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P52484 (UBC21_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ubiquitin-conjugating enzyme E2 21

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein 21
Ubiquitin-protein ligase 21
Gene names
Name:ubc-21
ORF Names:C06E2.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Contains 1 UBA domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ubiquitin-protein transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 214214Probable ubiquitin-conjugating enzyme E2 21
PRO_0000082518

Regions

Domain172 – 21443UBA

Sites

Active site1061Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P52484 [UniParc].

Last modified January 25, 2012. Version 3.
Checksum: F061FFE2FB9EF130

FASTA21424,204
        10         20         30         40         50         60 
MSVSKLNKMQ FSDKMSNLAL ARVTRKCKEV ANASDITEAG IHVEIKENNL MDIKGFIKGP 

        70         80         90        100        110        120 
EGTPYAGGTF EIKVDIPEHY PFEPPKAKFV TRIWHPNISS QTGTICLDIL KDKWTASLTL 

       130        140        150        160        170        180 
RTVLLSLQAM LCSPEPSDPQ DAVVAKQFIN NYPMFTATAV YWTSYFANSK KDVEPDFNRK 

       190        200        210 
VGRLIEMGIR ETEAIVYLSC NNWKLEQALQ FIFD 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080381 Genomic DNA. Translation: CCD63324.1.
PIRT15432.
RefSeqNP_509502.3. NM_077101.3.
UniGeneCel.25724.

3D structure databases

ProteinModelPortalP52484.
SMRP52484. Positions 17-213.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.C06E2.3.

Proteomic databases

PaxDbP52484.
PRIDEP52484.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC06E2.3; C06E2.3; WBGene00006716.
GeneID182321.
KEGGcel:CELE_C06E2.3.
UCSCC06E2.3. c. elegans.

Organism-specific databases

CTD182321.
WormBaseC06E2.3; CE46306; WBGene00006716; ubc-21.

Phylogenomic databases

eggNOGCOG5078.
GeneTreeENSGT00670000098059.
HOGENOMHOG000233455.
InParanoidP52484.
OMACKEVANA.
OrthoDBEOG7F513F.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF46934. SSF46934. 1 hit.
SSF54495. SSF54495. 1 hit.
PROSITEPS50030. UBA. 1 hit.
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio917164.

Entry information

Entry nameUBC21_CAEEL
AccessionPrimary (citable) accession number: P52484
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 25, 2012
Last modified: June 11, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase