P52465 (UL34_HHV6U) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Virion egress protein U34

Alternative name(s):
Primary envelopment factor U34

Gene names

Name:	U34
Synonyms:	XILF2

Organism

Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) [Reference proteome]

Taxonomic identifier

10370 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Roseolovirus › Human herpesvirus 6A

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays a major role in virion nuclear egress, the first step of virion release from infected cell. Viral capsids are initially assembled within the nucleus, U37/U34 complex induces capsids budding and envelopment into the perinuclear space. Then U37/U34 complex promotes fusion of perinuclear virion envelope with the outer nuclear membrane, releasing viral capsid into the cytoplasm where it will engages budding sites in the Golgi or trans-Golgi network By similarity.
Subunit structure	Forms a complex with protein U37 By similarity.
Subcellular location	Host nucleus inner membrane; Single-pass membrane protein. Note: Localizes also at the transient membrane of perinuclear virions By similarity.
Sequence similarities	Belongs to the herpesviridae UL34 family.

Ontologies

Keywords
Cellular component	Host membrane Host nucleus Membrane
Developmental stage	Late protein
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell nuclear inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Virion egress protein U34		PRO_0000116029
Regions
	Topological domain	1 – 245	245	Perinuclear space Potential
	Transmembrane	246 – 264	19	Helical; Potential
	Topological domain	265 – 276	12	Nuclear Potential
	Region	124 – 163	40	Interaction with protein U37 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P52465 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 5C5ED509CF9CE937	FASTA	276	31,671
	10 20 30 40 50 60 MANVLKEKMY DELLSATCRI LKLGSHDYRI TERNLLSKNP KFPLCDIILK LDYAYNLEYL 70 80 90 100 110 120 LSLWEHVTKQ EPRFVFKNTG GAVSMSCYLH APVKVEGHHA VRECNILRVN ECLTVRMSDI 130 140 150 160 170 180 VAMKPSTFAV FTKCIIRRNR DDTYVVEFVA FGPENESEYI SLLKAIFLKK CSMGKQHLES 190 200 210 220 230 240 NRFCQGLRRR SSHVLEKGRF ESSGKVVNKA SAVVTSQESI KQFYEKEKSL LSGVKFWRLS 250 260 270 ERHCRFALVG ICFLLALYFC YVLLKKTPTP ASGSVV

References

[1]

"The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution." Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J., Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A. Virology 209:29-51(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X83413 Genomic DNA. Translation: CAA58414.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
ProtClustDB	PHA3326.
Family and domain databases
InterPro	IPR007626. Herpesvirus_viron_egress-type. [Graphical view]
Pfam	PF04541. Herpes_U34. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UL34_HHV6U

Accession

Primary (citable) accession number: P52465

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program