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P52485

- UBCD2_DROME

UniProt

P52485 - UBCD2_DROME

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Protein
Ubiquitin-conjugating enzyme E2-24 kDa
Gene
UbcD2, CG6720
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei170 – 1701Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro
  3. ubiquitin-protein transferase activity Source: FlyBase

GO - Biological processi

  1. lipid storage Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_181662. Separation of Sister Chromatids.
REACT_182058. Senescence-Associated Secretory Phenotype (SASP).
REACT_210493. Inactivation of APC/C via direct inhibition of the APC/C complex.
REACT_224351. Regulation of APC/C activators between G1/S and early anaphase.
REACT_33104. APC/C:Cdc20 mediated degradation of Cyclin B.
REACT_92044. APC/C:Cdc20 mediated degradation of Securin.
SignaLinkiP52485.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2-24 kDa (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein
Ubiquitin-protein ligase
Gene namesi
Name:UbcD2
ORF Names:CG6720
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0015320. UbcD2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Ubiquitin-conjugating enzyme E2-24 kDa
PRO_0000082520Add
BLAST

Proteomic databases

PaxDbiP52485.
PRIDEiP52485.

Expressioni

Gene expression databases

BgeeiP52485.

Interactioni

Protein-protein interaction databases

BioGridi60561. 16 interactions.
DIPiDIP-17329N.
IntActiP52485. 5 interactions.
MINTiMINT-334725.

Structurei

3D structure databases

ProteinModelPortaliP52485.
SMRiP52485. Positions 86-232.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
InParanoidiP52485.
KOiK06689.
OMAiAKPNPKM.
OrthoDBiEOG7PCJGX.
PhylomeDBiP52485.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52485-1 [UniParc]FASTAAdd to Basket

« Hide

MSSTPAAGSA AEVATSSATS NAPSAPSTTA SNVSNTSQPT TAGTPQARGG    50
RGSNANGGAS GSNAGGGDEP RKEAKTTPRI SRALGTSAKR IQKELAEITL 100
DPPPNCSAGP KGDNLYEWVS TILGPPGSVY EGGVFFLDIH FSPEYPFKPP 150
KVTFRTRIYH CNINSQGVIC LDILKDNWSP ALTISKVLLS ICSLLTDCNP 200
ADPLVGSIAT QYLQNREEHD RIARLWTKRY AT 232
Length:232
Mass (Da):24,435
Last modified:October 1, 1996 - v1
Checksum:iDE71AFD8EB618C86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92663 mRNA. Translation: CAA63351.1.
AE014134 Genomic DNA. Translation: AAF53008.1.
RefSeqiNP_001260362.1. NM_001273433.1.
NP_477137.1. NM_057789.4.
NP_723616.1. NM_164943.2.
UniGeneiDm.6395.

Genome annotation databases

EnsemblMetazoaiFBtr0080115; FBpp0079704; FBgn0015320.
FBtr0080116; FBpp0079705; FBgn0015320.
FBtr0333492; FBpp0305676; FBgn0015320.
GeneIDi34487.
KEGGidme:Dmel_CG6720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92663 mRNA. Translation: CAA63351.1 .
AE014134 Genomic DNA. Translation: AAF53008.1 .
RefSeqi NP_001260362.1. NM_001273433.1.
NP_477137.1. NM_057789.4.
NP_723616.1. NM_164943.2.
UniGenei Dm.6395.

3D structure databases

ProteinModelPortali P52485.
SMRi P52485. Positions 86-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 60561. 16 interactions.
DIPi DIP-17329N.
IntActi P52485. 5 interactions.
MINTi MINT-334725.

Proteomic databases

PaxDbi P52485.
PRIDEi P52485.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0080115 ; FBpp0079704 ; FBgn0015320 .
FBtr0080116 ; FBpp0079705 ; FBgn0015320 .
FBtr0333492 ; FBpp0305676 ; FBgn0015320 .
GeneIDi 34487.
KEGGi dme:Dmel_CG6720.

Organism-specific databases

CTDi 34487.
FlyBasei FBgn0015320. UbcD2.

Phylogenomic databases

eggNOGi COG5078.
InParanoidi P52485.
KOi K06689.
OMAi AKPNPKM.
OrthoDBi EOG7PCJGX.
PhylomeDBi P52485.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_181662. Separation of Sister Chromatids.
REACT_182058. Senescence-Associated Secretory Phenotype (SASP).
REACT_210493. Inactivation of APC/C via direct inhibition of the APC/C complex.
REACT_224351. Regulation of APC/C activators between G1/S and early anaphase.
REACT_33104. APC/C:Cdc20 mediated degradation of Cyclin B.
REACT_92044. APC/C:Cdc20 mediated degradation of Securin.
SignaLinki P52485.

Miscellaneous databases

ChiTaRSi UbcD2. drosophila.
GenomeRNAii 34487.
NextBioi 788724.

Gene expression databases

Bgeei P52485.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel family of ubiquitin-conjugating enzymes with distinct amino-terminal extensions."
    Matuschewski K., Hauser H.P., Treier M., Jentsch S.
    J. Biol. Chem. 271:2789-2794(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DP CN BW.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.

Entry informationi

Entry nameiUBCD2_DROME
AccessioniPrimary (citable) accession number: P52485
Secondary accession number(s): Q9VKQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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