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P52476 (AL1B1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase X, mitochondrial
EC=1.2.1.3
Alternative name(s):
ALDH class 2
ALDHX
Aldehyde dehydrogenase family 1 member B1
Gene names
Name:ALDH1B1
Synonyms:ALDH1B2, ALDH5, ALDHX
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length511 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. In the cornea, this enzyme may help in the absorption of the damaging UV-B, as well as in the detoxification of the UV-induced peroxidic aldehydes.

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandNAD
   Molecular functionOxidoreductase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processethanol catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide‹1 – 11›11Mitochondrion Potential
Chain12 – 511500Aldehyde dehydrogenase X, mitochondrial
PRO_0000056477

Regions

Nucleotide binding256 – 2616NAD By similarity

Sites

Active site2791Proton acceptor By similarity
Active site3131Nucleophile By similarity
Site1801Transition state stabilizer By similarity

Amino acid modifications

Modified residue451N6-acetyllysine By similarity
Modified residue461N6-acetyllysine; alternate By similarity
Modified residue461N6-succinyllysine; alternate By similarity
Modified residue751N6-succinyllysine By similarity
Modified residue3771N6-acetyllysine; alternate By similarity
Modified residue3771N6-succinyllysine; alternate By similarity
Modified residue3931N6-acetyllysine; alternate By similarity
Modified residue3931N6-succinyllysine; alternate By similarity
Modified residue4201N6-acetyllysine; alternate By similarity
Modified residue4201N6-succinyllysine; alternate By similarity
Modified residue4231N6-acetyllysine By similarity

Experimental info

Sequence conflict3081N → S in AAB26659. Ref.2
Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P52476 [UniParc].

Last modified January 9, 2007. Version 2.
Checksum: D032C6E84D9799B3

FASTA51156,770
        10         20         30         40         50         60 
PRLFALHHSA TQYFSAAALP SPIPNPDIPD NQLFISNKWH DAVSKKTFPT VSPATGEVIG 

        70         80         90        100        110        120 
HVAEGDWADV DLAAKAARAA FRLGSPWRWM DALKRGWLLN HLADLVERDC VYLASLESLD 

       130        140        150        160        170        180 
NGKPFQESYV LDLDEVIKVY RYFAGWADKW HGKTIPMDGE HFCFTRHEPV GVCCQIIPWN 

       190        200        210        220        230        240 
FPLVMQSWKL ALALAMGNTV VTKVAEQTPF SALYLASLIK EVGLPPGLVN IVTGYGPTAG 

       250        260        270        280        290        300 
AAIAHHMDIG KVAFTGSTKV GHLIQKAAGN SSLKRVTLEL GGKSLSIVLA DADMDHAVEQ 

       310        320        330        340        350        360 
RQEALFFNMG QCCCPGSWTF IEESIYDEFL ERTVEKAKQR RVGNPFDLDT QQGPQVDRER 

       370        380        390        400        410        420 
FERILGYIQL GQKEGAKLLC GGEHFRQQCF FIKPTVFGGV QDDMRIAREE IFGPVQPLFK 

       430        440        450        460        470        480 
FKKIEEVIER ADNTRYGLAA AVFTQDLDKA MYFTQALQTG TVWVNTYNVV TCHTPLGGFK 

       490        500        510 
EPGNGRELGE DGLKAYTEVK TVTIKVPQKN S

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of taurine cattle: a window to ruminant biology and evolution."
The bovine genome sequencing and analysis consortium
Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hereford.
[2]"Bovine corneal aldehyde dehydrogenases: evidence for multiple gene products (ALDH3 and ALDHX)."
Algar E.M., Cheung B., Hayes J., Holmes R.S., Beacham I.R.
Adv. Exp. Med. Biol. 328:153-157(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 284-409.
Tissue: Cornea.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAFC03050684 Genomic DNA. No translation available.
S61045 mRNA. Translation: AAB26659.1.
PIRI46935.
UniGeneBt.13145.

3D structure databases

ProteinModelPortalP52476.
SMRP52476. Positions 18-511.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000027172.

Proteomic databases

PRIDEP52476.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
HOVERGENHBG000097.
InParanoidP52476.

Enzyme and pathway databases

UniPathwayUPA00780; UER00768.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAL1B1_BOVIN
AccessionPrimary (citable) accession number: P52476
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

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