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Protein

Adenylyl cyclase-associated protein 2

Gene

Cap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have a regulatory bifunctional role.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl cyclase-associated protein 2
Short name:
CAP 2
Gene namesi
Name:Cap2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi620310. Cap2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002057022 – 477Adenylyl cyclase-associated protein 2Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei301PhosphoserineCombined sources1
Modified residuei309PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP52481.
PRIDEiP52481.

PTM databases

iPTMnetiP52481.
PhosphoSitePlusiP52481.

Expressioni

Tissue specificityi

Found at relatively high levels in testes, at moderate levels in brain, heart and skeletal muscle, at lower levels in lung, skin, kidney and small intestine, and is undetectable in liver or spleen.

Gene expression databases

BgeeiENSRNOG00000043350.
GenevisibleiP52481. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250538. 1 interactor.
STRINGi10116.ENSRNOP00000062591.

Structurei

3D structure databases

ProteinModelPortaliP52481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini318 – 455C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST138

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi233 – 247Poly-ProAdd BLAST15

Sequence similaritiesi

Belongs to the CAP family.Curated
Contains 1 C-CAP/cofactor C-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2675. Eukaryota.
ENOG410XPXJ. LUCA.
GeneTreeiENSGT00390000017955.
HOVERGENiHBG003080.
InParanoidiP52481.
KOiK17261.
OMAiAQGGQTR.
OrthoDBiEOG091G0DLX.
PhylomeDBiP52481.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
InterProiIPR001837. Adenylate_cyclase-assoc_CAP.
IPR013912. Adenylate_cyclase-assoc_CAP_C.
IPR013992. Adenylate_cyclase-assoc_CAP_N.
IPR017901. C-CAP_CF_C-like.
IPR016098. CAP/MinC_C.
IPR028418. CAP2.
IPR028417. CAP_CS_C.
IPR018106. CAP_CS_N.
IPR006599. CARP_motif.
[Graphical view]
PANTHERiPTHR10652. PTHR10652. 1 hit.
PTHR10652:SF2. PTHR10652:SF2. 1 hit.
PfamiPF08603. CAP_C. 1 hit.
PF01213. CAP_N. 1 hit.
[Graphical view]
SMARTiSM00673. CARP. 2 hits.
[Graphical view]
SUPFAMiSSF101278. SSF101278. 1 hit.
SSF69340. SSF69340. 1 hit.
PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
PS01088. CAP_1. 1 hit.
PS01089. CAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADMLGLMQR LEFAVSRLER LSSGLHEPPG GCGEVNSLSR GIVAPSVEAF
60 70 80 90 100
DKLINSMVAE FLKNSRVLAG DVETHAEMVH GAFQAQRAFL LMVSQHQQPQ
110 120 130 140 150
ENEVAVLLKP ISEKIQEIQT FRERNRGSDM FNHLSAVSES IAALGWIAVS
160 170 180 190 200
PKPGPYVKEM NDAATFYTNR VLRDYKHSDL RHVDWVRSYL KIWSELQAYI
210 220 230 240 250
KEHHTTGLTW SKTGPVASTA SAFSILSSGP GLPPPPPPPP PPGPPPPFEN
260 270 280 290 300
EGGKEEPSPS RSALFAQLNQ GEAITKGLRH VTDDKKIYKN PSLRAQGQIR
310 320 330 340 350
SPTKTRTPSP TSSKSNSPQK HAPVLELEGK KWRVEYQEDR NDLVISETEL
360 370 380 390 400
KQVAYIFKCD KSTLQIKGKV NSITVDNCKK FGLVFDHVVG IVEVINSKDI
410 420 430 440 450
QIQVMGRVPT ISINKTEGCH LYLSKDALDC EIVSAKSSEM NVLVPQGDDY
460 470
REFPIPEQFK TIWDGSKLIT EPAEIMA
Length:477
Mass (Da):52,912
Last modified:October 1, 1996 - v1
Checksum:iCFCD65E8F256655B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31935 mRNA. Translation: AAA92298.1.
PIRiJC4386.
RefSeqiNP_446326.1. NM_053874.1.
XP_006253815.1. XM_006253753.3.
XP_006253816.1. XM_006253754.2.
UniGeneiRn.10229.

Genome annotation databases

EnsembliENSRNOT00000065742; ENSRNOP00000062591; ENSRNOG00000043350.
ENSRNOT00000078992; ENSRNOP00000074020; ENSRNOG00000043350.
GeneIDi116653.
KEGGirno:116653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31935 mRNA. Translation: AAA92298.1.
PIRiJC4386.
RefSeqiNP_446326.1. NM_053874.1.
XP_006253815.1. XM_006253753.3.
XP_006253816.1. XM_006253754.2.
UniGeneiRn.10229.

3D structure databases

ProteinModelPortaliP52481.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250538. 1 interactor.
STRINGi10116.ENSRNOP00000062591.

PTM databases

iPTMnetiP52481.
PhosphoSitePlusiP52481.

Proteomic databases

PaxDbiP52481.
PRIDEiP52481.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000065742; ENSRNOP00000062591; ENSRNOG00000043350.
ENSRNOT00000078992; ENSRNOP00000074020; ENSRNOG00000043350.
GeneIDi116653.
KEGGirno:116653.

Organism-specific databases

CTDi10486.
RGDi620310. Cap2.

Phylogenomic databases

eggNOGiKOG2675. Eukaryota.
ENOG410XPXJ. LUCA.
GeneTreeiENSGT00390000017955.
HOVERGENiHBG003080.
InParanoidiP52481.
KOiK17261.
OMAiAQGGQTR.
OrthoDBiEOG091G0DLX.
PhylomeDBiP52481.

Miscellaneous databases

PROiP52481.

Gene expression databases

BgeeiENSRNOG00000043350.
GenevisibleiP52481. RN.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
InterProiIPR001837. Adenylate_cyclase-assoc_CAP.
IPR013912. Adenylate_cyclase-assoc_CAP_C.
IPR013992. Adenylate_cyclase-assoc_CAP_N.
IPR017901. C-CAP_CF_C-like.
IPR016098. CAP/MinC_C.
IPR028418. CAP2.
IPR028417. CAP_CS_C.
IPR018106. CAP_CS_N.
IPR006599. CARP_motif.
[Graphical view]
PANTHERiPTHR10652. PTHR10652. 1 hit.
PTHR10652:SF2. PTHR10652:SF2. 1 hit.
PfamiPF08603. CAP_C. 1 hit.
PF01213. CAP_N. 1 hit.
[Graphical view]
SMARTiSM00673. CARP. 2 hits.
[Graphical view]
SUPFAMiSSF101278. SSF101278. 1 hit.
SSF69340. SSF69340. 1 hit.
PROSITEiPS51329. C_CAP_COFACTOR_C. 1 hit.
PS01088. CAP_1. 1 hit.
PS01089. CAP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAP2_RAT
AccessioniPrimary (citable) accession number: P52481
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.