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Protein

Portal protein

Gene

U76

Organism
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocates the viral DNA, termed terminase.UniRule annotation

GO - Biological processi

Keywordsi

Biological processViral genome packaging, Viral release from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Portal proteinUniRule annotation
Gene namesi
Name:U76
Synonyms:HDLF1
OrganismiHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Taxonomic identifieri10370 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009295 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001159071 – 662Portal proteinAdd BLAST662

Interactioni

Subunit structurei

Homododecamerizes. Interacts with terminase subunits TRM1 and TRM3.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae portal protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900002I.

Family and domain databases

HAMAPiMF_04012. HSV_PORTL. 1 hit.
InterProiView protein in InterPro
IPR002660. Herpes_Portal.
PfamiView protein in Pfam
PF01763. Herpes_UL6. 1 hit.

Sequencei

Sequence statusi: Complete.

P52453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRASANSLL NSVSGSMMWR NQSSGRRPSK RLSDNEATLS TINSILGAED
60 70 80 90 100
MLSKNLLSYL PPNNEEIDMI YPSEQIMTFI EMLHGHKNFF KGQTIHNALR
110 120 130 140 150
DSAVLKKQIA YGVAQALLNS VSIQQIHDEW KRHVRSFPFH NKKLSFQDYF
160 170 180 190 200
SVWAHAIKQV ILGDISNIIN FILQSIDNSH YNRYVDWICT VGIVPFMRTT
210 220 230 240 250
HTAPNLYNLL QQVSSKLIHD IVRHKQNIVT PVLLGLSSVI IPDFHNIKIF
260 270 280 290 300
RDRNSEQISC FKNKKAIAFF TYSTPYVIRN RLMLTTPLAH LSPELKKHNS
310 320 330 340 350
LRRHQKMCQL LNTFPIKVLT TAKTDVTNKK IMDMIEKEEK SSDAKKSLIK
360 370 380 390 400
FLLNLSDSKS KIGIRDSVEG FIQEITPSII DQNKLMLNRG QFRKRSAIDT
410 420 430 440 450
GERDVRDLFK KQIIKCMEEQ IQTQMDEIET LKTTNQMFER KIKDLHSLLE
460 470 480 490 500
TNNDCDRYNP NLDHDLENLS LSRALNIVQR LPFTSVSIDD TRSVANSFFS
510 520 530 540 550
QYIPDTQYAD KRIDQLWEME YMRTFRLRKN VNNQGQEESI TYSNYSIELL
560 570 580 590 600
IVPFLRRFLN IYNLESIPEE FLFLSLGEIL LAIYESSKIK HYLRLVYVRE
610 620 630 640 650
LNQISEVFNL TQTHPENSEP IFDSNIFSPN PENEILEKIK RIRNLRRIQH
660
LTRPNYPKGD QD
Length:662
Mass (Da):77,235
Last modified:October 1, 1996 - v1
Checksum:i95D555757B3A7F99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13194 Genomic DNA. Translation: AAA68467.1.
X83413 Genomic DNA. Translation: CAA58368.1.

Similar proteinsi

Entry informationi

Entry nameiPORTL_HHV6U
AccessioniPrimary (citable) accession number: P52453
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families