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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

Gene

Ndufs6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Biological processi

  • cardiovascular system development Source: MGI
  • fatty acid metabolic process Source: MGI
  • mitochondrial electron transport, NADH to ubiquinone Source: GO_Central
  • mitochondrion morphogenesis Source: MGI
  • multicellular organism aging Source: MGI
  • multicellular organism growth Source: MGI
  • muscle contraction Source: MGI
  • reproductive system development Source: MGI
  • respiratory electron transport chain Source: MGI
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Alternative name(s):
Complex I-13kD-A
Short name:
CI-13kD-A
NADH-ubiquinone oxidoreductase 13 kDa-A subunit
Gene namesi
Name:Ndufs6
Synonyms:Ip13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:107932. Ndufs6.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex I Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2020MitochondrionBy similarityAdd
BLAST
Chaini21 – 11696NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialPRO_0000043171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei90 – 901N6-acetyllysineCombined sources
Modified residuei112 – 1121N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP52503.
MaxQBiP52503.
PaxDbiP52503.
PeptideAtlasiP52503.
PRIDEiP52503.

PTM databases

iPTMnetiP52503.
PhosphoSiteiP52503.

Expressioni

Gene expression databases

BgeeiP52503.
CleanExiMM_NDUFS6.
ExpressionAtlasiP52503. baseline and differential.
GenevisibleiP52503. MM.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Protein-protein interaction databases

BioGridi240437. 1 interaction.
IntActiP52503. 1 interaction.
STRINGi10090.ENSMUSP00000022097.

Structurei

3D structure databases

ProteinModelPortaliP52503.
SMRiP52503. Positions 77-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFS6 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3456. Eukaryota.
ENOG4111W6X. LUCA.
GeneTreeiENSGT00390000015775.
HOGENOMiHOG000161276.
HOVERGENiHBG006549.
InParanoidiP52503.
KOiK03939.
OMAiPPEDCGD.
PhylomeDBiP52503.
TreeFamiTF315128.

Family and domain databases

Gene3Di2.60.260.40. 1 hit.
InterProiIPR016668. NADH_Ub_cplx-1_Fe-S_6_mit.
IPR019401. Znf_CHCC.
[Graphical view]
PfamiPF10276. zf-CHCC. 1 hit.
[Graphical view]
PIRSFiPIRSF016564. CI-13KD-A. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVLTFRRL LTLPRAARGF GVQVSPSGEK ITHTGQVYDE KDYRRVRFVD
60 70 80 90 100
RQKEVNENFA IDLIAQQPVN EVEHRIIACD GGGGALGHPK VYINLDKETK
110
TGTCGYCGLQ FKQHHH
Length:116
Mass (Da):13,020
Last modified:December 6, 2005 - v2
Checksum:i29C5FDCB491C4B2C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371V → VTM in AAB64010 (PubMed:7607554).Curated
Sequence conflicti75 – 751R → H in AAB64010 (PubMed:7607554).Curated
Sequence conflicti85 – 873ALG → SLV in AAB64010 (PubMed:7607554).Curated
Sequence conflicti105 – 1051G → A in AAB64010 (PubMed:7607554).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086933 mRNA. Translation: AAH86933.1.
L38438 Genomic DNA. Translation: AAB64010.1.
CCDSiCCDS26630.1.
RefSeqiNP_035018.1. NM_010888.2.
UniGeneiMm.29897.

Genome annotation databases

EnsembliENSMUST00000022097; ENSMUSP00000022097; ENSMUSG00000021606.
GeneIDi407785.
KEGGimmu:407785.
UCSCiuc007rdh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086933 mRNA. Translation: AAH86933.1.
L38438 Genomic DNA. Translation: AAB64010.1.
CCDSiCCDS26630.1.
RefSeqiNP_035018.1. NM_010888.2.
UniGeneiMm.29897.

3D structure databases

ProteinModelPortaliP52503.
SMRiP52503. Positions 77-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi240437. 1 interaction.
IntActiP52503. 1 interaction.
STRINGi10090.ENSMUSP00000022097.

PTM databases

iPTMnetiP52503.
PhosphoSiteiP52503.

Proteomic databases

EPDiP52503.
MaxQBiP52503.
PaxDbiP52503.
PeptideAtlasiP52503.
PRIDEiP52503.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022097; ENSMUSP00000022097; ENSMUSG00000021606.
GeneIDi407785.
KEGGimmu:407785.
UCSCiuc007rdh.2. mouse.

Organism-specific databases

CTDi4726.
MGIiMGI:107932. Ndufs6.

Phylogenomic databases

eggNOGiKOG3456. Eukaryota.
ENOG4111W6X. LUCA.
GeneTreeiENSGT00390000015775.
HOGENOMiHOG000161276.
HOVERGENiHBG006549.
InParanoidiP52503.
KOiK03939.
OMAiPPEDCGD.
PhylomeDBiP52503.
TreeFamiTF315128.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiP52503.
SOURCEiSearch...

Gene expression databases

BgeeiP52503.
CleanExiMM_NDUFS6.
ExpressionAtlasiP52503. baseline and differential.
GenevisibleiP52503. MM.

Family and domain databases

Gene3Di2.60.260.40. 1 hit.
InterProiIPR016668. NADH_Ub_cplx-1_Fe-S_6_mit.
IPR019401. Znf_CHCC.
[Graphical view]
PfamiPF10276. zf-CHCC. 1 hit.
[Graphical view]
PIRSFiPIRSF016564. CI-13KD-A. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  2. "Genomic sequence, structural organization and evolutionary conservation of the 13.2-kDa subunit of rat NADH:ubiquinone oxidoreductase."
    Watson J.D., Beckett-Jones B., Roy R.N., Green N.C., Flynn T.G.
    Gene 158:275-280(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-113.
    Strain: CD-1.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-90 AND LYS-112, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNDUS6_MOUSE
AccessioniPrimary (citable) accession number: P52503
Secondary accession number(s): Q5M9J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 6, 2005
Last modified: July 6, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.