ALDH1B1

Functionⁱ

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. In the cornea, this enzyme may help in the absorption of the damaging UV-B, as well as in the detoxification of the UV-induced peroxidic aldehydes.

Catalytic activityⁱ

An aldehyde + NAD⁺ + H₂O = a carboxylate + NADH.

Pathwayⁱ: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

no protein annotated in this organism
Aldehyde dehydrogenase X, mitochondrial (ALDH1B1), Aldehyde dehydrogenase, mitochondrial (ALDH2), Aldehyde dehydrogenase family 3 member B1 (ALDH3B1)

This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature key	Position(s)	Length	Description
Siteⁱ	180 – 180	1	Transition state stabilizerBy similarity
Active siteⁱ	279 – 279	1	Proton acceptorBy similarity
Active siteⁱ	313 – 313	1	NucleophileBy similarity

Regions

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Nucleotide bindingⁱ	256 – 261	6	NADBy similarity

GO - Molecular functionⁱ

aldehyde dehydrogenase (NAD) activity Source: GO_Central

GO - Biological processⁱ

ethanol catabolic process Source: UniProtKB-UniPathway

Complete GO annotation...

Keywords - Molecular functionⁱ

Oxidoreductase

Keywords - Ligandⁱ

NAD

Enzyme and pathway databases

UniPathwayⁱ	UPA00780; UER00768.

UniPathwayⁱ

UPA00780; UER00768.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aldehyde dehydrogenase X, mitochondrial (EC:1.2.1.3) Alternative name(s): ALDH class 2 ALDHX Aldehyde dehydrogenase family 1 member B1
Gene namesⁱ	Name:ALDH1B1 Synonyms:ALDH1B2, ALDH5, ALDHX
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Unplaced

Subcellular locationⁱ

Mitochondrion matrix By similarity

GO - Cellular componentⁱ

mitochondrial matrix Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Mitochondrion

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Transit peptideⁱ	‹1 – 11	›11	MitochondrionSequence analysis			Add BLAST
Chainⁱ	12 – 511	500	Aldehyde dehydrogenase X, mitochondrial		PRO_0000056477	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description
Modified residueⁱ	45 – 45	1	N6-acetyllysineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:Q9CZS1 (AL1B1_MOUSE)
Modified residueⁱ	46 – 46	1	N6-acetyllysine; alternateBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:Q9CZS1 (AL1B1_MOUSE)
Modified residueⁱ	46 – 46	1	N6-succinyllysine; alternateBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:Q9CZS1 (AL1B1_MOUSE)
Modified residueⁱ	75 – 75	1	N6-succinyllysineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:Q9CZS1 (AL1B1_MOUSE)
Modified residueⁱ	377 – 377	1	N6-acetyllysine; alternateBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:Q9CZS1 (AL1B1_MOUSE)
Modified residueⁱ	377 – 377	1	N6-succinyllysine; alternateBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:Q9CZS1 (AL1B1_MOUSE)
Modified residueⁱ	393 – 393	1	N6-acetyllysine; alternateBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:Q9CZS1 (AL1B1_MOUSE)
Modified residueⁱ	393 – 393	1	N6-succinyllysine; alternateBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:Q9CZS1 (AL1B1_MOUSE)
Modified residueⁱ	420 – 420	1	N6-acetyllysine; alternateBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:Q9CZS1 (AL1B1_MOUSE)
Modified residueⁱ	420 – 420	1	N6-succinyllysine; alternateBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:Q9CZS1 (AL1B1_MOUSE)
Modified residueⁱ	423 – 423	1	N6-acetyllysineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:Q9CZS1 (AL1B1_MOUSE)

Keywords - PTMⁱ

Acetylation

Proteomic databases

PaxDbⁱ	P52476.
PRIDEⁱ	P52476.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSBTAG00000020385.

Bgeeⁱ

ENSBTAG00000020385.

Interactionⁱ

Subunit structureⁱ

Homotetramer.By similarity

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000027172.

STRINGⁱ

9913.ENSBTAP00000027172.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P52476.
SMRⁱ	P52476. Positions 18-511.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG2450. Eukaryota. COG1012. LUCA.
HOGENOMⁱ	HOG000271505.
HOVERGENⁱ	HBG000097.
InParanoidⁱ	P52476.

Family and domain databases

Gene3Dⁱ	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterProⁱ	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfamⁱ	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAMⁱ	SSF53720. SSF53720. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P52476-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
PRLFALHHSA TQYFSAAALP SPIPNPDIPD NQLFISNKWH DAVSKKTFPT 
        60         70         80         90        100
VSPATGEVIG HVAEGDWADV DLAAKAARAA FRLGSPWRWM DALKRGWLLN 
       110        120        130        140        150
HLADLVERDC VYLASLESLD NGKPFQESYV LDLDEVIKVY RYFAGWADKW 
       160        170        180        190        200
HGKTIPMDGE HFCFTRHEPV GVCCQIIPWN FPLVMQSWKL ALALAMGNTV 
       210        220        230        240        250
VTKVAEQTPF SALYLASLIK EVGLPPGLVN IVTGYGPTAG AAIAHHMDIG 
       260        270        280        290        300
KVAFTGSTKV GHLIQKAAGN SSLKRVTLEL GGKSLSIVLA DADMDHAVEQ 
       310        320        330        340        350
RQEALFFNMG QCCCPGSWTF IEESIYDEFL ERTVEKAKQR RVGNPFDLDT 
       360        370        380        390        400
QQGPQVDRER FERILGYIQL GQKEGAKLLC GGEHFRQQCF FIKPTVFGGV 
       410        420        430        440        450
QDDMRIAREE IFGPVQPLFK FKKIEEVIER ADNTRYGLAA AVFTQDLDKA 
       460        470        480        490        500
MYFTQALQTG TVWVNTYNVV TCHTPLGGFK EPGNGRELGE DGLKAYTEVK 
       510 
TVTIKVPQKN S

Length:511

Mass (Da):56,770

Last modified:January 9, 2007 - v2

Checksum:ⁱD032C6E84D9799B3

GO

Experimental Info

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Non-terminal residueⁱ	1 – 1	1
Sequence conflictⁱ	308 – 308	1	N → S in AAB26659 (PubMed:8493893).Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAFC03050684 Genomic DNA. No translation available. S61045 mRNA. Translation: AAB26659.1.
PIRⁱ	I46935.
UniGeneⁱ	Bt.13145.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAFC03050684 Genomic DNA. No translation available. S61045 mRNA. Translation: AAB26659.1.
PIRⁱ	I46935.
UniGeneⁱ	Bt.13145.

3D structure databases

ProteinModelPortalⁱ	P52476.
SMRⁱ	P52476. Positions 18-511.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000027172.

STRINGⁱ

9913.ENSBTAP00000027172.

Proteomic databases

PaxDbⁱ	P52476.
PRIDEⁱ	P52476.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	KOG2450. Eukaryota. COG1012. LUCA.
HOGENOMⁱ	HOG000271505.
HOVERGENⁱ	HBG000097.
InParanoidⁱ	P52476.

Enzyme and pathway databases

UniPathwayⁱ	UPA00780; UER00768.

UniPathwayⁱ

UPA00780; UER00768.

Gene expression databases

Bgeeⁱ	ENSBTAG00000020385.

Bgeeⁱ

ENSBTAG00000020385.

Family and domain databases

Gene3Dⁱ	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterProⁱ	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfamⁱ	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAMⁱ	SSF53720. SSF53720. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

AL1B1_BOVIN

Accessionⁱ

Primary (citable) accession number: P52476

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 9, 2007
Last modified:	September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P52476 (AL1B1_BOVIN)

UniProt

P52476 - AL1B1_BOVIN

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Aldehyde dehydrogenase X, mitochondrial

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>Describes the metabolic pathway(s) associated with a protein.</p><p><a href='../manual/pathway' target='_top'>More...</a></p>Pathwayi: ethanol degradation

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: ethanol degradation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ