P52500 (GRPR_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gastrin-releasing peptide receptor
Short name=GRP-R

Alternative name(s):
GRP-preferring bombesin receptor

Gene names

Name:

Grpr

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	learning or memory Inferred from mutant phenotype PubMed 17097693. Source: RGD social behavior Inferred from mutant phenotype PubMed 17097693. Source: RGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from direct assay PubMed 2542758. Source: RGD plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	bombesin receptor activity Traceable author statement PubMed 11463790. Source: RGD neuropeptide binding Inferred from direct assay PubMed 2542758. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Gastrin-releasing peptide receptor		PRO_0000069664
Regions
	Topological domain	1 – 39	39	Extracellular Potential
	Transmembrane	40 – 63	24	Helical; Name=1; Potential
	Topological domain	64 – 77	14	Cytoplasmic Potential
	Transmembrane	78 – 97	20	Helical; Name=2; Potential
	Topological domain	98 – 115	18	Extracellular Potential
	Transmembrane	116 – 137	22	Helical; Name=3; Potential
	Topological domain	138 – 153	16	Cytoplasmic Potential
	Transmembrane	154 – 175	22	Helical; Name=4; Potential
	Topological domain	176 – 209	34	Extracellular Potential
	Transmembrane	210 – 235	26	Helical; Name=5; Potential
	Topological domain	236 – 265	30	Cytoplasmic Potential
	Transmembrane	266 – 286	21	Helical; Name=6; Potential
	Topological domain	287 – 299	13	Extracellular Potential
	Transmembrane	300 – 326	27	Helical; Name=7; Potential
	Topological domain	327 – 384	58	Cytoplasmic Potential
Amino acid modifications
	Lipidation	340	1	S-palmitoyl cysteine By similarity
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Glycosylation	20	1	N-linked (GlcNAc...) Potential
	Glycosylation	24	1	N-linked (GlcNAc...) Potential
	Disulfide bond	114 ↔ 197		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P52500 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 0C6114939B22A043	FASTA	384	43,209
	10 20 30 40 50 60 MDPNNCSHLN LEVDPFLSCN NTFNQTLSPP KMDNWFHPGI IYVIPAVYGL IIVIGLIGNI 70 80 90 100 110 120 TLIKIFCTVK SMRNVPNLFI SSLALGDLLL LVTCAPVDAS KYLADRWLFG RIGCKLIPFI 130 140 150 160 170 180 QLTSVGVSVF TLTALSADRY KAIVRPMDIQ ASHALMKICL KAALIWIVSM LLAIPEAVFS 190 200 210 220 230 240 DLHPFHVKDT NQTFISCAPY PHSNELHPKI HSMASFLVFY IIPLSIISVY YYFIARNLIQ 250 260 270 280 290 300 SAYNLPVEGN IHVKKQIESR KRLAKTVLVF VGLFAFCWLP NHVIYLYRSY HYSEVDTSML 310 320 330 340 350 360 HFITSICARL LAFTNSCVNP FALYLLSKSF RKQFNTQLLC CQPSLLNRSH STGRSTTCMT 370 380 SFKSTNPSAT FSLINGNICH EGYV

References

[1]	"Two distinct bombesin receptor subtype subtypes in ppostnatal rat central nervous system." Wada E., Way J., Shapira H., Battey J.F. Mol. Cell. Neurosci. 3:446-460(1992) Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreatic acinar cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X56661 mRNA. Translation: CAA39988.1.
IPI	IPI00207071.
PIR	I57682.
RefSeq	NP_036838.1. NM_012706.2.
UniGene	Rn.10316.
3D structure databases
ProteinModelPortal	P52500.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000005559.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P52500.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	24938.
KEGG	rno:24938.
UCSC	RGD:2750. rat.
Organism-specific databases
CTD	2925.
RGD	2750. Grpr.
Phylogenomic databases
eggNOG	NOG328649.
HOGENOM	HOG000230781.
HOVERGEN	HBG004898.
InParanoid	P52500.
KO	K04169.
OrthoDB	EOG476K0C.
Gene expression databases
Genevestigator	P52500.
GermOnline	ENSRNOG00000004124. Rattus norvegicus.
Family and domain databases
InterPro	IPR001556. Bombsn_rcpt. IPR001966. Gastrin_pep_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00358. BOMBESINR. PR00640. GASTRINRELPR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P52500.
ChEMBL	CHEMBL4280.
NextBio	604927.

Entry information

Entry name

GRPR_RAT

Accession

Primary (citable) accession number: P52500

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program