ID   UBC21_CAEEL             Reviewed;         229 AA.
AC   P52484;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 2.
DT   16-JUN-2009, entry version 59.
DE   RecName: Full=Probable ubiquitin-conjugating enzyme E2 21;
DE            EC=6.3.2.19;
DE   AltName: Full=Ubiquitin-protein ligase 21;
DE   AltName: Full=Ubiquitin carrier protein 21;
GN   Name=ubc-21; ORFNames=C06E2.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Catalyzes the covalent attachment of ubiquitin to other
CC       proteins (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP +
CC       diphosphate + protein N-ubiquityllysine.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC   -!- SIMILARITY: Contains 1 UBA domain.
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DR   EMBL; U39674; AAA80415.2; -; Genomic_DNA.
DR   PIR; T15432; T15432.
DR   RefSeq; NP_509502.2; -.
DR   UniGene; Cel.25724; -.
DR   HSSP; P21734; 1FZY.
DR   Ensembl; C06E2.3; Caenorhabditis elegans.
DR   GeneID; 182321; -.
DR   KEGG; cel:C06E2.3; -.
DR   WormBase; WBGene00006716; ubc-21.
DR   WormPep; C06E2.3; CE40013.
DR   OMA; P52484; CKEVANA.
DR   BRENDA; 6.3.2.19; 672.
DR   NextBio; 917164; -.
DR   ArrayExpress; P52484; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC.
DR   GO; GO:0019941; P:modification-dependent protein catabolic pr...; IEA:UniProtKB-KW.
DR   GO; GO:0043687; P:post-translational protein modification; IEA:InterPro.
DR   GO; GO:0051246; P:regulation of protein metabolic process; IEA:InterPro.
DR   InterPro; IPR015940; UBA/transl_elong_EF1B_N_euk.
DR   InterPro; IPR016135; UBQ-conjugat/RWD-like.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   Gene3D; G3DSA:3.10.110.10; UBQ-conjugat_E2; 1.
DR   Pfam; PF00179; UQ_con; 1.
DR   ProDom; PD000461; UBQ_conjugat; 1.
DR   SMART; SM00212; UBCc; 1.
DR   PROSITE; PS50030; UBA; 1.
DR   PROSITE; PS00183; UBIQUITIN_CONJUGAT_1; 1.
DR   PROSITE; PS50127; UBIQUITIN_CONJUGAT_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Ligase; Nucleotide-binding;
KW   Ubl conjugation pathway.
FT   CHAIN         1    229       Probable ubiquitin-conjugating enzyme E2
FT                                21.
FT                                /FTId=PRO_0000082518.
FT   DOMAIN      187    229       UBA.
FT   ACT_SITE    121    121       Glycyl thioester intermediate (By
FT                                similarity).
SQ   SEQUENCE   229 AA;  26065 MW;  7FBE05784F66386C CRC64;
     MSVSKLNKMQ FSDKMSNLAL ARVTRKCKEV ANASDITEAG IHVEIKENNL MDIKGFIKGP
     EGTPYAGGTF EIKVDIPEHY PFEPPKVTEI IFHIRAFEYI QAKFVTRIWH PNISSQTGTI
     CLDILKDKWT ASLTLRTVLL SLQAMLCSPE PSDPQDAVVA KQFINNYPMF TATAVYWTSY
     FANSKKDVEP DFNRKVGRLI EMGIRETEAI VYLSCNNWKL EQALQFIFD
//