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Reviewed, UniProtKB/Swiss-Prot P52482 (UB2E1_MOUSE)

Last modified November 3, 2009. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ubiquitin-conjugating enzyme E2 E1
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase E1
    Ubiquitin carrier protein E1
    UbcM3
Gene names
Name: Ube2e1
Synonyms: Ubce5, Ubcm3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with RNF14.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 193193Ubiquitin-conjugating enzyme E2 E1
PRO_0000082471

Regions

Compositional bias9 – 1810Poly-Ser

Sites

Active site1311Glycyl thioester intermediate By similarity

Amino acid modifications

Modified residue771Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P52482-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: B535B3095EF6C445

FASTA19321,333
        10         20         30         40         50         60 
MSDDDSRAST SSSSSSSSNQ QTEKEGSTPK KKESKVSMSK NSKLLSTSAK RIQKELADIT 

        70         80         90        100        110        120 
LDPPPNCSAG PKGDNIYEWR STILGPPGSV YEGGVFFLDI TFTPEYPFKP PKVTFRTRIY 

       130        140        150        160        170        180 
HCNINSQGVI CLDILKDNWS PALTISKVLL SICSLLTDCN PADPLVGSIA TQYMTNRAEH 

       190 
DRMARQWTKR YAT 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel family of ubiquitin-conjugating enzymes with distinct amino-terminal extensions."
Matuschewski K., Hauser H.P., Treier M., Jentsch S.
J. Biol. Chem. 271:2789-2794(1996) [PubMed: 8576256] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

X92665 mRNA. Translation: CAA63353.1.
BC003781 mRNA. Translation: AAH03781.1.
IPIIPI00127542.
RefSeqNP_033481.1.
UniGeneMm.4429

3D structure databases

HSSPHSSP built from PDB template 1QCQ based on UniProtKB P15731.
SMRP52482. Positions 46-193.
ModBaseSearch...

Protein-protein interaction databases

STRINGP52482.

PTM databases

PhosphoSiteP52482.

Proteomic databases

PRIDEP52482.

Genome annotation databases

EnsemblENSMUST00000022296; ENSMUSP00000022296; ENSMUSG00000021774; Mus musculus. [Genome view]
GeneID22194.
KEGGmmu:22194.
UCSCuc007shu.1. mouse.

Organism-specific databases

CTD22194.
MGIMGI:107411. Ube2e1.

Phylogenomic databases

HOGENOMP52482.
HOVERGENP52482.
OMAKETNAPK.

Enzyme and pathway databases

BRENDA6.3.2.19. 244.

Gene expression databases

ArrayExpressP52482.
BgeeP52482.
GenevestigatorP52482.
GermOnlineENSMUSG00000021774. Mus musculus.

Family and domain databases

InterProIPR016135. UBQ-conjugat/RWD-like.
IPR000608. UBQ-conjugat_E2.
[Graphical view]
Gene3DG3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
ProDomPD000461. UBQ_conjugat. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00212. UBCc. 1 hit.
[Graphical view]
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio302173.
SOURCESearch...

Entry information

Entry nameUB2E1_MOUSE
AccessionPrimary (citable) accession number: P52482
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 3, 2009
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents