P52494 (TREA_CANAX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neutral trehalase
EC=3.2.1.28

Alternative name(s):
Alpha,alpha-trehalase
Alpha,alpha-trehalose glucohydrolase

Gene names

Name:

NTC1

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	907 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose.
Sequence similarities	Belongs to the glycosyl hydrolase 37 family.

Ontologies

Keywords
Molecular function	Glycosidase Hydrolase
Gene Ontology (GO)
Biological_process	phosphate-containing compound metabolic process Inferred from electronic annotation. Source: InterPro trehalose catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	alpha,alpha-trehalase activity Inferred from electronic annotation. Source: EC calcium ion binding Inferred from electronic annotation. Source: InterPro inorganic diphosphatase activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 907	907	Neutral trehalase		PRO_0000173792
Natural variations
	Natural variant	687	1	K → N in strain: 3153A.

Sequences

	Sequence		Length	Mass (Da)
	P52494 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 6B21D4CCD900C793	FASTA	907	104,023
	10 20 30 40 50 60 MFTKNHRRMS STSSDDDPFD VAEKYYGEER KKKLNRVRTF SAFESTKYGA GPISPLRPTY 70 80 90 100 110 120 EPPPVIKETS EPLSSSSSTS SPPTLTPQTS QVQFNLGVGK TKNGSAIHSD SEEEEEDEDP 130 140 150 160 170 180 VSNTKKGEAD EKDPFDTTDS KLENENSTPS SITGKEIIPH PTGFRGSSEE SAIRRKPSII 190 200 210 220 230 240 PIYHDNISQE SVIRNANTPT TYNREKFHLR RGSLDESTFI RPKKYYINDV QGTLRELLAN 250 260 270 280 290 300 EDTDNNCQIT IEDTGPKVLR LGTANSLGIN QSSIRGTYRL SNLLQELTIA SRFGRHQIVL 310 320 330 340 350 360 DEARLSENPV DRMKRLISTS FWNNLTRIIT KENIVDMAKD TKIKESWIDD QGKLHENQES 370 380 390 400 410 420 HRIYVPYNRK DQYEFFQLIK KQRSDIQLDV QYLPQKIDAD YIKSINKKPG LLSIATRPDP 430 440 450 460 470 480 QAPDSGSLIS WPYVVPGGRF NELYGWDSYM ETLGLLTDVK IDPSGNPRNL RHLELARGMA 490 500 510 520 530 540 ENFIYEIHHY GKILNANRSY YLGRSQPPFL TDMALRIFNK TIEVTPELMD EAIDFLKRAT 550 560 570 580 590 600 LAAIKEYETI WCAHPRLDDK TGLSCYHPEG KGIPPETEPT HFNALLKPYL AKYNDIDQLD 610 620 630 640 650 660 FIEKYNSGEI KEPELDEYFL HDRAVRESGH DTSYRLEGKC AYLATVDLNS LLYKYENDIA 670 680 690 700 710 720 FILQSFFNDN LQDPYDDNNS NKIHSSKIWL ERSHQRKLNV DKYLWNEQDG IYYDYNVKLQ 730 740 750 760 770 780 QQTNYESATT FWPLYAKLAS SNQAAKLIDQ SLHKFEEHGG LVAGTLKSRG EVGLTRPSRQ 790 800 810 820 830 840 WDYPFGWAPQ QILAWIGLVN YGYDGIARRL AYRWLFMMTK SFVDYNGVIV EKYNVTKGAV 850 860 870 880 890 900 PHRVDAEYGN QGLDFKGVAT EGFGWVNASY VFGLTFLNLY AQRALGSLTP PEIFLRNMHP EQRKQYK

References

[1]

"A neutral trehalase gene from Candida albicans: molecular cloning, characterization and disruption." Eck R., Bergmann C., Ziegelbauer K., Schoenfeld W., Kuenkel W. Microbiology 143:3747-3756(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. Strain: 3153A and Rueck.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X95099 Genomic DNA. Translation: CAA64476.1.
3D structure databases
ProteinModelPortal	P52494.
ModBase	Search...
Protein family/group databases
CAZy	GH37. Glycoside Hydrolase Family 37.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG1626.
Family and domain databases
InterPro	IPR008928. 6-hairpin_glycosidase-like. IPR001661. Glyco_hydro_37. IPR018232. Glyco_hydro_37_CS. IPR008162. Pyrophosphatase. IPR011120. Trehalase_Ca-bd. [Graphical view]
PANTHER	PTHR23403. PTHR23403. 1 hit.
Pfam	PF01204. Trehalase. 1 hit. PF07492. Trehalase_Ca-bi. 1 hit. [Graphical view]
PRINTS	PR00744. GLHYDRLASE37.
SUPFAM	SSF48208. Glyco_trans_6hp. 1 hit.
PROSITE	PS00927. TREHALASE_1. 1 hit. PS00928. TREHALASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TREA_CANAX

Accession

Primary (citable) accession number: P52494

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program