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Protein

Ubiquitin-conjugating enzyme E2-24 kDa

Gene

Ubc2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei170Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: FlyBase

GO - Biological processi

  • lipid storage Source: FlyBase
  • protein polyubiquitination Source: FlyBase

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-DME-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-DME-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-DME-176408 Regulation of APC/C activators between G1/S and early anaphase
R-DME-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-DME-176412 Phosphorylation of the APC/C
R-DME-179409 APC-Cdc20 mediated degradation of Nek2A
R-DME-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DME-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DME-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiP52485
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2-24 kDa (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 2
Ubiquitin carrier protein
Ubiquitin-protein ligase
Gene namesi
Name:Ubc2Imported
Synonyms:UbcD2
ORF Names:CG6720Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0015320 Ubc2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825201 – 232Ubiquitin-conjugating enzyme E2-24 kDaAdd BLAST232

Proteomic databases

PaxDbiP52485
PRIDEiP52485

Expressioni

Gene expression databases

BgeeiFBgn0015320
ExpressionAtlasiP52485 baseline and differential
GenevisibleiP52485 DM

Interactioni

Protein-protein interaction databases

BioGridi60561, 17 interactors
DIPiDIP-17329N
IntActiP52485, 8 interactors
STRINGi7227.FBpp0305676

Structurei

3D structure databases

ProteinModelPortaliP52485
SMRiP52485
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
InParanoidiP52485
KOiK20217
OMAiGDRAKHD
OrthoDBiEOG091G0GF8
PhylomeDBiP52485

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52485-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTPAAGSA AEVATSSATS NAPSAPSTTA SNVSNTSQPT TAGTPQARGG
60 70 80 90 100
RGSNANGGAS GSNAGGGDEP RKEAKTTPRI SRALGTSAKR IQKELAEITL
110 120 130 140 150
DPPPNCSAGP KGDNLYEWVS TILGPPGSVY EGGVFFLDIH FSPEYPFKPP
160 170 180 190 200
KVTFRTRIYH CNINSQGVIC LDILKDNWSP ALTISKVLLS ICSLLTDCNP
210 220 230
ADPLVGSIAT QYLQNREEHD RIARLWTKRY AT
Length:232
Mass (Da):24,435
Last modified:October 1, 1996 - v1
Checksum:iDE71AFD8EB618C86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92663 mRNA Translation: CAA63351.1
AE014134 Genomic DNA Translation: AAF53008.1
RefSeqiNP_001260362.1, NM_001273433.1
NP_001285814.1, NM_001298885.1
NP_477137.1, NM_057789.4
NP_723616.1, NM_164943.2
UniGeneiDm.6395

Genome annotation databases

EnsemblMetazoaiFBtr0080115; FBpp0079704; FBgn0015320
FBtr0080116; FBpp0079705; FBgn0015320
FBtr0333492; FBpp0305676; FBgn0015320
FBtr0345437; FBpp0311562; FBgn0015320
GeneIDi34487
KEGGidme:Dmel_CG6720

Similar proteinsi

Entry informationi

Entry nameiUBCD2_DROME
AccessioniPrimary (citable) accession number: P52485
Secondary accession number(s): Q9VKQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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