - v2
Checksum:i340A12BFF005463F
GO

Mass spectrometryi

Molecular mass is 10751.6 Da from positions 69 - 156. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102128 mRNA. Translation: AAI02129.1.
X61997 mRNA. Translation: CAA43970.1.
PIRiS16967.
RefSeqiNP_001035578.1. NM_001040488.2.
UniGeneiBt.321.

Genome annotation databases

GeneIDi327702.
KEGGibta:327702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102128 mRNA. Translation: AAI02129.1.
X61997 mRNA. Translation: CAA43970.1.
PIRiS16967.
RefSeqiNP_001035578.1. NM_001040488.2.
UniGeneiBt.321.

3D structure databases

ProteinModelPortaliP52505.
SMRiP52505. Positions 69-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP52505. 42 interactions.
STRINGi9913.ENSBTAP00000008382.

Chemistry

BindingDBiP52505.
ChEMBLiCHEMBL614865.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiP52505.
PRIDEiP52505.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi327702.
KEGGibta:327702.

Organism-specific databases

CTDi4706.

Phylogenomic databases

eggNOGiKOG1748. Eukaryota.
COG0236. LUCA.
HOGENOMiHOG000178184.
HOVERGENiHBG024318.
InParanoidiP52505.
KOiK03955.

Miscellaneous databases

NextBioi20810166.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_01217. Acyl_carrier.
InterProiIPR003231. Acyl_carrier.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
ProDomiPD000887. PD000887. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  2. "Presence of an acyl carrier protein in NADH:ubiquinone oxidoreductase from bovine heart mitochondria."
    Runswick M.J., Fearnley I.M., Skehel J.M., Walker J.E.
    FEBS Lett. 286:121-124(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-156, PROTEIN SEQUENCE OF 69-90, MASS SPECTROMETRY.
    Tissue: Heart.
  3. "Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme."
    Sazanov L.A., Peak-Chew S.Y., Fearnley I.M., Walker J.E.
    Biochemistry 39:7229-7235(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, SUBUNIT, IDENTIFICATION IN COMPLEX I.
  4. "Subunit analysis of bovine heart complex I by reversed-phase high-performance liquid chromatography, electrospray ionization-tandem mass spectrometry, and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry."
    Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A., Robinson N.C.
    Anal. Biochem. 382:116-121(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, IDENTIFICATION IN COMPLEX I.

Entry informationi

Entry nameiACPM_BOVIN
AccessioniPrimary (citable) accession number: P52505
Secondary accession number(s): Q3T150
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 4, 2006
Last modified: May 11, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.