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P52478

- UBC1_CAEEL

UniProt

P52478 - UBC1_CAEEL

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Protein
Ubiquitin-conjugating enzyme E2 1
Gene
ubc-1, C35B1.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro
  3. damaged DNA binding Source: WormBase
  4. protein binding Source: IntAct
  5. ubiquitin protein ligase binding Source: WormBase
  6. ubiquitin-protein transferase activity Source: WormBase
Complete GO annotation...

GO - Biological processi

  1. DNA repair Source: WormBase
  2. protein ubiquitination Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 1 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein 1
Ubiquitin-protein ligase 1
Gene namesi
Name:ubc-1
ORF Names:C35B1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiC35B1.1; CE27822; WBGene00006701; ubc-1.

Pathology & Biotechi

Disruption phenotypei

Worms are viable, fertile, and do not show any obvious anomaly.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Ubiquitin-conjugating enzyme E2 1
PRO_0000082514Add
BLAST

Proteomic databases

PaxDbiP52478.

Interactioni

Subunit structurei

Interacts with ubr-1 and rfp-1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
rfp-1P345377EBI-316677,EBI-316712

Protein-protein interaction databases

BioGridi42306. 11 interactions.
IntActiP52478. 8 interactions.
MINTiMINT-226915.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1815
Beta strandi24 – 296
Beta strandi32 – 4110
Beta strandi44 – 463
Turni47 – 504
Beta strandi52 – 587
Turni61 – 655
Beta strandi69 – 746
Beta strandi85 – 873
Helixi90 – 923
Turni93 – 953
Helixi102 – 11110
Helixi124 – 1329
Helixi134 – 14815
Turni149 – 1513

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q34X-ray2.90A/B/C1-163[»]
1Z3DX-ray2.50A1-154[»]
ProteinModelPortaliP52478.
SMRiP52478. Positions 2-152.

Miscellaneous databases

EvolutionaryTraceiP52478.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00730000110565.
HOGENOMiHOG000233454.
InParanoidiP52478.
KOiK10573.
OMAiIVEQSWV.
PhylomeDBiP52478.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P52478-1 [UniParc]FASTAAdd to Basket

« Hide

MTTPSRRRLM RDFKKLQEDP PAGVSGAPTE DNILTWEAII FGPQETPFED    50
GTFKLSLEFT EEYPNKPPTV KFISKMFHPN VYADGSICLD ILQNRWSPTY 100
DVAAILTSIQ SLLDEPNPNS PANSLAAQLY QENRREYEKR VQQIVEQSWL 150
NFGENEGDAV LKDDVEIEEI AAPGANDADD DRMDEGASGS NA 192
Length:192
Mass (Da):21,513
Last modified:October 1, 1996 - v1
Checksum:i7CF26B8FB96EF33D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U08139 Genomic DNA. Translation: AAA83388.1.
FO080784 Genomic DNA. Translation: CCD66736.1.
PIRiT32959.
RefSeqiNP_500480.1. NM_068079.5.
UniGeneiCel.18169.

Genome annotation databases

EnsemblMetazoaiC35B1.1; C35B1.1; WBGene00006701.
GeneIDi177170.
KEGGicel:CELE_C35B1.1.
UCSCiC35B1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U08139 Genomic DNA. Translation: AAA83388.1 .
FO080784 Genomic DNA. Translation: CCD66736.1 .
PIRi T32959.
RefSeqi NP_500480.1. NM_068079.5.
UniGenei Cel.18169.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Q34 X-ray 2.90 A/B/C 1-163 [» ]
1Z3D X-ray 2.50 A 1-154 [» ]
ProteinModelPortali P52478.
SMRi P52478. Positions 2-152.
ModBasei Search...

Protein-protein interaction databases

BioGridi 42306. 11 interactions.
IntActi P52478. 8 interactions.
MINTi MINT-226915.

Proteomic databases

PaxDbi P52478.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C35B1.1 ; C35B1.1 ; WBGene00006701 .
GeneIDi 177170.
KEGGi cel:CELE_C35B1.1.
UCSCi C35B1.1. c. elegans.

Organism-specific databases

CTDi 177170.
WormBasei C35B1.1 ; CE27822 ; WBGene00006701 ; ubc-1.

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00730000110565.
HOGENOMi HOG000233454.
InParanoidi P52478.
KOi K10573.
OMAi IVEQSWV.
PhylomeDBi P52478.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

EvolutionaryTracei P52478.
NextBioi 895652.
PROi P52478.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Caenorhabditis elegans UBC-1, a ubiquitin-conjugating enzyme homologous to yeast RAD6/UBC2, contains a novel carboxy-terminal extension that is conserved in nematodes."
    Leggett D.S., Jones D., Candido E.P.M.
    DNA Cell Biol. 14:883-891(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Characterization of C. elegans RING finger protein 1, a binding partner of ubiquitin-conjugating enzyme 1."
    Crowe E., Candido E.P.M.
    Dev. Biol. 265:446-459(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBR-1 AND RFP-1, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiUBC1_CAEEL
AccessioniPrimary (citable) accession number: P52478
Secondary accession number(s): O45062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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