P52502 (VNCS_PAVPK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-capsid protein NS-1

Alternative name(s):
Non-structural protein NS1

Gene names

Name:

NS1

Organism

Porcine parvovirus (strain Kresse) (PPV) [Complete proteome]

Taxonomic identifier

73487 [NCBI]

Taxonomic lineage

Viruses › ssDNA viruses › Parvoviridae › Parvovirinae › Parvovirus

Virus host

Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length	662 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Seems necessary for viral DNA replication.
Sequence similarities	Belongs to the parvoviruses non-capsid protein family. Contains 1 SF3 helicase domain.

Ontologies

Keywords
Biological process	DNA replication Initiation of viral infection Viral penetration into host cytoplasm Viral penetration via permeabilization of host organellar membrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 662	662	Non-capsid protein NS-1		PRO_0000222472
Regions
	Domain	372 – 527	156	SF3 helicase
	Nucleotide binding	398 – 405	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P52502 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: B53F76D9F9FBD613	FASTA	662	75,591
	10 20 30 40 50 60 MAAGNTYSEE VLKATNWLQD NAQKEAFSYV FKTQKVNLNG KEIAWNNYNK DTTDAEMINL 70 80 90 100 110 120 QRGAETSWDQ ATDMEWESEI DSLTKRQVLI FDSLVKKCLF EGILQKNLSP SDCYWFIQHE 130 140 150 160 170 180 HGQDTGYHCH VLLGGKGLQQ AMGKWFRKQL NNLWSRWLIM QCKVPLTPVE RIKLRELAED 190 200 210 220 230 240 GEWVSLLTYT HKQTKKQYTK MTHFGNMIAY YFLNKKRKTT EREHGYYLSS DSGFMTNFLK 250 260 270 280 290 300 EGERHLVSHL FTEANKPETV ETTVTTAQEA KRGRIQTKKE VSIKCTIRDL VNKRCTSIED 310 320 330 340 350 360 WMMTDPDSYI EMMAQTGGEN LIKNTLEITT LTLARTKTAY DLILEKAKPS MLPTFNISNT 370 380 390 400 410 420 RTCKIFSMHN WNYIKVCHAI TCVLNRQGGK RNTILFHGPA STGKSIIAQH IANLVGNVGC 430 440 450 460 470 480 YNAANVNFPF NDCTNKNLIW IEEAGNFSNQ VNQFKAICSG QTIRIDQKGK GSKQIEPTPV 490 500 510 520 530 540 IMTTNEDITK VRIGCEERPE HTQPIRDRML NINLTRKLPG DFGLLEETEW PLICAWLVKK 550 560 570 580 590 600 GYQATMASYM HHWGNVPDWS EKWEEPKMQT PINTPTDSQI STSVKTSPAD NNYAATPIQE 610 620 630 640 650 660 DLDLALALEP WSEPTTPTFT NLHLTPTPPD SAIRTPSPTW SEIETDIRAC FGENCAPTTN LE

References

[1]	"Genome organization of the Kresse strain of porcine parvovirus: identification of the allotropic determinant and comparison with those of NADL-2 and field isolates." Bergeron J., Hebert B., Tijssen P. J. Virol. 70:2508-2515(1996) [PubMed: 8642680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genomic organization and mapping of transcription and translation products of the NADL-2 strain of porcine parvovirus." Bergeron J., Menezes J., Tijssen P. Virology 197:86-98(1993) [PubMed: 8212598] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U44978 Genomic DNA. Translation: AAC40229.1. L23427 Unassigned DNA. No translation available.
PIR	UYPVNA. A36217.
RefSeq	NP_757369.1. NC_001718.1.
3D structure databases
ProteinModelPortal	P52502.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1489594.
Family and domain databases
InterPro	IPR014015. Helicase_SF3_DNA-vir. IPR021972. Parvovirus_NS1_C. IPR001257. Parvovirus_NS1_helicase. IPR021076. Parvovirus_NS1_N. [Graphical view]
Pfam	PF12117. DUF3580. 1 hit. PF01057. Parvo_NS1. 1 hit. PF12433. PV_NSP1. 1 hit. [Graphical view]
PROSITE	PS51206. SF3_HELICASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VNCS_PAVPK

Accession

Primary (citable) accession number: P52502

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	September 21, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program