ALDH1B1

Functionⁱ

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. In the cornea, this enzyme may help in the absorption of the damaging UV-B, as well as in the detoxification of the UV-induced peroxidic aldehydes.

Catalytic activityⁱ

An aldehyde + NAD⁺ + H₂O = a carboxylate + NADH.

Pathwayⁱ: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

no protein annotated in this organism
Aldehyde dehydrogenase X, mitochondrial (ALDH1B1), Aldehyde dehydrogenase family 3 member B1 (ALDH3B1), Aldehyde dehydrogenase, mitochondrial (ALDH2)

This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	180	Transition state stabilizerBy similarity	1
Active siteⁱ	279	Proton acceptorBy similarity	1
Active siteⁱ	313	NucleophileBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	256 – 261	NADBy similarity		6

GO - Molecular functionⁱ

aldehyde dehydrogenase (NAD) activity Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

ethanol catabolic process Source: UniProtKB-UniPathway

Complete GO annotation...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	NAD

Enzyme and pathway databases

UniPathwayⁱ	UPA00780; UER00768.

UniPathwayⁱ

UPA00780; UER00768.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aldehyde dehydrogenase X, mitochondrial (EC:1.2.1.3) Alternative name(s): ALDH class 2 ALDHX Aldehyde dehydrogenase family 1 member B1
Gene namesⁱ	Name:ALDH1B1 Synonyms:ALDH1B2, ALDH5, ALDHX
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Unplaced

Keywords - Cellular componentⁱ

Mitochondrion

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	‹1 – 11	MitochondrionSequence analysisAdd BLAST		›11
ChainⁱPRO_0000056477	12 – 511	Aldehyde dehydrogenase X, mitochondrialAdd BLAST		500

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	45	N6-acetyllysineBy similarity	1
Modified residueⁱ	46	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	46	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	75	N6-succinyllysineBy similarity	1
Modified residueⁱ	377	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	377	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	393	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	393	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	420	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	420	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	423	N6-acetyllysineBy similarity	1

Keywords - PTMⁱ

Acetylation

Proteomic databases

PaxDbⁱ	P52476.

PaxDbⁱ

P52476.

Interactionⁱ

Subunit structureⁱ

Homotetramer.By similarity

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000027172.

STRINGⁱ

9913.ENSBTAP00000027172.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P52476.
SMRⁱ	P52476.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG2450. Eukaryota. COG1012. LUCA.
HOGENOMⁱ	HOG000271505.
HOVERGENⁱ	HBG000097.
InParanoidⁱ	P52476.

Family and domain databases

Gene3Dⁱ	3.40.605.10. 1 hit.
InterProⁱ	View protein in InterPro IPR016161. Ald_DH/histidinol_DH. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00171. Aldedh. 1 hit.
SUPFAMⁱ	SSF53720. SSF53720. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P52476-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
PRLFALHHSA TQYFSAAALP SPIPNPDIPD NQLFISNKWH DAVSKKTFPT 
        60         70         80         90        100
VSPATGEVIG HVAEGDWADV DLAAKAARAA FRLGSPWRWM DALKRGWLLN 
       110        120        130        140        150
HLADLVERDC VYLASLESLD NGKPFQESYV LDLDEVIKVY RYFAGWADKW 
       160        170        180        190        200
HGKTIPMDGE HFCFTRHEPV GVCCQIIPWN FPLVMQSWKL ALALAMGNTV 
       210        220        230        240        250
VTKVAEQTPF SALYLASLIK EVGLPPGLVN IVTGYGPTAG AAIAHHMDIG 
       260        270        280        290        300
KVAFTGSTKV GHLIQKAAGN SSLKRVTLEL GGKSLSIVLA DADMDHAVEQ 
       310        320        330        340        350
RQEALFFNMG QCCCPGSWTF IEESIYDEFL ERTVEKAKQR RVGNPFDLDT 
       360        370        380        390        400
QQGPQVDRER FERILGYIQL GQKEGAKLLC GGEHFRQQCF FIKPTVFGGV 
       410        420        430        440        450
QDDMRIAREE IFGPVQPLFK FKKIEEVIER ADNTRYGLAA AVFTQDLDKA 
       460        470        480        490        500
MYFTQALQTG TVWVNTYNVV TCHTPLGGFK EPGNGRELGE DGLKAYTEVK 
       510 
TVTIKVPQKN S

Length:511

Mass (Da):56,770

Last modified:January 9, 2007 - v2

Checksum:ⁱD032C6E84D9799B3

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1			1
Sequence conflictⁱ	308	N → S in AAB26659 (PubMed:8493893).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAFC03050684 Genomic DNA. No translation available. S61045 mRNA. Translation: AAB26659.1.
PIRⁱ	I46935.
UniGeneⁱ	Bt.13145.

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P52476	G5E5P4	Bos taurus (Bovine)	511	UniRef100_P52476	Cluster: Aldehyde dehydrogenase X, mitochondrial (Fragment)	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P52476	G5E5P4 UPI0003C00F99 UPI0001D56DB4 UPI000576CADF UPI00042CCAA6	Bos taurus (Bovine) Bos mutus (wild yak) Bison bison bison Bubalus bubalis (Domestic water buffalo)	511	UniRef90_P52476	Cluster: Aldehyde dehydrogenase X, mitochondrial (Fragment)	6

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P52476	P00352 V9HW83 G2HJM2 B4DDF8 UPI0007DB8ED3 Q5SYQ8 Q5SYQ7 UPI00083F4552 UPI0007DBCEAB UPI0005F546A2 +663	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Papio anubis (Olive baboon) Macaca nemestrina (Pig-tailed macaque) Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) Octodon degus (Degu) (Sciurus degus) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Oryctolagus cuniculus (Rabbit) Octopus bimaculoides (California two-spotted octopus) Anthracocystis flocculosa PF-1 And more	501	UniRef50_P00352	Cluster: Retinal dehydrogenase 1	674

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAFC03050684 Genomic DNA. No translation available. S61045 mRNA. Translation: AAB26659.1.
PIRⁱ	I46935.
UniGeneⁱ	Bt.13145.

3D structure databases

ProteinModelPortalⁱ	P52476.
SMRⁱ	P52476.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000027172.

STRINGⁱ

9913.ENSBTAP00000027172.

Proteomic databases

PaxDbⁱ	P52476.

PaxDbⁱ

P52476.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	KOG2450. Eukaryota. COG1012. LUCA.
HOGENOMⁱ	HOG000271505.
HOVERGENⁱ	HBG000097.
InParanoidⁱ	P52476.

Enzyme and pathway databases

UniPathwayⁱ	UPA00780; UER00768.

UniPathwayⁱ

UPA00780; UER00768.

Family and domain databases

Gene3Dⁱ	3.40.605.10. 1 hit.
InterProⁱ	View protein in InterPro IPR016161. Ald_DH/histidinol_DH. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00171. Aldedh. 1 hit.
SUPFAMⁱ	SSF53720. SSF53720. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AL1B1_BOVIN
Accessionⁱ	P52476Primary (citable) accession number: P52476
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	January 9, 2007
	Last modified:	August 30, 2017
	This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P52476 (AL1B1_BOVIN)

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Aldehyde dehydrogenase X, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: ethanol degradation

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: ethanol degradation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ