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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

Gene

Ndufs6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Biological processi

  • cardiovascular system development Source: MGI
  • fatty acid metabolic process Source: MGI
  • mitochondrial electron transport, NADH to ubiquinone Source: GO_Central
  • mitochondrion morphogenesis Source: MGI
  • multicellular organism aging Source: MGI
  • multicellular organism growth Source: MGI
  • muscle contraction Source: MGI
  • reproductive system development Source: MGI
  • respiratory electron transport chain Source: MGI
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Alternative name(s):
Complex I-13kD-A
Short name:
CI-13kD-A
NADH-ubiquinone oxidoreductase 13 kDa-A subunit
Gene namesi
Name:Ndufs6
Synonyms:Ip13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:107932. Ndufs6.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex I Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2020MitochondrionBy similarityAdd
BLAST
Chaini21 – 11696NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialPRO_0000043171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei90 – 901N6-acetyllysineCombined sources
Modified residuei112 – 1121N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP52503.
MaxQBiP52503.
PaxDbiP52503.
PeptideAtlasiP52503.
PRIDEiP52503.

PTM databases

iPTMnetiP52503.
PhosphoSiteiP52503.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021606.
CleanExiMM_NDUFS6.
ExpressionAtlasiP52503. baseline and differential.
GenevisibleiP52503. MM.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Protein-protein interaction databases

BioGridi240437. 1 interaction.
IntActiP52503. 1 interaction.
STRINGi10090.ENSMUSP00000022097.

Structurei

3D structure databases

ProteinModelPortaliP52503.
SMRiP52503. Positions 77-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFS6 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3456. Eukaryota.
ENOG4111W6X. LUCA.
GeneTreeiENSGT00390000015775.
HOGENOMiHOG000161276.
HOVERGENiHBG006549.
InParanoidiP52503.
KOiK03939.
OMAiPPEDCGD.
OrthoDBiEOG091G12A5.
PhylomeDBiP52503.
TreeFamiTF315128.

Family and domain databases

Gene3Di2.60.260.40. 1 hit.
InterProiIPR016668. NADH_Ub_cplx-1_Fe-S_6_mit.
IPR019401. Znf_CHCC.
[Graphical view]
PfamiPF10276. zf-CHCC. 1 hit.
[Graphical view]
PIRSFiPIRSF016564. CI-13KD-A. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVLTFRRL LTLPRAARGF GVQVSPSGEK ITHTGQVYDE KDYRRVRFVD
60 70 80 90 100
RQKEVNENFA IDLIAQQPVN EVEHRIIACD GGGGALGHPK VYINLDKETK
110
TGTCGYCGLQ FKQHHH
Length:116
Mass (Da):13,020
Last modified:December 6, 2005 - v2
Checksum:i29C5FDCB491C4B2C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371V → VTM in AAB64010 (PubMed:7607554).Curated
Sequence conflicti75 – 751R → H in AAB64010 (PubMed:7607554).Curated
Sequence conflicti85 – 873ALG → SLV in AAB64010 (PubMed:7607554).Curated
Sequence conflicti105 – 1051G → A in AAB64010 (PubMed:7607554).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086933 mRNA. Translation: AAH86933.1.
L38438 Genomic DNA. Translation: AAB64010.1.
CCDSiCCDS26630.1.
RefSeqiNP_035018.1. NM_010888.2.
UniGeneiMm.29897.

Genome annotation databases

EnsembliENSMUST00000022097; ENSMUSP00000022097; ENSMUSG00000021606.
GeneIDi407785.
KEGGimmu:407785.
UCSCiuc007rdh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086933 mRNA. Translation: AAH86933.1.
L38438 Genomic DNA. Translation: AAB64010.1.
CCDSiCCDS26630.1.
RefSeqiNP_035018.1. NM_010888.2.
UniGeneiMm.29897.

3D structure databases

ProteinModelPortaliP52503.
SMRiP52503. Positions 77-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi240437. 1 interaction.
IntActiP52503. 1 interaction.
STRINGi10090.ENSMUSP00000022097.

PTM databases

iPTMnetiP52503.
PhosphoSiteiP52503.

Proteomic databases

EPDiP52503.
MaxQBiP52503.
PaxDbiP52503.
PeptideAtlasiP52503.
PRIDEiP52503.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022097; ENSMUSP00000022097; ENSMUSG00000021606.
GeneIDi407785.
KEGGimmu:407785.
UCSCiuc007rdh.2. mouse.

Organism-specific databases

CTDi4726.
MGIiMGI:107932. Ndufs6.

Phylogenomic databases

eggNOGiKOG3456. Eukaryota.
ENOG4111W6X. LUCA.
GeneTreeiENSGT00390000015775.
HOGENOMiHOG000161276.
HOVERGENiHBG006549.
InParanoidiP52503.
KOiK03939.
OMAiPPEDCGD.
OrthoDBiEOG091G12A5.
PhylomeDBiP52503.
TreeFamiTF315128.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiP52503.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021606.
CleanExiMM_NDUFS6.
ExpressionAtlasiP52503. baseline and differential.
GenevisibleiP52503. MM.

Family and domain databases

Gene3Di2.60.260.40. 1 hit.
InterProiIPR016668. NADH_Ub_cplx-1_Fe-S_6_mit.
IPR019401. Znf_CHCC.
[Graphical view]
PfamiPF10276. zf-CHCC. 1 hit.
[Graphical view]
PIRSFiPIRSF016564. CI-13KD-A. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUS6_MOUSE
AccessioniPrimary (citable) accession number: P52503
Secondary accession number(s): Q5M9J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.