##gff-version 3 P52480 UniProtKB Chain 1 531 . . . ID=PRO_0000112089;Note=Pyruvate kinase PKM P52480 UniProtKB Region 307 531 . . . Note=Interaction with POU5F1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Region 389 433 . . . Note=Intersubunit contact P52480 UniProtKB Binding site 70 70 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 73 73 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P52480 UniProtKB Binding site 75 78 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 75 75 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 77 77 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 106 106 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 113 113 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 114 114 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 120 120 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 207 207 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 270 270 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P52480 UniProtKB Binding site 272 272 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 295 295 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P52480 UniProtKB Binding site 296 296 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 296 296 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P52480 UniProtKB Binding site 328 328 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P30613 P52480 UniProtKB Binding site 432 437 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 464 464 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 482 482 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 489 489 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Binding site 516 521 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Site 270 270 . . . Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P00549 P52480 UniProtKB Site 433 433 . . . Note=Crucial for phosphotyrosine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Modified residue 3 3 . . . Note=N6%2CN6%2CN6-trimethyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Modified residue 37 37 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Modified residue 41 41 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Modified residue 62 62 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 P52480 UniProtKB Modified residue 66 66 . . . Note=N6-succinyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 P52480 UniProtKB Modified residue 89 89 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Modified residue 97 97 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11980 P52480 UniProtKB Modified residue 100 100 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P11980 P52480 UniProtKB Modified residue 105 105 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18034455;Dbxref=PMID:18034455 P52480 UniProtKB Modified residue 127 127 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Modified residue 148 148 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18034455;Dbxref=PMID:18034455 P52480 UniProtKB Modified residue 166 166 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 P52480 UniProtKB Modified residue 166 166 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 P52480 UniProtKB Modified residue 175 175 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Modified residue 195 195 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Modified residue 266 266 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Modified residue 270 270 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 P52480 UniProtKB Modified residue 305 305 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Modified residue 322 322 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 P52480 UniProtKB Modified residue 322 322 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 P52480 UniProtKB Modified residue 403 403 . . . Note=4-hydroxyproline;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Modified residue 408 408 . . . Note=4-hydroxyproline;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Modified residue 433 433 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Modified residue 475 475 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 P52480 UniProtKB Modified residue 498 498 . . . Note=N6-succinyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 P52480 UniProtKB Cross-link 115 115 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Cross-link 166 166 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Cross-link 266 266 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Cross-link 270 270 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14618 P52480 UniProtKB Alternative sequence 389 433 . . . ID=VSP_025057;Note=In isoform M1. IYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTK->MFHRLLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16141072;Dbxref=PMID:16141072 P52480 UniProtKB Mutagenesis 367 367 . . . Note=Abolishes pyruvate kinase activity without affecting interaction with the ribosome. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28575669;Dbxref=PMID:28575669 P52480 UniProtKB Mutagenesis 464 464 . . . Note=Abolishes amino-acid binding without affecting interaction with the translating ribosome. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28575669;Dbxref=PMID:28575669 P52480 UniProtKB Sequence conflict 8 8 . . . Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 P52480 UniProtKB Sequence conflict 121 121 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 P52480 UniProtKB Sequence conflict 158 158 . . . Note=W->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 P52480 UniProtKB Sequence conflict 166 166 . . . Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 P52480 UniProtKB Sequence conflict 170 170 . . . Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 P52480 UniProtKB Sequence conflict 177 177 . . . Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P52480 UniProtKB Sequence conflict 230 230 . . . Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 P52480 UniProtKB Sequence conflict 299 299 . . . Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 P52480 UniProtKB Sequence conflict 309 309 . . . Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P52480 UniProtKB Sequence conflict 327 327 . . . Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P52480 UniProtKB Sequence conflict 333 333 . . . Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 P52480 UniProtKB Sequence conflict 485 485 . . . Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305