P52484 (UBC21_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable ubiquitin-conjugating enzyme E2 21
EC=6.3.2.19

Alternative name(s):
Ubiquitin carrier protein 21
Ubiquitin-protein ligase 21

Gene names

Name:	ubc-21
ORF Names:	C06E2.3

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family. Contains 1 UBA domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 214	214	Probable ubiquitin-conjugating enzyme E2 21		PRO_0000082518
Regions
	Domain	172 – 214	43	UBA
Sites
	Active site	106	1	Glycyl thioester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P52484 [UniParc]. Last modified January 25, 2012. Version 3. Checksum: F061FFE2FB9EF130	FASTA	214	24,204
	10 20 30 40 50 60 MSVSKLNKMQ FSDKMSNLAL ARVTRKCKEV ANASDITEAG IHVEIKENNL MDIKGFIKGP 70 80 90 100 110 120 EGTPYAGGTF EIKVDIPEHY PFEPPKAKFV TRIWHPNISS QTGTICLDIL KDKWTASLTL 130 140 150 160 170 180 RTVLLSLQAM LCSPEPSDPQ DAVVAKQFIN NYPMFTATAV YWTSYFANSK KDVEPDFNRK 190 200 210 VGRLIEMGIR ETEAIVYLSC NNWKLEQALQ FIFD

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080381 Genomic DNA. Translation: CCD63324.1.
PIR	T15432.
RefSeq	NP_509502.3. NM_077101.3.
3D structure databases
ProteinModelPortal	P52484.
SMR	P52484. Positions 17-213.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.C06E2.3.
Proteomic databases
PaxDb	P52484.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C06E2.3; C06E2.3; C06E2.3.
GeneID	182321.
KEGG	cel:CELE_C06E2.3.
UCSC	C06E2.3. c. elegans.
Organism-specific databases
CTD	182321.
WormBase	C06E2.3; CE46306; WBGene00006716; ubc-21.
Phylogenomic databases
eggNOG	COG5078.
GeneTree	ENSGT00670000098059.
HOGENOM	HOG000233455.
InParanoid	P52484.
OMA	SESDIHH.
Enzyme and pathway databases
UniPathway	UPA00143.
Family and domain databases
Gene3D	3.10.110.10. 1 hit.
InterPro	IPR009060. UBA-like. IPR015940. UBA/transl_elong_EF1B_N_euk. IPR000608. UBQ-conjugat_E2. IPR023313. UBQ-conjugating_AS. IPR016135. UBQ-conjugating_enzyme/RWD. [Graphical view]
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
SUPFAM	SSF46934. UBA_like. 1 hit. SSF54495. UBQ-conjugat/RWD-like. 1 hit.
PROSITE	PS50030. UBA. 1 hit. PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	917164.

Entry information

Entry name

UBC21_CAEEL

Accession

Primary (citable) accession number: P52484

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 25, 2012
Last modified:	May 1, 2013
This is version 95 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project