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P52484

- UBC21_CAEEL

UniProt

P52484 - UBC21_CAEEL

Protein

Probable ubiquitin-conjugating enzyme E2 21

Gene

ubc-21

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 3 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei106 – 1061Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin-conjugating enzyme E2 21 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein 21
    Ubiquitin-protein ligase 21
    Gene namesi
    Name:ubc-21
    ORF Names:C06E2.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiC06E2.3; CE46306; WBGene00006716; ubc-21.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 214214Probable ubiquitin-conjugating enzyme E2 21PRO_0000082518Add
    BLAST

    Proteomic databases

    PaxDbiP52484.
    PRIDEiP52484.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.C06E2.3.

    Structurei

    3D structure databases

    ProteinModelPortaliP52484.
    SMRiP52484. Positions 17-213.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini172 – 21443UBAPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation
    Contains 1 UBA domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    GeneTreeiENSGT00670000098059.
    HOGENOMiHOG000233455.
    InParanoidiP52484.
    OMAiCKEVANA.
    OrthoDBiEOG7F513F.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    SSF54495. SSF54495. 1 hit.
    PROSITEiPS50030. UBA. 1 hit.
    PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P52484-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVSKLNKMQ FSDKMSNLAL ARVTRKCKEV ANASDITEAG IHVEIKENNL    50
    MDIKGFIKGP EGTPYAGGTF EIKVDIPEHY PFEPPKAKFV TRIWHPNISS 100
    QTGTICLDIL KDKWTASLTL RTVLLSLQAM LCSPEPSDPQ DAVVAKQFIN 150
    NYPMFTATAV YWTSYFANSK KDVEPDFNRK VGRLIEMGIR ETEAIVYLSC 200
    NNWKLEQALQ FIFD 214
    Length:214
    Mass (Da):24,204
    Last modified:January 25, 2012 - v3
    Checksum:iF061FFE2FB9EF130
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080381 Genomic DNA. Translation: CCD63324.1.
    PIRiT15432.
    RefSeqiNP_509502.3. NM_077101.3.
    UniGeneiCel.25724.

    Genome annotation databases

    EnsemblMetazoaiC06E2.3; C06E2.3; WBGene00006716.
    GeneIDi182321.
    KEGGicel:CELE_C06E2.3.
    UCSCiC06E2.3. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080381 Genomic DNA. Translation: CCD63324.1 .
    PIRi T15432.
    RefSeqi NP_509502.3. NM_077101.3.
    UniGenei Cel.25724.

    3D structure databases

    ProteinModelPortali P52484.
    SMRi P52484. Positions 17-213.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.C06E2.3.

    Proteomic databases

    PaxDbi P52484.
    PRIDEi P52484.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C06E2.3 ; C06E2.3 ; WBGene00006716 .
    GeneIDi 182321.
    KEGGi cel:CELE_C06E2.3.
    UCSCi C06E2.3. c. elegans.

    Organism-specific databases

    CTDi 182321.
    WormBasei C06E2.3 ; CE46306 ; WBGene00006716 ; ubc-21.

    Phylogenomic databases

    eggNOGi COG5078.
    GeneTreei ENSGT00670000098059.
    HOGENOMi HOG000233455.
    InParanoidi P52484.
    OMAi CKEVANA.
    OrthoDBi EOG7F513F.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 917164.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    SSF54495. SSF54495. 1 hit.
    PROSITEi PS50030. UBA. 1 hit.
    PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiUBC21_CAEEL
    AccessioniPrimary (citable) accession number: P52484
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 103 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3