Reviewed, UniProtKB/Swiss-Prot P52492 (UBC11_YEAST)

Names and origin

Protein names

Recommended name:
    Ubiquitin-conjugating enzyme E2-18 kDa
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase
    Ubiquitin carrier protein

Gene names

Name:	UBC11
Ordered Locus Names:	YOR339C
ORF Names:	O6268

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW protein monoubiquitination Traceable author statement. Source: SGD protein polyubiquitination Traceable author statement. Source: SGD regulation of protein metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred by curator. Source: SGD
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 156	156	Ubiquitin-conjugating enzyme E2-18 kDa		PRO_0000082559
Sites
	Active site	93	1	Glycyl thioester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P52492-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 950C69F224900197	FASTA	156	17,753
	10 20 30 40 50 60 MAVEEGGCVT KRLQNELLQL LSSTTESISA FPVDDNDLTY WVGYITGPKD TPYSGLKFKV 70 80 90 100 110 120 SLKFPQNYPF HPPMIKFLSP MWHPNVDKSG NICLDILKEK WSAVYNVETI LLSLQSLLGE 130 140 150 PNNRSPLNAV AAELWDADME EYRKKVLACY EEIDDY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence analysis of a 40 kb segment on the right arm of yeast chromosome XV reveals 18 open reading frames including a new pyruvate kinase and three homologues to chromosome I genes." Purnelle B., Goffeau A. Yeast 12:1475-1481(1996) [PubMed: 8948102] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 90843 / S288c / FY73.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed: 9169874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"Functional analysis of the Saccharomyces cerevisiae UBC11 gene." Townsley F.M., Ruderman J.V. Yeast 14:747-757(1998) [PubMed: 9675819] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X95720 Genomic DNA. Translation: CAA65027.1. Z75247 Genomic DNA. Translation: CAA99663.1.
PIR	S67248.
RefSeq	NP_014984.1.
3D structure databases
HSSP	HSSP built from PDB template 2E2C based on UniProtKB Q95044.
ModBase	Search...
Protein-protein interaction databases
IntAct	P52492. 1 interaction.
STRING	P52492.
Genome annotation databases
Ensembl	YOR339C; YOR339C; YOR339C; Saccharomyces cerevisiae. [Genome view]
GeneID	854517.
GenomeReviews	Gene locus YOR339C in contig Y13140_GR.
KEGG	sce:YOR339C.
NMPDR	fig|4932.3.peg.6101.
Organism-specific databases
CYGD	YOR339c.
SGD	S000005866. UBC11.
Phylogenomic databases
HOGENOM	P52492.
OMA	KEKWSAV.
Enzyme and pathway databases
BRENDA	6.3.2.19. 250.
Gene expression databases
ArrayExpress	P52492.
Genevestigator	P52492.
GermOnline	YOR339C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR015582. Ubiquitin-conj_enz_E2_H10. IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view]
Gene3D	G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
PANTHER	PTHR11621:SF26. UbcH10. 1 hit.
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
ProDom	PD000461. UBQ_conjugat. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00212. UBCc. 1 hit. [Graphical view]
PROSITE	PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	976882.

Entry information

Entry name

UBC11_YEAST

Accession

Primary (citable) accession number: P52492

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 3, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)