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P52484

- UBC21_CAEEL

UniProt

P52484 - UBC21_CAEEL

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Protein
Probable ubiquitin-conjugating enzyme E2 21
Gene
ubc-21, C06E2.3
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei106 – 1061Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 21 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein 21
Ubiquitin-protein ligase 21
Gene namesi
Name:ubc-21
ORF Names:C06E2.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiC06E2.3; CE46306; WBGene00006716; ubc-21.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Probable ubiquitin-conjugating enzyme E2 21
PRO_0000082518Add
BLAST

Proteomic databases

PaxDbiP52484.
PRIDEiP52484.

Interactioni

Protein-protein interaction databases

STRINGi6239.C06E2.3.

Structurei

3D structure databases

ProteinModelPortaliP52484.
SMRiP52484. Positions 17-213.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 21443UBA
Add
BLAST

Sequence similaritiesi

Contains 1 UBA domain.

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00670000098059.
HOGENOMiHOG000233455.
InParanoidiP52484.
OMAiCKEVANA.
OrthoDBiEOG7F513F.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54495. SSF54495. 1 hit.
PROSITEiPS50030. UBA. 1 hit.
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52484-1 [UniParc]FASTAAdd to Basket

« Hide

MSVSKLNKMQ FSDKMSNLAL ARVTRKCKEV ANASDITEAG IHVEIKENNL    50
MDIKGFIKGP EGTPYAGGTF EIKVDIPEHY PFEPPKAKFV TRIWHPNISS 100
QTGTICLDIL KDKWTASLTL RTVLLSLQAM LCSPEPSDPQ DAVVAKQFIN 150
NYPMFTATAV YWTSYFANSK KDVEPDFNRK VGRLIEMGIR ETEAIVYLSC 200
NNWKLEQALQ FIFD 214
Length:214
Mass (Da):24,204
Last modified:January 25, 2012 - v3
Checksum:iF061FFE2FB9EF130
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080381 Genomic DNA. Translation: CCD63324.1.
PIRiT15432.
RefSeqiNP_509502.3. NM_077101.3.
UniGeneiCel.25724.

Genome annotation databases

EnsemblMetazoaiC06E2.3; C06E2.3; WBGene00006716.
GeneIDi182321.
KEGGicel:CELE_C06E2.3.
UCSCiC06E2.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080381 Genomic DNA. Translation: CCD63324.1 .
PIRi T15432.
RefSeqi NP_509502.3. NM_077101.3.
UniGenei Cel.25724.

3D structure databases

ProteinModelPortali P52484.
SMRi P52484. Positions 17-213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.C06E2.3.

Proteomic databases

PaxDbi P52484.
PRIDEi P52484.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C06E2.3 ; C06E2.3 ; WBGene00006716 .
GeneIDi 182321.
KEGGi cel:CELE_C06E2.3.
UCSCi C06E2.3. c. elegans.

Organism-specific databases

CTDi 182321.
WormBasei C06E2.3 ; CE46306 ; WBGene00006716 ; ubc-21.

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00670000098059.
HOGENOMi HOG000233455.
InParanoidi P52484.
OMAi CKEVANA.
OrthoDBi EOG7F513F.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 917164.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
SSF54495. SSF54495. 1 hit.
PROSITEi PS50030. UBA. 1 hit.
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiUBC21_CAEEL
AccessioniPrimary (citable) accession number: P52484
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 25, 2012
Last modified: September 3, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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