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P52485

- UBCD2_DROME

UniProt

P52485 - UBCD2_DROME

Protein

Ubiquitin-conjugating enzyme E2-24 kDa

Gene

UbcD2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins.

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei170 – 1701Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. ubiquitin-protein transferase activity Source: FlyBase

    GO - Biological processi

    1. lipid storage Source: FlyBase

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_181662. Separation of Sister Chromatids.
    REACT_182058. Senescence-Associated Secretory Phenotype (SASP).
    REACT_210493. Inactivation of APC/C via direct inhibition of the APC/C complex.
    REACT_224351. Regulation of APC/C activators between G1/S and early anaphase.
    REACT_33104. APC/C:Cdc20 mediated degradation of Cyclin B.
    REACT_92044. APC/C:Cdc20 mediated degradation of Securin.
    SignaLinkiP52485.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2-24 kDa (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein
    Ubiquitin-protein ligase
    Gene namesi
    Name:UbcD2
    ORF Names:CG6720
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0015320. UbcD2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 232232Ubiquitin-conjugating enzyme E2-24 kDaPRO_0000082520Add
    BLAST

    Proteomic databases

    PaxDbiP52485.
    PRIDEiP52485.

    Expressioni

    Gene expression databases

    BgeeiP52485.

    Interactioni

    Protein-protein interaction databases

    BioGridi60561. 16 interactions.
    DIPiDIP-17329N.
    IntActiP52485. 5 interactions.
    MINTiMINT-334725.

    Structurei

    3D structure databases

    ProteinModelPortaliP52485.
    SMRiP52485. Positions 86-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    InParanoidiP52485.
    KOiK06689.
    OMAiAKPNPKM.
    OrthoDBiEOG7PCJGX.
    PhylomeDBiP52485.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52485-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSTPAAGSA AEVATSSATS NAPSAPSTTA SNVSNTSQPT TAGTPQARGG    50
    RGSNANGGAS GSNAGGGDEP RKEAKTTPRI SRALGTSAKR IQKELAEITL 100
    DPPPNCSAGP KGDNLYEWVS TILGPPGSVY EGGVFFLDIH FSPEYPFKPP 150
    KVTFRTRIYH CNINSQGVIC LDILKDNWSP ALTISKVLLS ICSLLTDCNP 200
    ADPLVGSIAT QYLQNREEHD RIARLWTKRY AT 232
    Length:232
    Mass (Da):24,435
    Last modified:October 1, 1996 - v1
    Checksum:iDE71AFD8EB618C86
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92663 mRNA. Translation: CAA63351.1.
    AE014134 Genomic DNA. Translation: AAF53008.1.
    RefSeqiNP_001260362.1. NM_001273433.1.
    NP_477137.1. NM_057789.4.
    NP_723616.1. NM_164943.2.
    UniGeneiDm.6395.

    Genome annotation databases

    EnsemblMetazoaiFBtr0080115; FBpp0079704; FBgn0015320.
    FBtr0080116; FBpp0079705; FBgn0015320.
    FBtr0333492; FBpp0305676; FBgn0015320.
    GeneIDi34487.
    KEGGidme:Dmel_CG6720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92663 mRNA. Translation: CAA63351.1 .
    AE014134 Genomic DNA. Translation: AAF53008.1 .
    RefSeqi NP_001260362.1. NM_001273433.1.
    NP_477137.1. NM_057789.4.
    NP_723616.1. NM_164943.2.
    UniGenei Dm.6395.

    3D structure databases

    ProteinModelPortali P52485.
    SMRi P52485. Positions 86-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 60561. 16 interactions.
    DIPi DIP-17329N.
    IntActi P52485. 5 interactions.
    MINTi MINT-334725.

    Proteomic databases

    PaxDbi P52485.
    PRIDEi P52485.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0080115 ; FBpp0079704 ; FBgn0015320 .
    FBtr0080116 ; FBpp0079705 ; FBgn0015320 .
    FBtr0333492 ; FBpp0305676 ; FBgn0015320 .
    GeneIDi 34487.
    KEGGi dme:Dmel_CG6720.

    Organism-specific databases

    CTDi 34487.
    FlyBasei FBgn0015320. UbcD2.

    Phylogenomic databases

    eggNOGi COG5078.
    InParanoidi P52485.
    KOi K06689.
    OMAi AKPNPKM.
    OrthoDBi EOG7PCJGX.
    PhylomeDBi P52485.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_181662. Separation of Sister Chromatids.
    REACT_182058. Senescence-Associated Secretory Phenotype (SASP).
    REACT_210493. Inactivation of APC/C via direct inhibition of the APC/C complex.
    REACT_224351. Regulation of APC/C activators between G1/S and early anaphase.
    REACT_33104. APC/C:Cdc20 mediated degradation of Cyclin B.
    REACT_92044. APC/C:Cdc20 mediated degradation of Securin.
    SignaLinki P52485.

    Miscellaneous databases

    ChiTaRSi UbcD2. drosophila.
    GenomeRNAii 34487.
    NextBioi 788724.

    Gene expression databases

    Bgeei P52485.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel family of ubiquitin-conjugating enzymes with distinct amino-terminal extensions."
      Matuschewski K., Hauser H.P., Treier M., Jentsch S.
      J. Biol. Chem. 271:2789-2794(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DP CN BW.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.

    Entry informationi

    Entry nameiUBCD2_DROME
    AccessioniPrimary (citable) accession number: P52485
    Secondary accession number(s): Q9VKQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3