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P52476 - AL1B1_BOVIN

UniProt

P52476 - AL1B1_BOVIN

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Protein

Aldehyde dehydrogenase X, mitochondrial

Gene

ALDH1B1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. In the cornea, this enzyme may help in the absorption of the damaging UV-B, as well as in the detoxification of the UV-induced peroxidic aldehydes.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei180 – 1801Transition state stabilizerBy similarity
Active sitei279 – 2791Proton acceptorBy similarity
Active sitei313 – 3131NucleophileBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi256 – 2616NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase X, mitochondrial (EC:1.2.1.3)
Alternative name(s):
ALDH class 2
ALDHX
Aldehyde dehydrogenase family 1 member B1
Gene namesi
Name:ALDH1B1
Synonyms:ALDH1B2, ALDH5, ALDHX
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei‹1 – 11›11MitochondrionSequence AnalysisAdd
BLAST
Chaini12 – 511500Aldehyde dehydrogenase X, mitochondrialPRO_0000056477Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451N6-acetyllysineBy similarity
Modified residuei46 – 461N6-acetyllysine; alternateBy similarity
Modified residuei46 – 461N6-succinyllysine; alternateBy similarity
Modified residuei75 – 751N6-succinyllysineBy similarity
Modified residuei377 – 3771N6-acetyllysine; alternateBy similarity
Modified residuei377 – 3771N6-succinyllysine; alternateBy similarity
Modified residuei393 – 3931N6-acetyllysine; alternateBy similarity
Modified residuei393 – 3931N6-succinyllysine; alternateBy similarity
Modified residuei420 – 4201N6-acetyllysine; alternateBy similarity
Modified residuei420 – 4201N6-succinyllysine; alternateBy similarity
Modified residuei423 – 4231N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP52476.

Expressioni

Gene expression databases

ExpressionAtlasiP52476. baseline.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027172.

Structurei

3D structure databases

ProteinModelPortaliP52476.
SMRiP52476. Positions 18-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiP52476.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P52476-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
PRLFALHHSA TQYFSAAALP SPIPNPDIPD NQLFISNKWH DAVSKKTFPT 
        60         70         80         90        100
VSPATGEVIG HVAEGDWADV DLAAKAARAA FRLGSPWRWM DALKRGWLLN 
       110        120        130        140        150
HLADLVERDC VYLASLESLD NGKPFQESYV LDLDEVIKVY RYFAGWADKW 
       160        170        180        190        200
HGKTIPMDGE HFCFTRHEPV GVCCQIIPWN FPLVMQSWKL ALALAMGNTV 
       210        220        230        240        250
VTKVAEQTPF SALYLASLIK EVGLPPGLVN IVTGYGPTAG AAIAHHMDIG 
       260        270        280        290        300
KVAFTGSTKV GHLIQKAAGN SSLKRVTLEL GGKSLSIVLA DADMDHAVEQ 
       310        320        330        340        350
RQEALFFNMG QCCCPGSWTF IEESIYDEFL ERTVEKAKQR RVGNPFDLDT 
       360        370        380        390        400
QQGPQVDRER FERILGYIQL GQKEGAKLLC GGEHFRQQCF FIKPTVFGGV 
       410        420        430        440        450
QDDMRIAREE IFGPVQPLFK FKKIEEVIER ADNTRYGLAA AVFTQDLDKA 
       460        470        480        490        500
MYFTQALQTG TVWVNTYNVV TCHTPLGGFK EPGNGRELGE DGLKAYTEVK 
       510 
TVTIKVPQKN S
Length:511
Mass (Da):56,770
Last modified:January 9, 2007 - v2
Checksum:iD032C6E84D9799B3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Sequence conflicti308 – 3081N → S in AAB26659. (PubMed:8493893)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03050684 Genomic DNA. No translation available.
S61045 mRNA. Translation: AAB26659.1.
PIRiI46935.
UniGeneiBt.13145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03050684 Genomic DNA. No translation available.
S61045 mRNA. Translation: AAB26659.1.
PIRiI46935.
UniGeneiBt.13145.

3D structure databases

ProteinModelPortaliP52476.
SMRiP52476. Positions 18-511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027172.

Proteomic databases

PRIDEiP52476.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiP52476.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Gene expression databases

ExpressionAtlasiP52476. baseline.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
    The bovine genome sequencing and analysis consortium
    Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.
  2. "Bovine corneal aldehyde dehydrogenases: evidence for multiple gene products (ALDH3 and ALDHX)."
    Algar E.M., Cheung B., Hayes J., Holmes R.S., Beacham I.R.
    Adv. Exp. Med. Biol. 328:153-157(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 284-409.
    Tissue: Cornea.

Entry informationi

Entry nameiAL1B1_BOVIN
AccessioniPrimary (citable) accession number: P52476
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 9, 2007
Last modified: January 7, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.