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Protein

Gastrin-releasing peptide receptor

Gene

Grpr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for gastrin-releasing peptide (GRP) (PubMed:8391296). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory.By similarity1 Publication

GO - Molecular functioni

  • bombesin receptor activity Source: RGD
  • G-protein coupled receptor activity Source: RGD
  • neuropeptide binding Source: RGD
  • neuropeptide receptor activity Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: RGD
  • learning or memory Source: RGD
  • motor behavior Source: UniProtKB
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • psychomotor behavior Source: Ensembl
  • regulation of cell proliferation Source: Ensembl
  • response to external biotic stimulus Source: Ensembl
  • social behavior Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin-releasing peptide receptor
Short name:
GRP-R
Alternative name(s):
GRP-preferring bombesin receptor
Gene namesi
Name:Grpr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi2750. Grpr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 63Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini64 – 77CytoplasmicSequence analysisAdd BLAST14
Transmembranei78 – 97Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini98 – 115ExtracellularSequence analysisAdd BLAST18
Transmembranei116 – 137Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini138 – 153CytoplasmicSequence analysisAdd BLAST16
Transmembranei154 – 175Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini176 – 209ExtracellularSequence analysisAdd BLAST34
Transmembranei210 – 235Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini236 – 265CytoplasmicSequence analysisAdd BLAST30
Transmembranei266 – 286Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini287 – 299ExtracellularSequence analysisAdd BLAST13
Transmembranei300 – 326Helical; Name=7Sequence analysisAdd BLAST27
Topological domaini327 – 384CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • membrane Source: RGD

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4280.
GuidetoPHARMACOLOGYi39.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696641 – 384Gastrin-releasing peptide receptorAdd BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 197PROSITE-ProRule annotation
Lipidationi340S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP52500.

PTM databases

PhosphoSitePlusiP52500.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004124.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005559.

Chemistry databases

BindingDBiP52500.

Structurei

3D structure databases

ProteinModelPortaliP52500.
SMRiP52500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiP52500.
KOiK04169.
OMAiLMTRSHS.
OrthoDBiEOG091G085Y.
PhylomeDBiP52500.
TreeFamiTF331292.

Family and domain databases

InterProiView protein in InterPro
IPR001556. Bombsn_rcpt-like.
IPR001966. Gastrin_pep_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00358. BOMBESINR.
PR00640. GASTRINRELPR.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P52500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNNCSHLN LEVDPFLSCN NTFNQTLNPP KMDNWFHPGI IYVIPAVYGL
60 70 80 90 100
IIVIGLIGNI TLIKIFCTVK SMRNVPNLFI SSLALGDLLL LVTCAPVDAS
110 120 130 140 150
KYLADRWLFG RIGCKLIPFI QLTSVGVSVF TLTALSADRY KAIVRPMDIQ
160 170 180 190 200
ASHALMKICL KAALIWIVSM LLAIPEAVFS DLHPFHVKDT NQTFISCAPY
210 220 230 240 250
PHSNELHPKI HSMASFLVFY IIPLSIISVY YYFIARNLIQ SAYNLPVEGN
260 270 280 290 300
IHVKKQIESR KRLAKTVLVF VGLFAFCWLP NHVIYLYRSY HYSEVDTSML
310 320 330 340 350
HFITSICARL LAFTNSCVNP FALYLLSKSF RKQFNTQLLC CQPSLLNRSH
360 370 380
STGRSTTCMT SFKSTNPSAT FSLINGNICH EGYV
Length:384
Mass (Da):43,236
Last modified:June 7, 2017 - v2
Checksum:i86C0671671812EEB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28N → S in CAA39988 (Ref. 1) 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56661 mRNA. Translation: CAA39988.1.
AABR07037836 Genomic DNA. No translation available.
CH474014 Genomic DNA. Translation: EDL90503.1.
PIRiI57682.
RefSeqiNP_036838.1. NM_012706.2.
UniGeneiRn.10316.

Genome annotation databases

EnsembliENSRNOT00000005559; ENSRNOP00000005559; ENSRNOG00000004124.
GeneIDi24938.
KEGGirno:24938.
UCSCiRGD:2750. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGRPR_RAT
AccessioniPrimary (citable) accession number: P52500
Secondary accession number(s): G3V6I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 7, 2017
Last modified: July 5, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families