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Protein

Ubiquitin-conjugating enzyme E2-18 kDa

Gene

UBC11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • anaphase-promoting complex-dependent catabolic process Source: GO_Central
  • protein monoubiquitination Source: SGD
  • protein polyubiquitination Source: SGD
  • regulation of mitotic metaphase/anaphase transition Source: GO_Central

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33814-MONOMER
ReactomeiR-SCE-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-SCE-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2-18 kDa (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 11
Ubiquitin carrier protein
Ubiquitin-protein ligase
Gene namesi
Name:UBC11
Ordered Locus Names:YOR339C
ORF Names:O6268
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR339C
SGDiS000005866 UBC11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825591 – 156Ubiquitin-conjugating enzyme E2-18 kDaAdd BLAST156

Proteomic databases

PaxDbiP52492
PRIDEiP52492

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34722, 43 interactors
DIPiDIP-7221N
IntActiP52492, 5 interactors
STRINGi4932.YOR339C

Structurei

3D structure databases

ProteinModelPortaliP52492
SMRiP52492
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00920000149047
HOGENOMiHOG000233454
InParanoidiP52492
KOiK06688
OMAiAELWDKD
OrthoDBiEOG092C50OL

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52492-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVEEGGCVT KRLQNELLQL LSSTTESISA FPVDDNDLTY WVGYITGPKD
60 70 80 90 100
TPYSGLKFKV SLKFPQNYPF HPPMIKFLSP MWHPNVDKSG NICLDILKEK
110 120 130 140 150
WSAVYNVETI LLSLQSLLGE PNNRSPLNAV AAELWDADME EYRKKVLACY

EEIDDY
Length:156
Mass (Da):17,753
Last modified:October 1, 1996 - v1
Checksum:i950C69F224900197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95720 Genomic DNA Translation: CAA65027.1
Z75247 Genomic DNA Translation: CAA99663.1
BK006948 Genomic DNA Translation: DAA11100.1
PIRiS67248
RefSeqiNP_014984.3, NM_001183759.3

Genome annotation databases

EnsemblFungiiYOR339C; YOR339C; YOR339C
GeneIDi854517
KEGGisce:YOR339C

Similar proteinsi

Entry informationi

Entry nameiUBC11_YEAST
AccessioniPrimary (citable) accession number: P52492
Secondary accession number(s): D6W334
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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