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Protein

Ubiquitin-conjugating enzyme E2 1

Gene

ubc-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotationCurated

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ubiquitin conjugating enzyme activity Source: WormBase
  • ubiquitin protein ligase activity Source: GO_Central
  • ubiquitin protein ligase binding Source: WormBase

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 1 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 1
Ubiquitin carrier protein 1
Ubiquitin-protein ligase 1
Gene namesi
Name:ubc-1
ORF Names:C35B1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC35B1.1 ; CE27822 ; WBGene00006701 ; ubc-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Worms are viable, fertile, and do not show any obvious anomaly.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825141 – 192Ubiquitin-conjugating enzyme E2 1Add BLAST192

Proteomic databases

EPDiP52478
PaxDbiP52478
PeptideAtlasiP52478
PRIDEiP52478

Expressioni

Gene expression databases

BgeeiWBGene00006701

Interactioni

Subunit structurei

Interacts with ubr-1 and rfp-1 (PubMed:14732404). Interacts with ubc-13 (PubMed:15530417).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
rfp-1P345377EBI-316677,EBI-316712

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: WormBase

Protein-protein interaction databases

BioGridi42306, 12 interactors
DIPiDIP-24573N
IntActiP52478, 8 interactors
MINTiP52478
STRINGi6239.C35B1.1.1

Structurei

Secondary structure

1192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 18Combined sources15
Beta strandi24 – 29Combined sources6
Beta strandi32 – 41Combined sources10
Beta strandi44 – 46Combined sources3
Turni47 – 50Combined sources4
Beta strandi52 – 58Combined sources7
Turni61 – 65Combined sources5
Beta strandi69 – 74Combined sources6
Beta strandi85 – 87Combined sources3
Helixi90 – 92Combined sources3
Turni93 – 95Combined sources3
Helixi102 – 111Combined sources10
Helixi124 – 132Combined sources9
Helixi134 – 148Combined sources15
Turni149 – 151Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q34X-ray2.90A/B/C1-163[»]
1Z3DX-ray2.50A1-154[»]
ProteinModelPortaliP52478
SMRiP52478
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP52478

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0419 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00900000140930
HOGENOMiHOG000233454
InParanoidiP52478
KOiK10573
OMAiRENMKEY
OrthoDBiEOG091G0UM8
PhylomeDBiP52478

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P52478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTPSRRRLM RDFKKLQEDP PAGVSGAPTE DNILTWEAII FGPQETPFED
60 70 80 90 100
GTFKLSLEFT EEYPNKPPTV KFISKMFHPN VYADGSICLD ILQNRWSPTY
110 120 130 140 150
DVAAILTSIQ SLLDEPNPNS PANSLAAQLY QENRREYEKR VQQIVEQSWL
160 170 180 190
NFGENEGDAV LKDDVEIEEI AAPGANDADD DRMDEGASGS NA
Length:192
Mass (Da):21,513
Last modified:October 1, 1996 - v1
Checksum:i7CF26B8FB96EF33D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08139 Genomic DNA Translation: AAA83388.1
FO080784 Genomic DNA Translation: CCD66736.1
PIRiT32959
RefSeqiNP_500480.1, NM_068079.5
UniGeneiCel.18169

Genome annotation databases

EnsemblMetazoaiC35B1.1; C35B1.1; WBGene00006701
GeneIDi177170
KEGGicel:CELE_C35B1.1
UCSCiC35B1.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiUBC1_CAEEL
AccessioniPrimary (citable) accession number: P52478
Secondary accession number(s): O45062
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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