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Protein

Gastrin-releasing peptide receptor

Gene

Grpr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • bombesin receptor activity Source: RGD
  • G-protein coupled receptor activity Source: RGD
  • neuropeptide binding Source: RGD

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: RGD
  • learning or memory Source: RGD
  • social behavior Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin-releasing peptide receptor
Short name:
GRP-R
Alternative name(s):
GRP-preferring bombesin receptor
Gene namesi
Name:Grpr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2750. Grpr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence analysisAdd
BLAST
Transmembranei40 – 6324Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 7714CytoplasmicSequence analysisAdd
BLAST
Transmembranei78 – 9720Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini98 – 11518ExtracellularSequence analysisAdd
BLAST
Transmembranei116 – 13722Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 15316CytoplasmicSequence analysisAdd
BLAST
Transmembranei154 – 17522Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini176 – 20934ExtracellularSequence analysisAdd
BLAST
Transmembranei210 – 23526Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini236 – 26530CytoplasmicSequence analysisAdd
BLAST
Transmembranei266 – 28621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini287 – 29913ExtracellularSequence analysisAdd
BLAST
Transmembranei300 – 32627Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini327 – 38458CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4280.
GuidetoPHARMACOLOGYi39.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Gastrin-releasing peptide receptorPRO_0000069664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence analysis
Disulfide bondi114 ↔ 197PROSITE-ProRule annotation
Lipidationi340 – 3401S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP52500.

PTM databases

PhosphoSiteiP52500.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005559.

Chemistry

BindingDBiP52500.

Structurei

3D structure databases

ProteinModelPortaliP52500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiP52500.
KOiK04169.
PhylomeDBiP52500.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt-like.
IPR001966. Gastrin_pep_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00640. GASTRINRELPR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNNCSHLN LEVDPFLSCN NTFNQTLSPP KMDNWFHPGI IYVIPAVYGL
60 70 80 90 100
IIVIGLIGNI TLIKIFCTVK SMRNVPNLFI SSLALGDLLL LVTCAPVDAS
110 120 130 140 150
KYLADRWLFG RIGCKLIPFI QLTSVGVSVF TLTALSADRY KAIVRPMDIQ
160 170 180 190 200
ASHALMKICL KAALIWIVSM LLAIPEAVFS DLHPFHVKDT NQTFISCAPY
210 220 230 240 250
PHSNELHPKI HSMASFLVFY IIPLSIISVY YYFIARNLIQ SAYNLPVEGN
260 270 280 290 300
IHVKKQIESR KRLAKTVLVF VGLFAFCWLP NHVIYLYRSY HYSEVDTSML
310 320 330 340 350
HFITSICARL LAFTNSCVNP FALYLLSKSF RKQFNTQLLC CQPSLLNRSH
360 370 380
STGRSTTCMT SFKSTNPSAT FSLINGNICH EGYV
Length:384
Mass (Da):43,209
Last modified:October 1, 1996 - v1
Checksum:i0C6114939B22A043
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56661 mRNA. Translation: CAA39988.1.
PIRiI57682.
RefSeqiNP_036838.1. NM_012706.2.
UniGeneiRn.10316.

Genome annotation databases

GeneIDi24938.
KEGGirno:24938.
UCSCiRGD:2750. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56661 mRNA. Translation: CAA39988.1.
PIRiI57682.
RefSeqiNP_036838.1. NM_012706.2.
UniGeneiRn.10316.

3D structure databases

ProteinModelPortaliP52500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005559.

Chemistry

BindingDBiP52500.
ChEMBLiCHEMBL4280.
GuidetoPHARMACOLOGYi39.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP52500.

Proteomic databases

PaxDbiP52500.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24938.
KEGGirno:24938.
UCSCiRGD:2750. rat.

Organism-specific databases

CTDi2925.
RGDi2750. Grpr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230781.
HOVERGENiHBG004898.
InParanoidiP52500.
KOiK04169.
PhylomeDBiP52500.

Miscellaneous databases

PROiP52500.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt-like.
IPR001966. Gastrin_pep_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00640. GASTRINRELPR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRPR_RAT
AccessioniPrimary (citable) accession number: P52500
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.