Reviewed, UniProtKB/Swiss-Prot P52484 (UBC21_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable ubiquitin-conjugating enzyme E2 21
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase 21
    Ubiquitin carrier protein 21

Gene names

Name:	ubc-21
ORF Names:	C06E2.3

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family. Contains 1 UBA domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	post-translational protein modification Inferred from electronic annotation. Source: InterPro regulation of protein metabolic process Inferred from electronic annotation. Source: InterPro ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Probable ubiquitin-conjugating enzyme E2 21		PRO_0000082518
Regions
	Domain	187 – 229	43	UBA
Sites
	Active site	121	1	Glycyl thioester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P52484-1 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: 7FBE05784F66386C	FASTA	229	26,065
	10 20 30 40 50 60 MSVSKLNKMQ FSDKMSNLAL ARVTRKCKEV ANASDITEAG IHVEIKENNL MDIKGFIKGP 70 80 90 100 110 120 EGTPYAGGTF EIKVDIPEHY PFEPPKVTEI IFHIRAFEYI QAKFVTRIWH PNISSQTGTI 130 140 150 160 170 180 CLDILKDKWT ASLTLRTVLL SLQAMLCSPE PSDPQDAVVA KQFINNYPMF TATAVYWTSY 190 200 210 220 FANSKKDVEP DFNRKVGRLI EMGIRETEAI VYLSCNNWKL EQALQFIFD

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U39674 Genomic DNA. Translation: AAA80415.2.
PIR	T15432.
RefSeq	NP_509502.2.
UniGene	Cel.25724
3D structure databases
HSSP	HSSP built from PDB template 1FZY based on UniProtKB P21734.
ModBase	Search...
Genome annotation databases
Ensembl	C06E2.3. Caenorhabditis elegans. [Contig view]
GeneID	182321.
KEGG	cel:C06E2.3.
Organism-specific databases
WormBase	WBGene00006716. ubc-21.
WormPep	C06E2.3. CE40013. [WorfDB]
Gene expression databases
ArrayExpress	P52484.
Family and domain databases
InterPro	IPR015940. UBA/transl_elong_EF1B_N_euk. IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view]
Gene3D	G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
PANTHER	PTHR11621. UBQ-conjugat_E2. 1 hit.
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
ProDom	PD000461. UBQ_conjugat. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00212. UBCc. 1 hit. [Graphical view]
PROSITE	PS50030. UBA. 1 hit. PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	917164.

Entry information

Entry name

UBC21_CAEEL

Accession

Primary (citable) accession number: P52484

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	September 5, 2006
Last modified:	November 25, 2008
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project