UniProtKB - P52476 (AL1B1_BOVIN)
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Protein
Aldehyde dehydrogenase X, mitochondrial
Gene
ALDH1B1
Organism
Bos taurus (Bovine)
Status
Functioni
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. In the cornea, this enzyme may help in the absorption of the damaging UV-B, as well as in the detoxification of the UV-induced peroxidic aldehydes.
Catalytic activityi
An aldehyde + NAD+ + H2O = a carboxylate + NADH.
: ethanol degradation Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Aldehyde dehydrogenase X, mitochondrial (ALDH1B1), Aldehyde dehydrogenase, mitochondrial (ALDH2), Aldehyde dehydrogenase family 3 member B1 (ALDH3B1)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 180 | Transition state stabilizerBy similarity | 1 | |
Active sitei | 279 | Proton acceptorBy similarity | 1 | |
Active sitei | 313 | NucleophileBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 256 – 261 | NADBy similarity | 6 |
GO - Molecular functioni
- aldehyde dehydrogenase (NAD) activity Source: GO_Central
GO - Biological processi
- ethanol catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
UniPathwayi | UPA00780; UER00768. |
Names & Taxonomyi
Protein namesi | Recommended name: Aldehyde dehydrogenase X, mitochondrial (EC:1.2.1.3)Alternative name(s): ALDH class 2 ALDHX Aldehyde dehydrogenase family 1 member B1 |
Gene namesi | Name:ALDH1B1 Synonyms:ALDH1B2, ALDH5, ALDHX |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | ‹1 – 11 | MitochondrionSequence analysisAdd BLAST | ›11 | |
ChainiPRO_0000056477 | 12 – 511 | Aldehyde dehydrogenase X, mitochondrialAdd BLAST | 500 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 45 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 46 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 46 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 75 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 377 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 377 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 393 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 393 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 420 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 420 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 423 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | P52476. |
Interactioni
Subunit structurei
Homotetramer.By similarity
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000027172. |
Structurei
3D structure databases
ProteinModelPortali | P52476. |
SMRi | P52476. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2450. Eukaryota. COG1012. LUCA. |
HOGENOMi | HOG000271505. |
HOVERGENi | HBG000097. |
InParanoidi | P52476. |
Family and domain databases
Gene3Di | 3.40.309.10. 1 hit. 3.40.605.10. 2 hits. |
InterProi | View protein in InterPro IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. |
Pfami | View protein in Pfam PF00171. Aldedh. 1 hit. |
SUPFAMi | SSF53720. SSF53720. 1 hit. |
i Sequence
Sequence statusi: Fragment.
: The displayed sequence is further processed into a mature form. Sequence processingi
P52476-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
PRLFALHHSA TQYFSAAALP SPIPNPDIPD NQLFISNKWH DAVSKKTFPT
60 70 80 90 100
VSPATGEVIG HVAEGDWADV DLAAKAARAA FRLGSPWRWM DALKRGWLLN
110 120 130 140 150
HLADLVERDC VYLASLESLD NGKPFQESYV LDLDEVIKVY RYFAGWADKW
160 170 180 190 200
HGKTIPMDGE HFCFTRHEPV GVCCQIIPWN FPLVMQSWKL ALALAMGNTV
210 220 230 240 250
VTKVAEQTPF SALYLASLIK EVGLPPGLVN IVTGYGPTAG AAIAHHMDIG
260 270 280 290 300
KVAFTGSTKV GHLIQKAAGN SSLKRVTLEL GGKSLSIVLA DADMDHAVEQ
310 320 330 340 350
RQEALFFNMG QCCCPGSWTF IEESIYDEFL ERTVEKAKQR RVGNPFDLDT
360 370 380 390 400
QQGPQVDRER FERILGYIQL GQKEGAKLLC GGEHFRQQCF FIKPTVFGGV
410 420 430 440 450
QDDMRIAREE IFGPVQPLFK FKKIEEVIER ADNTRYGLAA AVFTQDLDKA
460 470 480 490 500
MYFTQALQTG TVWVNTYNVV TCHTPLGGFK EPGNGRELGE DGLKAYTEVK
510
TVTIKVPQKN S
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 | ||
Sequence conflicti | 308 | N → S in AAB26659 (PubMed:8493893).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFC03050684 Genomic DNA. No translation available. S61045 mRNA. Translation: AAB26659.1. |
PIRi | I46935. |
UniGenei | Bt.13145. |
Similar proteinsi
Entry informationi
Entry namei | AL1B1_BOVIN | |
Accessioni | P52476Primary (citable) accession number: P52476 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | January 9, 2007 | |
Last modified: | February 28, 2018 | |
This is version 116 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |