Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable ubiquitin-conjugating enzyme E2 21

Gene

ubc-21

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei106Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 21 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 21
Ubiquitin carrier protein 21
Ubiquitin-protein ligase 21
Gene namesi
Name:ubc-21
ORF Names:C06E2.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC06E2.3; CE46306; WBGene00006716; ubc-21.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825181 – 214Probable ubiquitin-conjugating enzyme E2 21Add BLAST214

Proteomic databases

PaxDbiP52484.
PeptideAtlasiP52484.

Expressioni

Gene expression databases

BgeeiWBGene00006716.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.C06E2.3.

Structurei

3D structure databases

ProteinModelPortaliP52484.
SMRiP52484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 214UBAPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0418. Eukaryota.
COG5078. LUCA.
GeneTreeiENSGT00670000098059.
HOGENOMiHOG000233455.
InParanoidiP52484.
KOiK04649.
OMAiWTHAYAG.
OrthoDBiEOG091G0KVW.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR015940. UBA.
IPR009060. UBA-like.
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS50030. UBA. 1 hit.
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P52484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSKLNKMQ FSDKMSNLAL ARVTRKCKEV ANASDITEAG IHVEIKENNL
60 70 80 90 100
MDIKGFIKGP EGTPYAGGTF EIKVDIPEHY PFEPPKAKFV TRIWHPNISS
110 120 130 140 150
QTGTICLDIL KDKWTASLTL RTVLLSLQAM LCSPEPSDPQ DAVVAKQFIN
160 170 180 190 200
NYPMFTATAV YWTSYFANSK KDVEPDFNRK VGRLIEMGIR ETEAIVYLSC
210
NNWKLEQALQ FIFD
Length:214
Mass (Da):24,204
Last modified:January 25, 2012 - v3
Checksum:iF061FFE2FB9EF130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080381 Genomic DNA. Translation: CCD63324.1.
PIRiT15432.
RefSeqiNP_509502.3. NM_077101.3.
UniGeneiCel.25724.

Genome annotation databases

EnsemblMetazoaiC06E2.3; C06E2.3; WBGene00006716.
GeneIDi182321.
KEGGicel:CELE_C06E2.3.
UCSCiC06E2.3. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiUBC21_CAEEL
AccessioniPrimary (citable) accession number: P52484
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 25, 2012
Last modified: September 27, 2017
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families