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P52476

- AL1B1_BOVIN

UniProt

P52476 - AL1B1_BOVIN

Protein

Aldehyde dehydrogenase X, mitochondrial

Gene

ALDH1B1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. In the cornea, this enzyme may help in the absorption of the damaging UV-B, as well as in the detoxification of the UV-induced peroxidic aldehydes.

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei180 – 1801Transition state stabilizerBy similarity
    Active sitei279 – 2791Proton acceptorBy similarity
    Active sitei313 – 3131NucleophileBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi256 – 2616NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase X, mitochondrial (EC:1.2.1.3)
    Alternative name(s):
    ALDH class 2
    ALDHX
    Aldehyde dehydrogenase family 1 member B1
    Gene namesi
    Name:ALDH1B1
    Synonyms:ALDH1B2, ALDH5, ALDHX
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei‹1 – 11›11MitochondrionSequence AnalysisAdd
    BLAST
    Chaini12 – 511500Aldehyde dehydrogenase X, mitochondrialPRO_0000056477Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei45 – 451N6-acetyllysineBy similarity
    Modified residuei46 – 461N6-acetyllysine; alternateBy similarity
    Modified residuei46 – 461N6-succinyllysine; alternateBy similarity
    Modified residuei75 – 751N6-succinyllysineBy similarity
    Modified residuei377 – 3771N6-acetyllysine; alternateBy similarity
    Modified residuei377 – 3771N6-succinyllysine; alternateBy similarity
    Modified residuei393 – 3931N6-acetyllysine; alternateBy similarity
    Modified residuei393 – 3931N6-succinyllysine; alternateBy similarity
    Modified residuei420 – 4201N6-acetyllysine; alternateBy similarity
    Modified residuei420 – 4201N6-succinyllysine; alternateBy similarity
    Modified residuei423 – 4231N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP52476.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000027172.

    Structurei

    3D structure databases

    ProteinModelPortaliP52476.
    SMRiP52476. Positions 18-511.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    HOVERGENiHBG000097.
    InParanoidiP52476.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P52476-1 [UniParc]FASTAAdd to Basket

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    PRLFALHHSA TQYFSAAALP SPIPNPDIPD NQLFISNKWH DAVSKKTFPT    50
    VSPATGEVIG HVAEGDWADV DLAAKAARAA FRLGSPWRWM DALKRGWLLN 100
    HLADLVERDC VYLASLESLD NGKPFQESYV LDLDEVIKVY RYFAGWADKW 150
    HGKTIPMDGE HFCFTRHEPV GVCCQIIPWN FPLVMQSWKL ALALAMGNTV 200
    VTKVAEQTPF SALYLASLIK EVGLPPGLVN IVTGYGPTAG AAIAHHMDIG 250
    KVAFTGSTKV GHLIQKAAGN SSLKRVTLEL GGKSLSIVLA DADMDHAVEQ 300
    RQEALFFNMG QCCCPGSWTF IEESIYDEFL ERTVEKAKQR RVGNPFDLDT 350
    QQGPQVDRER FERILGYIQL GQKEGAKLLC GGEHFRQQCF FIKPTVFGGV 400
    QDDMRIAREE IFGPVQPLFK FKKIEEVIER ADNTRYGLAA AVFTQDLDKA 450
    MYFTQALQTG TVWVNTYNVV TCHTPLGGFK EPGNGRELGE DGLKAYTEVK 500
    TVTIKVPQKN S 511
    Length:511
    Mass (Da):56,770
    Last modified:January 9, 2007 - v2
    Checksum:iD032C6E84D9799B3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Sequence conflicti308 – 3081N → S in AAB26659. (PubMed:8493893)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFC03050684 Genomic DNA. No translation available.
    S61045 mRNA. Translation: AAB26659.1.
    PIRiI46935.
    UniGeneiBt.13145.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFC03050684 Genomic DNA. No translation available.
    S61045 mRNA. Translation: AAB26659.1 .
    PIRi I46935.
    UniGenei Bt.13145.

    3D structure databases

    ProteinModelPortali P52476.
    SMRi P52476. Positions 18-511.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000027172.

    Proteomic databases

    PRIDEi P52476.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    HOVERGENi HBG000097.
    InParanoidi P52476.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
      The bovine genome sequencing and analysis consortium
      Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hereford.
    2. "Bovine corneal aldehyde dehydrogenases: evidence for multiple gene products (ALDH3 and ALDHX)."
      Algar E.M., Cheung B., Hayes J., Holmes R.S., Beacham I.R.
      Adv. Exp. Med. Biol. 328:153-157(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 284-409.
      Tissue: Cornea.

    Entry informationi

    Entry nameiAL1B1_BOVIN
    AccessioniPrimary (citable) accession number: P52476
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3