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Protein

Probable ubiquitin-conjugating enzyme E2 21

Gene

ubc-21

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathway:iprotein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei106 – 1061Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 21 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein 21
Ubiquitin-protein ligase 21
Gene namesi
Name:ubc-21
ORF Names:C06E2.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC06E2.3; CE46306; WBGene00006716; ubc-21.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Probable ubiquitin-conjugating enzyme E2 21PRO_0000082518Add
BLAST

Proteomic databases

PaxDbiP52484.
PRIDEiP52484.

Interactioni

Protein-protein interaction databases

STRINGi6239.C06E2.3.

Structurei

3D structure databases

ProteinModelPortaliP52484.
SMRiP52484. Positions 17-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 21443UBAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00670000098059.
HOGENOMiHOG000233455.
InParanoidiP52484.
OMAiFTTRIWH.
OrthoDBiEOG7F513F.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54495. SSF54495. 1 hit.
PROSITEiPS50030. UBA. 1 hit.
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSKLNKMQ FSDKMSNLAL ARVTRKCKEV ANASDITEAG IHVEIKENNL
60 70 80 90 100
MDIKGFIKGP EGTPYAGGTF EIKVDIPEHY PFEPPKAKFV TRIWHPNISS
110 120 130 140 150
QTGTICLDIL KDKWTASLTL RTVLLSLQAM LCSPEPSDPQ DAVVAKQFIN
160 170 180 190 200
NYPMFTATAV YWTSYFANSK KDVEPDFNRK VGRLIEMGIR ETEAIVYLSC
210
NNWKLEQALQ FIFD
Length:214
Mass (Da):24,204
Last modified:January 25, 2012 - v3
Checksum:iF061FFE2FB9EF130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080381 Genomic DNA. Translation: CCD63324.1.
PIRiT15432.
RefSeqiNP_509502.3. NM_077101.3.
UniGeneiCel.25724.

Genome annotation databases

EnsemblMetazoaiC06E2.3; C06E2.3; WBGene00006716.
GeneIDi182321.
KEGGicel:CELE_C06E2.3.
UCSCiC06E2.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080381 Genomic DNA. Translation: CCD63324.1.
PIRiT15432.
RefSeqiNP_509502.3. NM_077101.3.
UniGeneiCel.25724.

3D structure databases

ProteinModelPortaliP52484.
SMRiP52484. Positions 17-213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C06E2.3.

Proteomic databases

PaxDbiP52484.
PRIDEiP52484.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC06E2.3; C06E2.3; WBGene00006716.
GeneIDi182321.
KEGGicel:CELE_C06E2.3.
UCSCiC06E2.3. c. elegans.

Organism-specific databases

CTDi182321.
WormBaseiC06E2.3; CE46306; WBGene00006716; ubc-21.

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00670000098059.
HOGENOMiHOG000233455.
InParanoidiP52484.
OMAiFTTRIWH.
OrthoDBiEOG7F513F.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi917164.
PROiP52484.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54495. SSF54495. 1 hit.
PROSITEiPS50030. UBA. 1 hit.
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiUBC21_CAEEL
AccessioniPrimary (citable) accession number: P52484
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 25, 2012
Last modified: June 24, 2015
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.